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  • 1
    Online Resource
    Online Resource
    External quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in primary laboratories in Germany
    Springer Science and Business Media LLC ; 2020
    In:  BMC Infectious Diseases Vol. 20, No. 1 ( 2020-12)
    Details
    In: BMC Infectious Diseases, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: Worldwide, an increase in antimicrobial resistance (AMR) of Neisseria gonorrhoeae has been observed. Until now, no protocol for an external quality assessment (EQA) has been available for Germany. The German gonococcal resistance network (GORENET) performed an EQA of primary laboratories in Germany in order to assess quality of antibiotic susceptibility testing, to gain information about laboratory procedures and to assess the impact of these procedures on test results. Methods Laboratories assessed drug susceptibility to cefixime, ceftriaxone, azithromycin, penicillin and ciprofloxacin for five N. gonorrhoeae strains, using their standard laboratory protocols. Minimal inhibitory concentrations (MICs) were compared to World Health Organisation (WHO) consensus results (or, if not available, reference laboratory results), while deviation by +/− one doubling dilution was accepted. Data on laboratory procedures were collected via a standardised questionnaire. Generalized linear models and conditional inference trees (CTREE) were used to assess relationships between laboratory procedures and testing outcomes. Results Twenty-one primary laboratories participated in the EQA in June 2018. 96% of ciprofloxacin MICs were reported within accepted deviations, as well as 88% for cefixime, 85% for ceftriaxone, 79% for penicillin and 70% for azithromycin. The use of interpretation standards and general laboratory procedures like agar base, incubation settings or the use of control strains strongly differed between laboratories. In statistical analysis, incubation time of cultures 〈  24 h was associated with correct measurements. Additionally, a 5% CO 2 concentration was associated with correct results regarding azithromycin compared to 3%. CTREE analysis showed that incubation time, humidity and CO 2 concentration had the greatest influence on the average deviation from consensus results. Conclusions In conclusion, we report the development of a protocol for N. gonorrhoeae antimicrobial susceptibility testing in Germany. While testing results were in accordance with the expected consensus results in 70–96%, depending on the antibiotic agent, laboratory methodology was heterogeneous and may significantly affect the testing quality. We therefore recommend the development of a standard operating procedure (SOP) for N. gonorrhoeae susceptibility testing in Germany.
    Type of Medium: Online Resource
    ISSN: 1471-2334
    URL: Article
    DOI: 10.1186/s12879-020-05234-w
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2041550-3
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  • 2
    Online Resource
    Online Resource
    The Digital Calibration Certificate (DCC) for an End-to-End Digital Quality Infrastructure for Industry 4.0
    MDPI AG ; 2023
    In:  Sci Vol. 5, No. 1 ( 2023-03-06), p. 11-
    Details
    In: Sci, MDPI AG, Vol. 5, No. 1 ( 2023-03-06), p. 11-
    Abstract: This article depicts the role of the Digital Calibration Certificate (DCC) for an end-to-end digital quality infrastructure and as the basis for developments that are designated by the keyword “Industry 4.0”. Furthermore, it describes the impact the DCC has on increasing productivity in the manufacturing of products and in global trade. The DCC project is international in its scope. Calibration certificates document the measurement capability of a measurement system. They do this independently and by providing traceability to measurement standards. Therefore, they do not only play an important role in the world of metrology, but they also make it possible for manufacturing and commercial enterprises to exchange measurement values reliably and correctly at the national and at the international level. Thus, a DCC concept is urgently needed for the end-to-end digitalization of industry for the era of Industry 4.0 and for Medicine 4.0. A DCC brings about important advantages for issuers and for users. The DCC leads to the stringent, end-to-end, traceable and process-oriented organization of manufacturing and trading. Digitalization is thus a key factor in the field of calibration as it enables significant improvements in product and process quality. The reason for this is that the transmission of errors will be prevented, and consequently, costs will be saved as the time needed for distributing and disseminating the DCCs and the respective calibration objects will be reduced. Furthermore, it will no longer be necessary for the test equipment administration staff to update the data manually, which is a time-consuming, tedious and error-prone process.
