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  • 1
    In: Frontiers in Physiology, Frontiers Media SA, Vol. 14 ( 2023-6-26)
    Abstract: Microplastics and pesticides are emerging contaminants in the marine biota, which cause many harmful effects on aquatic organisms, especially on fish. Fish is a staple and affordable food source, rich in animal protein, along with various vitamins, essential amino acids, and minerals. Exposure of fish to microplastics, pesticides, and various nanoparticles generates ROS and induces oxidative stress, inflammation, immunotoxicity, genotoxicity, and DNA damage and alters gut microbiota, thus reducing the growth and quality of fish. Changes in fish behavioral patterns, swimming, and feeding habits were also observed under exposures to the above contaminants. These contaminants also affect the Nrf-2, JNK, ERK, NF-κB, and MAPK signaling pathways. And Nrf2-KEAP1 signalling modulates redox status marinating enzymes in fish. Effects of pesticides, microplastics, and nanoparticles found to modulate many antioxidant enzymes, including superoxide dismutase, catalase, and glutathione system. So, to protect fish health from stress, the contribution of nano-technology or nano-formulations was researched. A decrease in fish nutritional quality and population significantly impacts on the human diet, influencing traditions and economics worldwide. On the other hand, traces of microplastics and pesticides in the habitat water can enter humans by consuming contaminated fish which may result in serious health hazards. This review summarizes the oxidative stress caused due to microplastics, pesticides and nano-particle contamination or exposure in fish habitat water and their impact on human health. As a rescue mechanism, the use of nano-technology in the management of fish health and disease was discussed.
    Type of Medium: Online Resource
    ISSN: 1664-042X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2564217-0
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  • 2
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2021
    In:  The Journal of Basic and Applied Zoology Vol. 82, No. 1 ( 2021-12)
    In: The Journal of Basic and Applied Zoology, Springer Science and Business Media LLC, Vol. 82, No. 1 ( 2021-12)
    Abstract: Although the apple snail Pila globosa is used as indicator species for human consumption locally and as fish feed, research on it in general is very scanty. It is used in food industry, in aquaculture as fish bait and used as food in many regions of India and many other countries, but research on it has been started in the 1970s. Only 40 articles are available on this organism in PubMed indicating an urgent need of basic research on it especially work on its spatiotemporal morphometry Therefore, sampling of P. globosa was done from different parts of India in different seasons (summer, winter and rainy), and different morphometric studies were performed on this organism to draw baseline information. Analysis was conducted to study morphometry, the relationship between shell length and the weight and relative condition factor of Indian apple snail Pila globosa collected from five zones (east, west, north, south and centre) of India during 2018–2019 year. Results The shell length (SL) (46.5 ± 13.33), shell width (SW) (40.22±11.5 mm), spire length (SPL) (2.99±0.15 mm), base length (BL) (12.53±2.94 mm), aperture length (AL) (21.95±4.36 mm), aperture width (AW) (2.74±0.47 mm) and shell weight (WT) (31.08±13.76 g) were observed to be varied among the individual sampled across India. Different relationships for SL/SW (Log SW=0.9889 Log SL + 0.9444), SL/SPL (Log SPL = 0.1452 Log SL+0.3815), SL/BL (Log BL=0.7789 Log SL+0.5814), SL/AL (Log AL= 0.6518 Log SL+0.9111) and SL/AW (Log AW=0.4475 Log SL+0.1422) were observed by considering shell length as basic index. The relationship between shell length and shell weight was found to be Log WT=2.0263 Log SL+0.1098. The relative condition factor revealed uninterrupted and good environmental condition observed for apple snails. A negative allometric growth pattern was observed from the length–weight relationship. Conclusion The environments of apple snail in India are not contaminated, and the results can be used as baseline data in aquaculture for model analysis and can be used as a reference for drawing relationship among different morphometric indices of P. globosa in India, as there is no such information available on it. The data can also be used for mass scale production of P. globosa for consumption by human and use in aquatic industries as fish feed.
    Type of Medium: Online Resource
    ISSN: 2090-990X
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2718645-3
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  • 3
    In: Cancers, MDPI AG, Vol. 14, No. 18 ( 2022-09-19), p. 4539-
    Abstract: The ongoing rise in the number of cancer cases raises concerns regarding the efficacy of the various treatment methods that are currently available. Consequently, patients are looking for alternatives to traditional cancer treatments such as surgery, chemotherapy, and radiotherapy as a replacement. Medicinal plants are universally acknowledged as the cornerstone of preventative medicine and therapeutic practices. Annona muricata is a member of the family Annonaceae and is familiar for its medicinal properties. A. muricata has been identified to have promising compounds that could potentially be utilized for the treatment of cancer. The most prevalent phytochemical components identified and isolated from this plant are alkaloids, phenols, and acetogenins. This review focuses on the role of A. muricata extract against various types of cancer, modulation of cellular proliferation and necrosis, and bioactive metabolites responsible for various pharmacological activities along with their ethnomedicinal uses. Additionally, this review highlights the molecular mechanism of the role of A. muricata extract in downregulating anti-apoptotic and several genes involved in the pro-cancer metabolic pathways and decreasing the expression of proteins involved in cell invasion and metastasis while upregulating proapoptotic genes and genes involved in the destruction of cancer cells. Therefore, the active phytochemicals identified in A. muricata have the potential to be employed as a promising anti-cancer agent.
