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  • 1
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    Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes
    American Association for the Advancement of Science (AAAS) ; 2015
    In:  Science Vol. 347, No. 6217 ( 2015-01-02)
    Details
    In: Science, American Association for the Advancement of Science (AAAS), Vol. 347, No. 6217 ( 2015-01-02)
    Kurzfassung: Comparison of several genomes reveals the genetic history of mosquitoes’ ability to vector malaria among humans. [Also see Perspective by Clark and Messer ]
    Materialart: Online-Ressource
    ISSN: 0036-8075 , 1095-9203
    URL: Article
    DOI: 10.1126/science.1258522
    RVK:
    TA 1000
    RVK:
    WA 15000
    Sprache: Englisch
    Verlag: American Association for the Advancement of Science (AAAS)
    Publikationsdatum: 2015
    ZDB Id: 128410-1
    ZDB Id: 2066996-3
    ZDB Id: 2060783-0
    SSG: 11
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
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    Endometrial expression of FOX proteins (FOXA1 and FOXA2) in women of reproductive age with different endometrial thickness: prospective cohort comparative study
    Consilium Medicum ; 2023
    In:  Gynecology Vol. 25, No. 3 ( 2023-10-04), p. 328-336
    Details
    In: Gynecology, Consilium Medicum, Vol. 25, No. 3 ( 2023-10-04), p. 328-336
    Kurzfassung: Aim. To evaluate the expression of FOX proteins (FOXA1 and FOXA2) in the endometrium during the implantation window in women with a history of reproductive dysfunctions with different thickness of the endometrium. Materials and methods. The prospective cohort comparative study was conducted. The main group included patients with "thin" endometrium (7 mm according to ultrasound on preovulatory days; n=52), the comparison group consisted of women with normal endometrial thickness (7 mm according to ultrasound; n=62; women of both groups with reproductive dysfunctions of unknown reason), the control group included 16 healthy fertile women. Aspiration biopsy of the endometrium was performed on the 68 days after ovulation, as well as venipuncture to obtain a sample of peripheral blood to determine the levels of sex steroids (estradiol E2 and progesterone P). A combined histological and immunohistochemical study of endometrial biopsies was performed. Results. All women had ovulatory values of progesterone P16.1 nmol/l (68 days after ovulation) and normoestrogenemia (E2, pmol/l) in the blood. E2/P was similar in all groups (p0, 05). A pronounced expression of FOXA1 was noted in women with thin endometrium significantly more often (p0.05) with various hormone-receptor characteristics of the endometrium (42% n=22 out of 52) compared with healthy participants (0%; n=0). Reduced FOXA2 expression in the uterine mucosa was significantly more often detected on 68 days after ovulation in women with "thin" endometrium (56% n=29 of 52) than in women with normal endometrial thickness, both in women from the comparison group and in healthy women from the control group (p0.05). In a generalized analysis of the expression of FOX proteins in the endometrium on days 68 after ovulation, it was generally found that every second (50%; n=57 out of 114) women with a history of reproductive disorders (with a reduced and normal M-echo value) expression of proteomic markers differed from healthy women. In the case of "thin" endometrium, more than two thirds of patients (71%; n=37 out of 52) showed differences in endometrial expression of FOX proteins compared with women without a burdened reproductive history. Conclusion. In the majority of women (71%) with a thin endometrium and a history of reproductive dysfunctions, the expression of FOX proteins in the endometrium differed from the control group. Overall, endometrial expression of FOX proteins, which is likely to be different from healthy women, in patients with reproductive dysfunctions of unknown origin is a significant predictor of reproductive failure. At the same time, such an isolated indicator as M-echo value 7 mm according to ultrasound data is not an absolute prognostic marker of endometrial receptivity disorders.
