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  • 1
    ISSN: 1460-9592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : The aims of this study were to evaluate pharmacokinetics, efficacy and safety of ropivacaine in infants aged 0–12 months following a single caudal injection.Methods : Term ASA I–III patients, scheduled for surgery, with a body weight of ≥2500 g received a caudal block with ropivacaine 2 mg·ml−1, 1.0 ml·kg−1. Plasma samples were collected at different time intervals up to 30 h, for analysis of total and unbound ropivacaine and alpha-1-acid glycoprotein (AAG). Pharmacokinetic data were characterized by population analysis. Unbound and total concentrations from 35 patients, median (min–max) postnatal age of 66 (4–351) days, were included in the nonlinear mixed effects modeling to provide estimates of pharmacokinetic parameters and the exploration of covariate relationships. Simulations were made to test the predictive performance of the final model and to describe the effect of significant covariates on systemic exposure.Results : The mean (min–max) peak plasma concentration of total ropivacaine was 0.83 (0.05–1.57) mg·l−1 at 0.5–5.7 h (median: 1.0 h) and the plasma concentration of unbound ropivacaine was 0.042 (0.012–0.081) mg·l−1 within 0.5–1 h. The observed unbound fraction in plasma was 6% (1%–14%). A one-compartment open model with first-order absorption and elimination, incorporating a linear-binding model of ropivacaine to AAG best described the data. The only significant covariate relationship was that of age on Clu/F according to the following relationship Clu/F = 3.01 × e0.00474 × Age. This predicts a Clu/F of 3.5 l·h−1·kg−1 at 30 days and 10.8 l·h−1·kg−1 at 270 days with corresponding terminal half-lives of 6.7 and 2.2 h. The interindividual variability (coefficient of variation, CV) in Clu/F was 39%. The population estimate (CV) of ka was 1.65 h−1 (30%), Vu/F was 33.6 (l·kg−1) (45%) and Ka was 1.78 l·mg−1 (14%). Thirty-five infants received supplementary analgesics (mostly paracetamol). The median time to first supplementary analgesic (based on all 37 patients) was 3.9 h. No safety concerns or signs of systemic toxicity were observed.Conclusions : Following a caudal block with ropivacaine 2 mg·kg−1 plasma concentrations of unbound ropivacaine were well below threshold levels for toxicity in adults. Apparent volume of distribution is unchanged, apparent unbound clearance increases and the terminal half-life decreases with age in 0–12-month-old neonates and infants. The postoperative pain management provided adequate analgesia and was well tolerated.
    Type of Medium: Electronic Resource
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  • 2
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    Unknown
    PANGAEA
    In:  Supplement to: Jungblut, Simon; Beermann, Jan; Boos, Karin; Saborowski, Reinhard; Hagen, Wilhelm (2017): Population development of the invasive crab Hemigrapsus sanguineus (De Haan, 1853) and its potential native competitor Carcinus maenas (Linnaeus, 1758) at Helgoland (North Sea) between 2009 and 2014. Aquatic Invasions, 12(1), 85-96, https://doi.org/10.3391/ai.2017.12.1.09
    Publication Date: 2023-11-14
    Description: The Asian shore crab Hemigrapsus sanguineus (De Haan, 1853) has recently established populations in the North Sea and now occurs within the native ranges of the green crab Carcinus maenas (Linnaeus, 1758). To determine potential competitive effects and to assess the progress of the invasion, species-specific population characteristics (numerical abundances, biomasses, and size distributions) of the two species around the island of Helgoland (German Bight, southern North Sea) were compared for surveys conducted in 2009 and 2014. Sampling sites were chosen based on accessibility and differed in their topography and wave exposure, which allowed testing for the influence of these factors on the establishment success of H. sanguineus. The numerical abundance and biomass of H. sanguineus increased markedly and approached those of C. maenas in 2014. At a sheltered site, H. sanguineus even outnumbered C. maenas, whereas the converse was observed at a site exposed to strong winds and waves. Although such contrasting abundance patterns between the native and the introduced shore crab may be the result of direct interference, the dominance of H. sanguineus at the sheltered site may also be explained by enhanced larval settling rates caused by odors of conspecifics. The results suggest that the invasion of H. sanguineus has not yet reached its equilibrium, and population abundances in the North Sea are expected to further increase in the future.