    Type of Medium: Online Resource
    ISSN: 2072-6694
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2527080-1
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  • 4
    Online Resource
    Online Resource
    Avinashilingam Institute for Home Science and Higher Education for Women ; 2021
    In:  The Indian Journal of Nutrition and Dietetics ( 2021-05-18), p. 81-91
    In: The Indian Journal of Nutrition and Dietetics, Avinashilingam Institute for Home Science and Higher Education for Women, ( 2021-05-18), p. 81-91
    Abstract: Herbal extracts are indicative of the most important areas of traditional medicine in the world. In order to establish their potential as a source of phytomedicine, the study of medicinal plants is important to facilitate the proper use of herbal medicine. Annona muricata L. commonly known as Soursop belongs to the family Annonaceae. The active constituents present in the plant have preventive effects for various diseases. "Acetogenins” are powerful phytochemicals present in the Annona muricata. These compounds collectively have shown antitumor, parasiticidal, pesticidal and antimicrobial activities. The objective of the present study is to isolate, identify acetogenin rich fraction from Annona muricata leaves and to evaluate the capacity of free radical scavenging. This evidence stated that acetogenin rich fraction could be isolated from Annona muricata leaves and this important phytochemical compound was easily identified by using kedde's reagent. All the four fractions (F1C, F2C, F3C and F4C) tested for radical scavenging activity possess considerable scavenging activity, among the extracts tested F4C fraction exhibited highest scavenging activity.
    Type of Medium: Online Resource
    ISSN: 2348-621X , 0022-3174
    Language: Unknown
    Publisher: Avinashilingam Institute for Home Science and Higher Education for Women
    Publication Date: 2021
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  • 5
    In: Life, MDPI AG, Vol. 12, No. 12 ( 2022-12-15), p. 2123-
    Abstract: In the present study, the anti-proliferative and apoptotic potential of Tabebuia roseo-alba in lung cancer was assessed. Silver nanoparticles (AgNPs) of T. roseo-alba were synthesized using an ethanolic extract and characterized by adopting various parameters. Herein, the eco-friendly, cost-effective, and green synthesis of AgNPs was evaluated using an ethanolic extract of T. roseo-alba. The as-synthesized AgNPs were then characterized using various characterization techniques, such as UV-visible spectroscopy (UV-vis), X-ray powder diffraction (XRD), dynamic light scattering (DLS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The AgNPs are crystalline, spherical, and highly stable AgNPs of varying sizes in the range of 5–20 nm. The anticancer activity of the ethanolic extract of T. roseo-alba and its AgNPs was determined using an MTT assay. The results indicated that, although both samples showed prominent anti-proliferative activity on lung cancer cell lines, the AgNPs of T. roseo-alba were found to be more potent than the ethanolic extract. Further, apoptosis induction ability was evaluated by FITC Annexin V and PI staining, the results of which demonstrated the efficiency of the ethanolic extract of T. roseo-alba and its AgNPs in causing oxidative stress and subsequent cellular death. This was subsequently further confirmed by measuring the mitochondrial membrane potential after staining the cells with JC1. The apoptotic mode of cell death was further confirmed by DNA fragmentation and caspase assays using Western blot analysis.
    Type of Medium: Online Resource
    ISSN: 2075-1729
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662250-6
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  • 6
    Online Resource
    Online Resource
    ScienSage ; 2021
    In:  Journal of Advanced Scientific Research Vol. 12, No. 03 Suppl 1 ( 2021-09-30), p. 76-85
    In: Journal of Advanced Scientific Research, ScienSage, Vol. 12, No. 03 Suppl 1 ( 2021-09-30), p. 76-85
    Abstract: Plant mediated green synthesis of silver nanoparticles has gained much importance in the current scenario. In this study, Tabebuia pallida leaves were used as a reducing agent for the sunlight mediated green synthesis of silver nanoparticles. The formation of silver nanoparticles was confirmed by UV-Vis spectroscopy which exhibited absorption maxima at 450 nm which is the characteristic of silver nanoparticles. Further, the characterization of the silver nanoparticles were carried out using Fourier transform infrared spectroscopy analysis, Field Emission Scanning Electron Microscope, Dynamic Light Scattering, and X-ray diffraction analysis. The size of the synthesized silver nanoparticles was found to be ranging between 31.76 nm-50.36 nm and is spherical in shape. The crystalline nature of the synthesized nanoparticles was confirmed by x-ray diffraction. Furthermore, the green synthesized silver nanoparticles were evaluated for their free radical scavenging activity using DPPH Radical Scavenging assay, ABTS radical scavenging assay, Hydroxyl radical scavenging activity, Reducing Power assay and Nitric oxide radical scavenging assay compared with the standard antioxidant Quercetin. Green synthesized silver nanoparticles exhibited a higher antioxidant activity against all the tested free radicals. From this evidences, it could be concluded that the green synthesized Tabebuia pallida silver nanoparticles can be used as a potential antioxidant for pharmaceutical applications.
