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  • 1
    Online-Ressource
    Online-Ressource
    Coordinating Organismal Physiology Through the Unfolded Protein Response. (2018)
    Cham :Springer International Publishing AG,
    Details
    Schlagwort(e): Proteins. ; Endoplasmic reticulum. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (218 pages)
    Ausgabe: 1st ed.
    ISBN: 9783319785301
    Serie: Current Topics in Microbiology and Immunology Series ; v.414
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=5356234
    Sprache: Englisch
    Anmerkung: Intro -- Preface -- Contents -- 56 Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response -- Abstract -- 1 Introduction -- 2 The UPR in Health and Disease -- 2.1 Development, Professional Secretory Cells, and Immunity -- 2.2 Emerging Functions of the UPR -- 2.3 Dysregulated ER Proteostasis and Disease -- 2.4 Concept Summary -- 3 Targeting the UPR to Modulate ER Proteostasis -- 3.1 Stress-Dependent Methods to Modulate the UPR -- 3.2 Stress-Independent Methods to Modulate the UPR -- 3.3 Activating the UPR to Address Diseases Linked to Dysregulated ER Proteostasis -- 3.4 Concept Summary -- 4 Beyond the UPR -- 4.1 Targeting ATP-Dependent Chaperone Systems in the ER -- 4.2 Targeting ERAD -- 4.3 Concept Summary -- 5 Conclusions -- References -- 38 Cell Non-autonomous UPRER Signaling -- Abstract -- 1 Introduction -- 1.1 Signaling in the UPRER -- 1.2 Activation of the UPRER -- 2 Caenorhabditis elegans (C. elegans) -- 2.1 Innate Immunity -- 2.2 Aging and Reproduction -- 3 Drosophila melanogaster (D. melanogaster) -- 3.1 Barrier Epithelia -- 4 Mammalian Systems -- 4.1 Metabolic Regulation -- 4.2 Immune Responses -- 4.3 Tumorigenesis -- 5 Conclusions -- Acknowledgements -- References -- 1 The Unfolded Protein Response in the Immune Cell Development: Putting the Caretaker in the Driving Seat -- Abstract -- 1 Introduction -- 2 Coordinating an Unfolded Protein Response -- 3 The UPR: Instrumental in Immune Cell Development -- 3.1 The UPR and Stem Cells -- 3.1.1 Hematopoietic Stem Cells -- 3.1.2 Intestinal Stem Cells -- 3.2 The UPR in Lymphopoiesis -- 3.2.1 B-cell Development -- 3.2.2 T-cell Development -- 3.3 Granulocytes and UPR -- 3.4 The UPR in the Mononuclear Phagocytic System -- 3.5 UPR Regulation at the Mucosal Barrier -- 4 Discussion -- References -- 2 Mitochondria-Associated Membranes and ER Stress -- Abstract. , 1 The Endoplasmic Reticulum: From Basal Homeostasis to Protein Folding Stress -- 1.1 Basics of ER Morphology: Rough Sheets and Smooth Tubules -- 1.2 The ER as a Central Organelle in the Cell -- 1.2.1 Protein Folding in the ER: The Basics -- 1.2.2 The ER as a Regulator of Ca2+ Signaling -- 1.2.3 Lipid Synthesis in the ER -- 1.3 When Protein Folding Goes Wrong: ER Stress -- 1.3.1 The Unfolded Protein Response -- 1.3.2 When the Rescue Fails: ER Stress and Apoptosis -- 2 The ER Connection: ER-Mitochondria Contact Sites -- 2.1 A Brief Introduction on MAMs Discovery and Characterization -- 2.2 MAMs-a Dynamic Connection at the ER-Mitochondria Interface Recruiting a Multitude of Proteins -- 2.3 ER-Mitochondria Contact Sites: Bridging Ca2+ Signals to the Cell's Fate -- 2.4 ER-Mitochondria Contact Sites -- a Greasy Connection -- 2.5 Regulation of the Mitochondrial Network Through the MAMs -- 3 UPR Signaling at the ER-Mitochondria Interface -- 3.1 Modulation of ER Stress Signaling at the MAMs -- 3.2 ER Stress, MAMs, and Autophagosome Formation -- 4 Conclusions -- References -- 41 Coordinating Organismal Metabolism During Protein Misfolding in the ER Through the Unfolded Protein Response -- Abstract -- 1 ER Stress and the Unfolded Protein Response (UPR) -- 2 The Autonomous UPR in Metabolism -- 2.1 The UPR in Pancreatic β Cells -- 2.2 The UPR in the Liver -- 2.3 The UPR in Adipose Tissue -- 2.4 The UPR in the Nervous System -- 3 The Non-autonomous UPR -- 3.1 Proximal Effects of the Non-autonomous UPR -- 3.2 Distal Effects of the Non-autonomous UPR -- 3.3 Potential Mechanism of the Non-autonomous UPR -- 4 Conclusions -- Acknowledgements -- References -- 52 ER Stress and Neurodegenerative Disease: A Cause or Effect Relationship? -- Abstract -- 1 Introduction -- 2 PMDs and ER Stress-Towards Causality? -- 3 Alzheimer's Disease -- 4 Parkinson's Disease. , 5 Amyotrophic Lateral Sclerosis -- 6 Huntington's Disease -- 7 Prion-Related Disorders -- 8 Closing Remarks -- Acknowledgements -- References -- 36 Driving Cancer Tumorigenesis and Metastasis Through UPR Signaling -- Abstract -- 1 ER Stress Signaling and Its Alterations in Cancer -- 2 Regulation of the Hallmarks of Cancer by the UPR -- 2.1 Sustaining Cancer Cell Proliferation and Promoting Tumor Dormancy -- 2.2 Cellular Energetics -- 2.3 Tumoral UPR Controls the Immune System -- 2.4 Driving Invasion and Metastasis -- 2.5 Inducing Angiogenesis -- 2.6 Genome Instability-Mutations of the UPR Machinery -- 2.6.1 Genome Instability -- 2.6.2 Cancer-Associated Somatic Mutations in UPR Genes -- 3 Targeting UPR in Cancer -- 4 Conclusion -- Acknowledgements -- References -- 54 ER Protein Quality Control and the Unfolded Protein Response in the Heart -- Abstract -- 1 Introduction -- 2 ER Protein Quality Control in Cardiac Myocytes -- 3 Physiological Conditions that Challenge the ER-PQC in Cardiac Myocytes -- 4 Pathological Conditions that Challenge the ER-PQC in Cardiac Myocytes -- 5 Experiment Methods and Models for Studying ER-PQC in Cardiac Pathology -- 6 Studies of ER-PQC in Cardiac Pathology -- 6.1 PERK/CHOP -- 6.2 IRE-1/XBP1 -- 6.3 ATF6 -- 7 Conclusions -- References.
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  • 2
    Online-Ressource
    Online-Ressource
    Coordinating Organismal Physiology Through the Unfolded Protein Response (2018)
    Cham : Springer International Publishing
    Details Verfügbarkeit
    Schlagwort(e): Medicine ; Biomedicine ; Cancer research ; Human physiology ; Immunology ; Neurosciences ; Infectious diseases ; Medicine ; Cancer research ; Human physiology ; Immunology ; Neurosciences ; Infectious diseases ; Unfolded Protein Response physiology ; Endoplasmic Reticulum Stress physiology ; Signal Transduction physiology ; Protein Aggregation, Pathological
    Beschreibung / Inhaltsverzeichnis: Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response -- Cell Non-Autonomous UPRER Signaling -- The unfolded protein response in the immune cell development: Putting the caretaker in the driving seat -- Mitochondria associated membranes and ER stress -- Coordinating Organismal Metabolism during Protein Misfolding in the ER Through the Unfolded Protein Response -- ER stress and neurodegenerative disease: a cause or effect relationship?- Driving cancer tumorigenesis and metastasis through UPR signaling -- ER Protein Quality Control and the Unfolded Protein Response in the Heart.
    Materialart: Online-Ressource
    Seiten: Online-Ressource (VII, 213 p, online resource)
    ISBN: 9783319785301
    Serie: Current Topics in Microbiology and Immunology 414
    URL: https://doi.org/10.1007/978-3-319-78530-1
    URL: http://dx.doi.org/10.1007/978-3-319-78530-1
    DOI: 10.1007/978-3-319-78530-1
    Sprache: Englisch
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  • 3
    facet.materialart.
