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  • 1
    Online-Ressource
    Online-Ressource
    Cambridge :Elsevier Science & Technology,
    Schlagwort(e): Bioactive compounds. ; Medicine. ; Electronic books.
    Beschreibung / Inhaltsverzeichnis: Bioactive materials play an increasingly important role in the biomaterials industry, and are used for a range of applications, including artificial organs, drug delivery systems, nanomedicine, and biosensors. Bioactive materials in medicine reviews the current status and ongoing development of bioactive materials for medical applications. Following an introduction to bioactive materials in medicine, part one covers the process of designing bioactive materials, including chapters on molecular design, nanotechnology, and tissue engineering. Part two focuses on the different applications of bioactive materials in medicine, with chapters discussing applications in orthopaedics, in the circulatory system,and as antibacterials. The final chapters focus on the uses of these materials in gene therapy, plastic surgery and body reconstruction, and in drug delivery systems. With its distinguished editors and international team of contributors, Bioactive materials in medicine is an essential reference for researchers and designers in industry, as well as those with an academic interest in the subject. Discusses the current status and ongoing development of bioactive materials for medical applications Explores the process of designing bioactive materials, including molecular design, nanotechnology, and tissue engineering Assesses different applications of bioactive materials in medicine featuring applications in orthopaedics, in the circulatory system,and as antibacterials.
    Materialart: Online-Ressource
    Seiten: 1 online resource (286 pages)
    Ausgabe: 1st ed.
    ISBN: 9780857092939
    Serie: Woodhead Publishing Series in Biomaterials Series ; v.33
    DDC: 610.28
    Sprache: Englisch
    Anmerkung: Cover -- Bioactive materials in medicine: Design and applications -- Copyright -- Contents -- Contributor contact details -- Foreword -- 1 Introduction to bioactive materials in medicine -- 1.1 Definition of bioactive materials -- 1.2 History of bioactive materials -- 1.3 Medical applications of bioactive materials -- 1.4 Design and commercialisation of bioactive materials -- 1.5 Future trends -- 1.6 References -- Part I Designing bioactive materials for use in medicine -- 2 Molecular design of bioactive materials with controlled bioactivity -- 2.1 Definition of bioactivity and bioactive materials -- 2.2 Influencing factors on bioactivity -- 2.3 Design of bioactive materials -- 2.4 Future trends -- 2.5 References -- 3 Bioactive materials and nanotechnology -- 3.1 Introduction -- 3.2 Bioactive materials under nanoscale (nanomaterials) -- 3.3 Nanofibres -- 3.4 Nanocomposites -- 3.5 Applications of nanomaterials -- 3.6 Limitations of nanomaterials -- 3.7 Future trends -- 3.8 References -- 4 Bioactive materials and tissue engineering -- 4.1 Introduction -- 4.2 Interaction between bioactive materials, cells and surrounding tissue -- 4.3 Bioactive materials as a scaffolding frame used in tissue engineering -- 4.4 Applications of bioactive materials in tissue engineering -- 4.5 Limitations of bioactive materials in tissue engineering -- 4.6 Future trends -- 4.7 References -- Part II Applications of bioactive materials in medicine -- 5 Antibacterial bioactive materials -- 5.1 Introduction -- 5.2 Antibacterial materials -- 5.3 Clinical applications of antibacterial materials -- 5.4 Limitations of antibacterial materials -- 5.5 Future trends -- 5.6 References -- 6 Bioactive materials in orthopaedics -- 6.1 Introduction -- 6.2 Biomaterials in orthopaedics -- 6.3 Clinical applications of bioactive materials in orthopaedics. , 6.4 Limitations of bioactive materials in orthopaedics -- 6.5 Future trends -- 6.6 References -- 7 Bioactive materials in the circulatory system -- 7.1 Introduction -- 7.2 Applications of bioactive materials in devices for the circulatory system -- 7.3 Limitations of bioactive materials in devices for the circulatory system -- 7.4 Future trends -- 7.5 References -- 8 Bioactive materials in gene therapy -- 8.1 Introduction -- 8.2 Applications of bioactive materials in gene therapy -- 8.3 Limitations of bioactive materials in gene therapy -- 8.4 Future trends -- 8.5 References -- 9 Bioactive materials in plastic surgery and body reconstruction -- 9.1 Introduction -- 9.2 Applications of bioactive materials in plastic surgery and body reconstruction -- 9.3 Limitations of bioactive materials in plastic surgery and body reconstruction -- 9.4 Future trends -- 9.5 References -- 10 Bioactive materials in drug delivery systems -- 10.1 Introduction -- 10.2 Applications of bioactive materials in drug delivery systems -- 10.3 Limitations of bioactive materials in drug delivery systems -- 10.4 Future trends -- 10.5 References -- Index.
