In:
PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 11 ( 2020-11-11), p. e0239303-
Abstract:
Prevalence of IgG antibodies against SARS-CoV-2 infection provides essential information for deciding disease prevention and mitigation measures. We estimate the seroprevalence of SARS-CoV-2 specific IgG antibodies in District Srinagar. Methods 2906 persons 〉 18 years of age selected from hospital visitors across District Srinagar participated in the study. We tested samples for the presence of SARS-CoV-2 specific IgG antibodies using a chemiluminescent microparticle immunoassay-based serologic test. Results Age- and gender-standardized seroprevalence was 3.6% (95% CI 2.9% to 4.3%). Age 30–69 years, a recent history of symptoms of an influenza-like-illness, and a history of being placed under quarantine were significantly related to higher odds of the presence of SARS-CoV-2 specific IgG antibodies. The estimated number of SARS-CoV-2 infections during the two weeks preceding the study, adjusted for test performance, was 32602 with an estimated (median) infection-to-known-case ratio of 46 (95% CI 36 to 57). Conclusions The seroprevalence of SARS-CoV-2 specific IgG antibodies is low in the District. A large proportion of the population is still susceptible to the infection. A sizeable number of infections remain undetected, and a substantial proportion of people with symptoms compatible with COVID-19 are not tested.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0239303
DOI:
10.1371/journal.pone.0239303.g001
DOI:
10.1371/journal.pone.0239303.g002
DOI:
10.1371/journal.pone.0239303.t001
DOI:
10.1371/journal.pone.0239303.t002
DOI:
10.1371/journal.pone.0239303.t003
DOI:
10.1371/journal.pone.0239303.t004
DOI:
10.1371/journal.pone.0239303.t005
DOI:
10.1371/journal.pone.0239303.s001
DOI:
10.1371/journal.pone.0239303.s002
DOI:
10.1371/journal.pone.0239303.s003
DOI:
10.1371/journal.pone.0239303.s004
DOI:
10.1371/journal.pone.0239303.s005
DOI:
10.1371/journal.pone.0239303.s006
DOI:
10.1371/journal.pone.0239303.r001
DOI:
10.1371/journal.pone.0239303.r002
DOI:
10.1371/journal.pone.0239303.r003
DOI:
10.1371/journal.pone.0239303.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2267670-3
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