    Type: Dataset
    Format: application/zip, 4 datasets
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  • 3
    Publication Date: 2023-11-14
    Keywords: Augusta Mole; Carcinus maenas, carapax width; Carcinus maenas, female; Carcinus maenas, male; DATE/TIME; Event label; Felswatt; HAND; Helgoland, North Sea; Kringel; Latitude of event; Longitude of event; Nordstrand; Northeastern_site; Northwestern_site; Sampling by hand; Southeastern_site; Southwestern_site
    Type: Dataset
    Format: text/tab-separated-values, 565 data points
    Location Call Number Limitation Availability
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  • 4
    Publication Date: 2023-11-14
    Keywords: Augusta Mole; DATE/TIME; Event label; Felswatt; HAND; Helgoland, North Sea; Hemigrapsus sanguineus, carapax width; Hemigrapsus sanguineus, female; Hemigrapsus sanguineus, male; Kringel; Latitude of event; Longitude of event; Nordstrand; Northeastern_site; Northwestern_site; Sampling by hand; Southeastern_site; Southwestern_site
    Type: Dataset
    Format: text/tab-separated-values, 199 data points
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  • 5
    Publication Date: 2023-11-14
    Keywords: Augusta Mole; Carcinus maenas, carapax width; Carcinus maenas, female; Carcinus maenas, male; DATE/TIME; Event label; Felswatt; HAND; Helgoland, North Sea; Kringel; Latitude of event; Longitude of event; Nordstrand; Northeastern_site; Northwestern_site; Sampling by hand; Southeastern_site; Southwestern_site
    Type: Dataset
    Format: text/tab-separated-values, 543 data points
    Location Call Number Limitation Availability
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  • 6
    Publication Date: 2023-11-14
    Keywords: Augusta Mole; DATE/TIME; Event label; Felswatt; HAND; Helgoland, North Sea; Hemigrapsus sanguineus, carapax width; Hemigrapsus sanguineus, female; Hemigrapsus sanguineus, male; Kringel; Nordstrand; Northeastern_site; Northwestern_site; Sampling by hand; Southeastern_site; Southwestern_site
    Type: Dataset
    Format: text/tab-separated-values, 473 data points
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  • 7
    Publication Date: 2024-04-11
    Description: Please note: Abstract created by PANGAEA data editor using Jungblut et al. (2017). Marine top predators (seabirds, marine mammals and other megafauna) were counted during POLARSTERN cruise ANT-XXVIII/1 passing the east Atlantic from Bremerhaven to Cape Town in fall 2011. Continuous half-hour transect counts were conducted by two observers from the bridge, situated approximately 18 meters above sea level, throughout daylight hours and while the vessel maintained its traveling speed (see Joiris & Falck 2011). Due to the width of the bridge, observations were limited to a 90° angle from the bow to one side, as it was impractical for one observer to simultaneously cover both sides. Species were initially identified with the naked eye and confirmed using binoculars (8 – 10 times magnification). Photos were used in retrospect to help identify rare or hard to classify specimens. Individuals following or circling around the ship were only counted once in a 30 min interval (i.e. during one 'transect count'). Water temperature and salinity were continuously and automatically recorded by a thermo-salinometer installed at the keel of the Polarstern (approximately 10 meters below sea level). Depth data were obtained either from the vessel's echosounder or hydrosweep. Data extraction was carried out from the DShip data system on board.
