In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 17, No. 1 ( 2023-1-24), p. e0011084-
Kurzfassung:
Canine Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and transmitted by insect triatomine vectors known as kissing bugs. The agent can cause cardiac damage and long-term heart disease and death in humans, dogs, and other mammals. In laboratory settings, treatment of dogs with systemic insecticides has been shown to be highly efficacious at killing triatomines that feed on treated dogs. Method We developed compartmental vector-host models of T . cruzi transmission between the triatomine and dog population accounting for the impact of seasonality and triatomine migration on disease transmission dynamics. We considered a single vector-host model without seasonality, and model with seasonality, and a spatially coupled model. We used the models to evaluate the effectiveness of the insecticide fluralaner with different durations of treatment regimens for reducing T . cruzi infection in different transmission settings. Results In low and medium transmission settings, our model showed a marginal difference between the 3-month and 6-month regimens for reducing T . cruzi infection among dogs. The difference increases in the presence of seasonality and triatomine migration from a sylvatic transmission setting. In high transmission settings, the 3-month regimen was substantially more effective in reducing T . cruzi infections in dogs than the other regimens. Our model showed that increased migration rate reduces fluralaner effectiveness in all treatment regimens, but the relative reduction in effectiveness is minimal during the first years of treatment. However, if an additional 10% or more of triatomines killed by dog treatment were eaten by dogs, treatment could increase T . cruzi infections in the dog population at least during the first year of treatment. Conclusion Our analysis shows that treating all peridomestic dogs every three to six months for at least five years could be an effective measure to reduce T . cruzi infections in dogs and triatomines in peridomestic transmission settings. However, further studies at the local scale are needed to better understand the potential impact of routine use of fluralaner treatment on increasing dogs’ consumption of dead triatomines.
Materialart:
Online-Ressource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0011084
DOI:
10.1371/journal.pntd.0011084.g001
DOI:
10.1371/journal.pntd.0011084.g002
DOI:
10.1371/journal.pntd.0011084.g003
DOI:
10.1371/journal.pntd.0011084.g004
DOI:
10.1371/journal.pntd.0011084.g005
DOI:
10.1371/journal.pntd.0011084.g006
DOI:
10.1371/journal.pntd.0011084.g007
DOI:
10.1371/journal.pntd.0011084.g008
DOI:
10.1371/journal.pntd.0011084.g009
DOI:
10.1371/journal.pntd.0011084.g010
DOI:
10.1371/journal.pntd.0011084.t001
DOI:
10.1371/journal.pntd.0011084.t002
DOI:
10.1371/journal.pntd.0011084.s001
DOI:
10.1371/journal.pntd.0011084.s002
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2023
ZDB Id:
2429704-5
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