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  • 1
    ISSN: 1520-4995
    Quelle: ACS Legacy Archives
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract. We have previously demonstrated that one dimensional (1D) proton (1H) magnetic resonance spectroscopy (MRS) can distinguish normal thyroid tissue from thyroid carcinoma using a spectral ratio of peak intensity at 1.7 ppm/0.9 ppm. Two dimensional (2D) 1H-MRS allows identification of specific molecules that have overlapping peaks in the 1D-MR spectrum. Specimens from 93 consecutive thyroid nodules were examined using 2D 1H-MRS on a Bruker AM-360 wide-bore spectrometer. There was a progressive increase in lipid cross peaks assigned to di-/triglycerides when comparing colloid/hyperplastic nodules to follicular adenoma, and adenoma to carcinoma. A specific cross peak attributable to cholesterol/cholesteryl esters was commonly seen in carcinomas. In contrast, two unassigned cross peaks unique to the thyroid were more prevalent in benign lesions. There was an overall increase in cross peaks attributable to cell surface fucosylation in carcinoma when compared to benign lesions, although the fucose spectral pattern was not specific for cancer. On this basis, a spectral ratio of peak intensity at 2.05 ppm/0.9 ppm more clearly distinguished benign follicular adenoma from carcinoma. 2D 1H-MRS thus identifies chemical changes that allow more specific tissue characterization of thyroid neoplasms.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    ISSN: 1432-2323
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé Le cancer de la thyroïde est rare mais parfois la thyroïdectomie est préconisée uniquement pour l'éliminer formellement. Le but de cette étude a été de déterminer le rendement de l'analyse des cancers folliculaires par l'utilisation de la résonance magnétique de protons. La spectroscopie par résonance magnétique a été employée sur les tissus thyroïdes prélevés à partir de 98 pièces opératoires consécutives, comportant soit des nodules solitaires soit des tissus à prédominance nodulaire, et les résultats ont été comparés a ceux obtenus à partir des prélèvements. A été évaluée l'économie potentielle chez tous les patients ayant
    Kurzfassung: Resumen El cáncer de la glándula tiroides es una entidad rara; sin embargo, muchas tiroidectomías continúan siendo realizadas simplemente para excluir el diagnóstico de malignidad. El propósito del presente estudio fue el de determinar los potencrales ahorros en costo asociados con el uso de resonancia magnética de protones para el estudio de neoplasmas foliculares. Se practicó espectrografía por resonancia magnética de protones en tejidos obtenidos, en el momento de la cirugía, de 98 nódulos solitarios consecutivos. También se practicaron biopsias con aguja fina de especímenes operatorios valorados por resonancia magnética y tales estudios fueron comparados con los logrados de los especímenes operatorios. Se hizo un estimativo de los potenciales ahorros en costos mediante la comparación de los datos de la resonancia magnética con las indicaciones para practicar cirugía y la patología en todos los pacients sometidos a tiroidectomía en un período de 10 años. La espectroscopia por resonancia magnética de protones fue capaz de distinguir entre un tejido tiroideo normal y un cáncer tiroideo invasivo con un grado de especificidad del 100%. Los adenomas folicular benignos caen en dos grupos: 44% con un patrón espectral comparable al de la tiroides normal, y 56% con un patrón espectral alterado más comparable al perfil de la resonancia magnética. La espectroscopia por resonancia magnetica de protones en biopsias con aguja fina reveló espectros similares a los de los tejidos del mismo paciente.
    Notizen: Abstract Thyroid cancer is rare, but many thyroidectomies continue to be performed simply to exclude a diagnosis of malignancy. The purpose of this study was to determine the potential financial savings associated with the use of proton magnetic resonance analysis of follicular neoplasms. Proton magnetic resonance spectroscopy was performed on tissue obtained at the time of surgery from 98 consecutive solitary or dominant thyroid nodules. Fine-needle biopsies were also performed on operative specimens, and the tissues assessed by proton magnetic resonance; these spectra were then compared with those obtained from tissue specimens. An estimate of potential savings was obtained by comparing the magnetic resonance data with the indications for surgery and pathology on all patients having thyroidectomy over a 10-year period. Proton magnetic resonance spectroscopy was able to distinguish between normal thyroid tissue and invasive thyroid cancer with 100% specificity. Benign follicular adenomas fall into two groups: 44% having a spectral pattern comparable with normal thyroid, and the remaining 56% demonstrating an altered spectral pattern more comparable to the malignant magnetic resonance profile. Proton magnetic resonance spectroscopy on fine-needle biopsy specimens produced spectra similar to those from tissues from the same patient. From a fine-needle biopsy specimen, proton magnetic resonance spectroscopy can identify a group of benign follicular adenomas with spectral profiles akin to those of normal thyroid cells, thus avoiding the need for unnecessary surgical excision. The potential savings in one surgical unit alone were over $1 million in 10 years.
    Materialart: Digitale Medien
    Standort Signatur Einschränkungen Verfügbarkeit
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