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    Electronic Resource
    Electronic Resource
    Sulfhydryl oxidation induces calcium release from fragmented sarcoplasmic reticulum even in the presence of glutathione (1993)
    Springer
    Cellular and molecular life sciences 49 (1993), S. 282-284 
    Details
    ISSN: 1420-9071
    Keywords: Sarcoplasmic reticulum ; Ca2+ release ; sulfhydryl oxidation ; alcian blue ; plumbagin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Alcian blue and plumbagin induced transient Ca2+ release from fragmented sarcoplasmic reticulum. Dithiothreitol (DTT) and glutathione (GSH) partially blocked Ca2+ release induced by these oxidizing compounds. Pretreatment of alcian blue and plumbagin with DTT or GSH for more than 1 min was required to abolish the ability of the oxidizing compounds to release Ca2+. Mg2+ and ruthenium red completely blocked alcian blue-and plumbagin-induced Ca2+ release. These results suggest that oxidation of sulfhydryls on Ca2+ release channels induces Ca2+ release even in the presence of GSH in situ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01923402
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