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  • 1
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 12 (2000), S. 2688-2690 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Fluorescent lighting is used to avoid reflections in the visualization of various flows in a large Taylor–Couette device. The inner cylinder is covered by a fluorescent film and the entire apparatus is illuminated with UV lights. The visible light emitted by the film allows visualization by transmission through the flow containing reflective flakes. This technique is ideal to identify different flows coexisting in the whole apparatus, whose detailed structure has been determined locally by other traditional means. The major advantage of the technique is the lighting uniformity and the absence of parasitic reflections on the whole setup. The technique will soon be applied to the discrimination between laminar and turbulent areas in the coexisting regimes. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Iron is abnormally accumulated in the substantia nigra pars compacta of patients with Parkinson's disease (PD). Because neuronal and glial iron uptake seems to be mediated by the binding of ferrotransferrin to a specific high-affinity receptor on the cell surface, the number of transferrin receptors could be altered in this disease. The regional distribution of specific binding sites for human 125I-diferric transferrin has been studied in the mesencephalon, on cryostat-cut sections from autopsy brains of control subjects and parkinsonian patients by in vitro autoradiography. Densities of binding sites were highest in the central gray substance (˜10 fmol/mg of tissue equivalent), intermediate in the catecholaminergic cell group A8, superior colliculus, and ventral tegmental area, and almost nonexistent in the substantia nigra. The density of 125I-transferrin binding sites was not significantly different between parkinsonian and control brains in any region analyzed. These results show that in the mesencephalon the regional density of transferrin binding sites is lowest in the dopaminergic cell groups, which are the most vulnerable to PD, and suggest that iron does not accumulate through an increased density of transferrin receptors at the level of the substantia nigra.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 170 (1990), S. 800-809 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0009-8981
    Keywords: Allergy ; Cyclic AMP phosphodiesterase ; Leukocytes ; Membranes ; Methy bransferase (basal level and noradrenaline-stimulated level)
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Analytical Biochemistry 133 (1983), S. 296-301 
    ISSN: 0003-2697
    Keywords: cyclic nucleotide phosphodiesterase ; enzyme inhibitors ; heart ; histochemical stain ; isoelectrofocusing ; isoenzyme analysis
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimie 66 (1984), S. 139-150 
    ISSN: 0300-9084
    Keywords: cyclic nucleotide phosphodiesterase ; cyclic nucleotides ; nucleotide cyclione phosphodiesterase ; nucleotides cycliques
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Molecular Cell Research 1176 (1993), S. 129-136 
    ISSN: 0167-4889
    Keywords: (Rat thymic lymphocyte) ; Cyclic nucleotide phosphodiesterase ; Phosphatidic acid
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0090-6980
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1435-1803
    Keywords: Key words Rabbit – preconditioning – diacylglycerol – molecular species – protein kinase C
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to give further insight into the potential role of PKC in beneficial effects of ischemic preconditioning, we have characterized the production of diacylglycerol, the endogenous activator of PKC, and its molecular species composition in ischemic control and preconditioned hearts. Preconditioning was induced by 1 cycle of 5 min of ischemia followed by 5 min of reperfusion. In control and preconditioned groups, hearts were harvested under deep anesthesia at baseline (preischemia) and at 2,5 and 10 min into the sustained coronary artery occlusion, i.e., preceding myocyte death. Diacylglycerol content and fatty acid composition were analysed by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC), respectively. Myocardial diacylglycerol content was increased at 2 min into the sustained ischemia in the control group (481 ± 34 vs 292 ± 64 ng.mg−1 at baseline; p 〈 0.05), but was comparable to the baseline value at 5 and 10 min. In the preconditioned group, diacylglycerol production remained unchanged throughout the 10-min test ischemia (317 ± 17 at 2 min vs 312 ± 38 ng.mg−1 at baseline; p = NS). A detailed analysis of the molecular species composition at the time of 2 min revealed a reduced contribution of phosphatidy-linositol to diacylglycerol production in preconditioned myocardium (global correlation coefficient 0.57 vs 0.66 in control myocardium) with a trend toward an enrichment of diacylglycerol composition with some species originating from phosphatidylcholine. Thus, our study revealed that brief preconditioning ischemia: (1) prevents the increase of diacylglycerol content in the early minutes of the sustained ischemia, and (2) emphasizes the contribution of phosphatidylcholine in diacylglycerol formation to the detriment of that of phosphatidylinositol.
    Type of Medium: Electronic Resource
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  • 10
    Publication Date: 2024-02-14
    Description: Sources of uncertainty (i.e., internal variability, model and scenario) in Atlantic Niño variability projections were quantified in 49 models participating in the Coupled Model Intercomparison Phases 5 (CMIP5) and 6 (CMIP6). By the end of the twenty‐first century, the ensemble mean change in Atlantic Niño variability is −0.07 ± 0.10˚C, with 80% of CMIP models projecting a decrease, and representing a 16% reduction relative to the 1981–2005 ensemble mean. Models' projections depict a large spread, with variability changes ranging from 0.23˚C to −0.50˚C. Internal variability is the main source of uncertainty until 2045 but model uncertainty dominates thereafter, eventually explaining up to 80% of the total uncertainty. The scenario uncertainty remains low (〈1%) throughout the twenty‐first century. The total uncertainty on Atlantic Niño variability projections is not improved when considering only CMIP models with a realistic zonal equatorial Atlantic sea surface temperature gradient. Plain Language Summary Sources of uncertainty (i.e., internal variability, model and scenario) in future projections of the Atlantic Niño variability were evaluated in global coupled models participating in the Coupled Model Intercomparison Phases 5 (CMIP5) and 6 (CMIP6). Relative to 1981–2005, models' projections depict a large spread, ranging from increasing Atlantic Niño variability by up to 0.23˚C to decreasing by up to −0.50˚C. By the end of the twenty‐first century, the ensemble mean Atlantic Niño variability change is −0.07 ± 0.10˚C with 80% of the global coupled models simulating a decrease. This change in the ensemble mean Atlantic Niño variability, relative to the period 1981–2005, represents a 16% reduction. During the first four decades of projection, the internal variability is the main contributor to the total uncertainty; thereafter model uncertainty dominates and explains up to 80% of the total uncertainty at the end of the twenty‐first century. The scenario uncertainty remains low (〈1%) throughout the twenty‐first century. The total uncertainty on Atlantic Niño variability projections is not improved when considering only CMIP models with a realistic zonal equatorial Atlantic sea surface temperature gradient. Key Points 80% of the CMIP models simulate a decrease of the Atlantic Niño variability at the end of the 21st century The model uncertainty explains about 80% of the total uncertainty on Atlantic Niño variability projections at the end of the 21st century Global warming signal is not detectable throughout scenarios due to large internal variability and model uncertainties
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
    Format: text
    Format: text
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