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  • 1
    Publication Date: 2022-03-31
    Description: Earth angular momentum forecasts are naturally accompanied by forecast errors that typically grow with increasing forecast length. In contrast to this behavior, we have detected large quasi‐periodic deviations between atmospheric angular momentum wind term forecasts and their subsequently available analysis. The respective errors are not random and have some hard to define yet clearly visible characteristics which may help to separate them from the true forecast information. These kinds of problems, which should be automated but involve some adaptation and decision‐making in the process, are most suitable for machine learning methods. Consequently, we propose and apply a neural network to the task of removing the detected artificial forecast errors. We found that a cascading forward neural network model performed best in this problem. A total error reduction with respect to the unaltered forecasts amounts to about 30% integrated over a 6‐days forecast period. Integrated over the initial 3‐days forecast period, in which the largest artificial errors are present, the improvements amount to about 50%. After the application of the neural network, the remaining error distribution shows the expected growth with forecast length. However, a 24‐hourly modulation and an initial baseline error of 2 × 10−8 became evident that were hidden before under the larger forecast error.
    Description: Plain Language Summary: Variations in Earth rotation can be described by changes in Earth angular momentum. Angular momentum functions are calculated from mass redistributions, for example, given by atmospheric models. Typically, atmospheric model forecasts are naturally accompanied by forecast errors that grow with increasing forecast length. In contrast to this behavior, atmospheric angular momentum wind term forecasts show large quasi‐periodic deviations when compared to their subsequently available model analysis data. The detected errors are not random and have some hard to define yet clearly visible characteristics. A postprocessing step using machine learning methods was established to remove the detected artificial forecast errors. A cascading forward neural network approach was able to reduce the forecast error by about 50% for the first forecast days and about 30% for a 6‐day forecast horizon. Moreover, the remaining error distribution shows the expected growth with forecast length. This postprocessing step improves atmospheric angular momentum forecasts without touching the numerical weather prediction model itself. Improved angular momentum forecasts should help to further decrease Earth rotation predictions errors.
    Description: Key Points: Motion terms of atmospheric angular momentum forecasts contain systematic errors. Machine learning is used to learn and reduce these errors. Remaining stochastic errors show modulations with a 24‐hr period.
    Description: http://esmdata.gfz-potsdam.de:8080/repository
    Keywords: ddc:551.51
    Language: English
    Type: doc-type:article
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 47 (1991), S. 728-730 
    ISSN: 1420-9071
    Keywords: Phenytoin ; fibroblasts ; inositol phosphates ; DNA synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Culture of L-929 fibroblasts in the presence of phenytoin (2.5–5.0 μg/ml) increased DNA synthesis, as indicated by increased [3H]thymidine uptake, while a higher dose (20 μg/ml) inhibited DNA synthesis. In like manner, a low dose of phenytoin (5.0 μg/ml) was effective in increasing inositol 1,4,5-trisphosphate formation while a higher dose (10 μg/ml) tended to inhibit this activity. These data suggest that the formation of inositol phosphate second messengers may play a role in phenytoin-induced fibroblast proliferation and connective tissue growth.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 28 (1972), S. 37-38 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Elektrolytische, ipsilaterale, kontralaterale oder bilaterale Läsionen blieben in den tiefen Kernen des Cerebellums ohne Einfluss auf Intensität oder Charakter von Dyskinesien, welche durch Injektionen von 1,5 μg Carbachol in den Caudatum-Putamen-Komplex ungehindert beweglicher Ratten hervorgerufen wurden.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 24 (1968), S. 145-146 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Deux espèces de souris (IHB et A) vécurent 1 an avec un régime d'eau de mer ad libitum et d'aliments secs. La haute osmolarité urinaire, la capacité élevée de concentrer le sodium et l'absence de diarrhée furent des facteurs qui leur permirent de supporter ce régime expérimental.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 24 (1968), S. 696-698 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Il a paru intéressant de préciser les relations de temps et de phase entre la réponse évoquée massive et la réponse des neurones du corps genouillé latéral. Des microéléctrodes ont été implantées dans le corps genouillé latéral du chat et des réponses ont été évoquées par stimulation visuelle. On a pu démontrer que la probabilité aussi bien que la fréquence de la décharge neuronique varient en raison de la première dérivée de la réponse massive à ondes lentes.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 215 (1986), S. 99-105 
