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  • 1
    Electronic Resource
    Electronic Resource
    Bisubstrate reaction templates. Examination of the consequences of identical versus different binding sites (1990)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 112 (1990), S. 8024-8034 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00178a027
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  • 2
    Electronic Resource
    Electronic Resource
    A bisubstrate reaction template (1989)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 111 (1989), S. 3744-3745 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00192a039
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  • 3
    Electronic Resource
    Electronic Resource
    Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome (2007)
    [s.l.] : Nature Publishing Group
    Nature genetics 39 (2007), S. 75-79 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Noonan syndrome is a developmental disorder characterized by short stature, facial dysmorphia, congenital heart defects and skeletal anomalies. Increased RAS-mitogen-activated protein kinase (MAPK) signaling due to PTPN11 and KRAS mutations causes 50% of cases of Noonan syndrome. Here, we report ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1939
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  • 4
    Electronic Resource
    Electronic Resource
    Two cases of ectopic hamartomatous thymoma (2000)
    Springer
    Virchows Archiv 437 (2000), S. 643-647 
    Details
    ISSN: 1432-2307
    Keywords: Ectopic hamartomatous thymoma Immunohistochemistry Myoid cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Ectopic hamartomatous thymoma (EHT) is a rare benign neoplasm. Since it was named by Rosai et al. in 1984, 24 cases have been reported. We herein report two cases of EHT, one of which presented with massive myoid cells, and review the literature related to EHT. Both of our cases displayed the typical features of EHT: (1) nests of epithelial cells, including solid, cystic, or glandular epithelial islands; (2) spindle cells dominating the microscopic picture; and (3) adipose cells which intermingle haphazardly to impart a hamartomatous quality to the tumor. In this paper, we observed massive myoid cells and the transition from spindle epithelial cell to myoid cell in one of our cases. Immunohistochemical examinations showed that the main component of EHT, spindle cells, was positive for cytokeratin and epithelial membrane antigen (EMA). Intriguingly, the myoid cells simultaneously expressed cytokeratin, EMA, myoglobin, and creatine kinase-mm, suggesting that myoid cells may originate from epithelial cells and are an intermediate state between epithelial cells and muscular cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004280000309
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  • 5
    Electronic Resource
    Electronic Resource
    Some Synthetic Studies Related to Perylenequinones (1993)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1993 (1993), S. 35-41 
    Details
    ISSN: 0170-2041
    Keywords: Fungus pigments ; Perylenequinones, synthesis of ; Selenium dioxide oxidation ; Ullmann coupling ; Double coupling of 1,2-naphthalenediols ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Two closely related routes to dimethyl 3,10-dihydro-2,11-dihydroxy-4,6,7,9-tetramethoxy-3,10-dioxo-1,12-perylenediacetate (10), one involving Ullmann phenol coupling and the other by double oxidative coupling are described. Regioselective demethylation of 10 followed by methylation or vice versa yields dimethyl 3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1,12-perylenediacetate (22) which, except for its side chains, structurally resembles some of the natural perylenequinones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199319930107
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  • 6
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    Projected land ice contributions to twenty-first-century sea level rise (2021)
    In:  EPIC3Nature, 593(7857), pp. 74-82, ISSN: 0028-0836
    Details
    Publication Date: 2022-09-26
    Description: The land ice contribution to global mean sea level rise has not yet been predicted1 using ice sheet and glacier models for the latest set of socio-economic scenarios, nor using coordinated exploration of uncertainties arising from the various computer models involved. Two recent international projects generated a large suite of projections using multiple models2,3,4,5,6,7,8, but primarily used previous-generation scenarios9 and climate models10, and could not fully explore known uncertainties. Here we estimate probability distributions for these projections under the new scenarios11,12 using statistical emulation of the ice sheet and glacier models. We find that limiting global warming to 1.5 degrees Celsius would halve the land ice contribution to twenty-first-century sea level rise, relative to current emissions pledges. The median decreases from 25 to 13 centimetres sea level equivalent (SLE) by 2100, with glaciers responsible for half the sea level contribution. The projected Antarctic contribution does not show a clear response to the emissions scenario, owing to uncertainties in the competing processes of increasing ice loss and snowfall accumulation in a warming climate. However, under risk-averse (pessimistic) assumptions, Antarctic ice loss could be five times higher, increasing the median land ice contribution to 42 centimetres SLE under current policies and pledges, with the 95th percentile projection exceeding half a metre even under 1.5 degrees Celsius warming. This would severely limit the possibility of mitigating future coastal flooding. Given this large range (between 13 centimetres SLE using the main projections under 1.5 degrees Celsius warming and 42 centimetres SLE using risk-averse projections under current pledges), adaptation planning for twenty-first-century sea level rise must account for a factor-of-three uncertainty in the land ice contribution until climate policies and the Antarctic response are further constrained.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 7
