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  • 1
    Online Resource
    Online Resource
    Gemeinsam auf dem Weg in die energieeffiziente urbane Moderne : Einrichtung eines akteursorientierten Energiemanagementsystems in Delitzsch : Abschlussbericht der Universität Leipzig (2017)
    [Leipzig] : [Professur für Energiemanagement und Nachhaltigkeit der Universität Leipzig]
    Details Availability
    Keywords: Forschungsbericht
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (214 Seiten, 5,65 MB) , Illustrationen, Diagramme
    URL: https://doi.org/10.2314/GBV:1018346082
    DOI: 10.2314/GBV:1018346082
    Language: German
    Note: Förderkennzeichen BMBF 03SF0408A. - Verbund-Nummer 01094225 , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden
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  • 2
    Online Resource
    Online Resource
    Wege in die energieeffiziente Moderne : Entwicklung eines akteursorientierten kommunalen Energiemanagementsystems in Delitzsch ; Abschlussbericht (2010)
    Leipzig [u.a.]
    Details Availability
    Keywords: Forschungsbericht
    Type of Medium: Online Resource
    Pages: Online-Ressource (77 S., 3,59 MB) , graph. Darst., Kt.
    URL: https://edocs.tib.eu/files/e01fb11/656073098.pdf
    URL: https://doi.org/10.2314/GBV:656073098
    URL: https://edocs.tib.eu/files/e01fb11/656073098l.pdf
    DOI: 10.2314/GBV:656073098
    Language: German
    Note: Förderkennzeichen BMBF 03SF0364 , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden. - Auch als gedr. Ausg. vorhanden , Systemvoraussetzungen: Acrobat reader.
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  • 3
    Electronic Resource
    Electronic Resource
    FC01.4
Occupational skin diseases in different metal-working industries (2004)
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Contact dermatitis 50 (2004), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives:  To analyse the yearly incidence rates and causes of occupational skin diseases (OSD) in different metal-working industries.Methods:  Between 1990 and 1999, all new cases of OSD and their causes were prospectively recorded in all metal-working enterprises of Northern Bavaria. We calculated the incidence rates according to the average employed population. Furthermore, we analysed the different allergens, irritants and constitutional factors (e.g. atopy) in the affected metal workers.Results:  In metal workers, a total of 700 OSDs were registered which comprise 18.8% of all OSDs in our register. They were classified into metal-surface processors (260 OSDs, yearly incidence per 10,000 employees = 10.4), metal processors (129 OSDs, 5.9), locksmiths and automobile mechanics (119 OSDs, 2.5), electrical industry (69 OSDs, 1.4), machinists (47 OSDs, 11.6), mechanics (40 OSDs, 6.6), electroplaters (22 OSDs, 20.6) and solderers (14 OSDs, 13.4). The proportion between allergic (ACD) and irritant contact dermatitis (ICD) varies conspicuously. While electroplaters and solderers predominantly suffer from ACD (82% resp. 71%), in other occupational groups ICD is more common: mechanics (60%), locksmiths and automobile mechanics (59%) or metal-surface processors (53%). The type IV allergens differ widely depending on the occupational exposure. The most important allergen in solderers is colophony, in electroplaters nickel sulphate and potassium dichromate. There is a wide range of allergens in metal working fluids and it is mandatory to patch test patient‘s own working materials due to the fact that important allergens are not yet included in the screening series.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2004.0309au.x
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  • 4
    Electronic Resource
    Electronic Resource
    FS09.7
Standardisation of the “strip” patch test: a multicentre study (2004)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Contact dermatitis 50 (2004), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives:  The strip patch test (SPT), proposed by Spier and Sixt (Hautarzt 1955;6:152–9), is a modification of the patch test (PT). This technique is used to enhance penetration through the stratum corneum for poorly penetrating substances such as medicaments. So far, a standardised procedure is lacking. This multicentre study aims at standardising the SPT procedure.Methods:  A total of 83 healthy volunteers participated. In each subject, we determined the number of strips (A) until the surface became glistening and then calculated the median number of strips in the sample (Ā = 26). We ascertained the median number of strips in the sample (ā = 11) that was necessary to achieve a first statistically significant and medically relevant increase of the TEWL revealing a