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  • 1
    Online Resource
    Online Resource
    Pharmacogenetics. (2006)
    Milton :Taylor & Francis Group,
    Details
    Keywords: Pharmacogenetics. ; Electronic books.
    Description / Table of Contents: The only source on the subject to offer both an overview and a disease-based approach, this reference text spans the wide array of technical, methodological, regulatory, and ethical issues related to pharmacogenetics and stresses the impact of pharmacogenetic data on patient care and management. Providing expertly selected references, tables, and figures in each chapter, this guide details the relevance of pharmacogenetic applications to disease based specialities including sections on pharmacogenetics of cardiovascular, respiratory, central nervous system, infectious, gastroenterological, oncologic, hematologic, metabolic, and rheumatologic disorders.
    Type of Medium: Online Resource
    Pages: 1 online resource (342 pages)
    Edition: 1st ed.
    ISBN: 9781420016697
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=1405358
    DDC: 615.19
    Language: English
    Note: Front Cover -- Foreword -- Preface -- Contents -- Contributors -- 1. Identification of Treatment Response Genes -- 2. Methods of Genotyping -- 3. Pharmacoproteomics -- 4. Potential Social, Ethical, and Legal Issues Raised by the Development of Pharmacogenetics -- 5. Pharmacogenetics of Adverse Drug Reactions -- 6. Pharmacogenetics of Respiratory Disease -- 7. Hematological Pharmacogenetics -- 8. Pharmacogenetics in Oncology -- 9. Pharmacogenetics in Infectious Diseases -- 10. Pharmacogenetics in Rheumatology -- 11. Polymorphisms in Cardiovascular Medicine: The Role of Genetic Variants in Disease Diagnosis and Drug Response -- 12. Pharmacogenetics and Metabolic Disease -- 13. Pharmacogenetics in Gastroenterology -- 14. The Genetics of Antipsychotic Response: Pharmacogenetic and Pharmacogenomic Investigations and Clinical Applications -- Index -- Back Cover.
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    GEOMAR EBL
  • 2
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    Strong glacial-interglacial variability in upper ocean hydrodynamics, biogeochemistry, and productivity in the southern Indian Ocean (2021)
    Nature Publishing Group UK
    Details
    Publication Date: 2024-02-28
    Description: In the southern Indian Ocean, the position of the subtropical front – the boundary between colder, fresher waters to the south and warmer, saltier waters to the north – has a strong influence on the upper ocean hydrodynamics and biogeochemistry. Here we analyse a sedimentary record from the Agulhas Plateau, located close to the modern position of the subtropical front and use alkenones and coccolith assemblages to reconstruct oceanographic conditions over the past 300,000 years. We identify a strong glacial-interglacial variability in sea surface temperature and productivity associated with subtropical front migration over the Agulhas Plateau, as well as shorter-term high frequency variability aligned with variations in high latitude insolation. Alkenone and coccolith abundances, in combination with diatom and organic carbon records indicate high glacial export productivity. We conclude that the biological pump was more efficient and strengthened during glacial periods, which could partly account for the reported reduction in atmospheric carbon dioxide concentrations.
    Description: Migration of the Subtropical Front during glacial and interglacial periods resulted in variability in the strength of the biological pump in the Southern Ocean sector of the Indian Ocean, according to sedimentary records from the Agulhas Plateau.
