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  • 1
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    Clinical efficacy of iodine complex in SARS-CoV-2-infected patients with mild to moderate symptoms: study protocol for a randomized controlled trial
    Springer Science and Business Media LLC ; 2022
    In:  Trials Vol. 23, No. 1 ( 2022-12)
    Details
    In: Trials, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2022-12)
    Abstract: Coronavirus disease 2019 (COVID-19) caused by the novel coronavirus-infected millions globally. Despite a wide range of advised options for the treatment of COVID-19, a single strategy to tackle this pandemic remains elusive, thus far. That is why we are conducting a clinical trial to find out the efficacy of iodine complex to clear a viral load of severe respiratory syndrome coronavirus-2 (SARS-CoV-2) along with a reduction in time taken to alleviate symptoms. Method The proposed study is a placebo-controlled, add-on, randomized trial using parallel group designs. This is a closed-label and adaptive with sample size reassessment, multi-centered design with a 1:1:1:1 allocation ratio and superiority framework. It will be conducted in Shaikh Zayed Post-Graduate Medical Complex, Ali Clinic, and Doctors Lounge, Lahore, Pakistan. This study will have three arms of mild to moderately symptomatic COVID-19 patients (50 patients in each) which will receive ionic-iodine polymer complex with 200 mg of elemental iodine: interventional arm A will have encapsulated, arm B will receive suspension syrup form, arm C will get throat spray, while arm X will be standard care with placebo. Data will be collected on self-constructed, close-ended questionnaires after obtaining written consent. Data will be analyzed using SAS version 9.4. COVID-19 patients will be monitored by RT-PCR and HRCT (high-resolution computed tomography) chest. In addition to these, the duration of the symptomatic phase and mortality benefits will be analyzed in both groups. Discussion The study is designed to measure the superior efficacy of the iodine complex as an add-on in treating COVID-19-positive patients with mild to moderate symptoms. This combination is hypothesized to improve various parameters like rapid viral load reduction, clinical and radiological improvement, lower mortality, and reduction in hospitalization. The trial will aid in devising a better strategy to cope with COVID-19 in a relatively inexpensive and accessible way. The implications are global, and this could prove itself to be the most manageable intervention against COVID-19 especially for patients from limited-resource countries with deprived socioeconomic status. Trial registration ClinicalTrials.gov NCT04473261. Registered on July 16, 2020.
    Type of Medium: Online Resource
    ISSN: 1745-6215
    URL: Article
    DOI: 10.1186/s13063-021-05848-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2040523-6
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  • 2
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    Antiarthritic potential of the butanol fraction of Sesuvium sesuvioides: An in vitro, in vivo, and in silico evaluation
    Frontiers Media SA ; 2023
    In:  Frontiers in Pharmacology Vol. 14 ( 2023-5-26)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 14 ( 2023-5-26)
    Abstract: Sesuvium sesuvioides (Fenzl) Verdc (Aizoaceae) has been traditionally used in the treatment of inflammation, arthritis, and gout. However, its antiarthritic potential has not been evaluated scientifically. The current study was designed to assess the antiarthritic properties of the n -butanol fraction of S. sesuvioides (SsBu) by phytochemical analysis, in vitro and in vivo pharmacological activities, and in silico studies. Phytochemical analysis showed total phenolic contents (90.7 ± 3.02 mg GAE/g) and total flavonoid contents (23.7 ± 0.69 mg RE/g), and further analysis by GC-MS identified possible bioactive phytocompounds