ISSN:
1432-1440
Keywords:
Microproteinuria
;
Essential hypertension
;
Nephropathy
;
Left ventricular hypertrophy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary To investigate the clinical importance of microproteinuria, we examined the prevalence of microproteinuria and its relation to cardiac structural adaptation in 80 male, middle-aged patients with essential hypertension. Patients with secondary causes of hypertension were ruled out. 14 out of 80 hypertensives (18 percent) were found to have microproteinuria defined as “negative” for urinary protein excretion in the conventional test, but “positive” (above the upper normal limit) in the 24-hour urine samples. Patients with microproteinuria had a similar age and body weight, but a higher systolic and diastolic pressure (161±14/104±12 vs 148±14/97±9 mmHg,p〈 0.02) and greater creatinine clearance (163±36 vs 136±33 ml/min,p〈0.01) than those with normal protein excretion. Also, hypertensives with microproteinuria had a greater left ventricular mass (241±57 vs 207±45 g,p〈0.05) and greater cross sectional area (22.2±2.8 vs 20.5±2.9 cm2,p〈 0.05) evaluated by 2-D guided M-mode echocardiography than the control group. A positive Sokolow-index was more prevalent in patients with microproteinuria than in those without (x 2=6.2,p〈0.02). Patients with essential hypertension and microproteinuria (prevalence 21 per cent) were characterized by a higher arterial pressure, by a higher degree of echocardiographic and electrographic evidence of left ventricular hypertrophy. Thus, microproteinuria might serve as a marker for early target organ damage in essential hypertension.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02116053
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