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  • 1
    Book
    Book
    Statistical decision theory and Bayesian analysis (1988)
    New York [u.a.] : Springer
    Details Availability
    Keywords: Bayessches Verfahren ; Entscheidung ; Bayes-Verfahren
    Type of Medium: Book
    Pages: XVI, 617 S , graph. Darst
    Edition: 2. ed., 2. print.
    ISBN: 0387960988 , 3540960988
    Series Statement: Springer series in statistics
    URL: http://www.gbv.de/dms/hbz/toc/ht003661822.pdf
    DDC: 519.5/42
    RVK:
    SK 830
    RVK:
    QH 233
    Language: English
    Note: 1. Aufl. u.d.T.: Statistical decision theory: foundations, concepts, and methods
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  • 2
    Online Resource
    Online Resource
    The Disarticulate : Language, Disability, and the Narratives of Modernity (2014)
    New York : NYU Press
    Details Availability
    Keywords: SOCIAL SCIENCE / People with Disabilities ; Electronic books ; Electronic books
    Description / Table of Contents: Language is integral to our social being. But what is the status of those who stand outside of language? The mentally disabled, ""wild"" children, people with autism and other neurological disorders, as well as animals, infants, angels, and artificial intelligences, have all engaged with language from a position at its borders. In the intricate verbal constructions of modern literature, the 'disarticulate'-those at the edges of language-have, paradoxically, played essential, defining roles. Drawing on the disarticulate figures in modern fictional works such as Billy Budd, The Sound and the Fu
    Type of Medium: Online Resource
    Pages: Online-Ressource (312 p)
    Edition: Online-Ausg.
    ISBN: 9780814708460
    Series Statement: Cultural Front v.8
    URL: https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=1674835
    DDC: 362.2
    Language: English
    Note: Description based upon print version of record , Cover; Contents; Acknowledgments; Introduction: Disarticulate and Dysarticulate; 1. The Bearing Across of Language: Care, Catachresis, and Political Failure; 2. Linguistic Impairment and the Default of Modernism: Totality and Otherness: Dys-/Disarticulate Modernity; 3. Post-Modern Wild Children, Falling Towers, and the Counter-Linguistic Turn; 4. Dys-/Disarticulation and Disability; 5. Alterity Is Relative: Impairment, Narrative, and Care in an Age of Neuroscience; Epilogue: "Language in Dissolution" and "A World without Words"; Notes; Works Cited; Index; A; B; C; D; E; F; G; H; J; K; L; M; N , OP; Q; R; S; T; V; W; Z; About the Author
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  • 3
    Electronic Resource
    Electronic Resource
    Nuclear differentiation and nucleic acid synthesis in well-fed exconjugants of Paramecium aurelia (1973)
    Springer
    Chromosoma 42 (1973), S. 247-268 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Paramecium aurelia exconjugants contain new macronuclear anlagen and numerous fragments of the old pre-zygotic macronucleus. Macronuclear anlagen develop during the first two cell cycles after conjugation. During this time their volume increases from about 11 μm3 to about 3700 μm3 and more than 10 doublings of DNA content occur. The rate of DNA synthesis is between two and three times as great as in the vegetative macronucleus. — In macronuclear fragments, however, DNA synthesis is suppressed. The rate of DNA synthesis in macronuclear fragments during the extended first cell cycle after conjugation (11 1/2 hr. vs. 5 1/2 hr. for the vegetative cell cycle) is only about one-third of the rate in vegetative macronuclei and there is only a 65% increase in the mean DNA content of fragments. The rate of fragment DNA synthesis continues to decrease during each of the subsequent two cell cycles. — Unlike the rate of DNA synthesis, the rate of RNA synthesis per unit of DNA is similar in macronuclear anlagen, macronuclear fragments and fully developed macronuclei. Macronuclear fragments continue to synthesize RNA at the normal rate long after the new macronuclei are fully developed. Fragments contribute about 80% of all RNA synthesized during the first two cell cycles after conjugation. RNA synthesis begins very early in the development of macronuclear anlagen and nucleolar material appears during the first half-hour of anlage development. — Chromosome-like structures were never observed during anlage development and there was no evidence of two periods of DNA synthesis separated by a “DNA poor” stage as has been observed in several hypotrichous Ciliates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284774
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  • 4
    Electronic Resource
    Electronic Resource
    The CCK-B Antagonist LY288513 Blocks Diazepam-Withdrawal-Induced Increases in Auditory Startle Response (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 713 (1994), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1994.tb44097.x
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  • 5
    Electronic Resource
    Electronic Resource
    Structural basis for gate-DNA recognition and bending by type IIA topoisomerases (2007)
    [s.l.] : Nature Publishing Group
    Nature 450 (2007), S. 1201-1205 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Type II topoisomerases disentangle DNA to facilitate chromosome segregation, and represent a major class of therapeutic targets. Although these enzymes have been studied extensively, a molecular understanding of DNA binding has been lacking. Here we present the structure of a complex between the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature06396
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  • 6
    Electronic Resource
    Electronic Resource
    Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module (1997)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 388 (1997), S. 691-693 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The low-density lipoprotein receptor (LDLR) is responsible for the uptake of cholesterol-containing lipoprotein particles into cells,. The amino-terminal region of LDLR, which consists of seven tandemly repeated, ∼40-amino-acid, cysteine-rich modules (LDL-A modules), mediates binding to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/388691a0
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  • 7
    Electronic Resource
    Electronic Resource
    STRUCTURE, MOLECULAR MECHANISMS, AND EVOLUTIONARY RELATIONSHIPS IN DNA TOPOISOMERASES (2004)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biophysics and Biomolecular Structure 33 (2004), S. 95-118 
    Details
    ISSN: 1056-8700
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology , Physics
    Notes: Topoisomerases are enzymes that use DNA strand scission, manipulation, and rejoining activities to directly modulate DNA topology. These actions provide a powerful means to effect changes in DNA supercoiling levels, and allow some topoisomerases to both unknot and decatenate chromosomes. Since their initial discovery over three decades ago, researchers have amassed a rich store of information on the cellular roles and regulation of topoisomerases, and have delineated general models for their chemical and physical mechanisms. Topoisomerases are now known to be necessary for the survival of cellular organisms and many viruses and are rich clinical targets for anticancer and antimicrobial treatments. In recent years, crystal structures have been obtained for each of the four types of topoisomerases in a number of distinct conformational and substrate-bound states. In addition, sophisticated biophysical methods have been utilized to study details of topoisomerase reaction dynamics and enzymology. A synthesis of these approaches has provided researchers with new physical insights into how topoisomerases employ chemistry and allostery to direct the large-scale molecular motions needed to pass DNA strands through each other.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.biophys.33.110502.140357
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  • 8
    Electronic Resource
    Electronic Resource
    A cdc2-Like Kinase Associated with Commitment to Division in Paramecium tetraurelia (1994)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 41 (1994), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: . Cell division in higher eukaryotes is mainly controlled by p34cdc2 or related kinases and by other components of these kinase complexes. We present evidence that cdc2-like kinases also occur in Paramecium. Two polypeptides reacted with an antibody directed against the perfectly conserved PSTAIR region found in cdc2 kinases in other eukaryotes. Only the less abundant peptide bound to p13suc1 from Schizosaccharomyces pombe. Using centrifugal elutriation to select cells on the basis of size, we isolated highly synchronous Paramecium G1 cells. With this procedure, we demonstrated that the p13suc1-associated cdc2-like histone H1 kinase was activated before cell division at the point of commitment to division in Paramecium. Further, we show that Paramecium cdc2-like proteins occurred principally as monomers and that these monomers were active as histone H1 kinases in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1994.tb06093.x
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  • 9
    Electronic Resource
    Electronic Resource
    The Full Schedule of Macronuclear DNA Synthesis is Not Required for Cell Division in Paramecium tetraurelia1 (1985)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 32 (1985), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Macronuclear DNA synthesis normally continues until late in the cell cycle in Paramecium; however, blockage of macronuclear DNA synthesis after 0.72 in the cell cycle does not alter the occurrence or timing of the subsequent cell division. When DNA synthesis is blocked after cells have reached the transition point, macronuclear DNA content at the following division is reduced to about 75% of the normal level. The point at which macronuclear DNA synthesis is no longer required for division corresponds to the beginning of micronuclear mitosis and the early stages of oral morphogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1985.tb03071.x
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  • 10
    Electronic Resource
    Electronic Resource
    Selective Autolysis of Nuclei as a Source of DNA Precursors in Paramecium aurelia Exconjugants (1974)
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 21 (1974), S. 0 
    Details
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The fate of labeled DNA in macronuclear fragments of starving Paramecium aurelia exconjugants was studied by quantitative autoradiography. Labeled material originally contained in DNA of macronuclear fragments is incorporated into macronuclear anlagen. During the starvation period the mean number of macronuclear fragments per cell decreased exponentially while there was an approximately exponential increase in the volume of macronuclear anlagen. Fragments appeared to be selectively and individually autolyzed. Labeled material originally contained in fragments was largely if not completely conserved through 108 hr of starvation during which more than 90% of the fragments were lost. Soluble labeled material was detectable after autolysis of fragments began, but finally almost all labeled material was incorporated into macronuclear anlagen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1550-7408.1974.tb03629.x
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