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  • 2
    Online-Ressource
    Online-Ressource
    Zurich :Trans Tech Publications, Limited,
    Schlagwort(e): Electronic books.
    Beschreibung / Inhaltsverzeichnis: Selected, peer reviewed papers from the 2014 International Conference on Material Engineering, Energy and Applied Technology (MEEA 2014), November 29-30, 2014, Hefei, China.
    Materialart: Online-Ressource
    Seiten: 1 online resource (466 pages)
    Ausgabe: 1st ed.
    ISBN: 9783038267539
    Serie: Advanced Materials Research Series ; v.Volume 1078
    Sprache: Englisch
    Anmerkung: Intro -- Advanced Research in Material Engineering, Machinery and Applied Technologies -- Preface, Committee and Sponsors -- Table of Contents -- Chapter 1: Materials Science, Chemical Materials and Chemical Technologies -- Effect of Nb Content on the Impact Toughness of Coarse-Grained Heat-Affected Zone of Pipeline Steels under Large Heat Input -- Study on Solidification Kinetics and Crystallization Analysis of Dynamically-Vulcanized PP/EPDM Blends -- Occurrence and Control of Crack on Counterweight of Forklift Cast with High Manganese Pig Iron -- Controllable Preparation of Zinc Phosphate Materials with Different Morphologies and Particle Size -- Analysis of Plastic Zone at a Crack Tip for I, II and III Mode Fracture with MY Criterion -- Characterization of Zirconia Sizing Nozzle Modifying Addictives Preparated by Sol-Gel Method -- Study on the Hydrolysis of PET Catalyzed by Carbonates under Microwave Irradiation -- The Facile Preparation and the Performance of Killing Oncomelania Snails of Zinc Oxide Nanoparticles -- Zein: A Novel Porogen for the Preparation of PVDF Porous Membrane -- Synthesis and Properties of the New Room Temperature Ionic Liquid -- Improved Antifouling Property of PVDF Membranes with Crosslinked PEG -- Effect of the Fixation Treatment on the Staining Results of Reactive Dyes for Dyeing Bamboo -- IPA Recycling by Hydrolysis Reaction of TDI Residue -- Pull-In Behavior of Carbon Nanotubes in Networks -- The Effect of TiH2 Oxidation Treatment on Preparing Aluminum Foam Sandwiches -- Research on Applied Equipment in Sport Teaching Based on Fiber-Reinforced Composites -- Determination of Henry Constants of Azelnidipine Enantiomers on Chiralpak AD Column at Different Temperatures -- Synthesis and Properties of 1-(3,5-dimethyl-4-isoxazole)-2-(2-methyl-(5-ethynyl)-3-thienyl)perfluorocyclopentene. , Synthesis and Photochromism Studies of 1-(2-methyl-3-benzofuran)-2-[2-methyl-5-naphthyl-3-thienyl]perfluorocyclopentene -- Synthesis and Application of 1-(2,5-dimethyl-3-thiazolyl)-2-[2-methyl-5-phenyl-(4-vinyl)-3-thiophene]perfluorocyclopentene -- Synthesis and Application of 1-[(2-methyl-3-benzothiophene)]-2-[2-methyl-5-(1,3-dioxolane)-3-thienyl]perfluorocyclopentene -- Synthesis and Properties of 1-(2-Methyl-3-benzothiophene)-2-[2-methyl-5-(3-fluoro-4-chloro)phenyl-3-thienyl]perfluorocyclopentene -- Synthesis and Application of 1-(2-methyl-3-benzothienyl)-2-[3-methyl-2-thienyl]perfluorocyclopentene -- Synthesis and Properties of 1-(2-methyl-3-benzothienyl)-2-[2-methyl-5-(3-trifluoromethyl)-3-thienyl]perfluorocyclopentene -- Synthesis and Application of 1-[2-methyl-5-(4-hydroxymethylphenyl)-3-thienyl]-2-[2-methyl-5-(4-azidomethylphenyl)-3-thienyl]perfluorocyclopentene -- Energy Efficiency Analysis of PET Hydrolyzed by Different Ways of Microwave Irradiation -- Preparation and Luminescent Property of EuxYy(TPTZ)2(POA)6 Complexes -- Application of Biological Materials on Countermeasures and Development in Exercise-Induced Meniscus Injury -- Chapter 2: Processing of Natural Resources, Environmental Engineering and Construction -- Study on Application of Low Velocity Non-Darcy Flow -- Research