    Keywords: Albatrosses; Alca torda; Alcidae sp.; Anous stolidus; ANT-XXVIII/1; Arctocephalus pusillus; Atlantic, transit cruise; Balaenoptera acutorostrata; Balaenoptera borealis; Balaenoptera brydei; Balaenoptera physalus; Beaked whale; Branta bernicla; Bulweria bulwerii; Calonectris diomedea; Calonectris edwardsii; Caretta caretta; Catharacta antarctica; Catharacta maccormicki; Catharacta skua; Chelonia mydas; Chlidonias niger; CT; Daption capense; DATE/TIME; Delphinus delphis; Depth, bathymetric; Dermochelys coriacea; Diomedea dabbenena; Diomedea epomophora; Diomedea exulans; Diomedea sanfordi; Diomedea sp.; Distance; Dolphins, unidentified; Eudyptes chrysocome; Fluorescence, chlorophyll; Fregata aquila; Fregata magnificens; Fregetta grallaria; Fulmarus glacialis; Garrodia nereis; Gavia arctica; Globicephala macrorhynchus; Globicephala melas; Globicephala sp.; Grampus griseus; Gulls; Hammerhead shark; Hydrobates pelagicus; Identification; Lagenorhynchus albirostris; Lagenorhynchus australis; Lagenorhynchus sp.; Larus argentatus; Larus canus; Larus dominicanus; Larus fuscus; Larus marinus; Larus melanocephalus; Larus michahellis; Larus minutus; Larus ridibundus; LATITUDE; LONGITUDE; Macronectes giganteus; Macronectes sp.; Manta sp.; Megaptera novaeangliae; Mola mola; Morus bassanus; Oceanites oceanicus; Oceanodroma castro; Oceanodroma leucorhoa; Orcinus orca; Pachyptila sp.; Pelagodroma marina; Pelecanoides magellani; Pelecanoides sp.; Penguins; Petrels; Phaethon aethereus; Phaethon lepturus; Phalacrocorax capensis; Phalacrocorax carbo; Phalacrocorax coronatus; Phalaropus fulicarius; Phocoena phocoena; Physeter catodon; Polarstern; Procellaria aequinoctialis; Procellaria conspicillata; PS79; PS79/1-track; Pterodroma arminjoniana; Pterodroma feae; Pterodroma incerta; Pterodroma macroptera; Pterodroma mollis; Puffinus assimilis; Puffinus baroli; Puffinus gravis; Puffinus griseus; Puffinus lherminieri; Puffinus mauretanicus; Puffinus puffinus; Ray; Rissa tridactyla; Salinity; Seabirds, unidentified; Sea turtles; Shark; Shearwaters; Skuas; Speed; Spheniscus magellanicus; Stenella clymene; Stenella coeruleoalba; Stenella frontalis; Stenella longirostris; Steno bredanensis; Stercorarius longicaudus; Stercorarius parasiticus; Stercorarius pomarinus; Sterna anaethetus; Sterna arctica; Sterna dougallii; Sterna fuscata; Sterna hirundo; Sterna sandvicensis; Storm-petrels; Sula capensis; Sula leucogaster; Sula sula; Temperature, water; Terns; Thalassarche cauta; Thalassarche chlororhynchos; Thalassarche melanophris; Thalasseus bergii; Thalasseus maximus; Tropicbirds; Tursiops truncatus; Underway cruise track measurements; Uria aalge; Whale, unidentified; Xema sabini; Ziphius cavirostris; Zone
    Type: Dataset
    Format: text/tab-separated-values, 74534 data points
    Location Call Number Limitation Availability
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  • 8
    Publication Date: 2024-04-11
    Description: Please note: Abstract created by PANGAEA data editor using Jungblut et al. (2017). Marine top predators (seabirds, marine mammals and other megafauna) were counted during POLARSTERN cruise ANT-XXIX/1 passing the east Atlantic from Bremerhaven to Cape Town in fall 2012. Continuous half-hour transect counts were conducted by two observers from the bridge, situated approximately 18 meters above sea level, throughout daylight hours and while the vessel maintained its traveling speed (see Joiris & Falck 2011). Due to the width of the bridge, observations were limited to a 90° angle from the bow to one side, as it was impractical for one observer to simultaneously cover both sides. Species were initially identified with the naked eye and confirmed using binoculars (8 – 10 times magnification). Photos were used in retrospect to help identify rare or hard to classify specimens. Individuals following or circling around the ship were only counted once in a 30 min interval (i.e. during one 'transect count'). Water temperature and salinity were continuously and automatically recorded by a thermo-salinometer installed at the keel of the Polarstern (approximately 10 meters below sea level). Depth data were obtained either from the vessel's echosounder or hydrosweep. Data extraction was carried out from the DShip data system on board.
