GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Ligand Design for Securing Ferromagnetic Exchange Coupling in Multimetallic Complexes (1995)
    Weinheim : Wiley-Blackwell
    Chemistry - A European Journal 1 (1995), S. 528-537 
    Details
    ISSN: 0947-6539
    Keywords: exchange coupling ; ferromagnetic properties ; ligand design ; magnetic properties ; multimetallic complexes ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An approach is suggested for using ligands to control exchange coupling in multinuclear ions. The idea arose from structural, EPR, and magnetic studies of [PPh4]3 (Scheme 1). Ferromagnetic coupling has been found between the CoII and each CoIII in 3 with J = -22 ± 5 cm-1 (JS1 · S2). It is suggested that dominant antiferromagnetic superexchange is absent because of the strong σ-donor capacity of the tetradentate ligand [k4-PAC*]4- (Fig. 1). The ligand interacts at CoIII primarily with a single d orbital; it is thus best able to participate in superexchange. The interaction makes the unique d orbital strongly σ-antibonding and empty for each d6, S = 1, CoIII ion in 3, that is, unavailable for antiferromagnetic coupling, but available for ferromagnetic pathways by a Goodenough-Kanamori mechanism. By corollary, when any [k4-PAC*]4--type ligand with any magnetic ion Ma in the tetradentate site binds any magnetic ion Mb in the bidentate site, ferromagnetic coupling should be favored provided Ma is not a d9 ion.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chem.19950010806
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    facet.materialart.
    Unknown
    Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases (2016)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2016-07-08
    Description: Nature Medicine 22, 723 (2016). doi:10.1038/nm.4120 Authors: Jing Ni, Shakti H Ramkissoon, Shaozhen Xie, Shom Goel, Daniel G Stover, Hanbing Guo, Victor Luu, Eugenio Marco, Lori A Ramkissoon, Yun Jee Kang, Marika Hayashi, Quang-De Nguyen, Azra H Ligon, Rose Du, Elizabeth B Claus, Brian M Alexander, Guo-Cheng Yuan, Zhigang C Wang, J Dirk Iglehart, Ian E Krop, Thomas M Roberts, Eric P Winer, Nancy U Lin, Keith L Ligon & Jean J Zhao Brain metastases represent the greatest clinical challenge in treating HER2-positive breast cancer. We report the development of orthotopic patient-derived xenografts (PDXs) of HER2-expressing breast cancer brain metastases (BCBM), and their use for the identification of targeted combination therapies. Combined inhibition of PI3K and mTOR resulted in durable tumor regressions in three of five PDXs, and therapeutic response was correlated with a reduction in the phosphorylation of 4EBP1, an mTORC1 effector. The two nonresponding PDXs showed hypermutated genomes with enrichment of mutations in DNA-repair genes, which suggests an association of genomic instability with therapeutic resistance. These findings suggest that a biomarker-driven clinical trial of PI3K inhibitor in combination with an mTOR inhibitor should be conducted for patients with HER2-positive BCBM.
    Print ISSN: 1078-8956
    Electronic ISSN: 1546-170X
    Topics: Biology , Medicine
    Published by Nature Publishing Group (NPG)
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    Closed‐loop one‐way‐travel‐time navigation using low‐grade odometry for autonomous underwater vehicles (2018)
    John Wiley & Sons
    Details
    Publication Date: 2022-05-25
    Description: © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Journal of FIeld Robotics 35 (2018): 421-434, doi:10.1002/rob.21746.
    Description: This paper extends the progress of single beacon one‐way‐travel‐time (OWTT) range measurements for constraining XY position for autonomous underwater vehicles (AUV). Traditional navigation algorithms have used OWTT measurements to constrain an inertial navigation system aided by a Doppler Velocity Log (DVL). These methodologies limit AUV applications to where DVL bottom‐lock is available as well as the necessity for expensive strap‐down sensors, such as the DVL. Thus, deep water, mid‐water column research has mostly been left untouched, and vehicles that need expensive strap‐down sensors restrict the possibility of using multiple AUVs to explore a certain area. This work presents a solution for accurate navigation and localization using a vehicle's odometry determined by its dynamic model velocity and constrained by OWTT range measurements from a topside source beacon as well as other AUVs operating in proximity. We present a comparison of two navigation algorithms: an Extended Kalman Filter (EKF) and a Particle Filter(PF). Both of these algorithms also incorporate a water velocity bias estimator that further enhances the navigation accuracy and localization. Closed‐loop online field results on local waters as well as a real‐time implementation of two days field trials operating in Monterey Bay, California during the Keck Institute for Space Studies oceanographic research project prove the accuracy of this methodology with a root mean square error on the order of tens of meters compared to GPS position over a distance traveled of multiple kilometers.
