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  • 1
    Electronic Resource
    Electronic Resource
    Comparative study of the cardiac and peripheral vascular effects of strophantin K and lanatoside C in coronary heart disease (1975)
    Springer
    European journal of clinical pharmacology 9 (1975), S. 27-37 
    Details
    ISSN: 1432-1041
    Keywords: Lanatoside C ; strophanthin K ; positive inotropic effect ; impedance plethysmography ; systolic time intervals ; coronary heart disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of intravenous strophanthin K (0.125 and 0.25 mg) and lanatoside C (0.4, 0.8 and 1.6 mg) on systolic time intervals (STI) and impedance plethysmographic (IP) values were studied in ten patients with compensated coronary heart disease. The heart rate decreased significantly during a two-hour study in the lying position after both glycosides and placebo; the systemic blood pressure remained unchanged. Electromechanical systole (QS2), left ventricular ejection time (LVET) and preejection period (PEP), corrected for heart rate (QS2I, LVETI, PEPI), showed no change after placebo. The glycosides caused no change in LVETI. QS2I was significantly shortened only after lanatoside C 1.6 mg. PEPI and ICT were significantly shortened by both doses of strophanthin K and lanatoside C; the effects were dose-related. Taking into consideration the effects of cardiac glycosides on STI, use of the index ICT/QS1, the quotient of isovolumic contraction time and electromechanical delay, is proposed, because it showed quite sensitively the increase in myocardial contractility after digitalis. The effect of strophanthin K could be detected 10 minutes, and that of lanatoside C 30–40 minutes, after injection. The amplitude of the IP curve and the relative pulse volume showed positive and negative changes without any trend after administration of placebo or glycoside. The data suggests that the usual therapeutic doses of these cardiac glycosides do not cause significant changes in the peripheral circulation in patients with compensated coronary heart disease, but their action on STI is quite marked, showing a positive inotropic effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613426
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Neurobrucellosis in children (1995)
    Springer
    European journal of pediatrics 154 (1995), S. 120-122 
    Details
    ISSN: 1432-1076
    Keywords: Key words Meningitis ; Meningo-encephalitis ; Brucella ; Neurobrucellosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Neurobrucellosis is an uncommon disease in children. The authors present two cases of brucellar meningo-encephalitis. Headache and vomiting were the main complaints and one child had also some behavioural disturbance as well as papilloedema and sixth cranial nerve palsy. The clinical diagnosis was suggested by epidemiological data in both cases. Blood and CSF cultures confirmed brucellar aetiology in one of the cases and positive serum and CSF specific antibodies in both. Clinical course was favourable after treatment with doxycycline, rifampicin and streptomycin. No relapse occurred and there were no sequelae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050260
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    Paper (German National Licenses)
    Fulltext
  • 3
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    Environmental forcing of the Campeche cold-water coral province, southern Gulf of Mexico (2014)
    Copernicus Publications on behalf of the European Geosciences Union
    Details
    Publication Date: 2022-05-26
    Description: © The Author(s), 2014. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Biogeosciences 11 (2014): 1799-1815, doi:10.5194/bg-11-1799-2014.
    Description: With an extension of 〉 40 km2 the recently discovered Campeche cold-water coral province located at the northeastern rim of the Campeche Bank in the southern Gulf of Mexico belongs to the largest coherent cold-water coral areas discovered so far. The Campeche province consists of numerous 20–40 m-high elongated coral mounds that are developed in intermediate water depths of 500 to 600 m. The mounds are colonized by a vivid cold-water coral ecosystem that covers the upper flanks and summits. The rich coral community is dominated by the framework-building Scleractinia Enallopsammia profunda and Lophelia pertusa, while the associated benthic megafauna shows a rather scarce occurrence. The recent environmental setting is characterized by a high surface water production caused by a local upwelling center and a dynamic bottom-water regime comprising vigorous bottom currents, obvious temporal variability, and strong density contrasts, which all together provide optimal conditions for the growth of cold-water corals. This setting – potentially supported by the diel vertical migration of zooplankton in the Campeche area – controls the delivering of food particles to the corals. The Campeche cold-water coral province is, thus, an excellent example highlighting the importance of the oceanographic setting in securing the food supply for the development of large and vivid cold-water coral ecosystems.
    Description: The research leading to these results has received support from the Deutsche Forschungsgemeinschaft (DFG) through funding of the WACOM – West Atlantic Cold-water Coral Ecosystems projects, grants HE 3412/17-1 and DU 129/47-1, and through providing ship time. A. Freiwald received funds from the Hessian LOEWE BiK-F Project A3.10, and G. P. Eberli acknowledges the donors of the American Chemical Society Petroleum Research Fund (grant no. 49017-ND8) for partial support of this research and the industrial associates of the CSL – Center for Carbonate Research at the University of Miami for additional funding. L. Matos has been supported by the FCT scholarship SFRH/BD/72149/2010.
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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    PAPER (OA)
  • 4
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    Environmental forcing of the Campeche cold-water coral province, southern Gulf of Mexico (2014)
    Copernicus Publications (EGU)
    In:  Biogeosciences (BG), 11 . pp. 1799-1815.