    Description: https://doi.pangaea.de/10.1594/PANGAEA.912467
    Keywords: ddc:551.46 ; palaeoceanography ; southern Indian Ocean ; Agulhas Plateau ; upper ocean hydrodynamics ; biogeochemistry
    Language: English
    Type: doc-type:article
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    CITATION GEO-LEO
  • 3
    Electronic Resource
    Electronic Resource
    Comparative Moessbauer effect study of tris(dimethyldithiocarbamato)iron and tris(diethyldithiocarbamato)iron and the phase transition in Fe[(C2H5)2dtc]3 (1987)
    s.l. : American Chemical Society
    Inorganic chemistry 26 (1987), S. 4138-4139 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00271a037
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Kinetics of the reaction of nitrate radical with hydroperoxo (1988)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 92 (1988), S. 5049-5054 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100328a043
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Intensified deep Pacific inflow and ventilation in Pleistocene glacial times (2001)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 412 (2001), S. 809-812 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The production of cold, deep waters in the Southern Ocean is an important factor in the Earth's heat budget. The supply of deep water to the Pacific Ocean is presently dominated by a single source, the deep western boundary current east of New Zealand. Here we use sediment records deposited ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35090552
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    Paper (German National Licenses)
    Fulltext
  • 6
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    Deep water variability on the Southern Agulhas Plateau over the past 1.5 Ma (2018)
    In:  EPIC3AGU Fall Meeting, Washington, D.C., U.S.A., 2018-12-10-2018-12-14
    Details
    Publication Date: 2018-12-21
    Description: An important element of the global ocean thermohaline circulation is the oceanic connection between the Indian and South Atlantic Oceans off South Africa. Variable amounts of warm, salt-enriched South Indian Ocean waters enter the South Atlantic, the so-called ‘warm water return route’, and provide a source for heat and salt to the Atlantic thermocline that ultimately preconditions the Atlantic meridional overturning circulation for convection in the north, the formation of North Atlantic Deep Water (NADW). This eastward surface return flow is compensated at depth by a westward setting deep flow into the southern Indian Ocean that consists of NADW exiting the South Atlantic and Southern Source Waters (SSW), influenced by the Antarctic Circumpolar Current (ACC). Here we present a high-resolution multi-proxy record of deep water variability from sediment core MD02-2588 (2907 m water depth) and IODP Site U1475 (2669 m water depth) both recovered from the southern flank of the Agulhas Plateau in the southernmost South Atlantic. The location is close to the interface between NADW and SSW in the Southern Ocean enabling the reconstruction of the timing and amplitude of changes in southward advection of NADW and Southern Ocean circulation. We concentrate on identifying the phasing between changes in ice volume, the location of surface ocean fronts, deep ventilation and near-bottom flow speeds over the past 1.5 Ma – across the Middle Pleistocene transition. Our benthic carbon isotope record from MD02-2588/Site U1475 strongly suggest that there was a continued mid-depth northern source water influence over the southern Agulhas Plateau during glacial periods of the past 1.5 Ma. Nonetheless, significantly increased near bottom flow speeds, ~5–10 cm s−1 (3–7 μm coarser), during glacial periods indicates that there must be additional controls on physical ventilation. We suggest that vigor of near bottom currents on the Southern Agulhas Plateau is likely influenced by the orbital scale meridional expansion and contraction of the ACC and its associated surface fronts.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 7
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    High-resolution Records of Major Element Ratios for the Plio-/Pleistocene at the Agulhas Plateau: Implications for Orbital Variations in Sediment Provenance, the Formation of Seismic Reflectors and Deep Water Flow Changes (2018)
    In:  EPIC3AGU Fall Meeting, Washington, D.C., U.S.A., 2018-12-10-2018-12-14
    Details
    Publication Date: 2018-12-21