critical stratum corneum strip depth. For the finally calculated number of strips for each subject (a/A = (ā/Ā)⇔a = A × (ā/Ā)), the actual increase in test sensitivity was substantiated employing SLS 0.125% aqueous.Standardisation results:  Perform stripping at one upper part of the back until the surface becomes glistening: gently press a 25 mm diameter adhesive tape downward vertically for about 2 seconds and then remove it in one quick movement at the angle in direction of adherence; continue stripping with a new tape cut on exactly the same skin area. Multiply number of strips by the correction factor (cf = ā/Ā = 11/26 = 0.4). Perform calculated number of strips likewise on the contralateral site and then apply there the test preparation for 24 hours.Conclusions:  If clinically an allergic contact dermatitis is expected but PT is negative, the SPT might reveal the potential allergen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2004.0309cj.x
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  • 5
    Electronic Resource
    Electronic Resource
    FS10.2
Occupational contact dermatitis in health care workers (2004)
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Contact dermatitis 50 (2004), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objectives:  Occupational skin diseases (OSDs) account for a large number of occupational diseases in Europe. Population-based epidemiological studies concerning certain occupations (e.g. Health care workers), however, are missing.Aim of our study was to analyse the reports of OSD in Health care workers (HCW) in the register of OSDs of Northern Bavaria and to assess the annual incidence in this occupational group in relationship to the total employed population in Northern Bavaria. Further, we investigated the spectrum of sensitizations with and without occupational relevance in this group.Methods:  A total of 5285 cases of OSD were assessed prospectively and registered from 1990–1999. Data of total employment were provided by the German Federal Employment office.Results:  A total of 3097 cases were confirmed as OSD in 24 occupational groups, of which 482 were confirmed in the group of HCW. The average annual incidence of OSD in this group accounted for 7.3 per 10,000 workers. In 1990 the incidences in this occupational group accounted for 11.4%, in 1999 for 5.0% per 10,000 workers with highest incidences in younger age groups. In the evaluated health care workers from the register of OSD in Northern Bavaria 54%(n = 260) had irritant and 51%(n = 244) had allergic contact dermatitis including 19%(n = 89) who suffered from both. Of the 482 HCW 13% had occupational relevant Type IV allergy to glutaraldehyde, 12% to thiurams, 6% to nickel (II) sulfate, 4% to formaldehyde or fragances, respectively, 2% to thimerosal, potassium (II) chloride, chloromethyl-isothiazolone and p-phenylendiamine (free base) each.Conclusions:  HCW belong to the occupational groups at exceedingly high risk for OSD. Higher frequencies of OSD occur in younger age groups. Irritant and allergic contact dermatitis are equally common causes of OSD in HCW. Sensitization to certain allergens (e.g. glutaraldehyde, thiurams and latex) are most often of occupational relevance, whereas others although frequently found (e.g. sensitization to nickel-II-sulfate, cobalt-II-chloride, fragance-mix) rarely are of occupational relevance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0105-1873.2004.0309cm.x
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  • 6
    Electronic Resource
    Electronic Resource
    Surveillance scheme for occupational skin disease in the Saarland, FRG (2002)
    Oxford, UK : Munksgaard International Publishers
    Contact dermatitis 46 (2002), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Occupational skin disease (OSD) is a significant public health concern. To keep OSDs under surveillance, a register of OSDs (BKH-S) was implemented in 1999 in the Saarland, FRG. We conducted a population-based register study to analyse all initial reports of OSDs reported to the BKH-S. 336 cases were prospectively assessed from July 1999 to June 2001. In 78% (n = 263) of the cases an occupational cause for the skin disease was stated, 91% (n = 240) of which fell within 16 occupational groups. This is equivalent to 6.8 cases per 10,000 workers per year within these occupational groups. Notably, young age groups (median age 35 years) were affected with a female predominance. The most frequent final diagnosis was irritant contact dermatitis (75%) followed by allergic contact dermatitis (34%) and atopic dermatitis (19%). The overall prevalence of occupationally relevant delayed-type reactors was 21% and of immediate-type reactors 17%. Work-related delayed-type sensitizations to potassium dichromate (n = 8) and immediate-type sensitizations to natural rubber latex (n = 11) were the most frequently observed. Questionnaire results showed frequent occupational skin contact with wet work (59%), detergents (48%), and disinfectants (38%). The second valid surveillance scheme for OSD in the FRG has been introduced and can be made available for further analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1600-0536.2002.460403.x
