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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 44 (1966), S. 652-653 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The role of Trasylol in the treatment of acute pancreatitis is still undetermined. In this study the influence of Trasylol on the secretoric function of the pancreas was investigated. The change of pancreatic secretion was not significant immediately after intravenous injection. 24–48 h later the volume of secretion as well as the activity of all enzymes was significantly diminished. The importance of this atropin-like effect of Trasylol for the treatment of the acute pancreatitis is discussed.
    Notes: Zusammenfassung Die Bedeutung des Trasylol für die Behandlung der akuten Pankreatitis ist noch immer nicht entschieden. Es wurde deshalb der Einfluß von Trasylol auf die sekretorische Funktion des Pankreas untersucht. Direkt nach intravenöser Injektion waren keine signifikanten Änderungen der Pankreassekretion nachweisbar. 24–48 Std später waren dagegen das Sekretvolumen und die Aktivität aller Enzyme signifikant vermindert. Die Bedeutung dieser atropinartigen Wirkung des Trasylol für die Behandlung der akuten Pankreatitis wird diskutiert.
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  • 2
    ISSN: 1432-1440
    Keywords: Circadian rhythm ; urine ; electrolytes ; catecholamines ; 17-hydroxycorticosteroids ; Tagesperiodik ; Harn ; Elektrolyte ; Katecholaminmetabolite ; 17-Hydroxycorticosteroide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Unter standardisierten Versuchsbedingungen wurden bei 6 gesunden männlichen Versuchspersonen in 3 Std-Intervallen die Ausscheidung von Natrium, Kalium, Calcium, Dopamin, Gesamtkatecholaminen, Vanillinmandelsäure und 17-Hydroxycorticosteroiden sowie die Rectaltemperatur an 4 aufeinanderfolgenden Versuchstagen bestimmt. Der tagesperiodische Verlauf jedes Bestandteiles wurde durch Gleichwert, Amplitude und Phase charakterisiert. Dabei wurden für die einzelnen Meßgrößen z.T. recht erhebliche Unterschiede sowohl zwischen den einzelnen Versuchspersonen als auch für die gleiche Versuchsperson an verschiedenen Versuchstagen ermittelt. In bezug auf die Schwingungsbreiten und die Phasenlage fanden sich beträchtliche Differenzen. Während die Schwingungsbreiten für Harnmenge, Calcium und Gesamtkatecholamine sehr groß sind, sind sie für Dopamin und Vanillinmandelsäure sehr klein. Das Minimum der 17-Hydroxycorticosteroidausscheidung erscheint um 2.50 Uhr mit nachfolgenden Minima der übrigen Bestandteile. Das späteste Minimum ist das der Temperatur um 6.10 Uhr.
    Notes: Summary Under standardized experimental conditions, the rectal temperature and the excretion of sodium, potassium, calcium, dopamine, total catecholamines, vanillinmandelic acid and 17-hydroxycorticosteroids were measured in 6 normal adult males at 3-hour intervals for 4 consecutive days. The daily rhythm of each constituent was characterized by its mean level, amplitude and phase. Despite considerable interand intra-individual variability, clearcut differences in the magnitude of the amplitudes and in the order of the minima were established. The amplitudes of urine volume, calcium and total catecholamines were much higher than those of dopamine and vanillinmandelic acid. The minimum of excretion of 17-hydroxycorticosteroids occurred at 2.50 a.m., followed by the minima of the other constituents. The latest minimum was that of the temperature at 6.10 a.m.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1076
    Keywords: Percutaneous ; Liver ; Biopsy ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Abstract In this study, 144 consecutive percutaneous liver biopsies performed with a 1.6 mm Menghini needle, during a 2-year period were reviewed. All the children were aged under 15 years, 57 patients less than 1 year and 87 more than 1 year. All biopsies were adequate and the mean number of portal tracts examined was 17.6 per biopsy (14.3 in patients weighing less than 10 kg and 19.1 in the others). There were no deaths and we observed only bleeding complications. In patients with normal coagulation (128 cases), 1 bleeding requiring transfusion occurred; and in patients with abnormal coagulation (16 cases), we observed 2 bleeding cases requiring transfusion. Conclusion Percutaneous liver biopsy can be performed with 1.6 mm needles in children. For increased safety, ultrasound-guided biopsies are recommended.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1076