belonging to phenols, flavonoids, steroids, and fatty acids. The in vitro antioxidant potential of SsBu was assessed by DPPH (175.5 ± 7.35 mg TE/g), ABTS (391.6 ± 17.1 mg TE/g), FRAP (418.2 ± 10.8 mg TE/g), CUPRAC (884.8 ± 7.97 mg TE/g), phosphomolybdenum (5.7 ± 0.33 mmol TE/g), and metal chelating activity (9.04 ± 0.58 mg EDTAE/g). Moreover, in the in vitro studies, inhibition (%) of egg albumin and bovine serum albumin denaturation assays showed that the anti-inflammatory effect of SsBu at the dose of 800 μg/ml was comparable to that of diclofenac sodium used as a standard drug. The in vivo antiarthritic activity was assessed to determine the curative impact of SsBu against formalin-induced (dose-dependent significant ( p & lt; 0.05) effect 72.2% inhibition at 750 mg/kg compared to standard; 69.1% inhibition) and complete Freund’s adjuvant-induced arthritis (40.8%; inhibition compared to standard, 42.3%). SsBu significantly controlled PGE-2 level compared to the control group ( p & lt; 0.001) and restored the hematological parameters in rheumatoid arthritis. Treatment with SsBu significantly reduced oxidative stress by reinstating superoxide dismutase, GSH, and malondialdehyde along with pro-inflammatory markers (IL-6 and TNF-α) in arthritic rats. Molecular docking revealed the antiarthritic role of major identified compounds. Kaempferol-3-rutinoside was found to be more potent for COX-1 (−9.2 kcal/mol) and COX-2 inhibition (−9.9 kcal/mol) than diclofenac sodium (COX-1, −8.0 and COX-2, −6.5 kcal/mol). Out of the 12 docked compounds, two for COX-1 and seven for COX-2 inhibition showed more potent binding than the standard drug. The results from the in vitro , in vivo , and in silico approaches finally concluded that the n -butanol fraction of S. sesuvioides had antioxidant and antiarthritic potential, which may be due to the presence of potential bioactive compounds.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    DOI: 10.3389/fphar.2023.1136459
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2587355-6
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  • 3
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    Design and analysis of robust fuzzy logic maximum power point tracking based isolated photovoltaic energy system
    Wiley ; 2020
    In:  Engineering Reports Vol. 2, No. 9 ( 2020-09)
    Details
    In: Engineering Reports, Wiley, Vol. 2, No. 9 ( 2020-09)
    Abstract: Photovoltaic (PV) energy is highly promising because of its renewable, green, and environment‐friendly nature. In this article, the design and analysis of an isolated PV system using a push‐pull converter with a fuzzy logic‐based maximum power point tracking (MPPT) algorithm is presented. Furthermore, DC‐DC converters, along with intelligent controllers fed with MPPT algorithms, are used to ensure the maximum extraction of incident energy. The proposed methodology utilizes fuzzy logic MPPT techniques based on an isolated push‐pull boost converter to optimize the power output of PV modules, as well as to achieve isolation and high DC gain for DC/AC inversion. This work also presents a single‐phase inverter with fuzzy logic close loop control analysis with LCL filter design. A Canadian solar panel of 250 W is assumed in this research work, which has an open circuit voltage 59.9 V, short circuit current 5.49 A at 25°C temperature, and 1000 W/m 2 irradiance. The voltages are tracked, through the MPPT algorithm. These voltages represent a boost to 340 V DC through push‐pull boost converter and are inverted up to 220 V AC through fuzzy logic voltage source inverter. In addition, a unipolar switching technique is used to remove the total harmonic distortion under linear load. The proposed methodology is simulated in MATLAB/Simulink. The simulation results verify that the proposed methodology can efficiently track the MPPT. Finally, the hardware prototype of the proposed system has been experimentally validated.