of Coupling Mechanism between Dynamic Damage of Fault Rock-Pillar and Gas Outburst in Front of Roadway -- The Study on Temporal and Spatial Distribution of Seabed Pipeline Spilt Oil's Floating Based on Energy Conservation -- The Physicochemical Properties and the Fate of Fly Ash along the Air Pollution Control Devices in Coal-Fired Power Plant -- Application of PP Model in Water Quality Evaluation of Dehuixin River -- Analysis of Acid Rain and the Main Effect Factors in Nanchang City -- Efficient and Circulation Raw Coal Processing Technology. , Dynamic Analysis on Explosion Resistance Performance of Reinforced Concrete Wall -- Research on Rib Stiffener Distribution and Ultimate Strength of Steel Tubular Tower's K-Joint -- Increase Water Resistance Decorative Coatings on the Basis of Calcareous Dry Building Mixtures -- Chapter 3: Advanced Technologies in Machinery, Mechatronics, Automation and Control -- Study on Optimizing the Queuing Theory Based on Car Diagnosis -- Experimental Analysis for Jet Noise Reduction of Chevron Pylon-Based Nozzles -- Research on the Steering Character for Kiloton all Terrain Crane -- Research on Parameter Optimization Method of v-SVRM Forecasting Model for Crane Load Spectrum -- Research on Aqueous Foam Jamming Device for Transport Vehicle -- Out-of-Plane Stability Analysis of Crane Jib with Auxiliary Bracing -- Applied Engine Electronic Control Technology in Situation and Analysis of Experimental Teaching System -- Transient Dynamics Analysis of the Reachstacker Speader Based on ANSYS -- Design of Multi-Legged Walking Machine -- Stability Analysis of Latticed Shells -- Design of Mousetrap Based on Solid Works Software -- Study of Jet Noise Reduction on Separated Exhaust System Using Chevron Nozzles -- Simulation Research of Engine's Electronic Control System Based on Modular Modeling Method -- The Research on Simulation Model of BF Raceway Based on Kinetic Theory of Granular Flow -- Application of Optical Fiber Laser Sensing Technology in Signal Detection -- Application of Improved Hash Function in the Message Authentication and Message Integrity -- Application Analysis of Smart Sensor Node Based on Data Mining Association Technology -- Study on High Specification PAC Motion Controller System -- Study on GPRS Mobile Terminal System for Rural Informatization -- Mechanics Analysis and Optimization of the Reachstacker Spreader. , Experimental Study on Spray Characteristics of Diesel Engines and Analysis of Fuel Dripping Phenomenon -- Visualization of the near Field Microscopic Spray Structure in Diesel Engine -- Multi-Stage Ejector Design and Numerical Simulation for Marine Gas Turbine -- Application of Object Oriented Computer Automatic Classification in Land Use -- Preference Selection Index Method for Machine Selection in a Flexible Manufacturing Cell -- An Automatic Modeling Method for Intersected Cross-Sections -- Segmentation and Localization of Microscopic Cell Image -- Analysis of the Antiplane Problem of Functionally Graded Coating with Generally Oriented Crack -- Chapter 4: Communication, Networks, Applied Information Technologies, Algorithms and Data Processing -- Design of Low Noise L-Band Frequency Source -- Design of the Weighted Series Feeding Microstrip Antenna Array -- Network Security Separated Card Based on Physical Isolation Technology Optimization -- Online Homework Correcting Integrate System Based on ASP.NET -- Wireless Sensor Network Link Selection Algorithm with Bayesian Technique -- Predictive Runtime Verification of Java Programs -- The Design and Application of Wireless Network Based on Digital Campus -- An Acquisition and Display Method for Multi-View 3D Models -- Development and Application of Information Technology in University Basketball