In:
Frontiers in Molecular Neuroscience, Frontiers Media SA, Vol. 16 ( 2023-6-23)
Kurzfassung:
Post-transcriptional gene regulation is a fundamental mechanism that helps regulate the development and healthy aging of the nervous system. Mutations that disrupt the function of RNA-binding proteins (RBPs), which regulate post-transcriptional gene regulation, have increasingly been implicated in neurological disorders including amyotrophic lateral sclerosis, Fragile X Syndrome, and spinal muscular atrophy. Interestingly, although the majority of RBPs are expressed widely within diverse tissue types, the nervous system is often particularly sensitive to their dysfunction. It is therefore critical to elucidate how aberrant RNA regulation that results from the dysfunction of ubiquitously expressed RBPs leads to tissue specific pathologies that underlie neurological diseases. The highly conserved RBP and alternative splicing factor Caper is widely expressed throughout development and is required for the development of Drosophila sensory and motor neurons. Furthermore, caper dysfunction results in larval and adult locomotor deficits. Nonetheless, little is known about which proteins interact with Caper, and which RNAs are regulated by Caper. Here we identify proteins that interact with Caper in both neural and muscle tissue, along with neural specific Caper target RNAs. Furthermore, we show that a subset of these Caper-interacting proteins and RNAs genetically interact with caper to regulate Drosophila gravitaxis behavior.
Materialart:
Online-Ressource
ISSN:
1662-5099
DOI:
10.3389/fnmol.2023.1114857
DOI:
10.3389/fnmol.2023.1114857.s001
DOI:
10.3389/fnmol.2023.1114857.s002
DOI:
10.3389/fnmol.2023.1114857.s003
DOI:
10.3389/fnmol.2023.1114857.s004
DOI:
10.3389/fnmol.2023.1114857.s005
DOI:
10.3389/fnmol.2023.1114857.s006
DOI:
10.3389/fnmol.2023.1114857.s007
DOI:
10.3389/fnmol.2023.1114857.s008
DOI:
10.3389/fnmol.2023.1114857.s009
DOI:
10.3389/fnmol.2023.1114857.s010
DOI:
10.3389/fnmol.2023.1114857.s011
DOI:
10.3389/fnmol.2023.1114857.s012
DOI:
10.3389/fnmol.2023.1114857.s013
DOI:
10.3389/fnmol.2023.1114857.s014
DOI:
10.3389/fnmol.2023.1114857.s015
Sprache:
Unbekannt
Verlag:
Frontiers Media SA
Publikationsdatum:
2023
ZDB Id:
2452967-9
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