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  • 1
    Keywords: Hochschulschrift
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (88 Seiten = 5 MB) , Karten, Graphen
    Edition: 2020
    Language: German
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Ocean dynamics 38 (1985), S. 7-22 
    ISSN: 1616-7228
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Description / Table of Contents: Zusammenfassung Strömungsdaten von 7 Verankerungen, die im nordöstlichen Atlantik über mehrere Jahre ausgelegt waren, wurden im Hinblick auf halbtägige barotrope und barokline sowie eintägige barotrope Gezeiten analysiert. Bei den halbtägigen Tiden M2 und S2 dominiert normalerweise die Energie der barotropen Eigenfunktion, nur in wenigen Fällen enthält die barokline Welle 1. Ordnung höhere Energie. Die Ellipsenorientierungen für die barotropen Komponenten entsprechen früheren Ergebnissen von Tiefseepegeln in diesem Gebiet. Es gibt jedoch signifikante Abweichungen bei den Amplituden. Die Gezeiten in diesem Gebiet sind fast ausschließlich fortschreitende Wellen, in einigen wenigen Fällen jedoch vom gemischten Typ. Die räumliche Änderung der Strömungsellipsen entspricht weitgehend den Ergebnissen, die Cartwright, Edden, Spencer et al. [1980] indirekt aus Pegelbeobachtungen erhielten.
    Abstract: Résumé Les mesures de courants provenant de 7 mouillages sur plusieurs années en Atlantique Nord-Est ont été analysées en ce qui concerne les marées semi-diurnes barotropes et baroclines et les marées diurnes barotropes. Pour les marées semi-diurnes M2 et S2 la répartition de l'énergie est généralement dominée par le mode barotrope; dans peu de cas seulement, le mode barocline de premier ordre renferme la plus haute énergie. Les orientations de l'ellipse relevant de la marée barotrope sont en accord avec les résultats d'observations marégraphiques antérieures dans cette région. Des écarts significatifs apparaissent toutefois en amplitude. Les résultats concernant la composante Ki sont également présentés. A quelques exceptions près, les marées, dans cette région, se sont trouvées être des ondes progressives. Le type d'ellipse des courants est semblable aux résultats obtenus indirectement par Cartwright, Edden, Spencer et al. [1980] à partir des observations marégraphiques.
    Notes: Summary Current data obtained from 7 moorings in the Northeast Atlantic in the course of many years are analysed with respect to semi-diurnal barotropic and baroclinic tides and diurnal barotropic tides. For semi-diurnal tides M2 and S2 the energy distribution is usually dominated by the barotropic mode; only in a few cases does the first-order baroclinic mode contain higher energy. Barotropic tidal ellipse orientations are found to be consistent with results from earlier tide gauge observations in this area. Significant deviations occur, however, in amplitudes. Results for the diurnal component K1 are also presented. With few exceptions, tides are found to be progressive waves in this area. The current ellipse pattern is similar to results obtained indirectly by Cartwright, Edden, Spencer et al. [1980] from tide gauge observations.
    Type of Medium: Electronic Resource
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  • 3
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    Unknown
    In:  (Diploma thesis), Christian-Albrechts-Universität Kiel, Kiel, Germany, 83 pp
    Publication Date: 2020-07-10
    Type: Thesis , NonPeerReviewed
    Format: text
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  • 4
    Publication Date: 2017-07-08
    Description: The F1F0 -ATP (F-ATP) synthase is essential for growth of Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). In addition to their synthase function most F-ATP synthases possess an ATP-hydrolase activity, which is coupled to proton-pumping activity. However, the mycobacterial enzyme lacks this reverse activity, but the reason for this deficiency is unclear. Here, we report that a Mycobacterium-specific, 36-amino acid long C-terminal domain in the nucleotide-binding subunit α (Mtα) of F-ATP synthase suppresses its ATPase activity and determined the mechanism of suppression. First, we employed vesicles to show that in intact membrane-embedded mycobacterial F-ATP synthases deletion of the C-terminal domain enabled ATPase and proton-pumping activity. We then generated a heterologous F-ATP synthase model system, which demonstrated that transfer of the mycobacterial C-terminal domain to a standard F-ATP synthase α subunit suppresses ATPase activity. Single-molecule rotation assays indicated that the introduction of this Mycobacterium-specific domain decreased the angular velocity of the power-stroke after ATP binding. Solution X-ray scattering data and NMR results revealed the solution shape of Mtα and the 3D structure of the subunit α C-terminal peptide 521PDEHVEALDEDKLAKEAVKV540 of M. tubercolosis (Mtα(521–540)), respectively. Together with cross-linking studies, the solution structural data lead to a model, in which Mtα(521–540) comes in close proximity with subunit γ residues 104–109, whose interaction may influence the rotation of the camshaft-like subunit γ. Finally, we propose that the unique segment Mtα(514–549), which is accessible at the C terminus of mycobacterial subunit α, is a promising drug epitope.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
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