    Type of Medium: Online Resource
    ISSN: 2577-8196 , 2577-8196
    URL: Issue
    URL: Article
    DOI: 10.1002/eng2.v2.9
    DOI: 10.1002/eng2.12234
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2947569-7
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  • 4
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    Prevalence of Benign and Malignant Lesions in the Head Region: An Observational Study
    Lahore Medical and Dental College ; 2021
    In:  Pakistan Journal of Medical and Health Sciences Vol. 15, No. 11 ( 2021-11-30), p. 3378-3382
    Details
    In: Pakistan Journal of Medical and Health Sciences, Lahore Medical and Dental College, Vol. 15, No. 11 ( 2021-11-30), p. 3378-3382
    Abstract: Objective: The objective of this study was to evaluate the frequency of head benign and malignant lesions with regard to age group, sex, site and type of lesion and clinical variety in a tertiary care hospital in Lahore. Methodology: Basic research design: An observational cross-sectional study, included collection and analysis of histopathological data over the last 4 years i.e. 2016-2019. Test of significance chi-square was done for data analysis in IBM SPSS v17. Clinical setting: Pathology Departments of Sheikh Zayed Hospital (tertiary care hospital). Results: Sample included a total of 952 patient records in this study, with 587 (61.7%) males and 365 (38.3%) females. There were 514 cases of the head region and 438 cases of the neck region. Out of 514 total head region cases, 66 were malignant and 458 were benign. Participants were divided into age groups (1-18, 19-35, 36-50, 51-70, 70+) years respectively. The prevalence of benign cancers in head region was calculated in percentages according to which most patients were of nasal polyp at 26.3%, pleomorphic adenoma were 3.4%, with fibro-epithelial polyp were 9.5%. In the malignant category though Squamous cell carcinoma (SCC) was the most prevalent malignant lesion with highest frequency recorded in tongue region were 4.0%, rest with SCC nose were 0.6%, with SCC soft palate were 2.1%. The results of the chi-square revealed that there was a significant difference found with regards to the prevalence of various benign lesions in the head region between males (X2 = 1003.041, P 〉 .001) and females (X2 = 593.937, P 〉 .001). In addition, the difference among males and females was found statistically significant with regards to the prevalence of different types of malignant tumors in head region (for males, X2 = 238.447, P 〉 .001, for females, X2 = 112.641, P 〉 .001). With regards to the age groups the prevalence of different types of benign cancers was found to be statistically significant at head region (X2 = 140.500, P 〉 .001), however there was a non-significant difference between the age-wise prevalence of different types of malignant cancers of head region (X2 = 44.702, P = .281). Conclusion: A reappraisal of neoplastic lesions of this important anatomical region in this study highlight the wide spectrum of tumors encountered along with its relative frequency. Squamous cell carcinoma constitutes the highest percentage of all the malignancies in the head region. Though head malignancies are a serious concern, good awareness, education, and early diagnosis can reduce their incidence.
    Type of Medium: Online Resource
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.53350/pjmhs211511
    DOI: 10.53350/pjmhs2115
    DOI: 10.53350/pjmhs2115113378
    Language: Unknown
    Publisher: Lahore Medical and Dental College
    Publication Date: 2021
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  • 5
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    A quadruple blinded placebo controlled randomised trial to evaluate the effectiveness of an Iodine complex for patients with mild to moderate COVID-19 in Pakistan (I-COVID-PK): A structured summary of a study protocol for a randomised controlled trial
    Springer Science and Business Media LLC ; 2021
    In:  Trials Vol. 22, No. 1 ( 2021-12)
    Details
    In: Trials, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2021-12)
    Abstract: The objective of the study is to measure the efficacy of ionic-iodine polymer complex [1] for clinical and radiological improvement in coronavirus disease 2019 (COVID-19) patients. Trial design The trial will be closed label, randomized and placebo-controlled with a 1:1:1:1 allocation ratio and superiority framework. Participants All PCR confirmed COVID-19 adult patients including non-pregnant females, with mild to moderate disease, will be enrolled from Shaikh Zayed Post-Graduate Medical Complex, Ali Clinic and Doctors Lounge in Lahore (Pakistan). Patients with any pre-existing chronic illness will be excluded from the study. Intervention and comparator In this multi-armed study ionic-iodine polymer complex with 200 mg of elemental iodine will be given using three formulations to evaluate efficacy. Patients will be receiving either