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  • 1
    Digitale Medien
    Digitale Medien
    Chicken microtubule-associated protein 4 (MAP4): a novel member of the MAP4 family (1996)
    Springer
    Histochemistry and cell biology 106 (1996), S. 341-349 
    Details
    ISSN: 1432-119X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Chicken gizzard smooth muscle has often been used as a source of proteins of the contractile and cytoskeletal apparatus. In the present study, we isolated a hitherto unknown doublet of proteins, with apparent molecular weights of 200 kDa, from embryonic chicken gizzard and showed its association with the microtubular cytoskeleton by cosedimentation with microtubules (MTs) and by immunofluorescence staining of cultured cells. Immunoblot analysis also revealed the ubiquitous expression of this protein in all embryonic chicken tissues examined. Molecular cloning techniques allowed its identification as the chicken homologue of the microtubule-associated protein 4 (MAP4), known from mammalian species, and revealed approximately 90% of its amino acid sequence. MAP4 is the major MAP of non-neuronal tissues and cross-species comparisons clearly demonstrated its highly conserved overall structure, consisting of a basic C-terminal MT-binding region and an acidic N-terminal projection domain of unknown function. Despite these conserved features, overall sequence homologies to its mammalian counterparts are rather low and focused to distinct regions of the molecule. Among these are a conserved 18-amino acid motif, which is known to mediate binding to MTs and a part of the MT-binding domain known as the proline-rich region, which is thought to be the regulatory domain of MAP4. The N-terminal 59 amino acids are a conserved and unique feature of the MAP4 sequence and might be an indication that MAP4 performs other functions besides the enhancement of MT assembly.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02473244
    Standort Signatur Einschränkungen Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 2
    Digitale Medien
    Digitale Medien
    Chicken microtubule-associated protein 4 (MAP4): a novel member of the MAP4 family (1996)
    Springer
    Histochemistry and cell biology 106 (1996), S. 341-349 
    Details
    ISSN: 1432-119X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract  Chicken gizzard smooth muscle has often been used as a source of proteins of the contractile and cytoskeletal apparatus. In the present study, we isolated a hitherto unknown doublet of proteins, with apparent molecular weights of 200 kDa, from embryonic chicken gizzard and showed its association with the microtubular cytoskeleton by cosedimentation with microtubules (MTs) and by immunofluorescence staining of cultured cells. Immunoblot analysis also revealed the ubiquitous expression of this protein in all embryonic chicken tissues examined. Molecular cloning techniques allowed its identification as the chicken homologue of the microtubule-associated protein 4 (MAP4), known from mammalian species, and revealed approximately 90% of its amino acid sequence. MAP4 is the major MAP of non-neuronal tissues and cross-species comparisons clearly demonstrated its highly conserved overall structure, consisting of a basic C-terminal MT-binding region and an acidic N-terminal projection domain of unknown function. Despite these conserved features, overall sequence homologies to its mammalian counterparts are rather low and focused to distinct regions of the molecule. Among these are a conserved 18-amino acid motif, which is known to mediate binding to MTs and a part of the MT-binding domain known as the proline-rich region, which is thought to be the regulatory domain of MAP4. The N-terminal 59 amino acids are a conserved and unique feature of the MAP4 sequence and might be an indication that MAP4 performs other functions besides the enhancement of MT assembly.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004180050050
    Standort Signatur Einschränkungen Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Phase II study of tamoxifen and high-dose retinyl acetate in patients with advanced breast cancer (1990)
    Springer
    Journal of cancer research and clinical oncology 116 (1990), S. 503-506 
    Details
    ISSN: 1432-1335