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  • 7
    Electronic Resource
    Electronic Resource
    The Objective Severity Assessment of Atopic Dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis (2005)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 153 (2005), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  The Objective Severity Assessment of Atopic Dermatitis (OSAAD) score is a recently developed scale for evaluation of severity of atopic dermatitis, constructed from the assessment of epidermal barrier function, and properties using noninvasive bioengineering methods and computer-assisted estimates of disease extent. The method has been validated for use in infants and children with atopic dermatitis and compared with a referent scoring system.Objectives  The aim of the present study was to test the validity, reliability and sensitivity of the OSAAD score as an objective tool for the assessment of the severity of atopic dermatitis in adult patients.Methods  Thirty-two adult patients with atopic dermatitis were included in the study. To assess the validity of the OSAAD score we tested it against the Severity Scoring of Atopic Dermatitis (SCORAD) index of the European Task Force on Atopic Dermatitis as a referent clinical severity scale, and the serum levels of interleukin (IL)-16 as a laboratory variable for monitoring the activity of atopic dermatitis. Responsiveness to change was assessed in a longitudinal study comparing OSAAD, SCORAD and serum levels of IL-16 before and after treatment. To test the reliability of the OSAAD score we studied the interobserver variability of the score recorded by three independent board-certified dermatologists in 16 patients and compared it with SCORAD.Results  We report a significant correlation between the OSAAD and the SCORAD index as an acknowledged referent severity scale. The OSAAD score correlated significantly with the serum levels of IL-16 in the acute stage of atopic dermatitis. In a longitudinal study, the OSAAD score decreased significantly, parallel with improvement of the skin findings and a significant decrease in the SCORAD score and IL-16 serum levels. We report improved interobserver variability for the OSAAD score compared with SCORAD.Conclusions  This is the first study validating the OSAAD score as a sensitive and reliable tool for the assessment of the severity of atopic dermatitis in adult patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06697.x
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  • 8
    Electronic Resource
    Electronic Resource
    Occupational skin disease in the construction industry (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 149 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Construction workers have a substantial risk of developing irritant and/or allergic contact dermatitis. Unfortunately, however, there is little population-based epidemiological data relating to occupational skin diseases (OSD) in the European construction industry that allow assessment of preventive measures.Objectives  In this investigation, the yearly incidence rates and causes of OSD in the construction industry were analysed on the basis of our register in Northern Bavaria.Methods  From 1990 until 1999, all incidences of OSD in the construction industry were recorded prospectively. This enables the calculation of incidence rates of OSD in relation to the employed population in Northern Bavaria as recorded by the German Federal Employment Office.Results  In the construction industry, a total of 335 OSD were registered. These comprise 9·0% of all OSD in the register. We classified them into four relevant groups: (A) tile setters and terrazzo workers (incidence per 10 000 employees = 19·9); (B) painters (7·8); (C) construction and cement workers (5·2); and (D) wood processors (2·6). The overall incidence was 5·1 per 10 000 employees over 10 years, which is a little below average for the entire register (6·7). Of these, 43·6% were at least 40 years old. Allergic contact dermatitis (61·5%) occurred more often than irritant contact dermatitis (44·5%). Potassium dichromate caused roughly half of all cases of sensitization found to be occupationally relevant in the construction industry (152 cases) followed by epoxy resin (40) and cobalt chloride (32).Conclusions  The results indicate that potassium dichromate is still the most important allergen in the construction industry of Northern Bavaria; there has been no significant decline during the 1990s. This contrasts with the Scandinavian countries, where the prevalence of potassium dichromate sensitization declined following the reduction of chromium VI levels resulting from the addition of ferrous sulphate to cement. Within the construction industry, tile setters and terrazzo workers have a strikingly high incidence of OSD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2003.05748.x