    Materialart: Online-Ressource
    ISSN: 2079-5831 , 2079-5696
    URL: Article
    DOI: 10.26442/20795696.2023.3.202358
    Sprache: Unbekannt
    Verlag: Consilium Medicum
    Publikationsdatum: 2023
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
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    Use of combined hormonal contraceptives in women with uterine fibroids: opinions of practitioners
    ECO-Vector LLC ; 2023
    In:  Journal of obstetrics and women's diseases Vol. 72, No. 2 ( 2023-05-18), p. 105-112
    Details
    In: Journal of obstetrics and women's diseases, ECO-Vector LLC, Vol. 72, No. 2 ( 2023-05-18), p. 105-112
    Kurzfassung: BACKGROUND:Uterine fibroids are increasingly diagnosed in patients of reproductive age. Combined hormonal contraceptives provide reliable protection against unwanted pregnancy and help to reduce or eliminate various clinical manifestations of uterine fibroids. In practice, obstetrician-gynecologists have barriers to prescribing combined hormonal contraceptives to patients with uterine fibroids. AIM:The aim of this work was to study the features of the clinical approach of obstetrician-gynecologists to the management of patients with uterine fibroids interested in combined hormonal contraception. MATERIALS AND METHODS:The method of voluntary anonymous questioning was applied to 366 obstetrician-gynecologists. The work experience of 62.1% (n= 227) of doctors was 10 years or more. The questionnaire included questions about various aspects of the use of combined hormonal contraceptives for contraception in women with uterine fibroids. RESULTS:Only every second (47.5%;n= 174) obstetrician-gynecologist correctly assigns uterine fibroids to the first category of acceptability for combined hormonal contraceptives. The presence of an asymptomatic submucous myomatous node (FIGO 12) or dysmenorrhea in women with uterine fibroids is considered by 29.0% (n= 106) and 5.7% (n= 21) of obstetrician-gynecologists, respectively, as a contraindication to the use of combined hormonal contraceptives. Every ninth participant (11.4%;n= 42) believes that the presence of uterine fibroids limits the duration of use of combined hormonal contraceptives for contraception to 15 years. Almost half (45.6%;n= 167) of the respondents believe that combined hormonal contraceptives have various effects on uterine fibroids (cause regression or growth of fibroids, increase the risk of new fibroids). More than half (53.3%;n= 195) of the respondents are not informed about the reduction in the risk of developing uterine fibroids when using combined hormonal contraceptives for five years or more. CONCLUSIONS:In the analyzed cohort of experienced obstetrician-gynecologists, we identified their barriers to prescribing combined hormonal contraceptives for contraception for women with uterine fibroids. Those are incomplete awareness of the acceptance criteria for combined hormonal contraceptives and insufficient awareness of the lack of effect of combined hormonal contraceptives on the size of existing myomatous nodes and a decrease in the risk of developing uterine fibroids when using combined hormonal contraceptives for five or more years.
    Materialart: Online-Ressource
    ISSN: 1683-9366 , 1684-0461
    URL: Issue
    URL: Article
    DOI: 10.17816/JOWD.722
    DOI: 10.17816/JOWD321247
    Sprache: Unbekannt
    Verlag: ECO-Vector LLC
    Publikationsdatum: 2023
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
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    Real clinical practice and contraception for young women with children
    Consilium Medicum ; 2021
    In:  Gynecology Vol. 23, No. 1 ( 2021-03-21), p. 25-32
    Details
    In: Gynecology, Consilium Medicum, Vol. 23, No. 1 ( 2021-03-21), p. 25-32
    Kurzfassung: The review presents the psychosocial characteristics of young women in todays millennial generation and survey data regarding their hormonal contraceptive requirements. The results of randomized clinical trials and real-life studies of the use of the combined oral contraceptive (COC) Qlaira containing estradiol valerate and dienogest (E2V/DNG) in a dynamic dosing regimen were analyzed, in which the reliability of the contraceptive effect of the drug was identified and confirmed, the restoration of fertility was population level after drug withdrawal, its minimal effect on metabolism and a reduced risk of cardiovascular complications (venous and arterial thrombosis) when using Qlaira COC in comparison with other COCs. The absence of a negative effect of COC E2V/DNG on body weight, sexual function and vaginal microbiocenosis in most women has been proven. The data on satisfactory characteristics of menstrual bleeding (lighter and shorter) in users of Qlaira COC and a decrease in symptoms associated with a hormone-free interval, which often occur when taking other COCs in the 21/7 regimen, are presented. The favorable efficacy and safety profile of COC E2V/DNG in real conditions, the advantages of estrogen bioidentical to the endogenous, in the composition of the drug, the dosage regimen 26/2, the positive effect on the lifestyle, determine the significant satisfaction of young women, including young women with children, and the ability to use the drug for a long time until menopause.
