Keywords:
Local government -- Pakistan.
;
Public administration -- Pakistan.
;
Administración local.
;
Administración pública.
;
Pakistán.
;
Electronic books.
Description / Table of Contents:
This book discusses, in relatively simple language, the importance of even minute amounts of certain trace elements for the protection of human health and how insufficiency or excess may produce serious diseases. It also examines the use of metal chelators in the treatment of such diseases.
Type of Medium:
Online Resource
Pages:
1 online resource (136 pages)
Edition:
1st ed.
ISBN:
9781847552198
Series Statement:
Issn Series
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=1186198
DDC:
612.3/924
Language:
English
Note:
Trace Element Medicine And Chelation Therapy -- Contents -- Chapter 1 Introduction -- What is Life? -- Evolution -- Composition and Structure of Living Systems -- Further Reading -- Chapter 2 The Elemental Composition of the Human Body -- The Elements in the Human Body -- Supplying Elements to the Body -- Metals and Human Health -- Further Reading -- Chapter 3 Metal Ions, Complexes, and Chemical Speciation -- Elements and the Periodic Table -- Solvents In Vivo -- Coordination Complexes -- Bonding -- Chelation -- Metal-Ligand Selectivity -- Hard and Soft Acids and Bases -- Bio-inorganic Chemistry -- Oxidation-Reduction Reactions -- Hydrolysis of Complexes -- Polynuclear Complexes -- Uncharged Metal-Ligand Complexes -- Labile and Inert Complexes -- Chemical Speciation Modelling -- Further Reading -- Chapter 4 Chelation, Ligands, and Drugs -- Bonding to Transition Metal Ions -- The Chelate Effect -- Metal-Ligand Selectivity, a Combination of the Chelate Effect and the HSAB Approach -- Metabolic Specificity In Vivo -- Chelating Drugs Designed for Mobilizing and/or Excreting Metal Ions from Humans -- Further Reading -- Chapter 5 Delivery of Trace Elements to Humans -- Means of Mineral Supplementation -- Absorption of Ligands from the Gastrointestinal Tract -- Iron, Zinc, and Copper Supplementation -- Biochemistry of Trace Element Delivery -- Further Reading -- Chapter 6 Agents Containing Metals -- Recommended Daily Amounts and Biological Half-lives -- Foods -- Food Additives -- Flavour Stimulants -- Supplements -- 'Health Foods' -- Folklore and Alternative Medicines -- Healthcare Agents -- Cosmetics -- Therapeuticals -- Chelation and Anticancer Activity -- Ulcer Therapy using Bismuth Compounds -- Parenteral Nutrition -- Wound Dressings -- Skin Protection and Decontamination -- Metals as Radioprotective Agents -- Meaningful Therapies.
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Concluding Remarks -- Further Reading -- Chapter 7 Chelating Agents and Therapy -- Introduction -- Selectivity of Ligand Drugs for Metal Ions using Formation Constant Data -- EDTA, its Evolution, and Use -- Chemical Properties of EDTA -- In Vivo Chelation of Radionuclides -- Toxicity of EDTA -- Nephrotoxicity and Heavy Metal Chelates -- Rate of Administration and Dosage of EDTA -- Sulfur-containing Agents -- Removal of an Excess of an Essential Metal, e.g. Iron -- Excretion and 'Topping-up' Therapy -- Criteria of Success -- Metal Complexes used in Diagnosis and Chemotherapy -- Concluding Remarks -- Further Reading -- Chapter 8 Dietary and Environmental Aspects -- Diet -- National Food Surveys -- Crop Protection -- Food Fortification -- Food Intolerance -- Foods Linked with Health and a Longer Life -- Environmental Aspects -- Further Reading -- Chapter 9 The Future -- Subject Index.
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