encapsulated iodine complex of 200 mg (arm A), iodine complex syrup form 40 ml (arm B), iodine complex throat spray of 2 puffs (arm C) or empty capsule (arm D) as placebo; all three times a day. All the 4 arms will be receiving standard care as per version 3.0 of the clinical management guidelines for COVID-19 established by the Ministry of National Health Services of Pakistan. Main outcomes Primary outcomes will be viral clearance with radiological and clinical improvement. SARS-CoV-2 RT-PCR and HRCT chest scans will be done on the admission day and then after every fourth day for 12 days or till the symptoms are resolved. RT-PCR will only be shown as positive or negative while HRCT chest scoring will be done depending on the area and severity of lung involvement [2]. Time taken for the alleviation of symptoms will be calculated by the number of days the patient remained symptomatic. 30-day mortality will be considered as a secondary outcome. Randomisation Stratification for initial COVID-19 status (or days from initial symptoms as a proxy), age groups, gender, baseline severity of symptoms and co-morbidities will be used to ensure that the study arms remain balanced in size for the 1:1:1:1 allocation ratio. Randomization will be done using the lottery method. As patients are being admitted at different times, they will be recruited after obtaining their voluntary written informed consent following all standard protocols of the infection, control and disinfection. Blinding (masking) This is a quadruple (participants, care providers, investigators and outcomes assessors) blinded study where only the study’s Primary Investigator will have information about the arms and their interventions. Numbers to be randomised (sample size) 200 patients will be randomized into four groups with three experimental and one placebo arm. Trial Status Protocol Version Number is 2.3 and it is approved from IRB Shaikh Zayed Hospital with ID SZMC/IRB/Internal0056/2020 on July 14 th , 2020. The recruitment is in progress. It was started on July 30, 2020, and the estimated end date for the trial is August 15, 2021. Trial registration Clinical Trial has been retrospectively registered on www.clinicaltrials.gov with registration ID NCT04473261 dated July 16, 2020. Full protocol The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). With the intention of expediting dissemination of this trial, the conventional formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. The study protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines.
    Type of Medium: Online Resource
    ISSN: 1745-6215
    URL: Article
    DOI: 10.1186/s13063-021-05081-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2040523-6
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  • 6
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    SARS-CoV-2 infection increases risk of acute kidney injury in a bimodal age distribution
    Springer Science and Business Media LLC ; 2022
    In:  BMC Nephrology Vol. 23, No. 1 ( 2022-12)
    Details
    In: BMC Nephrology, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2022-12)
    Abstract: Hospitalized patients with SARS-CoV2 develop acute kidney injury (AKI) frequently, yet gaps remain in understanding why adults seem to have higher rates compared to children. Our objectives were to evaluate the epidemiology of SARS-CoV2-related AKI across the age spectrum and determine if known risk factors such as illness severity contribute to its pattern. Methods Secondary analysis of ongoing prospective international cohort registry. AKI was defined by KDIGO-creatinine only criteria. Log-linear, logistic and generalized estimating equations assessed odds ratios (OR), risk differences (RD), and 95% confidence intervals (CIs) for AKI and mortality adjusting for sex, pre-existing comorbidities, race/ethnicity, illness severity, and clustering within centers. Sensitivity analyses assessed different baseline creatinine estimators. Results Overall, among 6874 hospitalized patients, 39.6% ( n  = 2719) developed AKI. There was a bimodal distribution of AKI by age with peaks in older age (≥60 years) and middle childhood (5–15 years), which persisted despite controlling for illness severity, pre-existing comorbidities, or different baseline creatinine estimators. For example, the adjusted OR of developing AKI among hospitalized patients with SARS-CoV2 was 2.74 (95% CI 1.66–4.56) for 10–15-year-olds compared to 30–35-year-olds and similarly was 2.31 (95% CI 1.71–3.12) for 70–75-year-olds, while adjusted OR dropped to 1.39 (95% CI 0.97–2.00) for 40–45-year-olds compared to 30–35-year-olds. Conclusions SARS-CoV2-related AKI is common with a bimodal age distribution that is not fully explained by known risk factors or confounders. As the pandemic turns to disproportionately impacting younger individuals, this deserves further investigation as the presence of AKI and SARS-CoV2 infection increases hospital mortality risk.