    Keywords: Albatrosses; Alca torda; Alcidae sp.; Anous stolidus; ANT-XXIX/1; Arctocephalus pusillus; Atlantic, transit cruise; Balaenoptera acutorostrata; Balaenoptera borealis; Balaenoptera brydei; Balaenoptera physalus; Beaked whale; Branta bernicla; Bulweria bulwerii; Calonectris diomedea; Calonectris edwardsii; Caretta caretta; Catharacta antarctica; Catharacta maccormicki; Catharacta skua; Chelonia mydas; Chlidonias niger; CT; Daption capense; DATE/TIME; Delphinus delphis; Depth, bathymetric; Dermochelys coriacea; Diomedea dabbenena; Diomedea epomophora; Diomedea exulans; Diomedea sanfordi; Diomedea sp.; Distance; Dolphins, unidentified; Eudyptes chrysocome; Fluorescence, chlorophyll; Fregata aquila; Fregata magnificens; Fregetta grallaria; Fulmarus glacialis; Garrodia nereis; Gavia arctica; Globicephala macrorhynchus; Globicephala melas; Globicephala sp.; Grampus griseus; Gulls; Hammerhead shark; Hydrobates pelagicus; Identification; Lagenorhynchus albirostris; Lagenorhynchus australis; Lagenorhynchus sp.; Larus argentatus; Larus canus; Larus dominicanus; Larus fuscus; Larus marinus; Larus melanocephalus; Larus michahellis; Larus minutus; Larus ridibundus; LATITUDE; LONGITUDE; Macronectes giganteus; Macronectes sp.; Manta sp.; Megaptera novaeangliae; Mola mola; Morus bassanus; Oceanites oceanicus; Oceanodroma castro; Oceanodroma leucorhoa; Orcinus orca; Pachyptila sp.; Pelagodroma marina; Pelecanoides magellani; Pelecanoides sp.; Penguins; Petrels; Phaethon aethereus; Phaethon lepturus; Phalacrocorax capensis; Phalacrocorax carbo; Phalacrocorax coronatus; Phalaropus fulicarius; Phocoena phocoena; Physeter catodon; Polarstern; Procellaria aequinoctialis; Procellaria conspicillata; PS81; PS81/1-track; Pterodroma arminjoniana; Pterodroma feae; Pterodroma incerta; Pterodroma macroptera; Pterodroma mollis; Puffinus assimilis; Puffinus baroli; Puffinus gravis; Puffinus griseus; Puffinus lherminieri; Puffinus mauretanicus; Puffinus puffinus; Ray; Rissa tridactyla; Salinity; Seabirds, unidentified; Sea turtles; Shark; Shearwaters; Skuas; Speed; Spheniscus magellanicus; Stenella clymene; Stenella coeruleoalba; Stenella frontalis; Stenella longirostris; Steno bredanensis; Stercorarius longicaudus; Stercorarius parasiticus; Stercorarius pomarinus; Sterna anaethetus; Sterna arctica; Sterna dougallii; Sterna fuscata; Sterna hirundo; Sterna sandvicensis; Storm-petrels; Sula capensis; Sula leucogaster; Sula sula; Temperature, water; Terns; Thalassarche cauta; Thalassarche chlororhynchos; Thalassarche melanophris; Thalasseus bergii; Thalasseus maximus; Tropicbirds; Tursiops truncatus; Underway cruise track measurements; Uria aalge; Whale, unidentified; Xema sabini; Ziphius cavirostris; Zone
    Type: Dataset
    Format: text/tab-separated-values, 51862 data points
    Location Call Number Limitation Availability
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  • 9
    Publication Date: 2024-04-11
    Description: Please note: Abstract created by PANGAEA data editor using Jungblut et al. (2017). Marine top predators (seabirds, marine mammals and other megafauna) were counted during POLARSTERN cruise ANT-XXVIII/5 crossing the Atlantic from Punta Arenas to Bremerhaven in spring 2012. Continuous half-hour transect counts were conducted by two observers from the bridge, situated approximately 18 meters above sea level, throughout daylight hours and while the vessel maintained its traveling speed (see Joiris & Falck 2011). Due to the width of the bridge, observations were limited to a 90° angle from the bow to one side, as it was impractical for one observer to simultaneously cover both sides. Species were initially identified with the naked eye and confirmed using binoculars (8 – 10 times magnification). Photos were used in retrospect to help identify rare or hard to classify specimens. Individuals following or circling around the ship were only counted once in a 30 min interval (i.e. during one 'transect count'). Water temperature and salinity were continuously and automatically recorded by a thermo-salinometer installed at the keel of the Polarstern (approximately 10 meters below sea level). Depth data were obtained either from the vessel's echosounder or hydrosweep. Data extraction was carried out from the DShip data system on board.