    Schlagwort(e): Tamoxifen ; Retinoids ; Breast cancer
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Retinoids have shown a tumor growth inhibition and a synergistic activity with hormonal manipulations in human breast cancer cell lines and rat mammary carcinoma. To investigate the potential usefulness of this synergistic activity in human breast cancer, 33 postmenopausal patients with advanced disease were treated with the combination of tamoxifen (10 mg p.o. three times a day) and retinyl acetate (300 000 IU p.o. daily). Out of 31 evaluable patients, 3 achieved complete response, 9 partial response (overall response rate: 38.5%, 95% confidence interval=21%–56%) and 16 (52%) showed no change. The median duration of response was 11.5 months (range: 3–19+months), while the 2-year overall survival rate for the entire group of patients was 63%. Toxicity was generally mild, hot flushes, nausea (and/or vomiting), headache and cutaneous itching being the most frequent side-effects. Only 1 patient discontinued treatment for severe toxicity. These preliminary results suggest that the combination of tamoxifen and high-dose retinyl acetate is a safe and effective regimen for breast cancer patients. However, the study design does not allow us to establish whether the very low rate of early disease progression we observed might be related to a possible synergistic effect between retinoids and antiestrogens or rather to the quite indolent disease of the patients who have been selected for entry into this trial.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01613002
    Standort Signatur Einschränkungen Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 4
    Digitale Medien
    Digitale Medien
    Effect of topical dorzolamide on optic nerve head blood flow (1999)
    Springer
    Graefe's archive for clinical and experimental ophthalmology 237 (1999), S. 495-500 
    Details
    ISSN: 1435-702X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  · Purpose: The topical carbonic anhydrase inhibitor dorzolamide has proven effective in lowering intraocular pressure in glaucoma patients. Because an impaired blood supply of the optic nerve has to be regarded as a major pathogenic risk factor it seems important to examine the effect of this new antiglaucomatous drug on capillary optic nerve head blood flow. · Methods: In a double-masked, randomized clinical trial, dorzolamide eye drops were applied to both eyes of 15 healthy subjects (8 female, 7 male, mean age 30.6 years) three times daily for 3 days. The control group (15 healthy volunteers, 9 female, 6 male, mean age 30.8 years) received a placebo preparation according to the same protocol. Intraocular pressure (IOP), blood pressure, heart rate, capillary optic nerve head blood flow and retinal blood flow were measured at baseline (1D0), 90 min after single instillation (1D90), and after 3 days of therapy (3D). Scanning laser Doppler flowmetry (Heidelberg Retina Flowmeter) and laser Doppler flowmetry according to Riva (Oculix 4000) were used to measure optic nerve head blood flow. · Results: IOP dropped in dorzolamide-treated subjects from 12.5 mmHg to 11.0/10.5 mmHg (1D0, 1D90, 3DO) and in the control group from 13.0 mmHg to 12.5/12.5 mmHg. Optic nerve blood flow as measured by scanning laser Doppler flowmetry showed no significant changes in dorzolamide-treated volunteers (temporal 310/329/315 AU, nasal 387/402/399 AU) or in the placebo group (temporal 238/306/276 AU, nasal 356/382/379 AU). Also as measured by laser Doppler flowmetry optic nerve head blood flow did not show significant changes in dorzolamide-treated volunteers (temporal 12.98/12.6/11.7 AU, nasal 16.6/16.9/15.7 AU) or in the placebo group (temporal 11.9/12.4/12.4 AU, nasal 16.1/15.8/17.7 AU). The systemic parameters blood pressure and heart rate remained unchanged during the treatment period. · Conclusion: The results showed the expected drop in IOP. However, capillary optic nerve head blood flow, measured by two different techniques, did not change during therapy. This may be due to the effective autoregulation in human optic nerve head circulation, which seems not to be affected by dorzolamide.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004170050268
    Standort Signatur Einschränkungen Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 5
    facet.materialart.