    Type of Medium: Online Resource
    ISSN: 1471-2369
    URL: Article
    DOI: 10.1186/s12882-022-02681-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041348-8
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  • 7
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    Frequency of CSF Rhinorrhoea in Patients Undergoing Endoscopic Transsphenoidal Surgery (ETSS) for Pituitary Macroadenoma
    Lahore Medical and Dental College ; 2022
    In:  Pakistan Journal of Medical and Health Sciences Vol. 16, No. 9 ( 2022-09-30), p. 400-402
    Details
    In: Pakistan Journal of Medical and Health Sciences, Lahore Medical and Dental College, Vol. 16, No. 9 ( 2022-09-30), p. 400-402
    Abstract: Introduction: Pituitary adenoma resection via the transsphenoidal approach (TSS)is a safe and common neurosurgical procedure that can be done both through microscopic and endoscopic methods. Objectives: The main objective of the study is to find the frequency of CSF rhinorrhoea in patients undergoing endoscopic transsphenoidal surgery (ETSS) for pituitary macroadenoma. Material and methods: The study data was collected from 1st Oct to 1st Nov 2022, in the departments of Neurosurgery of Hayatabad Medical complex, Khyber Teaching Hospital, Lady Reading Hospital, Peshawar. The data was collected through non-probability consecutive sampling technique. There were 315 patients which were included in the study. The surgical procedure is done under general anesthesia. All patient data was collected and a standardized form was filled by the attending surgeon caring for the patient. Importantly, the primary end points to be recorded were: (1) techniques of intraoperative cranium base reconstruction used, and (2) postoperative CSF rhinorrhoea biochemically confirmed and/or requiring intervention (CSF diversion and/or operative restoration). Results: Of the 315 consecutive patients diagnosed with pituitary adenomas, a total of 250 patients met the inclusion criteria and were included. The pathology included 187 (74.8%) non-functioning adenomas, 40 (16.0%) GH-secreting pituitary adenomas, 3 (1.2%) PRL-secreting pituitary adenomas, and 20 (8.0%) ACTH-secreting pituitary adenomas. There were 30 (12.0%) cases of microadenomas, 205 (82.0%) cases of macroadenomas, and 15 (6.0%) cases of giant adenomas. Intraoperative CSF leakages were determined throughout surgical procedure in eighty patients (32.0%). Postoperative CSF leaks occurred in 9 patients (3.6%), including seven patients with intraoperative CSF leaks. Practical implication: Practical implications of this study is: (1) easily find the CSF leakage (2) frequency of CSF rhinorrhoea in patients undergoing endoscopic transsphenoidal surgery Conclusion: It is concluded that macroadenoma ETSS surgery should be strictly monitored for post-operative CSF leakage and lumber drain is an effective prophylactic strategy. Keywords: Postoperative CSF Leakage, Pituitary Adenomas, ETSS, Surgery, Lumber
    Type of Medium: Online Resource
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.53350/pjmhs22169
    DOI: 10.53350/pjmhs2216
    DOI: 10.53350/pjmhs22169400
    Language: Unknown
    Publisher: Lahore Medical and Dental College
    Publication Date: 2022
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  • 8
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    Surgical Outcomes of Third Ventriculostomy in Patients of Obstructive Hydrocephalus
    Lahore Medical and Dental College ; 2022
    In:  Pakistan Journal of Medical and Health Sciences Vol. 16, No. 9 ( 2022-09-30), p. 391-393
    Details
    In: Pakistan Journal of Medical and Health Sciences, Lahore Medical and Dental College, Vol. 16, No. 9 ( 2022-09-30), p. 391-393
    Abstract: Introduction: Hydrocephalus is the accumulation of excess cerebrospinal fluid (CSF) in the ventricular system of the brain. Objectives: The main objective of this study is to find the surgical outcomes of third ventriculostomy in patients of obstructive hydrocephalus. Material and methods: The data was collected through non-probability consecutive sampling technique. There were 60 patients which were included in the study. A flexible endoscopic telecamera and a Bugbee electrocautery wire and monitor were used for the procedure. The main causes of hydrocephalus have been identified. history of meningitis, ventriculitis, or illness prior to the development of hydrocephalus; x-rays indicating separation or septa within the ventricles; or postoperative residue of hemosiderin or the presence of yellowish deposits were all taken into consideration of post infectious hydrocephalus. Results: There were 49 male and 11 female patients. The mean age of the patients was 39.38 ± 11.2 years. 27 (45%) patients had hydrocephalus due to tumors, 21 (35%) patients had aqueductal stenosis while 12 (20%) patients had benign cysts. Intraoperative bleeding occurred in 24 patients. ETV was successful in 54/60 – 90percent of the patients. A CSF leak was recognised in 09 patients. 07 patient developed a transient gaze palsy which had resolved when he came for his follow up visit on 10th post operative day. Practical implication: Use effective method for treatment of hydrocephalus in hospitals Conclusion: It is concluded that endoscopic third ventriculostomy, in general, is a very effective method of treatment for hydrocephalus. Keywords: Obstructive Hydrocephalus, ETV, Outcome, CSF, Brain, Ventricular