    Keywords: Albatrosses; Alca torda; Alcidae sp.; Anous stolidus; ANT-XXVIII/5; Arctocephalus pusillus; Atlantic, transit cruise; Balaenoptera acutorostrata; Balaenoptera borealis; Balaenoptera brydei; Balaenoptera physalus; Beaked whale; Branta bernicla; Bulweria bulwerii; Calonectris diomedea; Calonectris edwardsii; Caretta caretta; Catharacta antarctica; Catharacta maccormicki; Catharacta skua; Chelonia mydas; Chlidonias niger; CT; Daption capense; DATE/TIME; Delphinus delphis; Depth, bathymetric; Dermochelys coriacea; Diomedea dabbenena; Diomedea epomophora; Diomedea exulans; Diomedea sanfordi; Diomedea sp.; Distance; Dolphins, unidentified; Eudyptes chrysocome; Fluorescence, chlorophyll; Fregata aquila; Fregata magnificens; Fregetta grallaria; Fulmarus glacialis; Garrodia nereis; Gavia arctica; Globicephala macrorhynchus; Globicephala melas; Globicephala sp.; Grampus griseus; Gulls; Hammerhead shark; Hydrobates pelagicus; Identification; Lagenorhynchus albirostris; Lagenorhynchus australis; Lagenorhynchus sp.; Larus argentatus; Larus canus; Larus dominicanus; Larus fuscus; Larus marinus; Larus melanocephalus; Larus michahellis; Larus minutus; Larus ridibundus; LATITUDE; LONGITUDE; Macronectes giganteus; Macronectes sp.; Manta sp.; Megaptera novaeangliae; Mola mola; Morus bassanus; Oceanites oceanicus; Oceanodroma castro; Oceanodroma leucorhoa; Orcinus orca; Pachyptila sp.; Pelagodroma marina; Pelecanoides magellani; Pelecanoides sp.; Penguins; Petrels; Phaethon aethereus; Phaethon lepturus; Phalacrocorax capensis; Phalacrocorax carbo; Phalacrocorax coronatus; Phalaropus fulicarius; Phocoena phocoena; Physeter catodon; Polarstern; Procellaria aequinoctialis; Procellaria conspicillata; PS79; PS79/5-track; Pterodroma arminjoniana; Pterodroma feae; Pterodroma incerta; Pterodroma macroptera; Pterodroma mollis; Puffinus assimilis; Puffinus baroli; Puffinus gravis; Puffinus griseus; Puffinus lherminieri; Puffinus mauretanicus; Puffinus puffinus; Ray; Rissa tridactyla; Salinity; Seabirds, unidentified; Sea turtles; Shark; Shearwaters; Skuas; Speed; Spheniscus magellanicus; Stenella clymene; Stenella coeruleoalba; Stenella frontalis; Stenella longirostris; Steno bredanensis; Stercorarius longicaudus; Stercorarius parasiticus; Stercorarius pomarinus; Sterna anaethetus; Sterna arctica; Sterna dougallii; Sterna fuscata; Sterna hirundo; Sterna sandvicensis; Storm-petrels; Sula capensis; Sula leucogaster; Sula sula; Temperature, water; Terns; Thalassarche cauta; Thalassarche chlororhynchos; Thalassarche melanophris; Thalasseus bergii; Thalasseus maximus; Tropicbirds; Tursiops truncatus; Underway cruise track measurements; Uria aalge; Whale, unidentified; Xema sabini; Ziphius cavirostris; Zone
    Type: Dataset
    Format: text/tab-separated-values, 92206 data points
    Location Call Number Limitation Availability
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  • 10
    Publication Date: 2024-04-11
    Description: Please note: Abstract created by PANGAEA data editor using Jungblut et al. (2017). Marine top predators (seabirds, marine mammals and other megafauna) were counted during POLARSTERN cruise PS83 (ANT-XXIX/10) passing the east Atlantic from Cape Town to Bremerhaven in spring 2014. Continuous half-hour transect counts were conducted by two observers from the bridge, situated approximately 18 meters above sea level, throughout daylight hours and while the vessel maintained its traveling speed (see Joiris & Falck 2011). Due to the width of the bridge, observations were limited to a 90° angle from the bow to one side, as it was impractical for one observer to simultaneously cover both sides. Species were initially identified with the naked eye and confirmed using binoculars (8 – 10 times magnification). Photos were used in retrospect to help identify rare or hard to classify specimens. Individuals following or circling around the ship were only counted once in a 30 min interval (i.e. during one 'transect count'). Water temperature and salinity were continuously and automatically recorded by a thermo-salinometer installed at the keel of the Polarstern (approximately 10 meters below sea level). Depth data were obtained either from the vessel's echosounder or hydrosweep. Data extraction was carried out from the DShip data system on board.
