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  • 1
    Online Resource
    Online Resource
    [Backnang] : Tesat-Spacecom GmbH & Co. KG
    Keywords: Forschungsbericht
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (65 Seiten, 5,94 MB) , Diagramme
    Language: German
    Note: Förderkennzeichen BMBF 50 YB 1403 , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 21 (1993), S. 9-15 
    ISSN: 1434-0879
    Keywords: Dorsal prostate ; Enzyme activity ; Immunohistochemistry ; Mammary gland ; Secretory transglutaminase ; Tissue-type transglutaminase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Transglutaminases with different functions and tissue distribution patterns can be distinguished by specific antibodies and by inhibition of enzyme activity in the presence of guanosine triphosphate (GTP). The most common form is the so-called tissue-type transglutaminase that is apparently involved in membrane, stabilization processes, e.g. during apoptosis, and can be inhibited by incubation with GTP at low calcium concentrations. A secretory transglutaminase that cannot be inhibited by GTP is synthesized in an androgen-dependent manner in the dorsal prostate of the rat, the site suggested to represent the origin of the Dunning tumor used as an experimental model in prostate cancer research. Here we studied the expression of transglutaminases in different Dunning tumor lines — mainly in the highly differentiated H subline - and characterized the enzyme both biochemically and immunocytochemically. A very high enzyme activity was found only in the less well differentiated HI-F tumor line. Immunohistochemical reactions and Western blot analysis showed that there is no secretory transglutaminase present in any of the Dunning tumor lines studied. Transglutaminase activity of the Dunning tumor results from the so-called tissue-type enzyme that is nonorgan specific. The absence of a secretory form of transglutaminase does not suport the contention of a prostatic origin o the Dunning tumor.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1434-0879
    Keywords: Transglutaminases ; Prostate cancer ; Metastasis ; Cellular wound repair
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Using biochemical assays, we compared enzyme activities with the immunoreactivity of antibodies against rat seminal transglutaminase (TGase), human erythrocyte TGase and guinea pig liver TGase in human normal prostate, primary prostatic carcinomas and prostatic carcinoma cell lines. Glandular cells of the epithelium were only exceptionally positive with the antibody against (rat) secretory TGase. Using the antibodies against tissue-type TGase, most immunoreactive cells were found in the basal cell layer of prostatic epithelium as well as in stroma (fibroblasts, endothelial cells), whereas immunoreactive glandular cells were sparse. In the case of benign prostatic hyperplasia, few, irregularly distributed secretory cells along with a small number of stromal cells were also immunoreactive with the tissue-type TGase antibody. In dedifferentiated carcinomas, immunoreactive cells were nearly completely absent. Of the prostate cancer cell lines, the LNCaP line showed neither TGase enzyme activity nor immunoreactivity, whereas the PC-3 cell line displayed significant enzyme activity and immunoreactivity. No hormone-dependent changes in either enzyme activity or immunoreactivity were recorded after in vitro treatment of the respective cell lines with estrogens, androgens and antiandrogens. As there is no correlation between androgen deprivation and TGase expression in nonmalignant and malignant human prostatic epithelial cells, TGase activity more likely indicates cellular lesions and consecutive repair mechanisms.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 35 (1995), S. 1834-1851 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A hybrid two-/three-dimensional solution technique is presentedto model 3-D flow fields in resin transfer moeling using Darcy's low. The 3-D flow field is only solved for regions where all three velocity components are significant, thus largely reducing the number of unknowns. Elsewhere, the commonly used 2-D approximation for flow in thin gaps between plates is employe.d The method is applied to regions where the flow splits, such as T-joints. Because of the uncertainties associated with an accurate determination of the permeability in these regions, a simplified decompled procedure is procesed, which reduces the computational complexity. In this procedure, the flow front is advanced using the 2-D formulation. The 2-D formulation also provides the boundary conditions for the subsequent computation of the 3-D flow field without feedback of flow field information to the 2-d model. The governing equations are solved using boundary fitted coordinate systems (BFCS) together with the finite difference method (FDM). Numerical as well as algebraic grid generation and domain decomposition are employe dto generate grids that always concide with the continuously deforming and enlarging flow domain. Results that include the trackingof numerical tracer particles to visualize the three-dimensionality of the flow field are presented for isothermal flow of a Newtonian fluid through a T-joint. This detailed flow field description is expected to form the basis for a rather accurate simulation of quantitities that largely depend on the fluid particle pathlines, such as the degree of cure. The method is also extendable to shear-thinning fluids as well as to 3-D flow in the vicinity of the flow front.