    Type of Medium: Online Resource
    ISSN: 0976-9595
    Language: Unknown
    Publisher: ScienSage
    Publication Date: 2021
    detail.hit.zdb_id: 2710780-2
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  • 7
    Online Resource
    Online Resource
    IMR Press ; 2019
    In:  Frontiers in Bioscience Vol. 11, No. 1 ( 2019), p. 29-55
    In: Frontiers in Bioscience, IMR Press, Vol. 11, No. 1 ( 2019), p. 29-55
    Type of Medium: Online Resource
    ISSN: 1945-0516 , 1945-0524
    Language: English
    Publisher: IMR Press
    Publication Date: 2019
    detail.hit.zdb_id: 2573040-X
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  • 8
    Online Resource
    Online Resource
    IMR Press ; 2020
    In:  Frontiers in Bioscience Vol. 25, No. 6 ( 2020), p. 1058-1109
    In: Frontiers in Bioscience, IMR Press, Vol. 25, No. 6 ( 2020), p. 1058-1109
    Type of Medium: Online Resource
    ISSN: 1093-9946 , 1093-4715
    Language: English
    Publisher: IMR Press
    Publication Date: 2020
    detail.hit.zdb_id: 2704569-9
    detail.hit.zdb_id: 2084402-5
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  • 9
    In: Biomedicines, MDPI AG, Vol. 11, No. 1 ( 2023-01-14), p. 217-
    Abstract: Silver nanoparticles act as antitumor agents because of their antiproliferative and apoptosis-inducing properties. The present study aims to develop silver nanoparticle-loaded liposomes for the effective management of cancer. Silver nanoparticle-encapsulated liposomes were prepared using the thin-film hydration method coupled with sonication. The prepared liposomes were characterized by DLS (Dynamic Light Scattering analysis), FESEM (Field Emission Scanning Electron Microscope), and FTIR (Fourier Transform Infrared spectroscopy). The in vitro drug release profile of the silver nanoparticle-loaded liposomes was carried out using the dialysis bag method and the drug release profile was validated using various mathematical models. A high encapsulation efficiency of silver nanoparticle-loaded liposome was observed (82.25%). A particle size and polydispersity index of 172.1 nm and 0.381, respectively, and the zeta potential of −21.5 mV were recorded. FESEM analysis revealed spherical-shaped nanoparticles in the size range of 80–97 nm. The in vitro drug release profile of the silver nanoparticle-loaded liposomes was carried out using the dialysis bag method in three different pHs: pH 5.5, pH 6.8, and pH 7.4. A high silver nanoparticle release was observed in pH 5.5 which corresponds to the mature endosomes of tumor cells; 73.32 ± 0.68% nanoparticle was released at 72 h in pH 5.5. Among the various mathematical models analyzed, the Higuchi model was the best-fitted model as there is the highest value of the correlation coefficient which confirms that the drug release follows the diffusion-controlled process. From the Korsmeyer–Peppas model, it was confirmed that the drug release is based on anomalous non-Fickian diffusion. The results indicate that the silver nanoparticle-loaded liposomes can be used as an efficient drug delivery carrier to target cancer cells of various types.
    Type of Medium: Online Resource
    ISSN: 2227-9059
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2720867-9
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  • 10
    In: Frontiers in Environmental Science, Frontiers Media SA, Vol. 11 ( 2023-9-15)
    Abstract: Fish are among the best-studied aquatic animals due to their economic and ecological values. Fish meat is the most affordable protein source for the economically weaker section of people. The environment of almost all aquatic ecosystems has a specific influential role on or by fishes. Therefore, studying their stress biology, especially oxidative stress, is vital because it can influence their growth, production, reproduction, etc. To review the above topic, peer-reviewed electronic databases, including Web of Science, science direct, PubMed, Google Scholar, Scopus, and AGRICOLA, were searched with specific keywords associated with fish, oxidative stress, diseases, etc. The influence of abiotic stress, such as the effects of water dissolved oxygen, temperature, salinity, water hardness, alkalinity, pH, pollutants, heavy metals, and anthropogenic activities, was reviewed in the current article to draw a conclusion on the updated relation that exists between fish physiology, disease, and abiotic stressors. Oxidative stress and redox regulatory levels under the above parameters were reviewed as the stress or anti-stress responses differ in various fish models. Undoubtedly, the reviewed abiotic factors modulate fish oxidative health status to a greater extent, and therefore, these factors must be considered on a priority basis to improve the general health and immunity status of fish. The statement above remains valid in both saline and freshwater habitats.
    Type of Medium: Online Resource
    ISSN: 2296-665X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2741535-1
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