    Description: Contourite deposits found in the Indian-Atlantic ocean gateway hold detailed information on past changes in the bottom water flow history over long time intervals of the Cenozoic. Until IODP Exp. 361 only late Pleistocene paleoceanographic studies for the region were carried out using sediment samples obtained from piston cores. We present preliminary results from Site U1475 (Agulhas Plateau), a location proximal to the entrance of North Atlantic Deep Water (NADW) to the Southern Ocean and South Indian Ocean. The site is located over a sediment drift in 2669 m water depth and comprises a complete stratigraphic section of the last ∼7 Ma. The whole spliced sediment record (292 meters) of Site U1475 was measured using an X-ray fluorescence (XRF) core scanner to derive multi-centennial resolution records of major element intensities. Based on these measurements it is possible to derive of biogenic (e.g. %CaCO3) and siliciclastic (e.g. TiO2, K2O) mineral phases. Because the Ca counts almost exclusively stem from biogenic carbonate formed by microfossil shells the ratio of biogenic components vs. terrigenous is reflected in e.g. the Ca/Ti or Ca/Fe records. On the other hand, changes of elemental ratios such as K/Fe or Al/Ti show the variability within the terrigenous sediment fraction. While long-term changes in elemental ratios can be linked to the seismic reflection pattern associated with deep water circulation changes, short-term cyclicities in sediment provenance reflect orbital scale Plio-Pleistocene climate variations. E. g. power spectra performed on the ln(Ca/Ti) and ln(K/Fe) records for a peculiar Pliocene (~5.7 - 4.1 Ma) high sedimentation rate interval reveal significant spectral density peaks at periods close to the Milankovitch precession band (19 – 23 kyr). Such a high variability in the precession band is also evident in a number of other element ratios while changes in physical properties (e.g. density, seismic impedance) for the same interval seem to be dominated by eccentricity. We present evolutionary spectral analyses revealing how the orbital response of the different parameters have changed over time and derive an improved age model based on cyclostratigraphy.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 8
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    XRF core-scanning signal interpretation in Miocene carbonate and siliciclastic contourite deposits (IODP sites U1387 and U1475) (2017)
    In:  EPIC3XRF Core Scanning 2017, National Taiwan University, Taiwan, 2017-03-20-2017-03-24
    Details
    Publication Date: 2017-03-31
    Description: Contourites are deposits formed by along-slope bottom currents and are therefore sensitive to changes in current velocity, sediments supply and paleoceanographic conditions. They are typically associated with high accumulation rates making these archives ideal for paleoenviromental reconstructions. Nevertheless, they are also occasionally affected by winnowing of fine particles and erosion/deposition of allochthonous material, which alters the grain-size and mineralogy. These processes can, as such, promote significant bias in proxy interpretation compared with other pelagic deposits. X-ray fluorescence (XRF) core-scanning is ideal to assess elemental variations in these high accumulation rate sequences. The comparison between lithological changes, Natural Gamma Ray and other parameters with XRF scanning data, along with statistical analysis can provide very useful information to support improved proxy interpretation. Using this approach at Site U1387, (detrital contourite system at Gulf of Cadiz), results indicate that the Zr/Al ratio represents a promising proxy for bottom current speed and show the transition from a hemipelagic to a contouritic system during the Miocene/Pliocene transition. Carbonate content and Ba/Al ratio appear to represent paleo-productivity variations and later to be completely overprinted by current activit y. At Site U1475 (carbonate contourite system at Agulhas Plateau) Zr content is just one artifact associated with high Sr content and the Ca/Sr ratio appears to be a more promising proxy for contourite reconstruction that is influenced by carbonate dissolution by deep corrosive waters. Comparing both locations we can conclude that proxies associated with the continuous background sediment settling over the seafloor (e.g. planktonic foraminifera) do not appear to be severely biased in countourite systems.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 9
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    Atmosphere-ocean changes in the Pacific Southern Ocean over the past 1 Million years and implications for global climate (2017)
    SCAR
    In:  EPIC3Past Antarctic Ice Sheet Dynamics (PAIS) Conference, Trieste, 2017-09-10-2017-09-15SCAR
    Details
    Publication Date: 2018-08-10