Network Courses -- A Novel Information Fusion Method Based on Preference Selection Index -- A Mixed Method of Storing OWL Objects in Relational Database -- The Application Research of Information Theory in Education -- Research on the Application of Learning Analytics on Information Teaching Platform of Secondary Vocational School in Big Data Era -- Applied-Information Technology Based on Data Analysis in Teaching Reform -- The Image Compression Technology Based on Wavelet Transform. , Research on the Virtualization Construction of University Data Center Server Based on VMware vSphere -- Information System Construction in Higher Vocational Education -- Network Technology Based Intercollegiate Cooperation for Effective Learning -- Applied Technology for Evaluation Index Modeling on Sports-Related Museum -- Design and Development of Intelligent Logistics System Based on Data Mining and Association Rules Technology -- A Novel Method Combining Grey Target Decision Model with Close Value for Material Selection Problem -- A Graph-Based Image Segmentation Algorithm -- An Adaptive Image Segmentation Algorithm Based on AP Clustering -- An Effective Approach to Migrate Application to Secure Cloud -- The Realization of New Computing Model and System Research Related to Quantum Computer -- Research of an Improved Genetic Algorithm for Job Shop Scheduling -- An Application of Genetic Algorithms on the Synthesis Technique of Musical Instrument Tones -- Using Particle Swarm Optimization Algorithm to Construction Detection and Node Management System in Wireless Sensor Network -- Method of Data Processing Based on LaBVIEW -- Data Processing with Mathematical Modeling for Research-Oriented Learning -- Cloud-Based Next-Generation Data Center Design -- A Computation Methods for Analysis on the Effect of Stock Market and its Application -- Research on Digital Library Based on Cloud Computing -- Keywords Index -- Authors Index.
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  • 3
    facet.materialart.
    Unbekannt
    PANGAEA
    In:  Supplement to: Zhao, X; Dupont, Lydie M; Schefuß, Enno; Meadows, Michael E; Hahn, A; Wefer, Gerold (2016): Holocene vegetation and climate variability in the winter and summer rainfall zones of South Africa. The Holocene, 26(6), 843-857, https://doi.org/10.1177/0959683615622544
    Publikationsdatum: 2023-03-03
    Beschreibung: To better understand Holocene vegetation and hydrological changes in South Africa, we analyzed pollen and microcharcoal records of two marine sites GeoB8331 and GeoB8323 from the Namaqualand mudbelt offshore the west coast of South Africa covering the last 9900 and 2200 years, respectively. Our data corroborate findings from literature that climate developments apparently contrast between the summer rainfall zone (SRZ) and winter rainfall zone (WRZ) over the last 9900 years, especially during the early and middle Holocene. During the early Holocene (9900-7800 cal.yr BP), a minimum of grass pollen suggests low summer rainfall in the SRZ, and the initial presence of Renosterveld vegetation indicates relatively wet conditions in the WRZ. Towards the middle Holocene (7800-2400 cal. yr BP), a rather moist savanna/grassland rich in grasses suggests higher summer rainfall in the SRZ resulting from increased austral summer insolation and a decline of fynbos vegetation accompanied by an increasing Succulent Karoo vegetation in the WRZ possibly suggests a southward shift of the Southern Hemisphere westerlies. During the last 2200 years, a trend towards higher aridity was observed for the SRZ, while the climate in the WRZ remained relatively stable. The Little Ice Age (ca. 700-200 cal. yr BP) was rather cool in both rainfall zones and drier in the SRZ while wetter in the WRZ.