    Keywords: Albatrosses; Alca torda; Alcidae sp.; Anous stolidus; ANT-XXIX/10; Arctocephalus pusillus; Atlantic, transit cruise; Balaenoptera acutorostrata; Balaenoptera borealis; Balaenoptera brydei; Balaenoptera physalus; Beaked whale; Branta bernicla; Bulweria bulwerii; Calonectris diomedea; Calonectris edwardsii; Caretta caretta; Catharacta antarctica; Catharacta maccormicki; Catharacta skua; Chelonia mydas; Chlidonias niger; CT; Daption capense; DATE/TIME; Delphinus delphis; Depth, bathymetric; Dermochelys coriacea; Diomedea dabbenena; Diomedea epomophora; Diomedea exulans; Diomedea sanfordi; Diomedea sp.; Distance; Dolphins, unidentified; Eudyptes chrysocome; Fluorescence, chlorophyll; Fregata aquila; Fregata magnificens; Fregetta grallaria; Fulmarus glacialis; Garrodia nereis; Gavia arctica; Globicephala macrorhynchus; Globicephala melas; Globicephala sp.; Grampus griseus; Gulls; Hammerhead shark; Hydrobates pelagicus; Identification; Lagenorhynchus albirostris; Lagenorhynchus australis; Lagenorhynchus sp.; Larus argentatus; Larus canus; Larus dominicanus; Larus fuscus; Larus marinus; Larus melanocephalus; Larus michahellis; Larus minutus; Larus ridibundus; LATITUDE; LONGITUDE; Macronectes giganteus; Macronectes sp.; Manta sp.; Megaptera novaeangliae; Mola mola; Morus bassanus; Oceanites oceanicus; Oceanodroma castro; Oceanodroma leucorhoa; Orcinus orca; Pachyptila sp.; Pelagodroma marina; Pelecanoides magellani; Pelecanoides sp.; Penguins; Petrels; Phaethon aethereus; Phaethon lepturus; Phalacrocorax capensis; Phalacrocorax carbo; Phalacrocorax coronatus; Phalaropus fulicarius; Phocoena phocoena; Physeter catodon; Polarstern; Procellaria aequinoctialis; Procellaria conspicillata; PS83; PS83-track; Pterodroma arminjoniana; Pterodroma feae; Pterodroma incerta; Pterodroma macroptera; Pterodroma mollis; Puffinus assimilis; Puffinus baroli; Puffinus gravis; Puffinus griseus; Puffinus lherminieri; Puffinus mauretanicus; Puffinus puffinus; Ray; Rissa tridactyla; Salinity; Seabirds, unidentified; Sea turtles; Shark; Shearwaters; Skuas; Speed; Spheniscus magellanicus; Stenella clymene; Stenella coeruleoalba; Stenella frontalis; Stenella longirostris; Steno bredanensis; Stercorarius longicaudus; Stercorarius parasiticus; Stercorarius pomarinus; Sterna anaethetus; Sterna arctica; Sterna dougallii; Sterna fuscata; Sterna hirundo; Sterna sandvicensis; Storm-petrels; Sula capensis; Sula leucogaster; Sula sula; Temperature, water; Terns; Thalassarche cauta; Thalassarche chlororhynchos; Thalassarche melanophris; Thalasseus bergii; Thalasseus maximus; Tropicbirds; Tursiops truncatus; Underway cruise track measurements; Uria aalge; Whale, unidentified; Xema sabini; Ziphius cavirostris; Zone
    Type: Dataset
    Format: text/tab-separated-values, 86495 data points
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