    Additional Material: 22 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2024-02-07
    Description: The Milos, Christiana-Santorini-Kolumbo (CSK) and Kos-Yali-Nisyros (KYN) volcanic complexes of the Aegean Volcanic Arc have repeatedly produced highly explosive eruptions from at least ∼360 ka into historic times and still show recent unrest. We present the marine tephra record from an array of 50, up to 7.4 m long, sediment cores along the arc collected in 2017 during RV Poseidon cruise POS513, which complements earlier work on distal to ultra-distal eastern Mediterranean sediment cores. A unique set of glass-shard trace element (LA-ICPMS) compositions complements our major element (EMP) data on 220 primary ash layers and 40 terrestrial samples to support geochemical fingerprinting for correlations with 19 known tephras from all three volcanic complexes and with the 39 ka Campanian Ignimbrite from the Campi Flegrei, Italy. The correlations include eleven eruptions from CSK (Kameni, Kolumbo 1650, Minoan, Cape Riva, Cape Tripiti, Upper Scoriae 1 and 2, Middle Pumice, Cape Thera, Lower Pumice, Cape Therma 3). We identify a previously unknown widespread tephra from a plinian eruption on Milos (Firiplaka Tephra). Near the KYN we correlate marine tephras with the Kos Plateau Tuff, the Yali 1 and Yali 2 tephras, and the Upper and Lower Pumice on Nisyros. Between these two major tephras, we found two tephras from Nisyros not yet observed on land. The four Nisyros tephras form a systematic trend toward more evolved magma compositions. In the companion paper we use the tephrostratigraphic framework established here to constrain new eruption ages and magnitudes as a contribution to volcanic hazard assessment.
    Type: Article , PeerReviewed
    Format: other
    Format: other
    Format: other
    Format: text
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  • 6
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    In:  Protokoll über das 27. Schmucker-Weidelt-Kolloquium für Elektromagnetische Tiefenforschung : Breklum, 25.-29. September 2017
    Publication Date: 2020-02-12
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
    Format: application/pdf
    Format: application/pdf
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  • 7
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    In:  Protokoll über das Kolloquium Elektromagnetische Tiefenforschung: 18. Kolloquium: Altenberg, 20.3. - 24.3.2000
    Publication Date: 2021-04-26
    Description: Wir stellen ein SQUID-Magnetometer-System auf der Basis von Hochtemperatur-Supraleitern vor, das speziell für die Anwendung in der Transienten Elektromagnetik (TEM) entwickelt wurde. Es wird gezeigt, daß Messungen mit SQUID-Magnetometern insbesondere im späten Zeitbereich deutliche Vorteile gegenüber konventionellen Spulen bieten: Spulen messen dB/dt, die zeitliche Ableitung des magnetischen Feldes, welche mit zunehmender Zeit verschwindet; das SQUID misst hingegen B direkt und kann den Transienten solange verfolgen, bis er in dem natürlichen Feldrauschen untergeht. Dadurch kann im Explorationsgeschäft eine erhebliche Kostenersparnis verbunden werden, da mit SQUIDs bei gleicher Signalqualität viel weniger Mittelungen als mit Spulen nötig sind. Andererseits wird mit SQUIDs eine erweiterte Explorationstiefe möglich.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
    Format: application/pdf
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  • 8
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    In:  Protokoll zum 22. Kolloquium „Elektromagnetische Tiefenforschung“
    Publication Date: 2020-02-12
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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  • 9
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    In:  Protokoll über das Kolloquium Elektromagnetische Tiefenforschung: 16. Kolloquium: Burg Ludwigstein, 9.4.-12.4.1996
    Publication Date: 2021-11-03
    Language: German
    Type: info:eu-repo/semantics/conferenceObject
    Format: application/pdf
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  • 10
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    In:  Protokoll über das Kolloquium Elektromagnetische Tiefenforschung: 15. Kolloquium: Höchst im Odenwald, 28.03.- 31.03.1994
    Publication Date: 2022-02-17
    Language: German
    Type: info:eu-repo/semantics/conferenceObject
    Format: application/pdf
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