    Keywords: Carnitine palmitoyl transferase deficiency ; Fibroblasts ; Fatty acid oxidation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract An apparently healthy girl aged 2 years 9 months developed a coma with hepatomegaly within 24h after an influenza-like infection. Plasma glucose and urinary organic acid profile were normal but plasma and urinary carnitine concentrations were increased. Despite symptomatic therapy, she died 11 days later. Oxidation of [1-14C] palmitic acid in the patient's fibroblasts was severely decreased (13% of controls). Further investigations revealed a deficiency of carnitine palmitoyl transferase I (CPTI) in the patient's fibroblasts (15% of controls) whereas CPT II activity was normal. Only four patients with CPT I deficiency have been reported so far. The subtle clinical and biochemical, presentation of this disorder, which may account for the small number of cases diagnosed, is discussed.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 154 (1995), S. 621-623 
    ISSN: 1432-1076
    Keywords: Key words Percutaneous ; Liver ; Biopsy ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study, 144 consecutive percutaneous liver biopsies performed with a 1.6 mm Menghini needle, during a 2-year period were reviewed. All the children were aged under 15 years, 57 patients less than 1 year and 87 more than 1 year. All biopsies were adequate and the mean number of portal tracts examined was 17.6 per biopsy (14.3 in patients weighing less than 10 kg and 19.1 in the others). There were no deaths and we observed only bleeding complications. In patients with normal coagulation (128 cases), 1 bleeding requiring transfusion occurred; and in patients with abnormal coagulation (16 cases), we observed 2 bleeding cases requiring transfusion. Conclusion Percutaneous liver biopsy can be performed with 1.6 mm needles in children. For increased safety, ultrasound-guided biopsies are recommended.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1246
    Keywords: Human circadian rhythms ; Light-dark-cycle ; Social Zeitgebers ; Rectal temperature ; Urine metabolites ; Circadiane Periodik des Menschen ; Licht-Dunkel-Wechsel ; Soziale Zeitgeber ; Rectaltemperatur ; Harnmetaboliten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In einer 2mal 4 Tage dauernden Versuchsreihe wurden an 6 männlichen Versuchspersonen in 3stündigen Abständen die Urinmenge und die Harnausscheidung von Natrium, Kalium, Calcium, Dopamin, freien Gesamtkatecholaminen, Vanillinmandelsäure und 17-Hydroxycorticosteroiden, ferner tagsüber die motorische Aktivität und, kontinuierlich, die Rectaltemperatur gemessen. In beiden Versuchsabschnitten herrschte strenge Versuchsroutine mit festgesetzten Schlafzeiten. Im ersten Versuchsabschnitt kam dazu ein mit dem Wach-Schlaf-Cyclus phasengleicher Licht-Dunkel-Wechsel (LD), im zweiten Versuchsabschnitt herrschte für 96 Std Dunkelheit (DD). Die im LD beobachteten tagesrhythmischen Schwankungen bestanden im DD mit statistisch unveränderter Lage der Extremwerte zum Schlaf-Wach-Cyclus fort. Demnach war ein Licht-Dunkel-Wechsel für die Ausprägung und für die Synchronisation der Tagesperiodik der genannten Funktionen unter den Bedingungen dieses Versuchs nicht notwendig; soziale Zeitgeber wie Versuchsroutine und Schlaf-Wach-Cyclus reichten dazu aus. Die motorische Aktivität sowie Gleichwert und Schwingungsbreite der Calcium-Tageskurven waren im DD signifikant niedriger als im LD. Darüber hinaus zeigten sich Tendenzen zur Abnahme von Gleichwert und Schwingungsbreite bei den übrigen Funktionen — mit Ausnahme der 17-OHCS und der Rectaltemperatur, die im DD zu höheren Schwingungsbreiten tendierten.
