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  • 1
    Electronic Resource
    Electronic Resource
    Contact dermatitis from UV-A and UV-B filters in a patient with erythropoietic protoporphyria (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 28 (1993), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1993.tb03443.x
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  • 2
    Electronic Resource
    Electronic Resource
    Porphyrin concentrations in various human tissues (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 4 (1995), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract We measured the concentrations of total porphyrins and their metabolites (uro-, hepta-, hexa-, penta-, copro- and protoporphyrin) in various human tissues: liver, erythrocytes, skin, adipose tissue, and mammary gland. The porphyrin concentrations varied within minor limits, e.g., 3.1 ±2.3 nmol porphyrins/g liver and 0.50±0.10 nmol/g erythrocytes. No significant differences were detectable in other tissues in comparison with liver. In all tissues, the predominant metabolite was protoporphyrin, followed by coproporphyrin, whereas only low concentrations of higher carboxylatcd porphyrins such as uroporphyrin were detectable. It is concluded that porphyrin metabolism and its regulation is similar in all human tissues, perhaps with some small differences in the erythrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1995.tb00248.x
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  • 3
    Electronic Resource
    Electronic Resource
    Lipid composition and synthesis of HaCaT cells, an immortalized human keratinocyte line, in comparison with normal human adult keratinocytes (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 2 (1993), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Cultured keratinocytes are frequently employed for studies of epidermal lipid metabolism. Interpretation of experimental data may be complicated by donor to donor variability, the relatively short culture lifetime and variations between passages, problems thai are not encountered to the same extent with immortalized cell lines. The present study was undertaken to compare the lipid composition and synthesis of normal human adult keratinocytes (NHAK) with HaCaT cells, a long-lived. spontaneously immortalized human keratinocyte line, in relation to proliferation and differentiation. No differences between the two cell types were observed: a) in total lipid content; b) in the distribution of major lipid classes during growth at 50%, 75% and 100% confluence: c) in cultures grown at 0.6 mM calcium, at which differentiation is retarded, or at 1.6 mM calcium, at which some differentiation takes place; d) in the incorporation of [14C] acetate into cellular lipids at confluence, or e) in the fatty acid composition of major cellular lipid classes. At 100% confluence NHAK and HaCaT cells differ in their cholesterol metabolism. At all stages of growth, cholesterol synthesis in HaCaT cells is more LDL-dependent than in NHAK. Furthermore, NHAK become less LDL-dependent at confluence whereas HaCaT cells do not. HaCaT cells also revealed a significantly larger fraction of phosphatidyl-ethanolamine, -serine and -inositol at 0.6 mM calcium concentration than NHAK. These findings suggest that HaCaT cells do not differentiate as well as NHAK in vitro and may therefore serve as a model for the study of lipid metabolism in cells defective in terminal differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1993.tb00030.x
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  • 4
    Electronic Resource
    Electronic Resource
    3 cases of contact dermatitis from alkylammonium amidobenzoate (Osmaron B®) (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 27 (1992), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1992.tb03301.x
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  • 5
    Electronic Resource
    Electronic Resource
    UVA irradiation stimulates the synthesis of various matrix-metalloproteinases (MMPs) in cultured human fibroblasts (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 2 (1993), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract UVA irradiation leads to photoaging including clinical features such as wrinkle formation, reduced recoil capacity and blister formation of the skin. Besides synthesis of the extracellular matrix, its regulated degradation by various matrix-metalloproteinases (MMPs) determines the amount and the composition of the extracellular matrix within the dermis and the basement membrane of the dermo-epidermal junction. In this study we therefore ascertained whether UV irradiation could modulate the synthesis of MMPs with substrate specifities for dermal (collagen I, III, V) and basement membrane compounds (collagen IV, VII, proteoglycans, laminin) and whether synthesis of the counteracting tissue inhibitor of metalloproteinases (TIMP-I) was also affected. Following UVA irradiation specific mRNAs of MMPs 1, 2 and 3 were induced concomitantly up to 5-fold compared to mock irradiated controls. In contrast, TIMP-1 mRNA levels remained unaltered. Immunoprecipitation indicated that after UVA irradiation synthesis and secretion of MMPs 1, 2 and 3 into the supernatant increased. Taken together, our data show that UVA irradiation coordinately induced MMPs 1, 2 and 3 implying similar mechanisms in their regulatory pathways, while TIMP-I synthesis was not altered. Hence, unbalanced synthesis of MMPs potentially contributes to the dissolution of dermal and basement membrane compounds finally leading to blister formation and cutaneous photoaging.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1993.tb00015.x