    Materialart: Online-Ressource
    ISSN: 2079-5831 , 2079-5696
    URL: Article
    DOI: 10.26442/20795696.2021.1.200629
    Sprache: Unbekannt
    Verlag: Consilium Medicum
    Publikationsdatum: 2021
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    Endometrial receptivity in women of reproductive age with "thin" and "absolutely thin" endometrium
    Consilium Medicum ; 2023
    In:  Gynecology Vol. 24, No. 6 ( 2023-01-20), p. 478-486
    Details
    In: Gynecology, Consilium Medicum, Vol. 24, No. 6 ( 2023-01-20), p. 478-486
    Kurzfassung: Aim. To evaluate the expression of steroid receptors (estrogen [ER] and progesterone [PR] ) in the endometrium during the implantation window in females with a history of fertility disorders in "thin" and "absolutely thin" endometrium versus healthy females. Materials and methods. A prospective comparative study was conducted. The study group (n=42) included patients with "thin" endometrium (7 mm M-echo 5 mm at cycle days 1113 according to ultrasound); the comparison group (n=10) included females with "absolutely thin" (5 mm according to ultrasound in the pre-ovulatory days) endometrium (females in both groups had a history of infertility and miscarriage of unclear reasons in the anamnesis); the control group included 16 healthy fertile females. A Pipelle biopsy of the uterine mucosa was performed on day 68 after ovulation, and a peripheral blood sample was obtained to measure the concentration of sex steroids (estradiol [E2] and progesterone [P] ). Endometrial samples were examined by histological and immunohistochemical methods (ER, PR expression). Results. All study participants had an ovulatory cycle of P16.1 nmol/L (day 68 after ovulation) and normal estrogen levels (E2, pmol/L). E2/P was similar in all cohorts (p0.05 for all measures). ER and PR expression in the endometrium similar to those in healthy females was detected in 20% of patients in the study and comparison groups (M-echo = 4.83.1 mm): 21% (9/42) and 20% (2/10), respectively. ER and PR expression in the endometrial glands and ER expression in the endometrial stroma were significantly different (p0.05) from healthy females in 79% (41/52) of patients with "thin" endometrium and 80% (8/10) of patients with "absolutely thin" endometrium. No differences in the ER or PR expression in the endometrium in females with hypoplastic endometrium were found (p0.05). Conclusion. The M-echo value does not accurately determine endometrial hormonal-receptor abnormalities: 20% of the study participants with hypoplastic endometrium had ER and PR expression comparable to those in healthy females. No differences were found in the expression of endometrial estrogen and progesterone receptors in females with "thin" and "absolutely thin" endometrium.
    Materialart: Online-Ressource
    ISSN: 2079-5831 , 2079-5696
    URL: Article
    DOI: 10.26442/20795696.2022.6.201804
    Sprache: Unbekannt
    Verlag: Consilium Medicum
    Publikationsdatum: 2023
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
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    Prolonged hormonal contraception: current research and practice: A review
    Consilium Medicum ; 2022
    In:  Gynecology Vol. 24, No. 4 ( 2022-09-29), p. 252-260
    Details
    In: Gynecology, Consilium Medicum, Vol. 24, No. 4 ( 2022-09-29), p. 252-260
    Kurzfassung: This review presents information on demographic processes in Russia and the relevance of highly effective contraception for the prevention of artificial abortion. We present data on the etonogestrel implant (68 mg), an innovative single-stranded subcutaneous implant, a long-acting reversible contraceptive option with high efficacy (Pearl index 0.05) with optimal and typical use of the product. We analyzed the results of the studies that showed a favorable safety profile of the etonogestrel implant with no significant effect on the risks of thrombotic events, metabolic processes, depression incidence, bone mineral density, and characteristics of reproductive function after discontinuation of the drug. The article presents data on possible side effects in the form of changes in the characteristics of menstrual bleeding and a slight increase in body weight, which is comparable with the natural gain in an adult with age. The importance of qualified counseling of patients before and during the use of etonogestrel implants is emphasized.
