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  • 1
    Digitale Medien
    Digitale Medien
    Photoinduced electron transfer processes in oligothiophene/C60 composite films (1995)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 102 (1995), S. 2628-2635 
    Details
    ISSN: 1089-7690
    Quelle: AIP Digital Archive
    Thema: Physik , Chemie und Pharmazie
    Notizen: We present near steady-state photoinduced absorption (PIA) spectroscopy and steady-state light-induced electron spin resonance (LESR) studies on photoinduced electron transfer reactions in composite films of well defined α-oligothiophenes (Tn, n=6, 7, 9, and 11) as electron donor with buckminsterfullerene (C60) and a methanofullerene derivative (1-(3-cholestanoxycarbonyl)- propyl-1-phenyl-[6.6]C61) as electron acceptors. Dispersion on a molecular level of these fullerenes in oligothiophene films causes quenching of both the photoluminescence and intersystem crossing after photoexcitation across the π–π* energy gap as a result of a fast electron transfer reaction. The PIA spectra exhibit bands due to T+•n radical cations, fullerene radical anions and electroabsorption oscillations of the π–π* band edge resulting from strong local electric fields set up by the photoinduced charges. LESR spectra give additional unambiguous evidence of the photoinduced electron transfer reaction. Using PIA and LESR, we do not observe an effect of the conjugation length of the photoinduced electron transfer reaction or on the metastability of the charge-separated state. © 1995 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.468694
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  • 2
    Digitale Medien
    Digitale Medien
    Effects of water acidification on the distribution pattern and the reproductive success of amphibians (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 495-503 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Acidication ; pH ; calcium ; (heavy) metals ; ammonium ; amphibians ; development of eggs ; hatching percentage ; mortality of larvae
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Nine amphibian species were encountered in poorly buffered waters of The Netherlands (alkalinity ≦1 meq·l−1). These soft water systems are highly sensitive to acidifying precipitation. The number of species as well as the percentage of waters which harbour amphibian populations are strongly reduced in the extremely acid pH-class $$(\bar pH〈 4.0)$$ . The reproductive success of amphibians is negatively affected by low pH. The eggs become heavily infested with fungi (Saprolegniaceae). In acidifying systems many physico-chemical parameters are significantly correlated with the pH of the water. Strongly acidified waters are characterized by low alkalinity, conductivity and ionic content but high acidity and high concentrations of (heavy) metals and ammonium and a high relative sulphate concentration. Culture experiments with eggs and larvae ofRana arvalis. Rana ‘esculenta’, Rana temporaria andBufo bufo show that apart from the pH, elevated aluminium, cadmium and ammonium contents may also affect the reproductive success of amphibians.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01946687
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  • 3
    Digitale Medien
    Digitale Medien
    Risk factors for cytomegalovirus infection and disease in renal transplant recipients: HLA-DR7 and triple therapy (1994)
    Springer
    Transplant international 7 (1994), S. 362-367 
    Details
    ISSN: 1432-2277
    Schlagwort(e): CMV, kidney transplantation, HLA-DR7 ; CMV, kidney transplantation, triple therapy ; Kidney transplantation, CMV, HLA-DR7 ; HLA-DR7, CMV, kidney transplantation ; Triple therapy, kidney transplantation, CMV
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In a prospective study, an analysis of risk factors for the development of cytomegalovirus (CMV) infection and disease was performed on 77 renal allograft recipients. Twenty-five out of the 77 recipients (32%) had a CMV infection. Twenty-two of the recipients received triple immunosuppressive therapy (cyclosporin A, prednisolone, and azathioprine) while the remaining 55 received standard therapy (cyclosporin A and prednisolone). In 23 recipients (30%) acute rejection was diagnosed and the first positive parameter of infection occurred 22 days after rejection therapy. Infection occurred in 10 out of 18 HLA-DR7-positive recipients (56%) and in 15 out of 59 HLA-DR7-negative recipients (25%; P〈 0.02). In multiple regression analysis, HLA-DR7 was found to be a significant predictor of CMV infection (P〈 0.005). CMV disease was diagnosed in only 9 out of 25 recipients with an acute infection. Six recipients (67%) with CMV disease received triple therapy for maintenance immuuosuppression; this was significantly correlated to CMV disease (P〈 0.05) as compared to three recipients (33%) with CMV disease maintained with standard therapy. Our data suggest that HLA-DR7-positive recipients are more susceptible to CMV infection and that CMV disease is associated with triple immunosuppressive therapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00336713
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  • 4
    Digitale Medien
    Digitale Medien
    Evaluation of a new method for early detection of active cytomegalovirus infections. A study in kidney transplant recipients (1998)
    Springer