    Schlagwort(e): Center for Marine Environmental Sciences; MARUM; RAiN; Regional Archives for Integrated iNvestigations
    Materialart: Dataset
    Format: application/zip, 8 datasets
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  • 4
    facet.materialart.
    Unbekannt
    PANGAEA
    In:  Supplement to: Peng, Chao; Zhao, X; Liu, S; Shi, Wei; Han, Yu; Guo, Cheng; Peng, Xin; Chai, Xueliang; Liu, Guangxu (2017): Ocean acidification alters the burrowing behaviour, Ca2+/Mg2+-ATPase activity, metabolism, and gene expression of a bivalve species, Sinonovacula constricta. Marine Ecology Progress Series, 575, 107-117, https://doi.org/10.3354/meps12224
    Publikationsdatum: 2023-05-12
    Beschreibung: Although the effect of ocean acidification on fertilization success of marine organisms is increasingly well documented, the underlying mechanisms are not completely understood. The fertilization success of broadcast spawning invertebrates depends on successful sperm-egg collisions, gamete fusion, and standard generation of Ca2+oscillations. Therefore, the realistic effects of future ocean pCO2 levels on these specific aspects of fertilization of Tegillarca granosa were investigated in the present study through sperm velocity trials, fertilization kinetics model analysis, and intracellular Ca2+assays, respectively. Results obtained indicated that ocean acidification significantly reduced the fertilization success of T. granosa, which could be accountable by (i) decreased sperm velocity hence reducing the probability for sperm-egg collisions; (ii) lowered probability of gamete fusion for each gamete collision event; and (iii) disrupted intracellular Ca2+ oscillations.
    Schlagwort(e): Alkalinity, total; Alkalinity, total, standard error; Ammonium, excretion; Ammonium, excretion, standard error; Animalia; Aragonite saturation state; Aragonite saturation state, standard error; Behaviour; Benthic animals; Benthos; Bicarbonate ion; Calcite saturation state; Calcite saturation state, standard error; Carbon, inorganic, dissolved; Carbon, inorganic, dissolved, standard error; Carbonate ion; Carbonate system computation flag; Carbon dioxide; Coast and continental shelf; Containers and aquaria (20-1000 L or 〈 1 m**2); Digging depth; Enzyme activity, per protein; EXP; Experiment; Experiment duration; Figure; Fugacity of carbon dioxide (water) at sea surface temperature (wet air); Gene expression; Gene expression (incl. proteomics); Gene name; Laboratory experiment; Mollusca; Name; North Pacific; OA-ICC; Ocean Acidification International Coordination Centre; Other metabolic rates; Oxygen consumption, per mass; Oxygen consumption, standard error; Partial pressure of carbon dioxide (water) at sea surface temperature (wet air); Partial pressure of carbon dioxide (water) at sea surface temperature (wet air), standard error; pH; pH, standard error; Registration number of species; Replicate; Respiration; Salinity; Salinity, standard error; Single species; Sinonovacula constricta; Species; Temperate; Temperature, water; Temperature, water, standard error; Treatment; Type; Uniform resource locator/link to reference; Yueqing_Bay
    Materialart: Dataset
    Format: text/tab-separated-values, 3760 data points
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  • 5
    Publikationsdatum: 2024-03-15
    Beschreibung: Seawater acidification (SA) has been documented to either inhibit, enhance, or result in no effect on marine primary productivity (PP). In order to examine the effects of SA in changing environments, we investigated the influences of SA (a decrease of 0.4 pHtotal units with corresponding CO2 concentrations in the range of 22.0–39.7 µM) on PP through deck-incubation experiments at 101 stations in the Taiwan Strait and the South China Sea, including the continental shelf and slope, as well as the deep-water basin. The daily primary productivities in surface seawater under incident