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  • 1
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    In:  [Talk] In: Workshop to Integrate Subduction Factory and Seismogenic Zone Studies in Central America, 18.- 22.06, Heredia, Costa Rica .
    Publication Date: 2012-02-23
    Type: Conference or Workshop Item , NonPeerReviewed
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  • 2
    Publication Date: 2023-01-31
    Type: Conference or Workshop Item , NonPeerReviewed
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  • 3
    Publication Date: 2023-01-31
    Type: Conference or Workshop Item , NonPeerReviewed
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  • 4
    Publication Date: 2016-06-08
    Description: The ability of thermochronometric data to shed light on the geologic history of samples and localities through thermal history inverse modeling is enhanced by the degree to which additional geological information can be incorporated into the modeling process. In this contribution we describe a new set of methods and processes implemented in the HeFTy modeling software for specifying the stratigraphic relationships between samples down a well or borehole, allowing them to be modeled simultaneously, and demonstrate their use in bringing better definition to both pre-depositional and burial histories. Data from two wells in the Colombian Andes are examined, one in the Middle Magdalena Valley that experienced fast Miocene burial but also features a Mio-Pliocene unconformity, and one in the eastern foothills of the Eastern Cordillera in which burial was accomplished by a combination of sedimentation and overthrusting. Multiple-sample modeling in both wells considerably refines the results that are obtained from single-sample modeling. We also demonstrate how to use these methods to pose and evaluate distinct hypotheses concerning the geologic history. As a general rule, it is best practice to set up thermal history inverse models to pose specific geological questions while ruling out geologically impossible or inconsistent solutions. This article is protected by copyright. All rights reserved.
    Print ISSN: 0950-091X
    Electronic ISSN: 1365-2117
    Topics: Geosciences
    Published by Wiley-Blackwell
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  • 5
    Publication Date: 2017-10-31
    Description: Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease Nature Reviews Drug Discovery, Published online: 30 October 2017; doi:10.1038/nrd.2017.225
    Print ISSN: 1474-1776
    Electronic ISSN: 1474-1784
    Topics: Chemistry and Pharmacology , Medicine
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  • 6
    Publication Date: 2017-10-25
    Description: Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease Nature Reviews Drug Discovery, Published online: 6 October 2017; doi:10.1038/nrd.2017.170 New therapies for idiopathic pulmonary fibrosis (IPF) are urgently needed. Here, Mora et al . discuss our current understanding of the mechanisms driving IPF, highlighting the parallels between fibrosis and ageing. Potential avenues for drug discovery and development are described, including progress made and current obstacles.
    Print ISSN: 1474-1776
    Electronic ISSN: 1474-1784
    Topics: Chemistry and Pharmacology , Medicine
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  • 7
    Publication Date: 2012-11-02
    Description: The incidence and severity of fibrotic lung diseases increases with age but very little is known about how age-related changes affect the mechanisms that underlie disease emergence and progression. Normal aging includes accumulation of DNA mutations, oxidative and cell stresses, mitochondria dysfunction, increased susceptibility to apoptosis, telomere length dysfunction, and differential gene expression as a consequence of epigenetic changes and miR regulation. These inevitable aging-related phenomena may cause dysfunction and impaired repair capacity of lung epithelial cells, fibroblasts and MSCs. As a consequence the composition of the extracellular matrix changes and the dynamic interaction between cells and their environment is damaged resulting ultimately in predisposition for several disease. This review summarizes what is known about age-related molecular changes that are implicated in the pathobiology of lung fibrosis in lung tissue. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
    Print ISSN: 0022-3417
    Electronic ISSN: 1096-9896
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 8
    Publication Date: 2021-03-01
    Description: A new period of eruptive activity started at Turrialba volcano, Costa Rica, in 2010 after almost 150 years of quiescence. This activity has been characterized by sporadic explosions whose frequency clearly increased since October 2014. This study aimed to identify the mechanisms that triggered the resumption of this eruptive activity and characterize the evolution of the phenomena over the past 2 years. We integrate 3He/4He data available on fumarole gases collected in the summit area of Turrialba between 1999 and 2011 with new measurements made on samples collected between September 2014 and February 2016. The results of a petrological investigation of the products that erupted between October 2014 and May 2015 are also presented. We infer that the resumption of eruptive activity in 2010 was triggered by a replenishment of the plumbing system of Turrialba by a new batch of magma. This is supported by the increase in 3He/4He values observed since 2005 at the crater fumaroles and by comparable high values in September 2014, just before the onset of the new eruptive phase. The presence of a number of fresh and juvenile glassy shards in the erupted products increased between October 2014 and May 2015, suggesting the involvement of new magma with a composition similar to that erupted in 1864–1866. We conclude that the increase in 3He/4He at the summit fumaroles since October 2015 represents strong evidence of a new phase of magma replenishment, which implies that the level of activity remains high at the volcano.