    Transplant international 11 (1998), S. S107 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Key words Human cytomegalovirus ; Nucleic acid sequence-based amplification ; Kidney transplantation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Early detection of active cytomegalovirus (CMV) infection after organ transplantation is necessary to start effective antiviral treatment. In the present study, blood specimens of kidney transplant recipients (n = 38) were monitored for the expression of CMV immediate early (IE) and late (L) mRNA using nucleic acid sequence-based amplification (NASBA). Results were compared with virus isolation, pp65 antigenemia and serology. In patients developing active CMV infection, pp65 antigen and L mRNA were detected simultaneously. At the same time, positive cell culture results could be reported to the clinic. CMV was detected significantly earlier with IE NASBA than with the other assays. However, the specificity of IE NASBA is lower than that of antigenemia, late NASBA and cell culture. Early detection of IE mRNA is especially useful for patients at high risk of developing symptomatic CMV infection in order that early, adequate antiviral therapy may be started. Late NASBA can be used to monitor further development of CMV infection, comparable to antigenemia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001470050439
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  • 5
    Digitale Medien
    Digitale Medien
    Tacrolimus and cyclosporine efficacy in high-risk kidney transplantation (1998)
    Springer
    Transplant international 11 (1998), S. S73 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Key words Tacrolimus ; Cyclosporine ; Kidney transplantation ; High risk
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The efficacy and safety of tacrolimus- and cyclosporine-based immunosuppressive regimens were compared in a prospectively defined subgroup of kidney transplant recipients from the European, open, multicentre, 2 : 1 randomised, parallel group study. Patients were stratified as high risk for immunological events if they had a panel-reactive antibodies grade greater than 80 % and/or a previous transplant functional for less than 1 year. The primary efficacy variables evaluated were the incidence of acute rejection, steroid usage and patient and graft survival. Safety was assessed based on adverse events and laboratory evaluations. At 1 year, the tacrolimus group (n = 22) had a lower incidence of biopsy-proven acute rejection (31.8 %) and a higher graft survival (86.0 %) than the 11 patients in the cyclosporine group (54.5 % and 72.0 %, respectively). The frequencies of adverse events were similar between the two groups. The tacrolimus regimen appears more beneficial for high risk patients than cyclosporine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/PL00014036
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  • 6
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    Towards a standardised informed consent procedure for live donor nephrectomy: the PRINCE (Process of Informed Consent Evaluation) project--study protocol for a nationwide prospective cohort study (2016)
    BMJ Publishing
    In: BMJ Open
    Details
    Publikationsdatum: 2016-04-03
    Beschreibung: Introduction Informed consent is mandatory for all (surgical) procedures, but it is even more important when it comes to living kidney donors undergoing surgery for the benefit of others. Donor education, leading to informed consent, needs to be carried out according to certain standards. Informed consent procedures for live donor nephrectomy vary per centre, and even per individual healthcare professional. The basis for a standardised, uniform surgical informed consent procedure for live donor nephrectomy can be created by assessing what information donors need to hear to prepare them for the operation and convalescence. Methods and analysis The PRINCE (Process of Informed Consent Evaluation) project is a prospective, multicentre cohort study, to be carried out in all eight Dutch kidney transplant centres. Donor knowledge of the procedure and postoperative course will be evaluated by means of pop quizzes. A baseline cohort (prior to receiving any information from a member of the transplant team in one of the transplant centres) will be compared with a control group, the members of which receive the pop quiz on the day of admission for donor nephrectomy. Donor satisfaction will be evaluated for all donors who completed the admission pop-quiz. The primary end point is donor knowledge. In addition, those elements that have to be included in the standardised format informed consent procedure will be identified. Secondary end points are donor satisfaction, current informed consent practices in the different centres (eg, how many visits, which personnel, what kind of information is disclosed, in which format, etc) and correlation of donor knowledge with surgeons' estimation thereof. Ethics and dissemination Approval for this study was obtained from the medical ethical committee of the Erasmus MC, University Medical Center, Rotterdam, on 18 February 2015. Secondary approval has been obtained from the local ethics committees in six participating centres. Approval in the last centre has been sought. Results Outcome will be published in a scientific journal. Trial registration number NTR5374; Pre-results.
    Schlagwort(e): Open access, Ethics, Surgery
    Digitale ISSN: 2044-6055
    Thema: Medizin
    Publiziert von BMJ Publishing
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