In:
Diabetes, Obesity and Metabolism, Wiley, Vol. 19, No. 11 ( 2017-11), p. 1521-1528
Abstract:
To evaluate whether treatment with LY2409021 , a novel, selective glucagon receptor antagonist, is associated with changes in hepatic fat and other safety variables related to the benefit–risk profile for chronic use in patients with type 2 diabetes ( T2D ). Methods Safety and efficacy were assessed in patients with T2D taking metformin and sulphonylurea who were randomized to LY2409021 20 mg (n = 65), placebo (n = 68), or sitagliptin 100 mg (n = 41). Key endpoints included change from baseline to month 6 in hepatic fat fraction ( HFF ), assessed by magnetic resonance imaging; hepatic aminotransferases; blood pressure; lipid profile; fasting plasma glucose; and glycated haemoglobin ( HbA1c ). Results A significant increase in HFF was seen with LY2409021 vs sitagliptin (least squares [ LS ] mean difference 3.72%; P 〈 .001) and placebo (4.44%; P 〈 .001), accompanied by significant elevations in alanine aminotransferase levels with LY2409021 vs sitagliptin (6. 8 U / L ; P = .039) and vs placebo (10.7 U/L ; P 〈 .001). No patients had concomitant elevations in bilirubin levels. LY2409021 treatment showed significant HbA1c reductions vs placebo ( LS mean difference −0.77%; P 〈 .001) but not sitagliptin (−0.20%; P = .383). Similar results were observed for fasting plasma glucose. LY2409021 was also associated with significant increases in systolic blood pressure vs sitagliptin (4.9 mm Hg ; P = .030) and vs placebo (4.3 mm Hg ; P = .029), as well as significant increases in body weight and total cholesterol. All effects of LY2409021 were reversible. Conclusion In this cohort of patients with T2D , chronic glucagon receptor antagonism with LY2409021 was associated with glucose‐lowering but also demonstrated increases in hepatic fat, hepatic aminotransferases, and other adverse effects.
Type of Medium:
Online Resource
ISSN:
1462-8902
,
1463-1326
DOI:
10.1111/dom.2017.19.issue-11
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2004918-3
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