    Description: Published
    Description: 3V. Proprietà dei magmi e dei prodotti vulcanici
    Description: 4V. Dinamica dei processi pre-eruttivi
    Description: 5V. Dinamica dei processi eruttivi e post-eruttivi
    Description: JCR Journal
    Keywords: Turrialba volcano ; eruptive activity ; 3He/4He ; fumarole gases ; glassy shards ; juvenile component ; 04. Solid Earth::04.04. Geology::04.04.12. Fluid Geochemistry ; 04. Solid Earth::04.07. Tectonophysics::04.07.08. Volcanic arcs ; 04. Solid Earth::04.08. Volcanology::04.08.01. Gases ; 04. Solid Earth::04.08. Volcanology::04.08.03. Magmas ; 04. Solid Earth::04.08. Volcanology::04.08.05. Volcanic rocks ; 04. Solid Earth::04.08. Volcanology::04.08.06. Volcano monitoring ; 04. Solid Earth::04.08. Volcanology::04.08.08. Volcanic risk
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 9
    Publication Date: 2022-05-25
    Description: Author Posting. © The Authors, 2010. This article is posted here by permission of John Wiley & Sons for personal use, not for redistribution. The definitive version was published in Geophysical Journal International 181 (2010): 997-1016, doi:10.1111/j.1365-246X.2010.04552.x.
    Description: In the 2005 TICOCAVA explosion seismology study in Costa Rica we observed crustal turning waves with a dominant frequency of ~10 Hz on a linear array of short-period seismometers from the Pacific Ocean to the Caribbean Sea. On one of the shot records, from Shot 21 in the backarc of the Cordillera Central, we also observed two seismic phases with an unusually high dominant frequency (~20 Hz). These two phases were recorded in the forearc region of central Costa Rica and arrived ~7 s apart and 30 to 40 s after the detonation of Shot 21. We considered the possibility that these secondary arrivals were produced by a local earthquake that may have happened during the active-source seismic experiment. Such high-frequency phases following Shot 21 were not recorded after Shots 22, 23, and 24, all in the backarc of Costa Rica, which might suggest that they were produced by some other source. However, earthquake dislocation models cannot produce seismic waves of such high frequency with significant amplitude. In addition, we would have expected to see more arrivals from such an earthquake on other seismic stations in central Costa Rica. We therefore investigate whether the high-frequency arrivals may be the result of a deep seismic reflection from the subducting Cocos plate. The timing of these phases is consistent with a shear wave from Shot 21 that was reflected as a compressional (SxP) and a shear (SxS) wave at the top of the subducting Cocos slab between 35 and 55 km depth. The shift in dominant frequency from ~10 Hz in the downgoing seismic wave to ~20 Hz in the reflected waves requires a particular seismic structure at the interface between the subducting slab and the forearc mantle in order to produce a substantial increase in reflection coefficients with frequency. The spectral amplitude characteristics of the SxP and SxS phases from Shot 21 are consistent with a very high Vp/Vs ratio of 6 in ~5 m thick, slab-parallel layers. This result suggests that a system of thin shear zones near the plate interface beneath the forearc is occupied by hydrous fluids under near-lithostatic conditions. The overpressured shear zone probably takes up fluids from the downgoing slab, and it may control the lower limit of the seismogenic zone.
    Description: This work was funded by the US National Science Foundation MARGINS programme.
    Keywords: Controlled source seismology ; Body waves ; Wave propagation ; Subduction zone processes ; Continental margins: convergent
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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  • 10
    Publication Date: 2022-05-25
    Description: Author Posting. © American Geophysical Union, 2013. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry, Geophysics, Geosystems 14 (2013): 1087–1103, doi:10.1002/ggge.20079.
    Description: Island arcs are proposed to be essential building blocks for the crustal growth of continents; however, island arcs and continents are fundamentally different in bulk composition: mafic and felsic, respectively. The substrate upon which arcs are built (oceanic crust versus large igneous province) may have a strong influence on crustal genesis. We present results from an across-arc wide-angle seismic survey of the Costa Rican volcanic front which test the hypothesis that juvenile continental crust is actively forming at this location. Travel-time tomography constrains velocities in the upper arc to a depth of ~15 km where average velocities are 〈6.5 km/s. The upper 5 km of crust is constrained by velocities between 4.0 and 5.5 km/s, which likely represent sediments, volcaniclastics, flows, and small intrusions. Between 5 and 15 km depth, velocities increase slowly from 5.5 to 6.5 km/s. Crustal thickness and lower crustal velocities are roughly constrained by reflections from an inferred crust-mantle transition zone. Crustal thickness beneath the volcanic front in Costa Rica is ~40 km with best-fit average lower-crustal velocities between 6.8 and 7.1 km/s. Overall, velocities across the arc in central Costa Rica are at the high-velocity extreme of bulk continental crust velocities and are lower than modern island arc velocities, suggesting that continental compositions are created at this location. These data suggest that preexisting thick crust of the Caribbean Large Igneous Province has a measurable effect on bulk composition. This thickened arc crust may be a density filter for mafic material and thereby support differentiation toward continental compositions.
    Description: Funding was provided by the NSF-MARGINS and ODP programs, under NSF grant OCE-0405654 and project Nº 113- A4-408 from the University of Costa Rica.
    Description: 2013-10-29
    Keywords: Continental crust ; Island arc ; Seismic refraction ; Costa Rica
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
    Format: text/plain
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