    Unbekannt
    3D-Integrated Multi-Sensor Demonstrator System for Environmental Monitoring (2019)
    In:  Proceedings
    Details
    Publikationsdatum: 2022-02-09
    Materialart: info:eu-repo/semantics/conferenceObject
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    GFZ OAI
  • 4
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    Measuring Marine Plastic Debris from Space: Initial Assessment of Observation Requirements (2019)
    In:  Remote Sensing
    Details
    Publikationsdatum: 2020-02-12
    Materialart: info:eu-repo/semantics/article
    Format: application/pdf
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  • 5
    Digitale Medien
    Digitale Medien
    Modification of Parnas-Wagner-Pregl Micro-Kjeldahl Apparatus (1953)
    s.l. : American Chemical Society
    Analytical chemistry 25 (1953), S. 535-535 
    Details
    ISSN: 1520-6882
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ac60075a048
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  • 6
    Digitale Medien
    Digitale Medien
    The microstructure and electrical properties of nonalloyed epitaxial Au-Ge ohmic contacts to n-GaAs (1992)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 72 (1992), S. 4773-4780 
    Details
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: The microstructure and electrical properties of nonalloyed epitaxial Au-Ge contacts were studied. Ohmic behavior was obtained after a 3 h anneal at 320 °C with the lowest average contact resistance and specific contact resistivity found to be ∼0.28 Ω mm and ∼7×10−6 Ω cm2, respectively. Localized reactions in the form of islands were observed across the surface of the contact after annealing and were composed of Au, Ge, and As, as determined by secondary ion mass spectroscopy (SIMS) imaging and Auger depth profiling. Back side SIMS profiles indicate deep Ge and Au diffusion into the GaAs substrate in the island regions. Ohmic contact behavior was found to depend upon both the kinetics of the reactions (localized reactions and island growth) and the thermodynamics (substantial diffusion of both Au and Ge) of the system. A model describing the coupled Au and Ge in-diffusion with respect to the GaAs substrate is presented.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.352089
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  • 7
    Digitale Medien
    Digitale Medien
    Shallow ohmic contact to both n- and p-GaAs (1993)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 74 (1993), S. 754-756 
    Details
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: A shallow Pd/Ge/Ti/Pt/ohmic contact for both n- and p-GaAs has been investigated. The contacts were rapid thermally annealed in N2 for 15 s at temperatures from 350 to 550 °C. The lowest average specific contact resistances were 4.7×10−7 and 6.4×10−7 Ω cm2 for the n- and p-GaAs, respectively, when the n-GaAs was doped with Si to 2×1018 cm−3 and the p-GaAs was doped with carbon to 5×1019 cm−3. Electrical measurements and Auger depth profiles showed that the contacts were stable as they remained ohmic after an anneal at 300 °C for 20 h for both n- and p-GaAs. The p contact is more stable than the n contact at the higher temperatures where there is more As outdiffusion as determined by Auger depth profiles. Transmission electron microscopy showed that the interfaces between the p-GaAs and the contacts were smooth for both as-grown and annealed samples, and no oxides were detected.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.355248
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  • 8
    Digitale Medien
    Digitale Medien
    Magnetron reactive ion etching of GaAs: Residual damage study (1991)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 69 (1991), S. 695-697 
    Details
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: Residual damage of GaAs samples etched in a magnetron reactive ion etcher has been studied. Aligned yields from ion channeling measurements show that the amount of dechanneling in the etched samples is virtually identical to that of an unetched control sample, which indicates low concentration of disorder. Transmission electron microscopy reveals that the surface morphology of etched samples is extremely good with defects in the form of small dislocation loops of 20–40 A(ring) diam. It is shown that magnetron reactive ion etching is capable of yielding high etch rates with little surface damage.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.347351
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  • 9
    Digitale Medien
    Digitale Medien
    Thermal stability and performance reliability of Pt/Ti/WSi/Ni ohmic contacts to n-SiC for high temperature and pulsed power device applications (2002)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 91 (2002), S. 3864-3868 
    Details
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: Pt/Ti/WSi/Ni ohmic contacts to n-SiC, initially annealed at 950 and 1000 °C for 30 s, were evaluated for thermal stability via pulsed/cyclic thermal fatigue and aging experiments at 650 °C. Modifications of material properties in response to cyclic thermal fatigue and aging tests were quantitatively assessed via current–voltage measurements, field emission scanning microscopy, atomic force microscopy, and Rutherford backscattering spectrometry. Negligible changes in the electrical properties, microstructure, and surface morphology/roughness were observed for both annealed ohmic contacts in response to 100 cycles of acute cyclic thermal fatigue. Aging of the 950 °C annealed contact for 75 h at 650 °C resulted in electrical failure and chemical interdiffusion/reaction between the contact and SiC substrate. The 1000 °C annealed contact retained ohmicity after 100 h of aging and was found to be chemically and microstructurally stable. These findings indicate that the 1000 °C annealed Pt/Ti/WSi/Ni ohmic contact to n-SiC is thermally stable and merits strong potential for utilization in high temperature and pulsed power devices. © 2002 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.1450024
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  • 10
    Digitale Medien
    Digitale Medien
    Capillary condensation of helium in narrow slit pores (1993)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 99 (1993), S. 4064-4067 
    Details
    ISSN: 1089-7690
    Quelle: AIP Digital Archive
    Thema: Physik , Chemie und Pharmazie
    Notizen: We study the capillary condensation of liquid 4He films inside narrow slit pores with a density functional model and compare the result to the predictions of the Kelvin equation. Our investigation, in the wetting situation, indicates that pores with sizes up to 100 A(ring) are still too small for the macroscopic thermodynamic arguments used to derive the Kelvin equation to be successful. The discrepancy is tentatively attributed to the use of a slab-density model and bulk parameters in the region of very thin films.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.466102
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