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    Future Sea Level Change Under Coupled Model Intercomparison Project Phase 5 and Phase 6 Scenarios From the Greenland and Antarctic Ice Sheets (2021)
    In:  EPIC3Geophysical Research Letters, 48(16), pp. e2020GL091741, ISSN: 0094-8276
    Details
    Publication Date: 2022-09-26
    Description: Projections of the sea level contribution from the Greenland and Antarctic ice sheets (GrIS and AIS) rely on atmospheric and oceanic drivers obtained from climate models. The Earth System Models participating in the Coupled Model Intercomparison Project phase 6 (CMIP6) generally project greater future warming compared with the previous Coupled Model Intercomparison Project phase 5 (CMIP5) effort. Here we use four CMIP6 models and a selection of CMIP5 models to force multiple ice sheet models as part of the Ice Sheet Model Intercomparison Project for CMIP6 (ISMIP6). We find that the projected sea level contribution at 2100 from the ice sheet model ensemble under the CMIP6 scenarios falls within the CMIP5 range for the Antarctic ice sheet but is significantly increased for Greenland. Warmer atmosphere in CMIP6 models results in higher Greenland mass loss due to surface melt. For Antarctica, CMIP6 forcing is similar to CMIP5 and mass gain from increased snowfall counteracts increased loss due to ocean warming.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 8
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    ISMIP6 Antarctica: a multi-model ensemble of the Antarctic ice sheet evolution over the 21st century (2020)
    In:  EPIC3The Cryosphere, 14(9), pp. 3033-3070, ISSN: 1994-0424
    Details
    Publication Date: 2022-09-26
    Description: Ice flow models of the Antarctic ice sheet are commonly used to simulate its future evolution in response to different climate scenarios and assess the mass loss that would contribute to future sea level rise. However, there is currently no consensus on estimates of the future mass balance of the ice sheet, primarily because of differences in the representation of physical processes, forcings employed and initial states of ice sheet models. This study presents results from ice flow model simulations from 13 international groups focusing on the evolution of the Antarctic ice sheet during the period 2015–2100 as part of the Ice Sheet Model Intercomparison for CMIP6 (ISMIP6). They are forced with outputs from a subset of models from the Coupled Model Intercomparison Project Phase 5 (CMIP5), representative of the spread in climate model results. Simulations of the Antarctic ice sheet contribution to sea level rise in response to increased warming during this period varies between −7.8 and 30.0 cm of sea level equivalent (SLE) under Representative Concentration Pathway (RCP) 8.5 scenario forcing. These numbers are relative to a control experiment with constant climate conditions and should therefore be added to the mass loss contribution under climate conditions similar to present-day conditions over the same period. The simulated evolution of the West Antarctic ice sheet varies widely among models, with an overall mass loss, up to 18.0 cm SLE, in response to changes in oceanic conditions. East Antarctica mass change varies between −6.1 and 8.3 cm SLE in the simulations, with a significant increase in surface mass balance outweighing the increased ice discharge under most RCP 8.5 scenario forcings. The inclusion of ice shelf collapse, here assumed to be caused by large amounts of liquid water ponding at the surface of ice shelves, yields an additional simulated mass loss of 28 mm compared to simulations without ice shelf collapse. The largest sources of uncertainty come from the climate forcing, the ocean-induced melt rates, the calibration of these melt rates based on oceanic conditions taken outside of ice shelf cavities and the ice sheet dynamic response to these oceanic changes. Results under RCP 2.6 scenario based on two CMIP5 climate models show an additional mass loss of 0 and 3 cm of SLE on average compared to simulations done under present-day conditions for the two CMIP5 forcings used and display limited mass gain in East Antarctica.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 9
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    Insights into the vulnerability of Antarctic glaciers from the ISMIP6 ice sheet model ensemble and associated uncertainty (2023)
    Copernicus Publications
    In:  EPIC3The Cryosphere, Copernicus Publications, 17(12), pp. 5197-5217, ISSN: 1994-0416
    Details
    Publication Date: 2024-03-14
