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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Langenbeck's archives of surgery 329 (1971), S. 348-348 
    ISSN: 1435-2451
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Es wird über die Behandlungsergebnisse von 252 Coloncarcinomen aboral der linken Flexur und 60 Rectumresektionen mit zum Teil abdominellen, zum Teil sacralen Anastomosen berichtet, die zwischen 1955 und 1967 an der Chirurgischen Universitäts-Klinik Tübingen stationär aufgenommen wurden. Von 168 radikal möglichen Kontinuitätsresektionen wurden 139 dreizeitig nach Schloffer, 29 einzeitig vorgenommen. Nach 139 dreizeitigen Resektionen verstarb 1 Patient (= 0,7% prim. Op.-Letalität), nach 29 prim. Resektionen kamen 3 Kranke ad exitum (=10% Letalität). Aus Vergleichen mit entsprechenden Literaturangaben ergibt sich, daß die umständliche Schloffersche Methode maximale Sicherheit bietet bei einer hohen Gesamtresektionsquote (72,5%). Die Spätergebnisse wurden in Abhängigkeit vom Tumorstadium (nach der TNM-Klassifikation) anhand der 5-Jahresüberlebenskurven dargestellt: 73% der in Stadium I und II operierten Patienten überlebten die 5-Jahresgrenze, aber nur 40% der in Stadium III und 16% der in Stadium IV behandelten Fälle. 55% aller radikal Resezierten erreichten die 5-Jahresgrenze.
    Notizen: Summary The results of treatment in 252 carcinomas of the colon, aboral of the left flexure and 60 resections of the rectum, some with abdominal and some with sacral anastomoses, are reported. All the patients had been admitted for treatment to the Surgical University Clinic, Tilbingen, between 1955 and 1967. Of 168 cases where radical resection was possible, 139 were operated according to Schloffer's 3-stage method, and 29 had one-stage operations. Of 139 patients who underwent 3-stage operations, one died (=0.7% prim. op. mortality) and of the 29 primary resections, 3 patients died (=10% mortality). On comparing this with the corresponding literature, it is shown that the laborious Schloffer method gives maximum safety, while the total number of resections performed is kept high (72.5%). Long-term results are given, related to the stage of the tumour (according to the TNM classification) and based on 5-year survival curves. 73% of the patients operated on in Stages I and II survived the 5-year survival line, but only 40% of the patients treated in Stage III and 16% of those treated in Stage IV survived the 5 years. 55% of all the patients who underwent radical resection reached the 5-year limit.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 28 (1992), S. 0 
    ISSN: 1752-1688
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geographie
    Notizen: : A study was conducted to determine the effects of surface mining and reclamation on ground-water chemistry in three saturated zones in each of three small East-Central Ohio water-sheds. The extensive disturbances of mining and reclamation: (1) caused more changes in constituent concentrations in the upper zone than in lower zones, most of which were statistically significant increases (many were “drastic”); (2) affected ground-water chemistry in lower zones - those that were not physically disturbed; (3) tended to increase the frequency of exceedance of regulated constituents in all saturated zones; and (4) affected the chemistry of surface baseflow water at the watershed outlets. Several constituents were still changing at the end of the project within all sites and zones.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 28 (1992), S. 0 
    ISSN: 1752-1688
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geographie
    Notizen: : A study was conducted over a six-year period in East-Central Ohio to determine the effects of surface mining and reclamation on physical watershed conditions and on ground-water hydrology in three ground-water zones in three small experimental watersheds. Mining disturbances in watersheds adjacent to the experimental sites affected ground-water levels in the undisturbed experimental watersheds prior to actual mining in the experimental sites. New subsurface flow paths, with different characteristics, formed during mining and reclamation. At all three sites mining dewatered the saturated zone above the underclay of the mined coal seam. Mining and reclamation affected ground-water levels below the mined coal seam in the middle and lower zones within at least two sites. Ground-water level recovery in the mined upper saturated zone was slow and irregular both temporally and spatially after reclamation. Hydraulic conductivities of postmining (Phase 3) spoil were generally greater than those of Phase 1 bedrock, but wide spatial variability was observed. Modelers need to be aware of the complexities of new flow paths and physical characteristics of subsurface flow media that are introduced by mining and reclamation, including destruction of the upper-zone clay.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 33 (1997), S. 0 
    ISSN: 1752-1688
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geographie