    Details
    Publication Date: 2019-09-23
    Description: With an extension of 〉40 km2 the recently discovered Campeche cold-water coral province located at the northeastern rim of the Campeche Bank in the southern Gulf of Mexico belongs to the largest coherent cold-water coral areas discovered so far. The Campeche province consists of numerous 20 to 40 m high coral ridges that are developed in intermediate water depths of 500 to 600 m. The ridges are colonized by a vivid cold-water coral ecosystem that covers the upper flanks and summits. The rich coral community is dominated by the framework-building scleractinia Enallopsammia profunda and Lophelia pertusa while the associated benthic megafauna shows a rather scarce occurrence. The recent environmental setting is characterized by a high surface water production caused by a local upwelling center and a dynamic bottom water regime comprising vigorous bottom currents, internal waves and strong density contrasts, which all together provide optimal conditions for the growth of cold-water corals. The strong hydrodynamics – potentially supported by the diel vertical migration of zooplankton in the Campeche area – drive the delivering of food particles to the corals. The Campeche cold-water coral province is, thus, an excellent example highlighting the importance of the hydrographic setting in securing the food supply for the development of large and vivid cold-water coral ecosystems.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.5194/bg-11-1799-2014
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 5
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    Cold-water corals in the Bay of Biscay - occurrences and distribution in space and time (TransBiscay) - Cruise No. M84/5, May 31 - June 21, 2011, Vigo (Spain) - Brest (France) (2014)
    DFG-Senatskommission für Ozeanographie
    In:  METEOR-Berichte, 84/5 . DFG-Senatskommission für Ozeanographie, Bremen, 46 pp.
    Details
    Publication Date: 2019-09-23
    Description: The scientific objectives of METEOR cruise M84/5 focused on the measurement and analysis of the environmental controls of modern and fossil cold-water coral growth along a transect in the Bay of Biscay. In four working areas we successfully deployed lander systems and CTD/Ro’s to document the physical and hydrochemical characteristics of bottom water masses and the water column in general. These are used to shed light on potential linkages to modern cold-water coral growth and distribution. These investigations were flanked by plankton tows in surface waters. The base for all investigations was a thorough hydroacoustic survey to characterize potential cold-water coral bearing areas with living colonies. Based on these maps we deployed all video-guided gear such as the OFOS-video sled, the TV grab, and the lander systems. Benthic assemblages and sedimentary structures have been documented and sampled with the OFOS and a box corer. Simultaneously, genetic samples of the living coral material were taken for additional studies. Furthermore, we have taken gravity cores to investigate the paleoceanographic conditions as well as the timing of cold-water coral colonization in the Bay of Biscay. Along with the coring efforts, a detailed sampling and study of porewater properties was performed. An additional aim of this cruise was to investigate the influence of boundary exchange processes on the Neodymium isotopy in bottom waters along the pathway of the Mediterranean Outflow water (MOW) by taking multiple samples with the CTD/Ro. The new data and samples of this METEOR cruise will provide the framework to investigate the timing of cold-water coral colonization in the Bay of Biscay, as well as its interplay with the ambient hydrography and geochemistry. This successful cruise has provided the basis to investigate the scientific aims of this expedition in great detail.
    Type: Report , NonPeerReviewed
    Format: text
    DOI: 10.2312/cr_m84_5
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    OceanRep: Report - Cruise Report
  • 6
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    Report and preliminary results of R/V MARIA S. MERIAN cruise MSM20-4. WACOM - West-Atlantic Cold-water Coral Ecosystem: The West Side Story, Bridgetown-Freeport, 14 March - 07 April 2012 (2012)
    In:  Berichte aus dem MARUM und dem Fachbereich Geowissenschaften der Universität Bremen, 290 . UNSPECIFIED, Bremen, 120 pp.
    Details
    Publication Date: 2018-06-21
    Type: Report , NonPeerReviewed
    Format: text
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    OceanRep: Report - Cruise Report
  • 7
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    Role of Host-Driven Mutagenesis in Determining Genome Evolution of Sigma Virus (DMelSV; Rhabdoviridae) in Drosophila melanogaster (2016)
    Oxford University Press
    Details
    Publication Date: 2016-10-08
    Description: Sigma virus (DMelSV) is ubiquitous in natural populations of Drosophila melanogaster. Host-mediated, selective RNA editing of adenosines to inosines (ADAR) may contribute to control of viral infection by preventing transcripts from being transported into the cytoplasm or being translated accurately; or by increasing the viral genomic mutation rate. Previous PCR-based studies showed that ADAR mutations occur in DMelSV at low frequency. Here we use SOLiD TM deep sequencing of flies from a single host population from Athens, GA, USA to comprehensively evaluate patterns of sequence variation in DMelSV with respect to ADAR. GA dinucleotides, which are weak targets of ADAR, are strongly overrepresented in the positive strand of the virus, consistent with selection to generate ADAR resistance on this complement of the transient, double-stranded RNA intermediate in replication and transcription. Potential ADAR sites in a worldwide sample of viruses are more likely to be "resistant" if the sites do not vary among samples. Either variable sites are less constrained and hence are subject to weaker selection than conserved sites, or the variation is driven by ADAR. We also find evidence of mutations segregating within hosts, hereafter referred to as hypervariable sites. Some of these sites were variable only in one or two flies (i.e., rare); others were shared by four or even all five of the flies (i.e., common). Rare and common hypervariable sites were indistinguishable with respect to susceptibility to ADAR; however, polymorphism in rare sites were more likely to be consistent with the action of ADAR than in common ones, again suggesting that ADAR is deleterious to the virus. Thus, in DMelSV, host mutagenesis is constraining viral evolution both within and between hosts.
    Electronic ISSN: 1759-6653
    Topics: Biology
    Published by Oxford University Press
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    PAPER CURRENT
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