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  • 1
    Keywords: Forschungsbericht ; Neurotoxizität ; Wasserkreislauf ; Wasseranalyse ; Anthropogener Einfluss ; Umweltchemikalie ; Zebrabärbling
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (450 Seiten, 39,21 MB) , Illustrationen, Diagramme
    Language: German
    Note: Förderkennzeichen BMBF 02WRS1419A-F , Literaturangaben , Verbundnummer 01177793 , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden , Methodische Weiterentwicklung der dreistufigen In-vitro-Testbatterie zur Erfassung neurotoxischer Wirkungen und Koordination des Verbundes : Abschlussbericht Teilprojekt 1 , Neurotoxizität bei Fischen: Bedeutung für Mensch und Umwelt : Abschlussbericht Teilprojekt 2 , NeuroBox - "Methodische Weiterentwicklung zur Bewertung von neurotoxischen Effekten im Wasserkreislauf" - Identifikation von neurotoxischen Wirkungsmechanismen (in vivo) zur Entwicklung neuer wirkungsspezifischer Testverfahren. Teilprojekt 3 , In Vitro-Charakterisierung paralleler neuro-entwicklungstoxischer undendokriner Stoffwirkungen zur Identifikation diskriminierender Biomarker : Abschlußbericht : Projektlaufzeit: 3 Jahre (bis 29.02.2020) : Berichtszeitraum: 1.03.2017-30.04.2020, Corona-bedingte Schließung der Labore, Kostenneutral verlängert bis August 2020, Verlängerung bis 31.12.2020 , Teilprojekt der Landeswasserversorgung: Weiterentwicklung der Wirkungsbezogenen Analytik (WBA) in kombination mit der Non-Target-Analytik : Bewilligungszeitraum: 01.03.2017 bis 29.02.2020 verlängert bis 31.12.2020 , Teilprojekt 6: "Identifizierung und toxikologische Charakterisierung neuroaktiver Substanzen und Gemische in Oberflächenwässern als Beitrag zum Trinkwasserressourcenschutz" : Projektlaufzeit: 1.3.2017 bis 31.12.2020
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  • 2
    Online Resource
    Online Resource
    Berlin, Heidelberg :Springer Berlin / Heidelberg,
    Keywords: Watershed management. ; Watershed management-Europe. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (403 pages)
    Edition: 1st ed.
    ISBN: 9783642385988
    Series Statement: The Handbook of Environmental Chemistry Series ; v.29
    DDC: 333.952816094
    Language: English
    Note: Intro -- The Handbook of Environmental Chemistry Also Available Electronically -- Aims and Scope -- Series Preface -- Foreword -- Contents -- Introduction: The Need for Risk-Informed River Basin Management -- 1 River Ecosystems at Risk -- 2 River Basin Management-Related European Policy -- 3 RISKBASE -- 4 This Book: Guide to the Reader -- 4.1 The Book Structure: Four Sections (A-D) -- 4.2 A Common Perspective as Basis for This Book -- 4.2.1 Target Group -- 4.2.2 Risk Receptor -- 4.2.3 Risk Sources -- 4.2.4 Common Language -- 4.3 Risk-Informed Management -- References -- Section A: Understanding River Ecosystems -- Soil-Sediment-River Connections: Catchment Processes Delivering Pressures to River Catchments -- 1 Introduction -- 2 The Natural System (Ecosystem) -- 2.1 Continental Weathering and Erosion: The Soil Formation -- 2.2 The Solid Transportation Over Continent -- 2.3 The Anthropocene System -- 2.4 Relevant Pressures at the Basin Scale -- 2.5 Pressures and Biophysical Status -- 2.5.1 Erosion -- 2.5.2 Sealing -- 2.5.3 Compaction -- 2.5.4 Hydromorphological Changes -- 2.5.5 Salinisation -- 2.5.6 Contamination -- 2.5.7 Changes in Water Quantity -- 2.5.8 Acidification -- 2.5.9 Soil Organic Matter Reduction -- 3 Summary and Recommendations -- References -- Status and Causal Pathway Assessments Supporting River Basin Management -- 1 Introduction -- 2 Stressor Impact on the Site Scale and Its Propagation at the Basin Scale -- 2.1 Toxicity -- 2.1.1 Evaluation of Surveillance Data -- Abiotic Indicators -- Biological Indices -- 2.1.2 Confirmation of Toxicity as Causation of Degradation -- In Vitro and In Vivo Effect