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  • 1
    Electronic Resource
    Electronic Resource
    1,3-β-Glucan hydrolase from Citrus
    Amsterdam : Elsevier
    Phytochemistry 22 (1983), S. 2699-2701 
    Details
    ISSN: 0031-9422
    Keywords: 1,3-β-glucan hydrolase. ; Citrus aurantifolia ; Mexican lime ; Rutaceae ; polysaccharide degradation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0031-9422(00)97675-1
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    A visual-electrophoretic method for following the purification of ribulose-1,5-bisphosphate carboxylase oxygenase
    Amsterdam : Elsevier
    Biochemical Education 16 (1988), S. 234-236 
    Details
    ISSN: 0307-4412
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0307-4412(88)90137-9
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of Chilean hazel nut sweet cookies (1993)
    Springer
    Plant foods for human nutrition 43 (1993), S. 279-285 
    Details
    ISSN: 1573-9104
    Keywords: Hazel nut ; cookies ; chemical composition ; pharinological properties ; sensory evaluation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract A series of studies were carried out to test the effect of the incorporation of Chilean hazel nut flour in sweet cookies at the levels of 0%, 5%, 10%, 15% and 20%. The proximate chemical analysis of the different flour mixtures showed a regular increase from 7.2 to 12.2%, 14.5% to 18.8% and 1% to 2.2%, respectively, decreasing at the same time with the percentages of water and carbohydrates. Chemical amino acid scores of leucine and threonine in wheat flour improved with the incorporation of Chilean hazel nut flour. The farinographic evaluation made to the different blends showed several changes occurred with the incorporation of Chilean hazel nut flour to wheat flour. These included increase in water absorption, decrease in dough developing time and weakening of the dough. Sensory characteristics such as appearance, texture, flavor and also acceptability improved with the incorporation of Chilean hazel nut flour into the cookie formulaes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01886231
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    Paper (German National Licenses)
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  • 4
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    Mass of the b quark and B-meson decay constants from N_{f} =2+1+1 twisted-mass lattice QCD (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-06-08
    Description: Author(s): A. Bussone, N. Carrasco, P. Dimopoulos, R. Frezzotti, P. Lami, V. Lubicz, E. Picca, L. Riggio, G. C. Rossi, S. Simula, and C. Tarantino (ETM Collaboration) We present precise lattice computations for the b -quark mass, the quark mass ratios m b / m c and m b / m s as well as the leptonic B -decay constants. We employ gauge configurations with four dynamical quark flavors, up-down, strange and charm, at three values of the lattice spacing ( a ∼ 0.06 – 0.09     fm ) and fo… [Phys. Rev. D 93, 114505] Published Tue Jun 07, 2016
    Keywords: Lattice Methods
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 5
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    K→π semileptonic form factors with N_{f} =2+1+1 twisted mass fermions (2016)
    American Physical Society (APS)
    Details
    Publication Date: 2016-06-21
    Description: Author(s): N. Carrasco, P. Lami, V. Lubicz, L. Riggio, S. Simula, and C. Tarantino (ETM Collaboration) We present a lattice QCD determination of the vector and scalar form factors of the semileptonic K → π ℓ ν decay which are relevant for the extraction of the Cabibbo-Kobayashi-Maskawa matrix element | V u s | from experimental data. Our results are based on the gauge configurations produced by the European … [Phys. Rev. D 93, 114512] Published Mon Jun 20, 2016
    Keywords: Lattice Methods
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
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    Important roles of brain-specific carnitine palmitoyltransferase and ceramide metabolism in leptin hypothalamic control of feeding [Neuroscience] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-06-08
    Description: Brain-specific carnitine palmitoyltransferase-1 (CPT-1c) is implicated in CNS control of food intake. In this article, we explore the role of hypothalamic CPT-1c in leptin's anorexigenic actions. We first show that adenoviral overexpression of CPT-1c in hypothalamic arcuate nucleus of rats increases food intake and concomitantly up-regulates orexigenic neuropeptide Y (NPY) and Bsx (a transcription factor of NPY). Then, we demonstrate that this overexpression antagonizes the anorectic actions induced by central leptin or compound cerulenin (an inhibitor of fatty acid synthase). The overexpression of CPT-1c also blocks leptin-induced down-regulations of NPY and Bsx. Furthermore, the anorectic actions of central leptin or cerulenin are impaired in mice with brain CPT-1c deleted. Both anorectic effects require elevated levels of hypothalamic arcuate nucleus (Arc) malonyl-CoA, a fatty acid-metabolism intermediate that has emerged as a mediator in hypothalamic control of food intake. Thus, these data suggest that CPT-1c is implicated in malonyl-CoA action in leptin's hypothalamic anorectic signaling pathways. Moreover, ceramide metabolism appears to play a role in leptin's central control of feeding. Leptin treatment decreases Arc ceramide levels, with the decrease being important in leptin-induced anorectic actions and down-regulations of NPY and Bsx. Of interest, our data indicate that leptin impacts ceramide metabolism through malonyl-CoA and CPT-1c, and ceramide de novo biosynthesis acts downstream of both malonyl-CoA and CPT-1c in mediating their effects on feeding and expressions of NPY and Bsx. In summary, we provide insights into the important roles of malonyl-CoA, CPT-1c, and ceramide metabolism in leptin's hypothalamic signaling pathways.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 7
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    CPT1C and Dendritic Spinogenesis [Neurobiology] (2012)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Details
    Publication Date: 2012-06-22
