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  • 1
    Publication Date: 2024-02-28
    Description: Accurate spatiotemporal precipitation quantification is a crucial prerequisite for hydrological analyses. The optimal reconstruction of the spatial distribution, that is, the rainfall patterns, is particularly challenging. In this study, we reconstructed spatial rainfall on a countrywide scale for Germany by combining commercial microwave link and rain gauge observations for a better representation of the variability and spatial structure of rainfall. We further developed and applied the Random‐Mixing‐Whittaker‐Shannon method, enabling the stochastic reconstruction of ensembles of spatial fields via linear combinations of unconditional random fields. The pattern of rainfall objects is evaluated by three performance characteristics, that is, ensemble Structure‐, Amplitude‐, and Location‐error. Precipitation estimates obtained are in good agreement with the gauge‐adjusted weather radar product RADOLAN‐RW of the German Weather Service (DWD) which was used as a reference. Compared to reconstructions by Ordinary Kriging, Random Mixing showed clear advantages in the pattern representation via a five times smaller median structure error.
    Description: Plain Language Summary: Rainfall is commonly measured by dedicated sensors such as rain gauges or weather radars. Commercial microwave links (CMLs), which have the primary purpose of signal forwarding within cellular networks, can be used for rainfall measurements too. The signal, which is transmitted from one antenna to another, is being attenuated if it rains along the path. From the amount of attenuation an average rain rate can be retrieved. For many hydrological applications, it is of major interest to estimate area‐wide rainfall (i.e., rainfall maps) while observations provide only scattered information. In this study, we used the local information from almost 1,000 rain gauges and the information along the paths of 3,900 CMLs distributed over Germany to reconstruct rainfall maps. We did this by applying a method of stochastic simulation (called Random Mixing) which we compared to a more common method of estimation (Ordinary Kriging). To evaluate the quality of the obtained maps, we compared them to rainfall information from weather radars. We found that the general agreement is high, and that maps reconstructed by Random Mixing have particular advantages in representing the spatial structure, that is, the shape of rainfall cells.
    Description: Key Points: Geostatistical Random Mixing simulation now capable of countrywide spatial rainfall interpolation. Variability assessment via commercial microwave link path consideration and ensemble estimation. Realistic rainfall pattern representation quantified by ensemble Structure‐, Amplitude‐, and Location‐error metrics.
    Description: German Research Foundation
    Description: Federal Ministry of Education and Research
    Description: https://doi.org/10.5281/zenodo.4810169
    Description: https://opendata.dwd.de/climate_environment/CDC
    Description: https://maps.dwd.de/geoserver/web/wicket/bookmarkable/org.geoserver.web.demo.SRSDescriptionPage?10 26code=EPSG:1000001
    Description: https://doi.org/10.5281/zenodo.5380342
    Description: https://doi.org/10.5281/zenodo.7048941
    Description: https://doi.org/10.5281/zenodo.7049826
    Description: https://doi.org/10.5281/zenodo.7049846
    Keywords: ddc:551.5 ; precipitation estimation ; geostatistical simulation ; spatial pattern analysis ; commercial microwave links ; rain gauges ; random mixing
    Language: English
    Type: doc-type:article
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  • 2
    Publication Date: 2012-06-06
    Description: Background:  Peripheral immunoregulation depends on T regulatory cell trafficking into the allograft in order to modulate the local alloresponse. Little is known about the relevance of trafficking receptors for Tregs after solid organ transplantation in humans. In this study expression of the peripheral chemokine receptors CXCR3 and CCR5 on CD4 + FOXP3 + Treg cells subsets was analyzed and correlated with allograft function in renal transplant recipients. Methods:  Flow cytometry analysis of peripheral blood mononuclear cells of 54 renal transplant recipients receiving a calcineurininhibitorbased immunosuppression was performed for CD4, CD25, FOXP3, and CXCR3 and CCR5 within the first 18 months posttransplantation. Correlation analysis of chemokine receptor expression and glomerular filtration rate as calculated by MDRD (eGFR) was performed. Results:  Expression of the peripheral homing receptors CXCR3 (r=0.44, p〈0.05) and CCR5 (r=0.45, p〈0.05) on FOXP3 + Tregs correlated with renal allograft function (eGFR) in patients receiving tacrolimus (n=28), but not CsA (n=26). CsA but not tracrolimus reduced surface expression of CXCR3 on FOXP3 + Tregs in renal transplant recipients as correlated to trough levels (r-0.42, p〈0.05). In contrast to CD4 + CXCR3 + CD25 lo T cells, flow sorted CD4 + CXCR3 + CD25 hi Tregs isolated from healthy individuals did not produce IFNγ or IL-17 ex vivo and expressed high levels of GARP mRNA both at baseline as well as after TCR activation indicating functional regulatory activity. Conclusion:  Expression of the peripheral trafficking receptors CXCR3 and CCR5 on FOXP3 + Tregs is associated with renal allograft function. These results suggest that Treg trafficking may also depend on the interaction of CXCR3 or CCR5 and their respective ligands.
    Print ISSN: 0300-9475
    Electronic ISSN: 1365-3083
    Topics: Medicine
    Published by Wiley-Blackwell
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