Assessment -- Identification of Key Toxicants Causing the Effect -- Source Identification -- 2.1.3 Considerations for Site-Specific Risk Assessments and Downstream Risks -- Refinement of Exposure Assessment for Identified Key Toxicants. , Prediction of Site-Specific Toxic Risks to Populations, Communities and Ecosystems -- Prediction of Basin-Scale Effects -- 2.2 Acidification -- 2.2.1 Evaluation of Surveillance Monitoring Data -- Abiotic Indicators -- Biological Indices -- 2.2.2 Confirmation of Acidity as Causation of Degradation -- 2.2.3 Considerations for Site-Specific Risk Assessments and Downstream Risks -- 2.3 Salinisation -- 2.3.1 Evaluation of Surveillance Monitoring Data -- Abiotic Indicators -- Biological Indices -- 2.3.2 Confirmation of Salinisation as Causation of Degradation -- 2.3.3 Considerations for Site-Specific Risk Assessments and Downstream Risks -- Not All Salts Are the Same: Effects of Different Ionic Compositions -- Effects of Temporal Variation in Salinity -- Do Freshwater Systems Recover from the Effects of Salinisation? -- What Are the Joint Effects of Salt with Other Stressors? -- 2.4 Eutrophication and Oxygen Depletion -- 2.4.1 Evaluation of Surveillance Monitoring Data -- Abiotic Indicators -- Biological Indices -- 2.4.2 Confirmation of Eutrophication as Causation of Degradation -- 2.4.3 Considerations for Site-Specific Risk Assessments and Downstream Risks -- 2.5 Parasites and Pathogens -- 2.5.1 Evaluation of Surveillance Monitoring Data -- 2.5.2 Confirmation of Parasites and Pathogens as Causation of Degradation -- 2.5.3 Risk Assessment of Local Impacts and Downstream Risks -- 2.6 Invasive Alien Species -- 2.6.1 Evaluation of Surveillance Monitoring Data -- 2.6.2 Confirmation of Invasive Alien Species as Causation of Degradation -- 2.6.3 Considerations for Site-Specific Risk Assessments and Downstream Risks -- Environmental Indicators of IAS Connected to the DPSIR Framework -- Development of Early Warning Systems -- 2.7 Hydromorphological Degradation -- 2.7.1 Evaluation of Surveillance Monitoring Data -- Abiotic Indicators -- Biological Indices. , 2.7.2 Confirmation of Habitat Degradation as Causation of Degradation -- 2.7.3 Risk Assessment of Local Impacts and Downstream Risks -- 2.8 Changing Water Levels: Floods, Droughts and Water Level Regulations -- 2.8.1 Evaluation of Surveillance Monitoring Data -- Abiotic Indicators -- Biological Indices -- 2.8.2 Confirmation of Changing Water Levels as Causation for Degradation -- 2.8.3 Considerations for Site-Specific Risk Assessments and Downstream Risks -- Effect of European Legislation: Heavily Modified Water Bodies -- Mitigation of Regulated Lakes by Ecological Regulation Practice (ERP) in Finland -- Assessment of Downstream Risk: The Environmental Flow Approach -- 2.9 Sediment and Suspended Matter -- 2.9.1 Evaluation of Surveillance Monitoring Data -- Abiotic Indicators -- Biological Indicators -- 2.9.2 Confirmation of Sediments and Suspended Matter as Causation of Degradation -- Exposure Assessment -- Source Identification -- 2.9.3 Considerations for Site-Specific Risk Assessments and Downstream Risks -- 3 Conclusions and Recommendations -- References -- Monitoring Programmes, Multiple Stress Analysis and Decision Support for River Basin Management -- 1 Monitoring of Relevant Stressors -- 1.1 Historical Monitoring Programmes -- 1.2 WFD Monitoring -- 1.3 Monitoring Requirements for an Integrated Status Assessment -- 2 How Does One Assess Multiple Stressors? -- 2.1 Selection of Reference Conditions and Sites -- 2.2 Quantifying Biological Conditions Using RIVPACS Modelling -- 2.3 Multimetric Analysis -- 2.4 Quantitative Diagnostic Modelling -- 2.4.1 Application of Predictive Models and General Linear Models -- 2.4.2 Application of a GIS-Based Weight-of-Evidence Approach -- 2.4.3 Application of Self-Organising Maps and Artificial Neural