    Type of Medium: Online Resource
    ISSN: 2413-4155
    URL: Article
    DOI: 10.3390/sci5010011
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2963087-3
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  • 3
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    The fundamental architecture of the DCC
    Elsevier BV ; 2021
    In:  Measurement: Sensors Vol. 18 ( 2021-12), p. 100354-
    Details
    In: Measurement: Sensors, Elsevier BV, Vol. 18 ( 2021-12), p. 100354-
    Type of Medium: Online Resource
    ISSN: 2665-9174
    URL: Article
    DOI: 10.1016/j.measen.2021.100354
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 3068852-8
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  • 4
    Online Resource
    Online Resource
    Automatic Information Exchange in the Early Rescue Chain Using the International Standard Accident Number (ISAN)
    MDPI AG ; 2021
    In:  Healthcare Vol. 9, No. 8 ( 2021-08-04), p. 996-
    Details
    In: Healthcare, MDPI AG, Vol. 9, No. 8 ( 2021-08-04), p. 996-
    Abstract: Thus far, emergency calls are answered by human operators who interview the calling person in order to obtain all relevant information. In the near future—based on the Internet of (Medical) Things (IoT, IoMT)—accidents, emergencies, or adverse health events will be reported automatically by smart homes, smart vehicles, or smart wearables, without any human in the loop. Several parties are involved in this communication: the alerting system, the rescue service (responding system), and the emergency department in the hospital (curing system). In many countries, these parties use isolated information and communication technology (ICT) systems. Previously, the International Standard Accident Number (ISAN) has been proposed to securely link the data in these systems. In this work, we propose an ISAN-based communication platform that allows semantically interoperable information exchange. Our aims are threefold: (i) to enable data exchange between the isolated systems, (ii) to avoid data misinterpretation, and (iii) to integrate additional data sources. The suggested platform is composed of an alerting, responding, and curing system manager, a workflow manager, and a communication manager. First, the ICT systems of all parties in the early rescue chain register with their according system manager, which tracks the keep-alive. In case of emergency, the alerting system sends an ISAN to the platform. The responsible rescue services and hospitals are determined and interconnected for platform-based communication. Next to the conceptual design of the platform, we evaluate a proof-of-concept implementation according to (1) the registration, (2) channel establishment, (3) data encryption, (4) event alert, and (5) information exchange. Our concept meets the requirements for scalability, error handling, and information security. In the future, it will be used to implement a virtual accident registry.
    Type of Medium: Online Resource
    ISSN: 2227-9032
    URL: Article
    DOI: 10.3390/healthcare9080996
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2721009-1
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  • 5
    Online Resource
    Online Resource
    Maschinenlesbares und maschineninterpretierbares digitales Kalibrierzertifikat (DCC) und sein Einsatz in der Praxis
    Walter de Gruyter GmbH ; 2023
    In:  tm - Technisches Messen Vol. 0, No. 0 ( 2023-03-02)
    Details
    In: tm - Technisches Messen, Walter de Gruyter GmbH, Vol. 0, No. 0 ( 2023-03-02)
    Abstract: Der Prototyp eines maschinenlesbaren und maschineninterpretierbaren Digitalen Kalibrierscheins (DCC, engl. D igital C alibration C ertificate) wurde bereits im Jahr 2017 in den PTB-Mitteilungen [S. Hackel, F. Härtig, J. Hornig, und T. Wiedenhöfer, The Digital Calibration Certificate, PTB-Mitteilungen, vol. 127, Bd. 4, S. 7, 2017 [Online]. Verfügbar unter: https://oar.ptb.de/resources/show/10.7795/310.20170403 [Zugegriffen: Jul. 2, 2019].] veröffentlicht. Die Idee basiert auf dem im Jahr 2016 von der PTB skizzierten europäischen Forschungsvorhaben SmartCom (17IND02) [,,Welcome to SmartCom”, 2021 [Online]. Verfügbar unter: https://www.ptb.de/empir2018/smartcom/project/ [Zugegriffen: Februar. 15, 2023]; EURAMET-European Association of National Metrology Institutes, ,,Communication and validation of smart data in IoT-networks”, EURAMET , 2023 [Online]. Verfügbar unter: https://www.euramet.org/research-innovation/search-research-projects/details/project/communication-and-validation-of-smart-data-in-iot- networks [Zugegriffen: Februar. 