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  • 1
    Online Resource
    Online Resource
    Berlin, Heidelberg :Springer Berlin / Heidelberg,
    Keywords: Mathematics. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (254 pages)
    Edition: 1st ed.
    ISBN: 9783540324157
    Series Statement: Lecture Notes in Mathematics Series ; v.1872
    DDC: 510
    Language: English
    Note: Intro -- Modeling the Cell Division Cycle -- Baltazar D. Aguda -- 1 Introduction -- 2 Basic Biology of the Cell Division Cycle: Chromosome Cycle and Growth Cycle -- 3 The Molecular Regulators of the Cell Cycle: CDKs and APC -- 4 The Key Molecular Pathways -- 5 From Qualitative Network and Mechanisms to Dynamical Equations -- 6 Mammalian Cell Cycle and Checkpoints -- 7 Coupling Between the Cell Cycle and Apoptosis -- 8 Conclusions and Future Directions -- References -- Angiogenesis-A Biochemical/Mathematical Perspective -- Howard A. Levine and Marit Nilsen-Hamilton -- 1 Introduction -- 2 What is Angiogenesis? -- 3 What are the Key Events in Angiogenesis? -- 4 What are the Chemical and Cellular Contributions to Capillary Structure? -- 5 Interaction of Endothelial Cells with Their Environment -- 6 What are the Extracellular Events Leading to Vascularization? -- 7 Soluble Proteins that Modify the ECM and Influence EC Function: Proteases and Protease Inhibitors -- 8 Growth and Angiogenesis Factors: Factors that Stimulate Angiogenesis -- 9 Inhibitors of Angiogenesis -- 10 Cellular Events that Characterize Angiogenesis -- 11 Intracellular Signals (Signal Transduction) that Regulate Cellular Events -- 12 How does one Model These Events Mathematically? -- 13 Vocabulary -- References -- Mathematical Modelling of Proteolysisand Cancer Cell Invasion of Tissue -- Georgios Lolas -- 1 Introduction -- 2 Mathematical Modelling of Solid Tumour Growth and Invasion -- 3 Biological Background -- 4 The Mathematical Model of Proteolysisand Cancer Cell Invasion of Tissue -- 5 Numerical Simulation Results -- 6 Discussion -- References -- Mathematical Modelling of Spatio-temporal Phenomena in Tumour Immunology -- Mark Chaplain and Anastasios Matzavinos -- 1 Introduction -- 2 Tumour Immunology. , 3 Modelling the Spatio-temporal Response of Cytotoxic T-lymphocytes to a Solid Tumour -- 4 Discussion and Conclusions -- References -- Control Theory Approach to Cancer Chemotherapy: Benefiting from Phase Dependence and Overcoming Drug Resistance -- Marek Kimmel and Andrzej Swierniak -- 1 Introduction -- 2 Modeling the Cell Cycle -- 3 Control Problems with Cell-Cycle-Phase Dependence -- 4 Evolution of Resistance by Gene Amplification -- 5 Control Under Evolving Resistance -- 6 Remarks on Estimation of Parameters -- 7 Discussion -- References -- Cancer Models and Their Mathematical Analysis -- Avner Friedman -- 1 Introduction -- 2 Introduction to Tumors -- 3 Three Types of Cells -- 4 Two Types of Cells -- 4 Proliferating Cells -- 5 Tumors with Necrotic Core -- 6 Cancer Therapy -- 7 Concluding Remarks -- References.
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  • 2
    Online Resource
    Online Resource
    Berlin : Center for Stroke Research Berlin, Charité Universitätsmedizin Berlin
    Keywords: Forschungsbericht
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (21 Seiten, 202,48 KB)
    Language: German
    Note: Förderkennzeichen BMBF 01EW1212. - Verbund-Nummer 0111667 , Weiterer Autor dem Berichtsblatt entnommen , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden , Mit deutscher und englischer Zusammenfassung
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  • 3
    Publication Date: 2017-06-01
    Description: Given the need to describe, analyze and index large quantities of marine imagery data for exploration and monitoring activities, a range of specialized image annotation tools have been developed worldwide. Image annotation - the process of transposing objects or events represented in a video or still image to the semantic level, may involve human interactions and computer-assisted solutions. Marine image annotation software (MIAS) have enabled over 500 publications to date. We review the functioning, application trends and developments, by comparing general and advanced features of 23 different tools utilized in underwater image analysis. MIAS requiring human input are basically a graphical user interface, with a video player or image browser that recognizes a specific time code or image code, allowing to log events in a time-stamped (and/or geo-referenced) manner. MIAS differ from similar software by the capability of integrating data associated to video collection, the most simple being the position coordinates of the video recording platform. MIAS have three main characteristics: annotating events in real time, in posteriorly to annotation and interact with a database. These range from simple annotation interfaces, to full onboard data management systems, with a variety of toolboxes. Advanced packages allow to input and display of data from multiple sensors or multiple annotators via intranet or internet. Posterior human-mediated annotation often include tools for data display and image analysis, e.g. length, area, image segmentation, point count; and in a few cases the possibility of browsing and editing previous dive logs or to analyze annotation data. The interaction with a database allows the automatic integration of annotations from different surveys, repeated annotation and collaborative annotation of shared datasets, browsing and querying of data. Progress in the field of automated annotation is mostly in post processing, for stable platforms or still images. Integration into available MIAS is currently limited to semi-automated processes of pixel recognition through computer-vision modules that compile expert-based knowledge. Important topics aiding the choice of a specific software are outlined, the ideal software is discussed and future trends are presented.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 4