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  • 6
    Electronic Resource
    Electronic Resource
    Dapsone in the treatment of lupus erythematosus (1981)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 104 (1981), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Dapsone yielded excellent therapeutic results in certain forms of lupus erythematosus (LE), whereas discoid lesions and the maculo-papular rash of the systemic and disseminated chronic forms of discoid LE remained uninfluenced by the drug. On the basis of these observations, we suggest the following indications for dapsone treatment in LE:〈list xml:id="l1" style="custom"〉1Vasculitic urticaria2Oral ulceratino3Non-scarring form of chronic LE4Chloroquine intolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1981.tb01711.x
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  • 7
    Electronic Resource
    Electronic Resource
    Dinitrochlorobenzene: Influence on the cytochrome P-450 system and mutagenic effects (1979)
    Springer
    Archives of dermatological research 266 (1979), S. 315-318 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00418577
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  • 8
    Electronic Resource
    Electronic Resource
    Das Glaswoll-Haar (“Spun Glass” Hair) (1981)
    Springer
    Archives of dermatological research 270 (1981), S. 353-359 
    Details
    ISSN: 1432-069X
    Keywords: Hair shaft anomalies ; Microscopic and scanning electron microscopic appearance ; Physical properties of the hairs ; Glaswoll-Haare ; Haarschaftsanomalien ; mikroskopisches und rasterelektronen-mikroskopisches Bild ; physikalische Eigenschaften der Haare
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über ein 5jähriges Mädchen mit dem typischen Bild der Glaswollhaare (“spun glass hair”) berichtet. Die Besonderheit dieses Falles liegt darin, daß das Kind zusätzlich an einem endogenen Ekzem und ein weiteres Familien-Mitglied (Tante des Kindes) ebenfalls and dieser Haarschaftsanomalie leidet. Die Diagnose stützt sich auf das klinische Symptom des nicht frisierbaren Haares und sie wird durch die typischen triangulären oder nierenförmigen Haarquerschnitte bewiesen. Bemerkenswert sind weiterhin die Einkerbungen an der Haaroberfläche, wodurch sich Beziehungen zu den Pili canaliculi ergeben. Die physikalischen Eigenschaften dieser triangulären Haare: Faserdicke, Reißfestigkeit, Höchstzugkraftdehnung und Formsteifigkeit unterscheiden sich nicht von normalen Haaren.
    Notes: Summary A 5-year-old girl with the characteristic clinical picture of “spun glass hair” is described; additionally she suffers from atopic dermatitis. This case is of special interest since the child not only suffers also from endogenic eczema, but that another member of the family (child's aunt) also suffers from the same hair anomaly. The diagnosis is based upon the clinical symptom that the hair cannot be managed, and is proved by observation of triangular and kidney-shaped cross-sections taken from the child's hair. Electron scan microscopic examination of the hair revealed grooves on the surface of the hair which exhibit similarity to the hair-condition pili canaliculi. The following physical properties of these irregularily shaped hairs were measured: Fibre thickness, tensile strength, extent of fibre expansion shortly before breakage, and form elasticity. None of these properties were found to differ from those of normal hair.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403940
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  • 9
    Electronic Resource
    Electronic Resource
    Influence of topical photodynamic therapy with 5-aminolevulinic acid on porphyrin metabolism (1996)
    Springer
    Archives of dermatological research 288 (1996), S. 517-521 
    Details
    ISSN: 1432-069X
    Keywords: Key words Photodynamic therapy ; 5-Aminolevulinic ; acid ; Side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Photodynamic therapy (PDT) with topically applied 5-aminolaevulinic acid (5-ALA) is increasingly used for treating tumours. The efficacy of topical PDT is limited to superficial and initial tumours. The topically applied doses of 5-ALA vary from 0.02 to 7.0 g per session according to the type of lesion. There are no studies on the influence of topically applied 5-ALA on the systemic accumulation of porphyrins or porphyrin precursors. A group of 20 patients with actinic keratoses (AK) and basal cell carcinomas (BCC) were treated by topical PDT with 5-ALA. Prior to and 6 and 24 h after PDT, 5-ALA and total porphyrin concentrations were determined in red blood cells and plasma, respectively. In addition, before and after 5-ALA treatment, 24-h urine samples were collected and porphyrins and porphyrin precursors were measured. There was no significant alteration in porphyrin metabolism. In some patients, a slight but insignificant increase in erythrocyte and plasma porphyrins was found 6 h after 5-ALA PDT. This investigation confirms clearly the safety of this treatment modality and demonstrates that 5-ALA application (up to 7 g) in the course of PDT has no influence on the concentrations of porphyrins and porphyrin precursors measured in various compartments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050095
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of chloroquine on the PHA-induced lymphocyte transformation (1980)
    Springer
    Archives of dermatological research 267 (1980), S. 87-89 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00416926
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