solar radiation ranged from 17–306 µg C/µg Chl a/d, with the responses of PP to SA being region-dependent and the SA-induced changes varying from −88 % (inhibition) to 57 % (enhancement). The SA treatment stimulated PP in surface waters of coastal, estuarine, and shelf waters but suppressed it in the South China Sea basin. Such SA-induced changes in PP were significantly related to in situ pH and solar radiation in surface seawater but negatively related to salinity changes. Our results indicate that phytoplankton cells are more vulnerable to a pH drop in oligotrophic waters. Contrasting responses of phytoplankton productivity in different areas suggest that SA impacts on marine primary productivity are region-dependent and regulated by local environments.
    Schlagwort(e): Alkalinity, total; Alkalinity, total, standard deviation; Aragonite saturation state; Bicarbonate ion; Bicarbonate ion, standard deviation; Bottles or small containers/Aquaria (〈20 L); Calcite saturation state; Calculated using CO2SYS; Calculated using seacarb after Nisumaa et al. (2010); Carbon, inorganic, dissolved; Carbon, inorganic, dissolved, standard deviation; Carbonate ion; Carbonate ion, standard deviation; Carbonate system computation flag; Carbon dioxide; Carbon dioxide, standard deviation; Change; Chlorophyll a; Coast and continental shelf; Entire community; Fugacity of carbon dioxide (water) at sea surface temperature (wet air); Irradiance; Laboratory experiment; LATITUDE; LONGITUDE; North Pacific; OA-ICC; Ocean Acidification International Coordination Centre; Open ocean; Partial pressure of carbon dioxide, standard deviation; Partial pressure of carbon dioxide (water) at sea surface temperature (wet air); Pelagos; pH; pH, standard deviation; Primary production/Photosynthesis; Primary production of carbon per chlorophyll a; Salinity; Station label; Temperate; Temperature, water; Treatment; Type
    Materialart: Dataset
    Format: text/tab-separated-values, 6363 data points
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  • 6
    Publikationsdatum: 2024-04-20
    Beschreibung: This sea ice concentration dataset (SIC) was derived from the re-calibrated brightness temperature of the Microwave Radiation Imager (MWRI) sensors. The MWRI sensors are onboard the Chinese second generation of sun-synchronous meteorological satellites, i.e., FY-3A, FY-3B, FY-3C, and FY-3D, which were launched in 2008. The advanced Arctic Radiation and Turbulence Interaction Study Sea Ice (ASI) algorithm involving dynamic tie points was adopted to retrieve this SIC dataset. The MWRI-ASI SIC dataset was projected onto the polar stereographic grid true at 70 degrees at a 12.5-km spatial resolution in the Arctic and Antarctic. The time coverage of this dataset is from 12 November 2010 to 31 December 2019 with a temporary loss of 23 days in the Arctic and 82 days in the Antarctic. The MWRI-ASI SIC dataset is achieved in TIFF format. The data values have specific meanings: '0-100' for the percentage of SIC, '-1' for land, '-2' for the Pole Hole, and 'NoData' for missing data. The accuracy of this dataset was assessed by ship-based observational SIC. A total of 8887 and 3882 samples of SIC observations were used in the Arctic and Antarctic, respectively. The differences between this MWRI SIC and ship-based SIC are concentrated from -20% to 20% with the overall mean absolute deviation of 16.1% in the Arctic and 17.1% in the Antarctic, respectively. The treads of sea ice extent obtained from this MWRI-ASI SIC for both Arctic and Antarctic are consistent with those from the Sea Ice Index provided by the Ocean and Sea Ice Satellite Application Facility Norwegian Meteorological Institute (OSI-SAF) and the NASA National Snow and Ice Data Center (NSIDC). This dataset can be considered as an important backup of sea ice concentration or extent passive microwave products for multidisciplinary studies in the polar regions and beyond.
