In:
Science, American Association for the Advancement of Science (AAAS), Vol. 283, No. 5407 ( 1999-03-05), p. 1544-1548
Abstract:
Protein tyrosine phosphatase–1B (PTP-1B) has been implicated in the negative regulation of insulin signaling. Disruption of the mouse homolog of the gene encoding PTP-1B yielded healthy mice that, in the fed state, had blood glucose concentrations that were slightly lower and concentrations of circulating insulin that were one-half those of their PTP-1B +/+ littermates. The enhanced insulin sensitivity of the PTP-1B −/− mice was also evident in glucose and insulin tolerance tests. The PTP-1B −/− mice showed increased phosphorylation of the insulin receptor in liver and muscle tissue after insulin injection in comparison to PTP-1B +/+ mice. On a high-fat diet, the PTP-1B −/− and PTP-1B +/− mice were resistant to weight gain and remained insulin sensitive, whereas the PTP-1B +/+ mice rapidly gained weight and became insulin resistant. These results demonstrate that PTP-1B has a major role in modulating both insulin sensitivity and fuel metabolism, thereby establishing it as a potential therapeutic target in the treatment of type 2 diabetes and obesity.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.283.5407.1544
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
1999
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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