In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 166, No. 2 ( 2012-02), p. 255-260
Kurzfassung:
Several studies demonstrated that obese children have higher TSH than normal-weight children. The polymorphism rs4704397 in the phosphodiesterase 8B ( PDE8B ) gene showed an association with TSH. Objectives i) To assess the effect of PDE8B on TSH in obese children; ii) to dissect the role of obesity degree in modulating this association; and iii) to stratify the individual risk to show hyperthyrotropinaemia according to PDE8B genotype. Methods Eight hundred and sixty-seven Italian obese children were investigated. Clinical data and thyroid hormones were evaluated and the PDE8B rs4704397 was genotyped. Results PDE8B A/A homozygous subjects showed higher TSH ( P =0.0005) compared with A/G or G/G. No differences were found for peripheral thyroid hormones. Among A/A children, 22% had hyperthyrotropinaemia, compared with 11.6% of heterozygotes and 10.8% of G/G ( P =0.0008). Consistently, A/A had an odds ratio (OR) to show abnormal TSH level of 2.25 ( P =0.0004). Body mass index (BMI) appeared correlated with TSH ( P =0.0001), but the strength of the effect of PDE8B on TSH was independent of BMI ( P =0.1). Children were subdivided into six groups according to obesity degree and genotypes. PDE8B A/A with BMI SDS above 3 had the highest OR (OR 2.6, P =0.0015) to have hyperthyrotropinaemia, whereas G/G with BMI SDS below 3 showed the lowest possibilities (OR 0.3, P =0.005). Conclusions We have shown: i) in obese children, PDE8B is associated with TSH; ii) the interaction between adiposity and PDE8B on TSH is not synergistic, but follows an additive model; and iii) impact of this association in the stratification of individual risk to have hyperthyrotropinaemia.
Materialart:
Online-Ressource
ISSN:
0804-4643
,
1479-683X
Sprache:
Unbekannt
Verlag:
Oxford University Press (OUP)
Publikationsdatum:
2012
ZDB Id:
1485160-X
Permalink