    Materialart: Online-Ressource
    ISSN: 2079-5831 , 2079-5696
    URL: Article
    DOI: 10.26442/20795696.2022.4.201823
    Sprache: Unbekannt
    Verlag: Consilium Medicum
    Publikationsdatum: 2022
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
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    Receptivity at different endometrial thickness in women of reproductive age (literature review)
    Consilium Medicum ; 2022
    In:  Gynecology Vol. 24, No. 1 ( 2022-01-15), p. 4-10
    Details
    In: Gynecology, Consilium Medicum, Vol. 24, No. 1 ( 2022-01-15), p. 4-10
    Kurzfassung: Overcoming infertility and reducing miscarriage are important challenges in obstetrics and gynecology. In the Russian Federation, the frequency of infertile couples reaches 24%; the percentage of miscarriage does not decrease, accounting for up to 20% of all desired pregnancies. The endometrial factor plays an important role in the causes of gravidar losses. Inadequate phase transformation of the endometrium is a predictor of fetal egg implantation failures. An integral part of endometrial cyclic transformations is the full proliferation of the mucous membrane of the uterine body. However, there is a cohort of women who, due to the insufficiency of proliferative processes in the endometrium, have a syndrome of thin endometrium. The pathogenesis of the formation of a hypoplastic endometrium in women with normal characteristics of hormonal factors is still poorly understood. Particular attention is paid to determining the function of proteomic markers (leukemia inhibiting factor, Forkhead box-protein family, etc.) in the genesis of the hypoplastic endometrium. This review presents an analysis of modern Russian and foreign sources on the receptivity of the endometrium, including the syndrome of thin endometrium in women of reproductive age.
    Materialart: Online-Ressource
    ISSN: 2079-5831 , 2079-5696
    URL: Article
    DOI: 10.26442/20795696.2022.1.201120
    Sprache: Unbekannt
    Verlag: Consilium Medicum
    Publikationsdatum: 2022
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
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    CAMSA: a tool for comparative analysis and merging of scaffold assemblies
    Springer Science and Business Media LLC ; 2017
    In:  BMC Bioinformatics Vol. 18, No. S15 ( 2017-12)
    Details
    In: BMC Bioinformatics, Springer Science and Business Media LLC, Vol. 18, No. S15 ( 2017-12)
    Materialart: Online-Ressource
    ISSN: 1471-2105
    URL: Article
    DOI: 10.1186/s12859-017-1919-y
    Sprache: Englisch
    Verlag: Springer Science and Business Media LLC
    Publikationsdatum: 2017
    ZDB Id: 2041484-5
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
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    Overexpression of estrogen and progesterone receptors as indicator of endometrial receptivity disorder in women with early miscarriage
    LLC Science and Innovations ; 2020
    In:  Russian Open Medical Journal Vol. 9, No. 2 ( 2020-6-30)
    Details
    In: Russian Open Medical Journal, LLC Science and Innovations, Vol. 9, No. 2 ( 2020-6-30)
    Kurzfassung: Background ― The endometrial factor is important in miscarriage (MC) pathogenesis. Objective. To perform a morphofunctional evaluation of endometrium in the patients with uncertain MC cause in anamnesis. Material and methods ― We examined 48 women 23-40 yo [30 (27, 35)]: the main group consisted of 33 patients with early MC in their medical history, while the control group included 15 healthy fertile women. All women had an ovulatory menstrual cycle, normal levels of gonadotropic and thyroid hormones, prolactin, and androgens. Ultrasound and hormonal examinations, along with morphological investigation of endometrial biopsies were performed. Data presented as median with lower and upper quartiles – Me (LQ, UQ). Results ― In 64% (n=21) of women in the main group, we detected inferior secretory phase