    Description: The Antarctic Ice Sheet represents the largest source of uncertainty in future sea level rise projections, with a contribution to sea level by 2100 ranging from −5 to 43 cm of sea level equivalent under high carbon emission scenarios estimated by the recent Ice Sheet Model Intercomparison for CMIP6 (ISMIP6). ISMIP6 highlighted the different behaviors of the East and West Antarctic ice sheets, as well as the possible role of increased surface mass balance in offsetting the dynamic ice loss in response to changing oceanic conditions in ice shelf cavities. However, the detailed contribution of individual glaciers, as well as the partitioning of uncertainty associated with this ensemble, have not yet been investigated. Here, we analyze the ISMIP6 results for high carbon emission scenarios, focusing on key glaciers around the Antarctic Ice Sheet, and we quantify their projected dynamic mass loss, defined here as mass loss through increased ice discharge into the ocean in response to changing oceanic conditions. We highlight glaciers contributing the most to sea level rise, as well as their vulnerability to changes in oceanic conditions. We then investigate the different sources of uncertainty and their relative role in projections, for the entire continent and for key individual glaciers. We show that, in addition to Thwaites and Pine Island glaciers in West Antarctica, Totten and Moscow University glaciers in East Antarctica present comparable future dynamic mass loss and high sensitivity to ice shelf basal melt. The overall uncertainty in additional dynamic mass loss in response to changing oceanic conditions, compared to a scenario with constant oceanic conditions, is dominated by the choice of ice sheet model, accounting for 52 % of the total uncertainty of the Antarctic dynamic mass loss in 2100. Its relative role for the most dynamic glaciers varies between 14 % for MacAyeal and Whillans ice streams and 56 % for Pine Island Glacier at the end of the century. The uncertainty associated with the choice of climate model increases over time and reaches 13 % of the uncertainty by 2100 for the Antarctic Ice Sheet but varies between 4 % for Thwaites Glacier and 53 % for Whillans Ice Stream. The uncertainty associated with the ice–climate interaction, which captures different treatments of oceanic forcings such as the choice of melt parameterization, its calibration, and simulated ice shelf geometries, accounts for 22 % of the uncertainty at the ice sheet scale but reaches 36 % and 39 % for Institute Ice Stream and Thwaites Glacier, respectively, by 2100. Overall, this study helps inform future research by highlighting the sectors of the ice sheet most vulnerable to oceanic warming over the 21st century and by quantifying the main sources of uncertainty.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
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  • 10
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    A fossil pollen dataset of China (2023)
    Chinese Journal of Plant Ecology
    In:  EPIC3Chinese Journal of Plant Ecology, Chinese Journal of Plant Ecology, 47(10), pp. 1453-1463, ISSN: 1005-264X
    Details
    Publication Date: 2024-06-21
    Description: Fossil pollen and spore records provide highly creditable proxy data to investigate the past environmental changes such as palaeovegetation and palaeoclimate. Pollen database promotes past environmental studies from local to regional and global scales and from qualitative to quantitative reconstructions. This is of great significance on exploring the interactions among past vegetation, climates and anthropogenic disturbances at large spatial scale and long temporal scale, to better understand the evolution of the earth system. In this paper, a fossil pollen dataset of China is compiled, by synthesizing 372 original or digitized fossil pollen records including 790 pollen taxa in China’s land and ocean during the late-Quaternary (since 50 ka BP). The dataset includes site names, latitude, longitude and altitude, pollen data source, sample type, sediment length or span, sample number of each site, dating method and dating number, age span and reference, as well as the fossil pollen percentage of each sampling site. The pollen data, mostly published from late 1980s to present, are concentrated in vegetation regions of temperate and subtropical forests, temperate grasslands, temperate deserts and alpine vegetation on the Qingzang Plateau. Sample sites are distributed at different altitudes from deep sea to high Qingzang Plateau, but the majority of the sites are located between 0–2 000 m. The dataset comprises of 178 raw pollen records (47.8%) and 194 digitized pollen records (52.2%). Pollen samples are mainly from lake sediment (151 sites), alluvial/fluvial sediment (99 sites), and peat (67 sites), accounting for 85.2% of the total sampling sites. Radiocarbon is the main dating method that accounts for 93.8% of total samples, and most of the sites have 2–10 radiocarbon dating data. Each site has an average number of pollen taxa of 19, with the most sites having 4–30 pollen taxa. The temporal and spatial distribution of representative pollen taxa (Pinus, Quercus, Artemisia and Poaceae) reveals increasing trends both in their distributional range and pollen concentration from the last glacial maximum to Holocene, but such trends have various regional patterns in different parts of China. This fossil pollen dataset is a fruitful work of collection of pollen records in most territory of China that conducted by palynologists from China and overseas during the last half century. It consolidates the valuable and fundamental data that can be potentially utilized to explore the evolution of past environments and their driving mechanism of climate change and human disturbance.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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