Network Approaches -- 3 Decision Support for Risk Assessment and Management -- 3.1 Decision Support Systems. , 3.2 End User Involvement in DSS Development -- 3.3 The MODELKEY DSS: Methodological Approach and Technical Solutions -- 4 Conclusions and Recommendations -- References -- Section B: Anticipating Change -- Downscaling Scenarios as an Exploratory Tool for River Basin Management: An Introduction -- 1 Introduction -- 2 The SRES-Scenarios Have Become Popular -- 3 Downscaling SRES-Scenarios for the Scheldt River Basin -- 4 Conclusions and Recommendations -- References -- Informing River Basin Management on Flood and Drought Risks Taking Future Uncertainties into Account -- 1 Introduction -- 1.1 Economic Losses, Natural Hazards and Uncertainty -- 1.2 Frequency of Natural Hazards -- 2 Flood Management in Europe -- 2.1 Future Flood Risk Assessment -- 2.2 Dealing with Uncertainty in a Risk-Informed Approach -- 3 An Outlook to the Assessment of Drought Risk -- 4 Conclusions and Recommendations -- References -- Future Land Use Patterns in European River Basins: Scenario Trends in Urbanization, Agriculture and Land Use -- 1 Introduction -- 2 Methodology -- 2.1 Outline -- 2.2 Models -- 2.3 River Basins and Land Use Categories Included in the Analysis -- 3 Results and Discussion -- 3.1 Scenarios -- 3.2 Predicted Trends in Land Use -- 3.3 Predicted Trends per River Basin -- 3.4 Predicted Impacts on Hydrology -- 4 Conclusions -- References -- Framing the Uncertain Future: Articulating IPCC-SRES Scenarios for European River Basins -- 1 Introduction -- 2 Approach -- 3 Results -- 4 Discussion -- 5 Section B: Anticipating Change -- References -- Section C: Connecting to the Social System -- Integrated River Basin Management and Risk Governance -- 1 Water Management Under Transition -- 2 Policy Drivers for River Basin Management in Europe -- 2.1 Water-Related Environmental Policies -- 2.2 The Appropriate Scale for Management -- 2.3 The Wider Policy Arena. , 3 Risk Governance -- 3.1 What Is Risk? -- 3.2 A Framework for Risk Governance -- 3.3 Evaluation and Categorisation of Risk Problems -- 3.4 Informed Decisions and Risk Management Strategies -- 3.5 Risk Communication -- 4 Risk: Broadening the Notion -- 4.1 Risk and Concerns -- 4.2 A Risk-Informed Approach Towards IWRM -- 4.3 Managing Risk and Concerns -- 5 Adaptive Integrated Water Management -- 5.1 What Is It? -- 5.2 An Inspiring Example from Practice: Lonjsko Polje Floodplain Management -- 6 Conclusions -- References -- Ecosystem Services and River Basin Management -- 1 Introduction -- 2 Ecosystem Services Basics -- 2.1 Defining Ecosystem Services -- 2.2 Ecosystem Services Typology -- 2.3 Biodiversity and Ecosystem Services -- 3 Assessing Ecosystem Services in River Basins -- 3.1 Assessing Ecosystem Services Production and Changes in Their Delivery -- 3.1.1 Landscape Effects on Water -- 3.1.2 Whole-System Analysis -- 3.1.3 Marginal Impact Assessment -- 3.2 Assessing the Economic Value of Ecosystem Services -- 3.2.1 Capturing the Value -- 3.2.2 Economic Valuation Concepts -- 3.2.3 Scale and Equity -- 3.2.4 Valuation Methodologies -- 4 Integrating Ecosystem Services with Risk Assessment -- 4.1 Using Ecosystem Service Within a Risk Assessment Framework -- 4.2 Ecosystem Services and the IRGC Governance Framework -- 5 Benefits of Ecosystem Services for River Basin Management -- 5.1 Ecosystem Services Help to Set Priorities -- 5.2 Ecosystem Services as Common Language Facilitating Participation -- 5.3 Ecosystem Services Management as a European Policy Objective -- 5.4 Payment for Ecosystem Services -- 6 Examples of Ecosystem Services Application in Water Management Practice -- 6.1 Availability of Practical Examples -- 6.2 Dommel River Case Study, The Netherlands -- 6.3 Tamar River Case Study, United Kingdom. , 6.4 Vecht River Case Study, Transboundary Germany: The Netherlands.
