Description: Clofarabine salvage therapy before allogeneic hematopoietic stem cell transplantation in patients with relapsed or refractory AML: results of the BRIDGE trial Leukemia 30, 261 (February 2016). doi:10.1038/leu.2015.226 Authors: J M Middeke, R Herbst, S Parmentier, G Bug, M Hänel, G Stuhler, K Schäfer-Eckart, W Rösler, S Klein, W Bethge, U Bitz, B Büttner, H Knoth, N Alakel, M Schaich, A Morgner, M Kramer, K Sockel, M von Bonin, F Stölzel, U Platzbecker, C Röllig, C Thiede, G Ehninger, M Bornhäuser & J Schetelig

Description: his study presents an application of an innovative sampling strategy to assess soil moisture dynamics in a headwater of the Weißeritz in the German eastern Ore Mountains. A grassland site and a forested site were instrumented with two Spatial TDR clusters (STDR) that consist of 39 and 32 coated TDR probes of 60 cm length. Distributed time series of vertically averaged soil moisture data from both sites/ensembles were analyzed by statistical and geostatistical methods. Spatial variability and the spatial mean at the forested site were larger than at the grassland site. Furthermore, clustering of TDR probes in combination with long-term monitoring allowed identification of average spatial covariance structures at the small field scale for different wetness states. The correlation length of soil water content as well as the sill to nugget ratio at the grassland site increased with increasing average wetness and but, in contrast, were constant at the forested site. As soil properties at both the forested and grassland sites are extremely variable, this suggests that the correlation structure at the forested site is dominated by the pattern of throughfall and interception. We also found a very strong correlation between antecedent soil moisture at the forested site and runoff coefficients of rainfall-runoff events observed at gauge Rehefeld. Antecedent soil moisture at the forest site explains 92% of the variability in the runoff coefficients. By combining these results with a recession analysis we derived a first conceptual model of the dominant runoff mechanisms operating in this catchment. Finally, we employed a physically based hydrological model to shed light on the controls of soil- and plant morphological parameters on soil average soil moisture at the forested site and the grassland site, respectively. A homogeneous soil setup allowed, after fine tuning of plant morphological parameters, most of the time unbiased predictions of the observed average soil conditions observed at both field sites. We conclude that the proposed sampling strategy of clustering TDR probes is suitable to assess unbiased average soil moisture dynamics in critical functional units, in this case the forested site, which is a much better predictor for event scale runoff formation than pre-event discharge. Long term monitoring of such critical landscape elements could maybe yield valuable information for flood warning in headwaters. We thus think that STDR provides a good intersect of the advantages of permanent sampling and spatially highly resolved soil moisture sampling using mobile rods.

Description: The Northeast German Lowland Observatory (TERENO‐NE) was established to investigate the regional impact of climate and land use change. TERENO‐NE focuses on the Northeast German lowlands, for which a high vulnerability has been determined due to increasing temperatures and decreasing amounts of precipitation projected for the coming decades. To facilitate in‐depth evaluations of the effects of climate and land use changes and to separate the effects of natural and anthropogenic drivers in the region, six sites were chosen for comprehensive monitoring. In addition, at selected sites, geoarchives were used to substantially extend the instrumental records back in time. It is this combination of diverse disciplines working across different time scales that makes the observatory TERENO‐NE a unique observation platform. We provide information about the general characteristics of the observatory and its six monitoring sites and present examples of interdisciplinary research activities at some of these sites. We also illustrate how monitoring improves process understanding, how remote sensing techniques are fine‐tuned by the most comprehensive ground‐truthing site DEMMIN, how soil erosion dynamics have evolved, how greenhouse gas monitoring of rewetted peatlands can reveal unexpected mechanisms, and how proxy data provides a long‐term perspective of current ongoing changes.

Description: Der Kronendurchlass, d. h. der Anteil des Niederschlags, der durch das Kronendach des Waldes dringt, wird stark von der Art des Niederschlags und den Eigenschaften des Waldbestands beeinflusst. Das komplexe Zusammenspiel dieser Faktoren inklusive ihrer jahreszeitlichen Veränderungen zu entschlüsseln, ist eine große wissenschaftliche Herausforderung und nur mit langjährigem Monitoring in verschiedenen Waldbeständen möglich. Das Langzeit-Umweltobservatorium TERENO Nord-Ost zur Erforschung der regionalen Auswirkungen des Globalen Wandels liefert hierfür ideale Voraussetzungen.

Description: Above-ground cosmic-ray neutron sensing (CRNS) allows for the non-invasive estimation of the field-scale soil moisture content in the upper decimetres of the soil. However, large parts of the deeper vadose zone remain outside of its observational window. Retrieving soil moisture information from these deeper layers requires extrapolation, modelling or other methods, all of which come with methodological challenges. Against this background, we investigate CRNS for downhole soil moisture measurements in deeper layers of the vadose zone. To render calibration with in situ soil moisture measurements unnecessary, we rescaled neutron intensities observed below the terrain surface with intensities measured above a waterbody. An experimental set-up with a CRNS sensor deployed at different depths of up to 10 m below the surface in a groundwater observation well combined with particle transport simulations revealed the response of downhole thermal neutron intensities to changes in the soil moisture content at the depth of the downhole neutron detector as well as in the layers above it. The simulation results suggest that the sensitive measurement radius of several decimetres, which depends on soil moisture and soil bulk density, exceeds that of a standard active neutron probe (which is only about 30 cm). We derived transfer functions to estimate downhole neutron signals from soil moisture information, and we describe approaches for using these transfer functions in an inverse way to derive soil moisture from the observed neutron signals. The in situ neutron and soil moisture observations confirm the applicability of these functions and prove the concept of passive downhole soil moisture estimation, even at larger depths, using cosmic-ray neutron sensing.