    Description: The brain-specific isoform carnitine palmitoyltransferase 1C (CPT1C) has been implicated in the hypothalamic regulation of food intake and energy homeostasis. Nevertheless, its molecular function is not completely understood, and its role in other brain areas is unknown. We demonstrate that CPT1C is expressed in pyramidal neurons of the hippocampus and is located in the endoplasmic reticulum throughout the neuron, even inside dendritic spines. We used molecular, cellular, and behavioral approaches to determine CPT1C function. First, we analyzed the implication of CPT1C in ceramide metabolism. CPT1C overexpression in primary hippocampal cultured neurons increased ceramide levels, whereas in CPT1C-deficient neurons, ceramide levels were diminished. Correspondingly, CPT1C knock-out (KO) mice showed reduced ceramide levels in the hippocampus. At the cellular level, CPT1C deficiency altered dendritic spine morphology by increasing immature filopodia and reducing mature mushroom and stubby spines. Total protrusion density and spine head area in mature spines were unaffected. Treatment of cultured neurons with exogenous ceramide reverted the KO phenotype, as did ectopic overexpression of CPT1C, indicating that CPT1C regulation of spine maturation is mediated by ceramide. To study the repercussions of the KO phenotype on cognition, we performed the hippocampus-dependent Morris water maze test on mice. Results show that CPT1C deficiency strongly impairs spatial learning. All of these results demonstrate that CPT1C regulates the levels of ceramide in the endoplasmic reticulum of hippocampal neurons, and this is a relevant mechanism for the correct maturation of dendritic spines and for proper spatial learning.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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  • 8
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    Titan's atmosphere simulation experiment using continuum UV-VUV synchrotron radiation (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-02-23
    Description: [1]  A new reactor, named APSIS for Atmospheric Photochemistry SImulated by Synchrotron, is designed for simulating the reactivity occurring in planetary upper atmospheres. In this reactor, a gas mixture roughly reproducing the main Titan's atmosphere composition (N 2 /CH 4  = 90/10) is irradiated by a continuous-spectrum in the 60−350 nm range, provided by the DISCO beamline at SOLEIL synchrotron radiation facility. This spectral range enables the dissociation and ionization of N 2 and CH 4 , as observed in plasma reactors and Titan's ionosphere. The neutral products are detected in situ by quadrupole mass spectrometry, and collected with a cryogenic trap for ex-situ analysis by gas chromatography-mass spectrometry. The detected reaction products include C2, C3, C4 and probably C5 organic compounds, with important amounts of nitrogen-bearing species: HCN, CH 3 CN and C 2 N 2 . Neutral mass spectra obtained with APSIS are compared with INMS experiments of the Cassini space probe in the upper Titan atmosphere and with other results of current Titan atmosphere chemistry laboratory simulations.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
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  • 9
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    ΔS=2 and ΔC=2 bag parameters in the standard model and beyond from N_{f} =2+1+1 twisted-mass lattice QCD (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-08-27
    Description: Author(s): N. Carrasco, P. Dimopoulos, R. Frezzotti, V. Lubicz, G. C. Rossi, S. Simula, and C. Tarantino (ETM Collaboration) We present unquenched lattice QCD results for the matrix elements of four-fermion operators relevant to the description of the neutral K and D mixing in the standard model and its extensions. We have employed simulations with N f = 2 + 1 + 1 dynamical sea quarks at three values of the lattice spacings in t… [Phys. Rev. D 92, 034516] Published Wed Aug 26, 2015
    Keywords: Lattice Methods
    Print ISSN: 0556-2821
    Electronic ISSN: 1089-4918
    Topics: Physics
    Published by American Physical Society (APS)
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  • 10
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    CPT1C Regulation of AMPAR Expression [Neurobiology] (2015)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Details
    Publication Date: 2015-10-17
    Description: The regulation of AMPA-type receptor (AMPAR) abundance in the postsynaptic membrane is an important mechanism involved in learning and memory formation. Recent data suggest that one of the constituents of the AMPAR complex is carnitine palmitoyltransferase 1C (CPT1C), a brain-specific isoform located in the endoplasmic reticulum of neurons. Previous results had demonstrated that CPT1C deficiency disrupted spine maturation in hippocampal neurons and impaired spatial learning, but the role of CPT1C in AMPAR physiology had remained mostly unknown. In the present study, we show that CPT1C binds GluA1 and GluA2 and that the three proteins have the same expression profile during neuronal maturation. Moreover, in hippocampal neurons of CPT1C KO mice, AMPAR-mediated miniature excitatory postsynaptic currents and synaptic levels of AMPAR subunits GluA1 and GluA2 are significantly reduced. We show that AMPAR expression is dependent on CPT1C levels because total protein levels of GluA1 and GluA2 are decreased in CPT1C KO neurons and are increased in CPT1C-overexpressing neurons, whereas other synaptic proteins remain unaltered. Notably, mRNA levels of AMPARs remained unchanged in those cultures, indicating that CPT1C is post-transcriptionally involved. We demonstrate that CPT1C is directly involved in the de novo synthesis of GluA1 and not in protein degradation. Moreover, in CPT1C KO cultured neurons, GluA1 synthesis after chemical long term depression was clearly diminished, and brain-derived neurotrophic factor treatment was unable to phosphorylate the mammalian target of rapamycin (mTOR) and stimulate GluA1 protein synthesis. These data newly identify CPT1C as a regulator of AMPAR translation efficiency and therefore also synaptic function in the hippocampus.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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