    Description: This work was supported in part through funding from the Weston Howland Jr. Postdoctoral Scholar Award (BCC), the U.S. Navy's Civilian Institution program via the MIT/WHOI Joint Program (JHK),W. M. Keck Institute for Space Studies, and theWoods Hole Oceanographic Institution.
    Keywords: Acoustic ; Autonomous underwater vehicles ; Low grade odometry ; Navigation ; One way travel time
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 4
    facet.materialart.
    Unknown
    Satellites to seafloor : toward fully autonomous ocean sampling (2017)
    Oceanography Society
    Details
    Publication Date: 2022-05-26
    Description: Author Posting. © The Oceanography Society, 2017. This article is posted here by permission of The Oceanography Society for personal use, not for redistribution. The definitive version was published in Oceanography 30, no. 2 (2017): 160–168, doi:10.5670/oceanog.2017.238.
    Description: Future ocean observing systems will rely heavily on autonomous vehicles to achieve the persistent and heterogeneous measurements needed to understand the ocean’s impact on the climate system. The day-to-day maintenance of these arrays will become increasingly challenging if significant human resources, such as manual piloting, are required. For this reason, techniques need to be developed that permit autonomous determination of sampling directives based on science goals and responses to in situ, remote-sensing, and model-derived information. Techniques that can accommodate large arrays of assets and permit sustained observations of rapidly evolving ocean properties are especially needed for capturing interactions between physical circulation and biogeochemical cycling. Here we document the first field program of the Satellites to Seafloor project, designed to enable a closed loop of numerical model prediction, vehicle path-planning, in situ path implementation, data collection, and data assimilation for future model predictions. We present results from the first of two field programs carried out in Monterey Bay, California, over a period of three months in 2016. While relatively modest in scope, this approach provides a step toward an observing array that makes use of multiple information streams to update and improve sampling strategies without human intervention.
    Description: This work is funded by the Keck Institute for Space Studies (generously supported by the W.M. Keck Foundation) through the project “Science-driven Autonomous and Heterogeneous Robotic Networks: A Vision for Future Ocean Observation”
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER (OA)
  • 5
    facet.materialart.
    Unknown
    A parameterized geometric magnetic field calibration method for vehicles with moving masses with applications to underwater gliders (2017)
    Details
    Publication Date: 2022-05-26
    Description: Author Posting. © The Author(s), 2016. This is the author's version of the work. It is posted here by permission of John Wiley & Sons for personal use, not for redistribution. The definitive version was published in Journal of Field Robotics 34 (2017): 209-223, doi:10.1002/rob.21660.
    Description: The accuracy of magnetic measurements performed by autonomous vehicles is often limited by the presence of moving ferrous masses. This work presents a parameterized ellipsoid eld calibration method for magnetic measurements in the sensor frame. In this manner the ellipsoidal calibration coe cients are dependent on the locations of the moving masses. The parameterized calibration method is evaluated through eld trials with an autonomous underwater glider equipped with a low power precision uxgate sensor. A rst set of eld trials were performed in the East Arm of Bonne Bay, Newfoundland in December of 2013. During these trials a series of calibration pro les with the mass shifting and ballast mecha- nisms at di erent locations were performed before and after the survey portion of the trials. Further trials were performed in the Labrador Sea in July of 2014 with two reduced sets of calibration runs. The nominal ellipsoidal coe cients were extracted using the full set of measurements from a set of calibration pro les and used as the initial conditions for the polynomials which de ne each parameterized coe cient. These polynomials as well as the sensor misalignment matrix were then optimized using a gradient descent solver which minimizes both the total magnetic eld di erence and the vertical magnetic eld variance between the modeled and measured values. Including the vertical eld in this manner allows for convergence in spite of severe limitations on the platform's motion and for computation of the vehicle's magnetic heading.
    Description: This work was supported by the Natural Sciences and Engineering Research Council (NSERC) through the NSERC Canadian Field Robotics Network (NCFRN), the Research Development Corporation, the Marine Institute and Memorial University of Newfoundland.
    Description: 2017-06-07
    Repository Name: Woods Hole Open Access Server
    Type: Preprint
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER (OA)
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...