    Schlagwort(e): Antarctic; Arctic; Binary Object; Binary Object (File Size); FengYun-3; File content; Microwave Radiation Imager; sea ice concentration
    Materialart: Dataset
    Format: text/tab-separated-values, 6 data points
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  • 7
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract: Increasing evidence suggests that excessive activation of the calcium-activated neutral protease μ-calpain could play a major role in calcium-mediated neuronal degeneration after acute brain injuries. To further investigate the changes of the in vivo activity of μ-calpain after unilateral cortical impact injury in vivo, the ratio of the 76-kDa activated isoform of μ-calpain to its 80-kDa precursor was measured by western blotting. This μ-calpain activation ratio increased to threefold in the pellet of cortical samples ipsilateral to the injury site at 15 min, 1 h, 3 h, and 6 h after injury and returned to control levels at 24–48 h after injury. We also investigated the effect of μ-calpain activation on proteolysis of the neuronal cytoskeletal protein α-spectrin. Immunoreactivity for α-spectrin breakdown products was detectable within 15 min after injury in cortical samples ipsilateral to the injury site. The levels of α-spectrin breakdown products increased in a biphasic manner, with a large increase between 15 min and 6 h after injury, followed by a smaller increase between 6 and 24 h after the insult. No further accumulation of α-spectrin breakdown products was observed between 24 and 48 h after injury. Histopathological examinations using hematoxylin and eosin staining demonstrated dark, shrunken neurons within 15 min after traumatic brain injury. No evidence of μ-calpain autolysis, calpain-mediated α-spectrin degradation, or hematoxylin and eosin neuronal pathology was detected in the contralateral cortex. Although μ-calpain autolysis and cytoskeletal proteolysis occurred concurrently with early morphological alterations, evidence of calpain-mediated proteolysis preceded the full expression of evolutionary histopathological changes. Our results indicate that rapid and persistent μ-calpain activation plays an important role in cortical neuronal degeneration after traumatic brain injury. Our data also suggest that specific inhibitors of calpain could be potential therapeutic agents for the treatment of traumatic brain injury in vivo.
    Materialart: Digitale Medien
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  • 8
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 96 (1992), S. 9933-9939 
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
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  • 9
    Digitale Medien
    Digitale Medien
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 99 (1995), S. 945-954 
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
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  • 10
    Digitale Medien
    Digitale Medien
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 80 (1996), S. 5857-5860 
    ISSN: 1089-7550
    Quelle: AIP Digital Archive
    Thema: Physik
    Notizen: Magnetic Fe3C and α-Fe ultrafine particles were prepared by laser-induced pyrolysis of Fe(CO)5 and C2H4. It is found that after passivation, the Fe3C particles exhibit a high saturation magnetization of 132 emu/g compared to that of the α-Fe particle, 95 emu/g. By determining the oxygen content and the present states of oxygen the particles contained, it is found that not only oxygen content of the α-Fe particles is much higher than that of the Fe3C particles, but the oxygen is in differnt states for the two ultrafine particles. The oxygen present on the Fe3C particles is primarily in absorbed form, compared to chemically combined oxygen as in the α-Fe particles. Thin amorphous carbon layers, formed on the surfaces of the Fe3C particles, inhibit oxidation of the Fe3C and therefore result in higher saturation magnetization achieved by Fe3C particles, relative to the α-Fe particles on which no carbon layer was present. © 1996 American Institute of Physics.
    Materialart: Digitale Medien
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