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  • 3
    Online Resource
    Online Resource
    Berlin, Heidelberg :Springer Berlin / Heidelberg,
    Keywords: Pollution. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (357 pages)
    Edition: 1st ed.
    ISBN: 9783642183843
    Series Statement: The Handbook of Environmental Chemistry Series ; v.15
    DDC: 363.73
    Language: English
    Note: Intro -- Effect-Directed Analysis of Complex Environmental Contamination -- Series Preface -- Volume Preface -- Acknowledgments -- Contents -- Early Evolution of the Toxicity Identification Evaluation Process: Contributions from the United States Environmental Protecti -- Recent Developments in Whole Sediment Toxicity Identification Evaluations: Innovations in Manipulations and Endpoints -- Considerations for Incorporating Bioavailability in Effect-Directed Analysis and Toxicity Identification Evaluation -- Diagnostic Tools for Effect-Directed Analysis of Mutagens, AhR Agonists, and Endocrine Disruptors -- Separation Techniques in Effect-Directed Analysis -- Simultaneous Screening and Chemical Characterization of Bioactive Compounds Using LC-MS-Based Technologies (Affinity Chromatog -- Advanced GC-MS and LC-MS Tools for Structure Elucidation in Effect-Directed Analysis -- Computer Tools for Structure Elucidation in Effect-Directed Analysis -- Effect-Directed Analysis of Mutagens in Ambient Airborne Particles -- Effect-Directed Analysis of Endocrine Disruptors in Aquatic Ecosystems -- Effects-Directed Studies of Pulp and Paper Mill Effluents -- Effect-Directed Analysis of Ah-Receptor Mediated Toxicants, Mutagens, and Endocrine Disruptors in Sediments and Biota -- Ecological Relevance of Key Toxicants in Aquatic Systems -- Index.
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  • 4
    Publication Date: 2024-06-25
    Description: Plant protection products in the environment are partly responsible for the progressive loss of biodiversity. The mostly insufficient ecological status of surface waters is often explained by habitat degradation and excessive nutrient input. But what role do plant protection products play in this context? The Kleingewässermonitoring (KgM) project provides a worldwide unique quantitative assessment of the impact of pesticides from diffuse agricultural sources on small and medium-sized streams. The dataset comprises 124 monitoring stream sections all over Germany covering a wide pollution gradient where consistent measurements were carried out in 2018 and 2019 during the major pesticide application period from April to July. These measurements include event-driven sampling to record surface rainfall-induced short-term peak concentrations in addition to regular grab sampling of pesticides and a wide range of other pollutants resulting in more than 1,000 water samples. All further relevant anthropogenic and environmental parameters reigning ecological stream quality were recorded comprehensively (morphological and stream bed structure, temperature, flow velocity, dissolved oxygen, pH, catchment land use, stream profile). The dataset also contains effect monitoring data featuring sampled invertebrate communities and bioassay analyses of water samples. The data enables an assessment of pesticide exposure and related effects as well as the analysis of complex causal relationships in streams.
    Keywords: Germany; KgM; KgM_2018; KgM_2019; Kleingewässermonitoring; MULT; Multiple investigations
    Type: Dataset
    Format: application/zip, 52.3 MBytes
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  • 5
    Publication Date: 2024-06-21
    Description: 499 emerging chemicals (ECs) were investigated in 56 effluent samples from 52 European wastewater treatment plants (WWTPs). The samples were collected between August 2017 and April 2019, using on-site large volume solid phase extraction (LVSPE) (Schulze et al., 2017). Chemical target screening by liquid chromatography high-resolution mass spectrometry (LC-HRMS) resulted in 366 detected compounds. Different capacities and conventional treatment technologies, as well as two advanced treatment technologies are included. One sample was taken at a WWTP with activated carbon (AC) treatment. Three WWTPs applying ozonation were sampled before and after this treatment step, providing two samples each. One of these WWTPs had already been sampled before the upgrade, resulting in a total of 56 (52+4) samples. More information can be found in Finckh et al. (2022). The two main objectives were (1) to extend our knowledge on chemicals occurring in treated wastewater, and (2) to identify and prioritize compounds of concern based on three different risk assessment approaches for the identification of consensus mixture risk drivers of concern.