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  • 9
    Electronic Resource
    Electronic Resource
    251. Influence of oral contraceptives with various amounts of different estrogens and of estradiol valerianate, conjugated estrogens and estriol on antithrombin III
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 9 (1978), S. 864-865 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(78)90951-2
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  • 10
    Electronic Resource
    Electronic Resource
    Sex Difference in the Validity of Vertebral Deformities as an Index of Prevalent Vertebral Osteoporotic Fractures: A Population Survey of Older Men and Women (2000)
    Springer
    Osteoporosis international 11 (2000), S. 102-119 
    Details
    ISSN: 1433-2965
    Keywords: Key words:Bone mineral density – Differential diagnosis – Fractures – Osteoarthritis – Osteoporosis – Vertebral deformity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Morphometric methods have been developed for standardized assessment of vertebral deformities in clinical and epidemiologic studies of spinal osteoporosis. However, vertebral deformity may be caused by a variety of other conditions. To examine the validity of morphometrically assessed vertebral deformities as an index of osteoporotic vertebral fractures, we developed an algorithm for radiological differential classification (RDC) based on a combination of quantitative and qualitative assessment of lateral spinal radiographs. Radiographs were obtained in a population of 50- to 80-year-old German women (n= 283) and men (n = 297) surveyed in the context of the European Vertebral Osteoporosis Study (EVOS). Morphometric methods (Eastell 3 SD and 4 SD criteria, McCloskey) were validated against RDC and against bone mineral density (BMD) at the femur and the lumbar spine. According to RDC 36 persons (6.2%) had at least one osteoporotic vertebral fracture; among 516 (88.9%) nonosteoporotics 154 had severe spondylosis, 132 had other spinal disease and 219 had normal findings; 14 persons (2.4%) could not be unequivocally classified. The prevalence of morphometrically assessed vertebral deformities ranged from 7.3% to 19.2% in women and from 3.5% to 16.6% in men, depending on the stringency of the morphometric criteria. The agreement between RDC and morphometric methods was poor. In men, 62–86% of cases with vertebral deformities were classified as nonosteoporotic (severe spondylosis or other spinal disease) by RDC, compared with 31–68% in women. Among these, most had wedge deformities of the thoracic spine. On the other hand, up to 80% of osteoporotic vertebral fractures in men and up to 48% in women were missed by morphometry, in particular endplate fractures at the lumbar spine. In the group with osteoporotic vertebral fractures by RDC the proportion of persons with osteoporosis according to the WHO criteria (T-score 〈−2.5 SD) was 90.0% in women and 86.6% in men, compared with 67.9–85.0% in women and 20.8–50.0% in men with vertebral deformities by various methods. Although vertebral deformities by most definitions were significantly and inversely related to BMD as a continuous variable in both sexes [OR; 95% CI ranged between (1.70; 1.07–2.70) and (3.69; 1.33–10.25)], a much stronger association existed between BMD and osteoporotic fractures defined by RDC [OR; 95% CI between (4.85; 2.30–10.24) and (15.40; 4.65–51.02)]. In the nonosteoporotic group individuals with severe spondylosis had significantly higher BMD values at the femoral neck (p 〈0.01) and lumbar spine (p 〈0.0004) compared with the normal group. On the basis of internal (RDC) and external (BMD) validation, we conclude that assessment of vertebral osteoporotic fracture by quantitative methods alone will result in considerable misclassification, especially in men. Criteria for differential diagnosis as used within RDC can be helpful for a standardized subclassification of vertebral deformities in studies of spinal osteoporosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00004172
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