In:
Multiple Sclerosis Journal, SAGE Publications, Vol. 11, No. 1 ( 2005-02), p. 13-15
Abstract:
Using radioimmunoassay we measured serum levels of insulin-like growth factor (IGF)-1 and IGF binding protein (IGFBP)-3 in patients with relapsing multiple sclerosis (MS) and a benign course (Expanded Disability Status Scale (EDSS)≤ 3 despite 〉 10 years disease duration), relapsing MS with cumulative disability leading to an EDSS score 〉 4 within 10 years of disease duration, primary progressive MS and healthy controls. We found no differences in IGF-1 and IGFBP-3 serum levels, and the IGF-1/IGFBP-3 ratio between the four groups. However, there was a significant correlation (P=0.005) between IGFBP-3 serum levels and both the progression index of disability and the Multiple Sclerosis Severity Score in patients with primary progressive MS.
Type of Medium:
Online Resource
ISSN:
1352-4585
,
1477-0970
DOI:
10.1191/1352458505ms1123oa
Language:
English
Publisher:
SAGE Publications
Publication Date:
2005
detail.hit.zdb_id:
2008225-3
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