    Description: Atmosphere-ocean interactions play an important role for understanding processes and feedbacks in the Southern Ocean (SO) and are relevant for changes in Antarctic ice-sheets and atmospheric CO2 concentrations. The most important atmospheric forcing at high and mid-latitudes of the Southern Hemisphere is the westerly wind belt (SWW), which strongly affects the strength and extension of the Antarctic Circumpolar Current (ACC), upwelling of deep-water masses, and controls the back-flow of intermediate waters to the tropics. In order to address orbital and millennial-scale changes of the SWW and the ACC, we present sediment proxy records from the Pacific SO including the Chilean Margin and the Drake Passage. The Drake Passage (DP) represents the most important oceanic gateway along the ACC. Based on grain-size and geochemical properties of sediment records from the southernmost continental margin of South America, we reconstruct changes in DP throughflow dynamics over the past 65,000 years. In combination with published sediment records from the Scotia Sea and preliminary sediment records from the central Drake Passage (Polarstern cruise PS97, 2016), we argue for a considerable total reduction of DP transport and reveal an up to ~40% decrease in flow speed along the northernmost ACC pathway entering the DP during glacial times. Superimposed on this long-term decrease are high-amplitude millennial-scale variations, which parallel Southern Ocean and Antarctic temperature patterns. The glacial intervals of strong weakening of the ACC entering the DP imply a reduced Pacific-Atlantic exchange via the DP (“cold-water route”). The reduced Drake Passage glacial throughflow was accompanied by a pronounced northward extension of the Antarctic cold-water sphere in the Southeast Pacific sector and stronger export of northern ACC water into the South Pacific gyre. These oceanographic changes are consistent with reduced SWW within the modern maximum wind strength zone over the subantarctic ACC and reduced wind forcing due to extended sea-ice further south. Despite this reduction in winds in the core of the westerlies, we observe 3-fold higher dust deposition during glacial periods in Past Antarctic Ice Sheet Dynamics (PAIS) Conference September 10-15th 2017, Trieste - Italy the Pacific Southern Ocean (SO). This observation may be explained by a combination of factors including more expanded arid dust source areas in Australia and a northward extent or enhancement of the SWW over Southeast Australia during glacials that would plausibly increase the dust uptake and export into the Pacific SO. Such scenario would imply stronger SWW at the present northernmost margin of the wind belt coeval with weaker core westerlies in the south and reduced ACC strength, including Drake Passage throughflow during glacials. We conclude that changes in DP throughflow play a critical role for the global meridional overturning circulation and interbasin exchange in the Southern Ocean, most likely regulated by variations in the westerly wind field and changes in Antarctic sea-ice extent. Keywords: Pelagic Southern Ocean, Antarctic Circumpolar Current, Southern Westerlies, Teleconnections.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
    Format: application/pdf
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  • 10
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    Antarctic icebergs reorganize ocean circulation during Pleistocene glacials (2021)
    Nature Publishing Group
    In:  EPIC3Nature, Nature Publishing Group, 589(7841), pp. 236-241, ISSN: 0028-0836
    Details
    Publication Date: 2021-02-03
    Description: The dominant feature of large-scale mass transfer in the modern ocean is the Atlantic meridional overturning circulation (AMOC). The geometry and vigour of this circulation influences global climate on various timescales. Palaeoceanographic evidence suggests that during glacial periods of the past 1.5 million years the AMOC had markedly different features from today; in the Atlantic basin, deep waters of Southern Ocean origin increased in volume while above them the core of the North Atlantic Deep Water (NADW) shoaled. An absence of evidence on the origin of this phenomenon means that the sequence of events leading to global glacial conditions remains unclear. Here we present multi-proxy evidence showing that northward shifts in Antarctic iceberg melt in the Indian–Atlantic Southern Ocean (0–50°E) systematically preceded deep-water mass reorganizations by one to two thousand years during Pleistocene-era glaciations. With the aid of iceberg-trajectory model experiments, we demonstrate that such a shift in iceberg trajectories during glacial periods can result in a considerable redistribution of freshwater in the Southern Ocean. We suggest that this, in concert with increased sea-ice cover, enabled positive buoyancy anomalies to ‘escape’ into the upper limb of the AMOC, providing a teleconnection between surface Southern Ocean conditions and the formation of NADW. The magnitude and pacing of this mechanism evolved substantially across the mid-Pleistocene transition, and the coeval increase in magnitude of the ‘southern escape’ and deep circulation perturbations implicate this mechanism as a key feedback in the transition to the ‘100-kyr world’, in which glacial–interglacial cycles occur at roughly 100,000-year periods.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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