In:
Dose-Response, SAGE Publications, Vol. 18, No. 1 ( 2020-01-01), p. 155932582090233-
Kurzfassung:
To analyze changes in immune functions by detecting lymphocyte subsets in the peripheral blood of residents in the vicinity of radon from hot springs. Methods: Two groups were randomly selected; 61 residents in the vicinity of the hot springs were assigned to the radon group, and 51 residents with a similar lifestyle and habits but no contact with hot springs were assigned to the control group. The percentages of lymphocyte subsets (CD3 + , CD4 + CD8 − , CD4 − CD8 + , CD4 + /CD8 + , and TCR/CD3) in the 2 groups were evaluated on a FACS Aria flow cytometer. The absolute values of lymphocytes (LYMPH#) and percentages of lymphocytes (LYMPH%) were measured by an automatic blood analyzer. Results: In the radon group, the numbers of CD3 + ( Z = −0.140, P 〉 .05) and CD4 + CD8 − ( Z = −0.964, P 〉 .05) T cells were higher, as compared with the controls, but this difference was not significant. In addition, the number of CD4 − CD8 + ( t = −2.141, P 〈 .05) T cells was significantly lower in the radon group. Furthermore, the average ratios of CD4 + /CD8 + ( t = −2.201, P 〈 .05) and TCR/CD3 ( t = 2.047, P 〈 .05) cells were significantly higher in the radon group than in the controls. Compared with the control group, the LYMPH# ( t = −0.485, P 〉 .05) and LYMPH% (Z = −0.835, P 〉 .05) showed no significant change. Conclusion: Radon-rich hot springs could alter the proportions of lymphocyte subsets and possibly affect immunologic functions.
Materialart:
Online-Ressource
ISSN:
1559-3258
,
1559-3258
DOI:
10.1177/1559325820902338
Sprache:
Englisch
Verlag:
SAGE Publications
Publikationsdatum:
2020
ZDB Id:
2440820-7
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