15, 2023.] und ist seit dem Jahr 2017 integraler Bestandteil des Digitalisierungskonzepts der PTB. Der DCC bietet die weltweit eindeutige Identifikation und Speicherung der Eigenschaften eines beliebigen Kalibriergegenstandes und leistet damit mehr als den reinen Nachweis der metrologischen Rückführung. Der von der PTB prototypisch entwickelte DCC beruht auf dem Austauschformat XML und ist dami t sowohl zukunftssicher maschinenlesbar als auch maschineninterpretierbar. Darüber hinaus sind alle Anforderungen der DIN ISO 17025 [DIN EN ISO/IEC 17025:2018-03, Allgemeine Anforderungen an die Kompetenz von Prüf- und Kalibrierlaboratorien (ISO/IEC_17025:2017); Deutsche und Englische Fassung EN_ISO/IEC_17025:2017, Beuth Verlag GmbH [Online]. Verfügbar unter: https://www.beuth.de/de/-/-/278030106 [Zugegriffen: Sept. 24, 2021].] berücksichtigt. Für die Darstellung von Messwerten wurde im Projekt SmartCom ein auf den SI-Einheiten basiertes Datenmodell entworfen und ein prototypisches XML-Datenaustauschformat entwickelt. Dieses als D-SI (digitales SI [D. Hutzschenreuter u.a., SmartCom Digital-SI (D-SI) XML Exchange Format for Metrological Data Version 2.0.0, 2021 [Online]. Verfügbar unter: https://zenodo.org/record/4709001 [Zugegriffen: Mär. 10, 2022].] ) bezeichnete Format bildet unter anderem die Grundlage für die Angabe von Messdaten im DCC. Darüber hinaus ist es nutzbar für jeglichen anderen Austausch metrologischer Informationen. Alle Angaben einschließlich numerischer Kalibrierkurven können aus dem DCC heraus direkt und automatisiert in digitale Prozesse übernommen werden. Kryptografische Signaturen als Sicherungsverfahren sorgen für die Integrität und Authentizität eines DCC. Alle Konzepte wurden mit Partnern in Europa und der Welt diskutiert, abgestimmt und werden weiterentwickelt.
    Type of Medium: Online Resource
    ISSN: 0171-8096 , 2196-7113
    URL: Article
    DOI: 10.1515/teme-2022-0117
    RVK:
    ZG 1100
    RVK:
    ZS 0001
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2023
    detail.hit.zdb_id: 2025790-9
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    Proposing an International Standard Accident Number for Interconnecting Information and Communication Technology Systems of the Rescue Chain
    Georg Thieme Verlag KG ; 2021
    In:  Methods of Information in Medicine Vol. 60, No. S 01 ( 2021-06), p. e20-e31
    Details
    In: Methods of Information in Medicine, Georg Thieme Verlag KG, Vol. 60, No. S 01 ( 2021-06), p. e20-e31
    Abstract: Background The rapid dissemination of smart devices within the internet of things (IoT) is developing toward automatic emergency alerts which are transmitted from machine to machine without human interaction. However, apart from individual projects concentrating on single types of accidents, there is no general methodology of connecting the standalone information and communication technology (ICT) systems involved in an accident: systems for alerting (e.g., smart home/car/wearable), systems in the responding stage (e.g., ambulance), and in the curing stage (e.g., hospital). Objectives We define the International Standard Accident Number (ISAN) as a unique token for interconnecting these ICT systems and to provide embedded data describing the circumstances of an accident (time, position, and identifier of the alerting system). Materials and Methods Based on the characteristics of processes and ICT systems in emergency care, we derive technological, syntactic, and semantic requirements for the ISAN, and we analyze existing standards to be incorporated in the ISAN specification. Results We choose a set of formats for describing the embedded data and give rules for their combination to generate an ISAN. It is a compact alphanumeric representation that is generated easily by the alerting system. We demonstrate generation, conversion, analysis, and visualization via representational state transfer (REST) services. Although ISAN targets machine-to-machine communication, we give examples of graphical user interfaces. Conclusion Created either locally by the alerting IoT system or remotely using our RESTful service, the ISAN is a simple and flexible token that enables technological, syntactic, and semantic interoperability between all ICT systems in emergency care.
    Type of Medium: Online Resource
    ISSN: 0026-1270 , 2511-705X
    URL: Article
    DOI: 10.1055/s-0041-1728676
    RVK:
    XA 10000
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2021
    detail.hit.zdb_id: 3500-2
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