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Rats were treated daily for 9 days with 100, 50, or 25 mg/kg phenytoin i.p. This treatment resulted in a significant increase in the thickness of the connective tissue capsules of the liver, spleen, and pancreas, and of the subepithelial connective tissue of the mesentery but not the epicardium or visceral pleura of the lung where exposure to the drug was via the vascular route. Many areas of connective tissue growth exhibited obvious proliferation of fibroblasts and in some areas contained seemingly large numbers of macrophages and an increase in vascularity. It was demonstrated by electron microscopy that the macrophages occasionally were seen in intimate contact with the fibroblasts.Our observations clearly showed that intraperitoneal exposure of visceral connective tissues of the rat to phenytoin rapidly resulted in a dose-related proliferation of that tissue. The presence of numerous macrophages leads to the suggestion that macrophage-derived growth factor could be responsible for the increased growth.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Publication Date: 2011-08-31
    Description: Leptin has been shown to reduce hyperglycemia in rodent models of type 1 diabetes. We investigated the effects of leptin administration in University of California, Davis, type 2 diabetes mellitus (UCD-T2DM) rats, which develop adult-onset polygenic obesity and type 2 diabetes. Animals that had been diabetic for 2 mo were treated with s.c. injections of saline (control) or murine leptin (0.5 mg/kg) twice daily for 1 mo. Control rats were pair-fed to leptin-treated animals. Treatment with leptin normalized fasting plasma glucose and was accompanied by lowered HbA1c, plasma glucagon, and triglyceride concentrations and expression of hepatic gluconeogenic enzymes compared with vehicle (P 〈 0.05), independent of any effects on body weight and food intake. In addition, leptin-treated animals exhibited marked improvement of insulin sensitivity and glucose homeostasis compared with controls, whereas pancreatic insulin content was 50% higher in leptin-treated animals (P 〈 0.05). These effects coincided with activation of leptin and insulin signaling pathways and down-regulation of the PKR-like endoplasmic reticulum (ER) kinase/eukaryotic translation inhibition factor 2α (PERK-eIF2α) arm of ER stress in liver, skeletal muscle, and adipose tissue as well as increased pro-opiomelanocortin and decreased agouti-related peptide in the hypothalamus. In contrast, several markers of inflammation/immune function were elevated with leptin treatment in the same tissues (P 〈 0.05), suggesting that the leptin-mediated increase of insulin sensitivity was not attributable to decreased inflammation. Thus, leptin administration improves insulin sensitivity and normalizes fasting plasma glucose in diabetic UCD-T2DM rats, independent of energy intake, via peripheral and possibly centrally mediated actions, in part by decreasing circulating glucagon and ER stress.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 8
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    In:  Geophysical Research Abstracts, 18, EGU2016-16579, 2016
    Publication Date: 2020-02-12
    Description: We compute displacements of global SLR station coordinates by atmospheric loading based on surface pressure data from European Centre for Medium-Range Weather Forecasts (ECMWF) ERA-interim data. Inhouse we generate two branches: firstly straightforward following Farrel’s theory but using updated load Love numbers, secondly from utilizing localized Green’s functions instead of global ones. Externally provided displacements are available f.i. from the International Mass Loading Service (IMLS) based on different input data and modeling. We compare these displacements and apply them to Satellite Laser Ranging (SLR) data processing of a recent six years period of the LAGEOS, LARES, AJISAI, STARLETTE and STELLA geodetic missions. We assess the impact of the loading models on precise orbit determination and Earth parameters of interest.
