In:
eLife, eLife Sciences Publications, Ltd, Vol. 8 ( 2019-03-21)
Kurzfassung:
Several recent papers have reported strong signals of selection on European polygenic height scores. These analyses used height effect estimates from the GIANT consortium and replication studies. Here, we describe a new analysis based on the the UK Biobank (UKB), a large, independent dataset. We find that the signals of selection using UKB effect estimates are strongly attenuated or absent. We also provide evidence that previous analyses were confounded by population stratification. Therefore, the conclusion of strong polygenic adaptation now lacks support. Moreover, these discrepancies highlight (1) that methods for correcting for population stratification in GWAS may not always be sufficient for polygenic trait analyses, and (2) that claims of differences in polygenic scores between populations should be treated with caution until these issues are better understood. Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed ( 〈 xref ref-type="decision-letter" rid="SA1" 〉 see decision letter 〈 /xref 〉 ).
Materialart:
Online-Ressource
ISSN:
2050-084X
DOI:
10.7554/eLife.39725.001
DOI:
10.7554/eLife.39725.002
DOI:
10.7554/eLife.39725.003
DOI:
10.7554/eLife.39725.004
DOI:
10.7554/eLife.39725.005
DOI:
10.7554/eLife.39725.006
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10.7554/eLife.39725.007
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10.7554/eLife.39725.008
DOI:
10.7554/eLife.39725.009
DOI:
10.7554/eLife.39725.010
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10.7554/eLife.39725.011
DOI:
10.7554/eLife.39725.012
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10.7554/eLife.39725.013
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10.7554/eLife.39725.014
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10.7554/eLife.39725.015
DOI:
10.7554/eLife.39725.016
DOI:
10.7554/eLife.39725.017
DOI:
10.7554/eLife.39725.018
DOI:
10.7554/eLife.39725.019
DOI:
10.7554/eLife.39725.020
DOI:
10.7554/eLife.39725.021
DOI:
10.7554/eLife.39725.022
DOI:
10.7554/eLife.39725.023
DOI:
10.7554/eLife.39725.024
DOI:
10.7554/eLife.39725.025
DOI:
10.7554/eLife.39725.026
DOI:
10.7554/eLife.39725.027
DOI:
10.7554/eLife.39725.028
DOI:
10.7554/eLife.39725.029
DOI:
10.7554/eLife.39725.030
DOI:
10.7554/eLife.39725.031
DOI:
10.7554/eLife.39725.032
DOI:
10.7554/eLife.39725.033
DOI:
10.7554/eLife.39725.034
DOI:
10.7554/eLife.39725.035
DOI:
10.7554/eLife.39725.036
DOI:
10.7554/eLife.39725.037
DOI:
10.7554/eLife.39725.038
DOI:
10.7554/eLife.39725.050
DOI:
10.7554/eLife.39725.051
Sprache:
Englisch
Verlag:
eLife Sciences Publications, Ltd
Publikationsdatum:
2019
ZDB Id:
2687154-3
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