    Keywords: advanced treatment technologies; chemical concentration; chemicals of emerging concern; chemical target screening; emerging chemicals; emerging contaminants; emerging pollutants; Europe; LC-HRMS; liquid chromatography high-resolution mass spectrometry; organic micropollutants; wastewater treatment plant
    Type: Dataset
    Format: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet, 287.5 kBytes
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  • 6
    Publication Date: 2024-06-21
    Description: 79 potential endocrine disrupting chemicals (EDCs) were investigated in 56 effluent samples from 52 European wastewater treatment plants (WWTPs). The samples were collected between August 2017 and April 2019, using on-site large volume solid phase extraction (LVSPE) (Schulze et al., 2017). Chemical target analysis by liquid chromatography high-resolution and tandem mass spectrometry (LC-HRMS and LC-MS/MS, respectively) resulted in 56 detected compounds. Different capacities and conventional treatment technologies, as well as two advanced treatment technologies are included. One sample was taken at a WWTP with activated carbon treatment. Three WWTPs applying ozonation were sampled before and after this treatment step, providing two samples each. One of these WWTPs had already been sampled before the upgrade, resulting in a total of 56 (52+4) samples. More information can be found in Finckh et al. (2022). The two main objectives of this study were (i) to compare three different receptor-based estrogenicity assays (ERα-GeneBLAzer, p-YES, ERα-CALUX®), and (ii) to investigate a combined approach of chemical target analysis and receptor-based testing for estrogenicity, glucocorticogenic activity, androgenicity and progestagenic activity (ERα-, GR-, AR- and PR-GeneBLAzer assays, respectively) in treated wastewater.
    Keywords: advanced treatment technologies; androgens; chemical analysis; chemical concentration; EDC; effect-based analysis; endocrine disrupting chemicals; estrogens; Europe; glucocorticoids; LC-HRMS; LC-MS/MS; organic micropollutants; progestagens; receptor-based analysis; treated wastewater; wastewater treatment plant; water quality; WWTP
    Type: Dataset
    Format: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet, 42 kBytes
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  • 7
    Publication Date: 2024-06-21
    Description: The data file contains measured environmental concentrations of organic micropollutants in European streams and additional hydrological parameters (stream order, urban discharge fraction) of the investigated sites. A total of 445 surface water samples were collected during various sampling campaigns between 2016 and 2019. Chemical target screening of 610 compounds by liquid chromatography high-resolution mass spectrometry (LC-HRMS) resulted in 504 detected compounds. The measured environmental concentrations of the detected compounds ranged from 1 ng/L to 74 µg/L (3-cyclohexyl-1,1-dimethylurea). Detection frequencies ranged from one site (0.2 %) to 339 sites (76 %). More information can be found in Finckh and Carmona et al. (2024) DOI: 10.1016/j.envint.2023.108371. The main objective of this study was to quantify and characterise chemical footprints in European streams.
    Keywords: chemical footprint; chemicals of emerging concern; chemical target screening; Europe; freshwater contamination; LC-HRMS; measured environmental concentration; organic micropollutants; risk quotient; surface water; toxic unit; treated wastewater; WWTP
    Type: Dataset
    Format: application/vnd.openxmlformats-officedocument.spreadsheetml.sheet, 319.8 kBytes
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  • 8
    ISSN: 0888-7543
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0888-7543
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the past, positive as well as negative results pertaining to HIV-1/HIV-2 interference have been obtained. Therefore, in the present study attention was paid to the viral expression state of preinfected cells at the time of exposure to secondary virus. A clonal HIV-2 infected HUT-78 cell line was derived by endpoint dilution and subsequently inoculated with cell-free HIV-1. Superinfection with HIV-1 was ruled out by Western blot and PCR analysis. The chronically HIV-2 infected cells used for these studies showed a highly productive expression state, as evidenced by immunoperoxidase staining (IPS), Western blot profile and levels of reverse transcriptase (RT) activity. We discuss several mechanisms of interference in productively infected cells, which may confer resistance to superinfection with secondary virus.
    Type of Medium: Electronic Resource
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