    Notes: Summary During a continuous 8-day period, urine volume and urinary excretion of Na, K, Ca, dopamine, free total catecholamines, vanillin-mandelic-acid and 17-hydroxycorticosteroids were measured in 6 male subjects at 3-hour intervals. Gross motor activity (during daytime only) and rectal temperature were recorded continuously. During all 8 days there was a strict experimental routine with fixed sleeping-times. In the first 4 days the rhythm of wakefulness and sleep was accompanied by a simultaneous light-dark-cycle (LD); during the second 4 days, there was continuous darkness (DD). The phase-relationship of the 9 functions to the sleep-waking-rhythm was the same during LD as during DD. Since the social Zeitgebers, such as experimental routine and sleep-waking-rhythm were the same during LD as during DD, it is concluded that these are sufficient for the maintenance and the synchronization of human circadian rhythms under the experimental conditions cited, and that a light-dark-cycle is not needed. Motor activity and mean-level and range of Ca-excretion were significantly lower in DD. Beyond it, the other functions showed a tendency for lower mean-level and range in DD — with the exception of 17-hydroxycorticosteroids and rectal temperature which tended to higher ranges in DD.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 18 (1992), S. 175-176 
    ISSN: 1432-1238
    Keywords: Shock ; Streptococcus pyogenes ; Toxins ; Soft tissue infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two children with toxic shock-like syndrome due to streptococcal infection are reported. In both cases (one fatal) the site of infection was in the soft tissues. Both strains of group A hemolytic streptococci isolated from blood culture produced large amounts of erythrogenic toxin B (ET B) small amounts of ET C but no ET A. This report confirms the implication ofStreptococcus pyogenes in toxic shock like syndromes. When ET A seems to be responsible for most cases observed in the USA, our cases and others observed in Europe could be related to strains producing large amounts of ET B.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 11 (1965), S. 135-143 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Description of a simple flame photometric method of atom absorption for estimation of iron in 20 ml blood and also haemoglobin in the blood volume as a whole, sufficiently accurate for clinical purposes.
    Notes: Zusammenfassung Es wird eine einfache und für klinische Zwecke genügend genaue flammenphotometrische Atomabsorptionsmethode zur Bestimmung von Eisen in 20 μl Gesamtblut und damit von Hämoglobin im Gesamtblut beschrieben.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    International journal of legal medicine 93 (1984), S. 219-225 
    ISSN: 1437-1596
    Keywords: Quality assurance, thallium ; Interlaboratory survey, thallium ; Thallium, quality assurance ; Thallium, Qualitätskontrollen ; Ringversuch, Thallium ; Qualitätskontrollen, Thallium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Qualitätssicherung von Analysenergebnissen erhielt in der Bundesrepublik Deutschland durch das Eichgesetz vom 11. 7. 1969 und die Eichpflicht-Ausnahmeverordnung vom 29. 6. 1970 eine gesetzliche Basis. Danach sind im Bereich der Heilkunde bei Verwendung nicht geeichter Volumenmeßgeräte die Richtlinien der Bundesärztekammer zur Durchführung von Maßnahmen der Qualitätssicherung zu befolgen. Seit dem 1. 1. 1974 hat das Eichgesetz seine völlige Gültigkeit erlangt. Von den in rechtsmedizinischen Instituten durchgeführten Untersuchungen stellen mindestens die klinisch-toxikologischen eine Tätigkeit im Bereich der Heilkunde dar. Soweit es sich um quantitative Bestimmungen handelt, unterliegen sie damit sicher den Bestimmungen des Eichgesetzes bzw. den Richtlinien der Bundesärztekammer. Zur Durchführung des Basisprogrammes der Bundesärztekammer sind geeignete Kontrollproben und die Durchführung von Ringversuchen erforderlich. Für toxikologische Fragestellungen gibt es hierfür praktisch noch keine Basis. Deshalb wurde ein Kontrollurin für Metalle konzipiert, mit dem lang- und kurzfristige Ringversuche zur Thalliumbestimmung durchgeführt wurden. Über die Ergebnisse wird berichtet.
    Notes: Summary Quality assurance of analytic results was legalized in the Federal Republic of Germany by the law regulating the calibration of measuring devices of July 11, 1969, and the ordinance concerning the exception from compulsory calibration dated June 29, 1970. Accordingly, in the field of health care the Guidelines of the Medical Society of West Germany for the realization of quality assurance activities have to be followed. Since January 1, 1974, the law regulating the calibration of measuring devices has been fully effective. In the field of legal medicine the clinico-toxicologic analysis is considered to be a part of health care. As far as quantitative determinations are considered, these analyses have to follow the regulations mentioned above. To fulfil the basic program, adequate control samples are necessary. For toxicologic analysis there have been no control samples so far. Therefore, a control sample for thallium has been developed which can be used for long- and short-term interlaboratory surveys. The results are reported.
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