    Type of Medium: Online Resource
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.53350/pjmhs22169
    DOI: 10.53350/pjmhs2216
    DOI: 10.53350/pjmhs22169391
    Language: Unknown
    Publisher: Lahore Medical and Dental College
    Publication Date: 2022
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  • 9
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    Exploring the physical properties of Rb2TlSbM6 (M = Cl, Br) inorganic halide perovskites for solar cell applications: A DFT study
    Elsevier BV ; 2024
    In:  Inorganic Chemistry Communications ( 2024-5), p. 112528-
    Details
    In: Inorganic Chemistry Communications, Elsevier BV, ( 2024-5), p. 112528-
    Type of Medium: Online Resource
    ISSN: 1387-7003
    URL: Article
    DOI: 10.1016/j.inoche.2024.112528
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 2026959-6
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  • 10
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    Global Incidence and Risk Factors Associated With Postoperative Urinary Retention Following Elective Inguinal Hernia Repair : The Retention of Urine After Inguinal Hernia Elective Repair (RETAINER I) Study
    American Medical Association (AMA) ; 2023
    In:  JAMA Surgery Vol. 158, No. 8 ( 2023-08-01), p. 865-
    Details
    In: JAMA Surgery, American Medical Association (AMA), Vol. 158, No. 8 ( 2023-08-01), p. 865-
    Abstract: Postoperative urinary retention (POUR) is a well-recognized complication of inguinal hernia repair (IHR). A variable incidence of POUR has previously been reported in this context, and contradictory evidence surrounds potential risk factors. Objective To ascertain the incidence of, explore risk factors for, and determine the health service outcomes of POUR following elective IHR. Design, Setting, and Participants The Retention of Urine After Inguinal Hernia Elective Repair (RETAINER I) study, an international, prospective cohort study, recruited participants between March 1 and October 31, 2021. This study was conducted across 209 centers in 32 countries in a consecutive sample of adult patients undergoing elective IHR. Exposure Open or minimally invasive IHR by any surgical technique, under local, neuraxial regional, or general anesthesia. Main Outcomes and Measures The primary outcome was the incidence of POUR following elective IHR. Secondary outcomes were perioperative risk factors, management, clinical consequences, and health service outcomes of POUR. A preoperative International Prostate Symptom Score was measured in male patients. Results In total, 4151 patients (3882 male and 269 female; median [IQR] age, 56 [43-68] years) were studied. Inguinal hernia repair was commenced via an open surgical approach in 82.2% of patients (n = 3414) and minimally invasive surgery in 17.8% (n = 737). The primary form of anesthesia was general in 40.9% of patients (n = 1696), neuraxial regional in 45.8% (n = 1902), and local in 10.7% (n = 446). Postoperative urinary retention occurred in 5.8% of male patients (n = 224), 2.97% of female patients (n = 8), and 9.5% (119 of 1252) of male patients aged 65 years or older. Risk factors for POUR after adjusted analyses included increasing age, anticholinergic medication, history of urinary retention, constipation, out-of-hours surgery, involvement of urinary bladder within the hernia, temporary intraoperative urethral catheterization, and increasing operative duration. Postoperative urinary retention was the primary reason for 27.8% of unplanned day-case surgery admissions (n = 74) and 51.8% of 30-day readmissions (n = 72). Conclusions The findings of this cohort study suggest that 1 in 17 male patients, 1 in 11 male patients aged 65 years or older, and 1 in 34 female patients may develop POUR following IHR. These findings could inform preoperative patient counseling. In addition, awareness of modifiable risk factors may help to identify patients at increased risk of POUR who may benefit from perioperative risk mitigation strategies.
    Type of Medium: Online Resource
    ISSN: 2168-6254
    URL: Article
    DOI: 10.1001/jamasurg.2023.2137
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2023
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