of their endometrial cycle, focal fibrosis of endometrial stroma; synchronous overexpression of estrogen (ER) and progesterone (PR) receptors in endometrial glands and stroma. ER in the glands was 240 (160, 280) vs. 130 (80, 210) in the stroma, while PR values were 270 (210, 290) in the glands vs. 270 (240, 280) in the stroma: differences from the control group were significant (p 〈 0.01). Remaining women in the main group (36%, n=12) and all women in the control group had full secretory transformation of the endometrium and normal expression of ER and PR. The levels of estradiol and PR in the blood of women with early MC in anamnesis, with different variants of ER and PR expression in the endometrium, did not differ significantly from the control group and corresponded to the reference values. Conclusion ― Nearly two-thirds of women with early miscarriage in anamnesis exhibited overexpression of ER and PR in the endometrium, which may be one of the indicators of its decreased receptivity status.
    Materialart: Online-Ressource
    ISSN: 2304-3415
    URL: Issue
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.15275/rusomj.2020
    DOI: 10.15275/rusomj.2020.02
    DOI: 10.15275/rusomj
    DOI: 10.15275/rusomj.2020.0211
    Sprache: Englisch
    Verlag: LLC Science and Innovations
    Publikationsdatum: 2020
    ZDB Id: 2675346-7
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
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    Emergency contraception among doctors and people without higher medical degree
    ECO-Vector LLC ; 2018
    In:  Journal of obstetrics and women's diseases Vol. 67, No. 4 ( 2018-12-15), p. 34-39
    Details
    In: Journal of obstetrics and women's diseases, ECO-Vector LLC, Vol. 67, No. 4 ( 2018-12-15), p. 34-39
    Kurzfassung: Background. In Russia, adherence to planned highly effective methods of contraception is still at a low level; therefore, emergency contraception (EC) can be the option for protection against unplanned pregnancy.Study design, materials and methods. The current analysis was undertaken to determine the frequency of EC use among women with and without higher medical degree (MD) and to find out the level of awareness about EC among women and men of the same categories. In order to this, the method of anonymous voluntary questioning was used. The questionnaire included items about the theoretical aspects of EC (filled in by both men and women) and data on the gynecological history and experience of EC application (filled in by women only).Results. Half of respondents (49.8%) had experience of EC use, 80% of them used EC only if unprotected sexual intercourse occurred in the middle of the menstrual cycle. Every forth (24.6%, n = 29) obstetrician-gynecologist mistakenly believes that repeated application of EC can lead to infertility. 45% (n = 64) participants without MD and 42% (n = 61) of doctors of other specialties have the same opinion. The use of EC is considered justified by 86% (n = 227) of doctors and 65% (n = 94) participants without MD. Every tenth responder, irrespective of education level, mistakenly believes in not using EC due to severe negative side effects.Conclusion. Almost a third (30%) of obstetrician-gynecologists do not possess complete information on EC. Awareness about EC is extremely inadequate and comparable to that of doctors of other specialties and people without MD. (For citation: Aganezov SS, Morotskaya AV, Aganezova NV. Emergency contraception among doctors and people without higher medical degree. Journal of Obstetrics and Women’s Diseases. 2018;67(4):34-39. doi: 10.17816/JOWD67434-39).
    Materialart: Online-Ressource
    ISSN: 1683-9366 , 1684-0461
    URL: Issue
    URL: Article
    DOI: 10.17816/JOWD674
    DOI: 10.17816/JOWD67434-39
    Sprache: Unbekannt
    Verlag: ECO-Vector LLC
    Publikationsdatum: 2018
    Standort Signatur Einschränkungen Verfügbarkeit
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