    Notizen: : A study was conducted to determine the effects of mining and reclaiming originally undisturbed watersheds on surface-water hydrology in three small experimental watersheds in Ohio. Approximately six years of data were collected at each site, with differing lengths of premining (Phase 1), mining and reclamation (Phase 2), and post-reclamation (Phase 3) periods. Mining and reclamation activities showed no consistent pattern iii base-flow, and caused slightly more frequent higher daily flow volumes. Phase 2 activities can cause reductions in seasonal variation in double mass curves compared with Phase 1. Restoration of seasonal variations was noticeably apparent at one site during Phase 3. The responses of the watersheds to rainfall intensities causing larger peak flow rates generally decreased due to mining and reclamation, but tended to exceed responses observed in Phase 1 during Phase 3. Natural Resources Conservation Service (NRCS) curve numbers increased due to mining and reclamation (Phase 2), ranging from 83 to 91. During Phase 3, curve numbers remained approximately constant from Phase 2, ranging from 87 to 91.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    The @journal of organic chemistry 29 (1964), S. 3723-3725 
    ISSN: 1520-6904
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Anaesthesia 43 (1988), S. 0 
    ISSN: 1365-2044
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Hepatic function was assessed pre-operatively and on the first and sixth postoperative days in 40 healthy patients who underwent prolonged maxillofacial surgery with isoflurane or halothane anaesthesia. No major changes were observed in hepatic enzymes or bilirubin. One-stage prothrombin time and Factor VII concentrations decreased on the first postoperative day and this change-was more pronounced in the halothane group. The results support the use of isoflurane rather than halothane for prolonged anaesthesia in respect of the synthesising function of the liver.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 7 (1980), S. 0 
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. When six female seropositive rheumatoid patients were given placebo therapy for 48 h, their mean plasma kininogen level, 9.2 ± 0.7 μg bradykinin equivalents (bk eq) per ml, was found to be 59% greater than that of a group of eight healthy female volunteers (5.8 ± 0.5 μg/ml).2. When the rheumatoid patients received aspirin therapy for 1 week, their mean plasma kininogen concentration fell by 31% to 6.3 ± 0.8 μg Bk eq/ml. This was accompanied by a 20.4% fall in mean plasma α2-globuKn level. Haematocrit and total plasma protein were not significantly altered (P 〉 0.05).3. The fall in kininogen was very rapid, the main reduction occurring within the first hour.4. Aspirin therapy greatly reduced the pain assessments but had no effect on plasma concentrations of IgG, IgA, IgM, complement component C3, nor on ESR, haemoglobin, leucocyte count, nor ring size. Left hand grip strength was increased while right hand grip strength was unchanged.5. The action of aspirin on plasma kininogen and α2-globulin was similar to that of indomethacin. Plasma kininogen has been considered to be an acute phase reactant. The possible diagnostic value of plasma kininogen estimation is discussed.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. The role of lumbar sympathectomy in the treatment of limb ischemia secondary to arteriosclerosis obliterans has been controversial. Increased temperature and rubor of the skin, which usually follow sympathectomy, have generally been interpreted as indicative of improved nutritive skin blood flow. However, the existence of a (nonnutritive) thermoregulatory level of skin microcirculation makes such an extrapolation questionable. We investigated the total (mainly thermoregulatory) skin blood flow (TSBF) in the hindlimb of 15 male Lewis rats by means of laser Doppler flowmetry and the nutritive skin blood flow (NSBF) by means of capillary microscopy (red blood cell velocity). Transcutaneous oximetry was used to assess skin oxygenation (SO). Measurements were performed before and 2 and 28 days after ligation of the common iliac and iliolumbar artery. Subsequently, either a surgical resection of the sympathetic chain (L2–L6) was performed or a sham operation. Measurements were repeated 2 and 28 days later. For the group of 15 rats as a whole, TSBF ( p 〈 0.05), NSBF ( p 〈 0.05), and SO ( p 〈 0.05) were found to be drastically reduced at day 2 after ligation compared to preligation values. This reduction partially recovered during the following weeks. TSBF ( p 〈 0.05) and NSBF ( p 〈 0.05), however were still reduced at day 28 after ligation compared to preligation values, whereas the SO at this time tended to be lower ( p = 0.11). In the sympathectomy group the TSBF was found to be increased at day 2 ( p 〈 0.05) and day 28 ( p 〈 0.05) after sympathectomy, both compared to values obtained at day 28 after ligation. Sympathectomy did not have an effect on NSBF and SO. The sham procedure had no effect on the TSBF, NSBF, or SO. These results indicate that in case of lower limb ischemia, sympathectomy improves skin blood flow at the thermoregulatory but not the nutritive level of skin microcirculation. This may be related to the fact that the thermoregulatory vessels are mainly sympathetically controlled, whereas the nutritive capillaries are mainly controlled by local (nonneural) factors.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Der Schmerz 11 (1997), S. 185-189 
