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  • 1
    Publication Date: 2018-11-19
    Description: The impact of tides on the simulated landfast ice cover is investigated. Pan-Arctic simulations are conducted with an ice-ocean (CICE-NEMO) model with a modified rheology and a grounding scheme. The reference experiment (without tides) indicates there is an overestimation of the extent of landfast ice in regions of strong tides such as the Gulf of Boothia, Prince Regent Inlet, and Lancaster Sound. The addition of tides in the simulation clearly leads to a decrease of the extent of landfast ice in some tidally active regions. This numerical experiment with tides is more in line with observations of landfast ice in all the regions studied. Thermodynamics and changes in grounding cannot explain the lower landfast ice area when tidal forcing is included. We rather demonstrate that this decrease in the landfast ice extent is dynamically driven by the increase of the ocean-ice stress due to the tides.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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  • 2
    Publication Date: 2012-05-15
    Description: Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell malignancy characterized by the presence of the chimeric BCR-ABL oncoprotein with deregulated tyrosine-kinase (TK) activity. Although conventional T cells are acknowledged as important players in the control of CML, a possible modification of invariant NKT (iNKT) cells, known for their anti-tumoral activity, has not been established as yet. Here, we showed that the expression of perforin, CD95 L and promyelocytic leukemia zinc finger (PLZF), a transcription factor required for maintenance of iNKT cell functions, was reduced or suppressed in CML patients at diagnosis, as compared with healthy individuals. The proliferation rate of blood iNKT cells in response to their cognate ligand was likewise diminished. These functional deficiencies were corrected in patients having achieved complete cytogenetic remission following TK inhibitor or IFN-α therapy. iNKT cells from CML patients in the chronic phase did not display increased TK activity, which argued against a direct autonomous action of BCR-ABL. Instead, we found that their anergic status originated from both intrinsic and APC-dependent dysfunctions. Our data demonstrate that chronic phase CML is associated with functional deficiencies of iNKT cells, that are restored upon remission. These results suggest a possible contribution to disease control by TK inhibitor therapies.
    Print ISSN: 0014-2980
    Electronic ISSN: 1521-4141
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 3
    Publication Date: 2018-07-21
    Description: Energies, Vol. 11, Pages 1904: Electrical Power Supply of Remote Maritime Areas: A Review of Hybrid Systems Based on Marine Renewable Energies Energies doi: 10.3390/en11071904 Authors: Anthony Roy François Auger Florian Dupriez-Robin Salvy Bourguet Quoc Tuan Tran Ocean energy holds out great potential for supplying remote maritime areas with their energy requirements, where the grid size is often small and unconnected to a continental grid. Thanks to their high maturity and competitive price, solar and wind energies are currently the most used to provide electrical energy. However, their intermittency and variability limit the power supply reliability. To solve this drawback, storage systems and Diesel generators are often used. Otherwise, among all marine renewable energies, tidal and wave energies are reaching an interesting technical level of maturity. The better predictability of these sources makes them more reliable than other alternatives. Thus, combining different renewable energy sources would reduce the intermittency and variability of the total production and so diminish the storage and genset requirements. To foster marine energy integration and new multisource system development, an up-to-date review of projects already carried out in this field is proposed. This article first presents the main characteristics of the different sources which can provide electrical energy in remote maritime areas: solar, wind, tidal, and wave energies. Then, a review of multi-source systems based on marine energies is presented, concerning not only industrial projects but also concepts and research work. Finally, the main advantages and limits are discussed.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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