In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 18, No. 7 ( 2022-7-11), p. e1010631-
Abstract:
The S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies characterizing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectiveness.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1010631
DOI:
10.1371/journal.ppat.1010631.g001
DOI:
10.1371/journal.ppat.1010631.g002
DOI:
10.1371/journal.ppat.1010631.g003
DOI:
10.1371/journal.ppat.1010631.g004
DOI:
10.1371/journal.ppat.1010631.g005
DOI:
10.1371/journal.ppat.1010631.g006
DOI:
10.1371/journal.ppat.1010631.g007
DOI:
10.1371/journal.ppat.1010631.g008
DOI:
10.1371/journal.ppat.1010631.t001
DOI:
10.1371/journal.ppat.1010631.s001
DOI:
10.1371/journal.ppat.1010631.s002
DOI:
10.1371/journal.ppat.1010631.s003
DOI:
10.1371/journal.ppat.1010631.s004
DOI:
10.1371/journal.ppat.1010631.r001
DOI:
10.1371/journal.ppat.1010631.r002
DOI:
10.1371/journal.ppat.1010631.r003
DOI:
10.1371/journal.ppat.1010631.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2205412-1
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