    Unbekannt
    The Baltic Sea Experiment (BALTEX): A European Contribution to the Investigation of the Energy and Water Cycle over a Large Drainage Basin (2001)
    AMS (American Meteorological Society)
    Details
    Publikationsdatum: 2022-03-09
    Beschreibung: The Baltic Sea Experiment (BALTEX) is one of the five continental–scale experiments of the Global Energy and Water Cycle Experiment (GEWEX). More than 50 research groups from 14 European countries are participating in this project to measure and model the energy and water cycle over the large drainage basin of the Baltic Sea in northern Europe. BALTEX aims to provide a better understanding of the processes of the climate system and to improve and to validate the water cycle in regional numerical models for weather forecasting and climate studies. A major effort is undertaken to couple interactively the atmosphere with the vegetated continental surfaces and the Baltic Sea including its sea ice. The intensive observational and modeling phase BRIDGE, which is a contribution to the Coordinated Enhanced Observing Period of GEWEX, will provide enhanced datasets for the period October 1999–February 2002 to validate numerical models and satellite products. Major achievements have been obtained in an improved understanding of related exchange processes. For the first time an interactive atmosphere–ocean–land surface model for the Baltic Sea was tested. This paper reports on major activities and some results.
    Materialart: Article , PeerReviewed
    Format: text
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    facet.materialart.
    Unbekannt
    Deficiency of the BMP Type I receptor ALK3 partly protects mice from anemia of inflammation (2018)
    BioMed Central
    Details
    Publikationsdatum: 2018-03-06
    Beschreibung: Inflammatory stimuli induce the hepatic iron regulatory hormone hepcidin, which contributes to anaemia of inflammation (AI). Hepcidin expression is regulated by the bone morphogenetic protein (BMP) and the int...
    Digitale ISSN: 1472-6793
    Thema: Medizin
    Publiziert von BioMed Central
    Standort Signatur Einschränkungen Verfügbarkeit
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    PAPER CURRENT
  • 7
    facet.materialart.
    Unbekannt
    Additional diagnostic value of implantable loop recorder in patients with initial diagnosis of real or apparent transient loss of consciousness of uncertain origin (2014)
    Oxford University Press
    In: Europace
    Details
    Publikationsdatum: 2014-07-30
    Beschreibung: Aims Non-syncopal transient loss of consciousness (T-LOC) encompasses disorders that sometimes resemble syncope, and the differential diagnosis with true syncope may be challenging. The implantable loop recorder (ILR) is potentially useful, but has never been systematically assessed. The aim of the study is to evaluate the diagnostic value of ILR in distinguishing syncope from non-syncopal forms of T-LOC. Methods and results We implanted an ILR in 58 patients (mean age 71 ± 17 years, 25 males) who had had 4.6 ± 2.3 episodes of real or apparent T-LOC, in order to distinguishing epilepsy from syncope (#28), unexplained fall from syncope (#29), or functional pseudo-syncope from syncope (#1). During 20 ± 13 months of follow-up, 33 patients (57%) had a spontaneous event documented by ILR. A diagnosis of syncope was established by ILR documentation of an arrhythmia in 15 (26%) patients: an asystole of 6 s (IQR 4–10 s) duration was documented at the time of the spontaneous event in seven patients with initial suspicion of epilepsy and in five patients with unexplained fall; atrial tachyarrhythmia was documented at the time of the spontaneous event in 1 and 1 patient, respectively, and ventricular tachycardia in 1 patient with unexplained fall. Conversely, in another 18 patients, ILR monitoring documented no significant rhythm abnormalities at the time of T-LOC recurrence, thus excluding an arrhythmic syncope. Finally, ILR was unable to document any syncopal episode in 25 (43%) patients. Among the 15 patients with an established diagnosis of arrhythmic syncope, syncope recurred during follow-up in 2 of 11 patients who were on pacemaker therapy and in 3 of 4 patients who were on other therapies. Conclusion Implantable loop recorder monitoring provides additional diagnostic value in ‘difficult’ patients with an initial diagnosis of non-syncopal real or apparent T-LOC.
    Print ISSN: 1099-5129
    Digitale ISSN: 1532-2092
    Thema: Medizin
    Publiziert von Oxford University Press
    Standort Signatur Einschränkungen Verfügbarkeit
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    PAPER CURRENT
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