    ISSN: 1432-2129
    Schlagwort(e): Schlüsselwörter Postoperative Schmerztherapie ; Epidural ; Bupivacain ; Fentanyl ; Physikochemische Stabilität ; Key words Postoperative analgesia ; Epidural ; Bupivacaine ; Fentanyl ; Physicochemical stability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Abstract Continuous epidural infusion of bupivacaine with the opioid fentanyl represents an effective analgesic method in the therapy of strong postoperative pain after major surgery. Preparation of the required infusion solution in syringes with a volume of 50 ml immediately prior to administration is routinely performed by nursing staff in Germany. The effort required for the preparation is associated with logistical and pharmaceutical difficulties. The preparation of a mixture of bupivacaine hydrochloride 0.06% and fentanyl 0.0002% in 250 ml infusion bags at the pharmacy of the University Hospital Mainz is described. To determine the physicochemical stability, the concentration of bupivacaine-HCl and fentanyl was assessed using HPLC over a period of 32 days; in addition the pH values were determined. After 32 days 95% of the bupivacaine hydrochloride and fentanyl baseline values were recorded. The pH baseline value had decreased from 5.48–5.52 to 0.5–0.7 units. The measured values confirm the physicochemical stability of the mixture of bupivacaine hydrochloride 0.06% and fentanyl 0.0002% over a period of 32 days. The infusion bag can be stored for 4 weeks at room temperature.
    Notizen: Zusammenfassung Die kontinuierliche epidurale Infusionsanalgesie ist eine effektive Möglichkeit zur Therapie starker postoperativer Schmerzen. Es ist in Deutschland üblich, daß geeignete Infusionslösungen unmittelbar vor der Anwendung durch Pflegekräfte zubereitet werden. Der damit verbundene Aufwand wirft logistische und pharmazeutische Probleme auf. Es wird beschrieben, wie in der Apotheke des Universitätsklinikums Mainz Infusionsbeutel zur Mischinfusion von Bupivacain-HCl 0,06% und Fentanyl 0,0002% mit einem Füllvolumen von jeweils 250 ml hergestellt und vorrätig gelagert werden. Durch die epidurale Infusion kommt eine ausreichende Analgesie zustande. Zur Untersuchung der physikalisch-chemischen Stabilität wurden über einen Zeitraum von 32 Tagen der pH-Wert und die Konzentration der Arzneistoffe im Infusionsbeutel mittels HPLC bestimmt. Nach 32 Tagen waren noch 95% der Ausgangskonzentration von Bupivacain-HCl und Fentanyl vorhanden, der initiale pH-Wert von 5,48–5,52 war um 0,5–0,7 Einheiten abgefallen. Mit diesen Messungen ist eine ausreichende physikochemische Stabilität der Mischinfusionslösung belegt. Die Anwendung der Infusionsbeutel ist für den Pflegebereich, aber auch für die Ärzte komfortabel und sicher. Ökonomische Vorteile liegen auf der Hand.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    ISSN: 1432-2013
    Schlagwort(e): Blood gases ; pH ; Vessel wall injury ; Thromboembolic reaction ; Arterioles ; Venules
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The influence of changes in systemic blood gas and pH values on the thromboembolic reaction following wall puncture was studied in rabbit mesenteric arterioles and venules (diameter 20–40 μm), using intravital videomicroscopy. Under normal circumstances the number of emboli produced was higher in arterioles than in venules (6 and 1, respectively). The initial thrombus growth, the number of emboli produced per vessel and the total duration of the embolisation period were not significantly influenced by changes in blood gas and pH values in both arterioles and venules. Therefore, the observed difference in thromboembolic reaction between arterioles and venules cannot be explained by differences in blood gas and pH values in these microvessels. Since reduced velocity, as a measure of wall shear rate, did not correlate with the thromboembolic reaction in arterioles or venules, fluid dynamics can also not explain the difference, indicating that the thrombogenic or anuthrombogenic activity of arteriolar and venular walls differs following injury. A combination of hypercapnia and hypoxia was found to result in a prolongation of the average time period needed to produce a new embolus in both vessel types. This prolongation in embolus production time was largely due to the occurrence of periods, in which the thrombus did not grow, reflecting hampering of the adhesion and aggregation of blood platelets to a growing thrombus under hypereapnic/hypoxic conditions.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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