    Type: info:eu-repo/semantics/conferenceObject
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  • 9
    Publication Date: 2020-02-12
    Description: The ability of any satellite gravity mission concept to monitor mass transport processes in the Earth system is typically tested well ahead of its implementation by means of various simulation studies. Those studies often extend from the simulation of realistic orbits and instrumental data all the way down to the retrieval of global gravity field solution time-series. Basic requirement for all these simulations are realistic representations of the spatio-temporal mass variability in the different sub-systems of the Earth, as a source model for the orbit computations. For such simulations, a suitable source model is required to represent (i) high-frequency (i.e., subdaily to weekly) mass variability in the atmosphere and oceans, in order to realistically include the effects of temporal aliasing due to non-tidal high-frequency mass variability into the retrieved gravity fields. In parallel, (ii) low-frequency (i.e., monthly to interannual) variability needs to be modelled with realistic amplitudes, particularly at small spatial scales, in order to assess to what extent a new mission concept might provide further insight into physical processes currently not observable. The new source model documented here attempts to fulfil both requirements: Based on ECMWF’s recent atmospheric reanalysis ERA-Interim and corresponding simulations from numerical models of the other Earth system components, it offers spherical harmonic coefficients of the time-variable global gravity field due to mass variability in atmosphere, oceans, the terrestrial hydrosphere including the ice-sheets and glaciers, as well as the solid Earth. Simulated features range from sub-daily to multiyear periods with a spatial resolution of spherical harmonics degree and order 180 over a period of 12 years. In addition to the source model, a de-aliasing model for atmospheric and oceanic high-frequency variability with augmented systematic and random noise is required for a realistic simulation of the gravity field retrieval process, whose necessary error characteristics are discussed. The documentation of the updated ESA Earth System Model (updated ESM) for gravity mission simulation studies is organized as follows: The characteristics of the updated ESM along with some basic validation is presented in Volume 1. A detailed comparison to the original ESA ESM (Gruber et al., 2011) is provided in Volume 2, while Volume 3 contains the description of a strategy to derive realistic errors for the de-aliasing model of high-frequency mass variability in atmosphere and ocean.
    Language: English
    Type: info:eu-repo/semantics/report
    Format: application/pdf
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  • 10
    Publication Date: 2020-02-12
    Description: We apply synthetic aperture radar data and geophysical modeling to assess ground deformation changes at the 284 km2 large Toktogul Reservoir in Kyrgyzstan, Central Asia, which is used for hydropower generation and irrigation. The reservoir’s water level is prone to significant changes during the year, but also shows inter-annual variations due to overall water recession or accumulation. We use Envisat ASAR data to analyse the ground deformation during a time of exaggerated use of water between 2004 – 2009 (net water level drop of 60 m / 13.5 km3 ) and Sentinel-1 data to derive the ground deformation during a time of overall water level increase between 2014 – 2016 (net water level plus of 51 m / 11.2 km3 ). The deformation pattern was measured by generating an interferometric time-series using the Small BAseline Subset (SBAS) approach. After removing heavily impacting atmospheric effects by applying the elevation dependent powerlaw approach, results show that both sensors are able to image related uplift and subsidence signals in the order of approximately 1 mm per 1 m water level change for the investigated time periods. Moreover, time-series results from Sentinel-1 also resolve intra-annual changes induced by 40 m periodical water level changes. Reasons for this superior behaviour of Sentinel-1 data are a short temporal baseline of 12 days and a small orbital tube, which both lead to a higher temporal sampling compared to the Envisat setting and at the same time to a better correlation of points within the interferograms. The derived spatial pattern of land-deformation rate is validated against modeling of the elastic deformation, based on a Love-number approach. The load forcing due to lake-level changes is derived from satellite-based radar altimetry.
    Type: info:eu-repo/semantics/conferenceObject
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