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    In:  XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
    Publication Date: 2023-07-06
    Description: We investigate the hydroclimate impacts of the major Santa Maria (1902) and Katmai (1912) eruptions, which were among the largest eruptions in the 20〈sup〉th〈/sup〉 century, in the greater tropical Atlantic region (encompassing the Atlantic Ocean, Africa, and the Americas), using recently-updated early instrumental data, historical reanalysis output, and climate models. Long-term observational datasets examined include gridded and station precipitation, tropical-Atlantic-flowing river discharge (Amazon, Congo, Paraná, Niger, and Senegal), and tropical Atlantic sea surface salinity, which provides insight into the marine surface freshwater balance (evaporation minus precipitation and surface runoff). We also study the mechanisms of hydroclimate impacts using latest-generation historical atmospheric reanalysis output and a medium-sized ensemble of prescribed volcanic-forcing experiments with the atmospheric general circulation model ECHAM6. Understanding these eruption impacts allows us to contextualize the hydroclimate impacts of better-observed large eruptions since the second half of the 20th century and better anticipate the impacts of future large eruptions. We find that both these volcanic eruptions caused detectable reductions in precipitation and discharge around the tropical Atlantic Basin; however, there were significant differences due to the eruption location and seasonality. In particular, the high-latitude Katmai eruption induced northern hemisphere cooling, driving a southward displacement of the Atlantic intertropical convergence zone (ITCZ) and Hadley circulation, weakening the West African summer monsoon; in contrast, though much closer in distance to the tropical Atlantic, the low-latitude Santa Maria eruption did not induce a comparable displacement of the marine ITCZ or summer monsoon response.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial & engineering chemistry 49 (1957), S. 1227-1230 
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A two-year study of recirculating induction heavy ion accelerators as low-cost driver for inertial-fusion energy applications was recently completed. The projected cost of a 4 MJ accelerator was estimated to be about $500 M (million) and the efficiency was estimated to be 35%. The principal technology issues include energy recovery of the ramped dipole magnets, which is achieved through use of ringing inductive/capacitive circuits, and high repetition rates of the induction cell pulsers, which is accomplished through arrays of field effect transistor (FET) switches. Principal physics issues identified include minimization of particle loss from interactions with the background gas, and more demanding emittance growth and centroid control requirements associated with the propagation of space-charge-dominated beams around bends and over large path lengths. In addition, instabilities such as the longitudinal resistive instability, beam-breakup instability and betatron-orbit instability were found to be controllable with careful design.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 73 (1998), S. 3932-3934 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The voltage–current characteristics of a superconducting coil, made of multifilamentary silver-sheathed Bi2Sr2Ca2Cu3O10+δ tape, are investigated. We find that a small ac current Iac superimposed on a relatively large dc current Idc causes a significant increase in the coil dc voltage, approximately proportional to Idc, Iac2, and the ac frequency. We attribute this effect to the nonlinear magnetoresistance of the coil, and discuss its significance in power applications of high Tc superconducting coils, such as fault current limiters and superconducting magnetic energy storage devices. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 85 (2003), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ferritin, the main iron storage protein, may be involved in triggering oxidative stress injury in Parkinson's disease. Aim: To determine the ratio of H and L chains of ferritin and the size of its iron-core in brain areas with high amounts of iron: substantia nigra (SN), globus pallidus (GP) and hippocampus (Hip). Methods: H/L ratio was determined by ELISA and iron size of ferritin by direct measurements of isolated ferritin with the use of electron microscopy (EM). Material: ELISA was made on 11 control and four Parkinsonian GP, Hip and SN. EM data were obtained from measurements of 50 iron-cores of ferritin in control GP, SN and Hip. Results: H/L ratios in control brains vs. PD brains were 5.92 ± 1.65 vs. 9.45 ± 1.93 for GP, 5.05 ± 1.67 vs. 11.41 ± 3.47 for SN, 16.01 ± 9.86 vs. 24.85 ± 5.88 for Hip. The sizes of iron-cores in control brains were 3.3 ± 0.5 nm for GP, 3.7 ± 0.5 nm for SN and 3.1 ± 0.5 nm for Hip. These results may suggest different iron metabolism both in different brain areas and between PD and control.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 638 (1991), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0732-0582
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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