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  • 1
    Online Resource
    Online Resource
    Patient Awareness about the indications for and complications of sleeve gastrectomy in the western region of Saudi Arabia
    Medi + World International ; 2022
    In:  World Family Medicine Journal /Middle East Journal of Family Medicine Vol. 20, No. 9 ( 2022-9)
    Details
    In: World Family Medicine Journal /Middle East Journal of Family Medicine, Medi + World International, Vol. 20, No. 9 ( 2022-9)
    Abstract: Introduction and Research Problem: Obesity can be defined as a BMI of 30 kg/m2 or higher. It has been recognized as the 2nd largest cause of avoidable early mortality in the USA. Bariatric surgery is a weight-loss surgical technique that is mostly suggested for morbidly obese individuals (BMI greater than 40) without comorbidities and BMI 35 with comorbidities. The goal of the study was to assess patient awareness about the indications for and complications of, sleeve gastrectomy, as there is an insignificant number of studies related to our topic, in Saudi Arabia. Materials and Methods: An observational cross-sectional study conducted in the western part of Saudi Arabia. The study’s population included all patients of sleeve gastrectomy from the Western Region of Saudi Arabia. The instrument used was an electronic questionnaire, which included questions about knowledge of sleeve gastrectomy indications and complications. Summary of Results: The questionnaire was sent to 451 patients who underwent sleeve gastrectomy, and about 444 patients gave consent to participate. It was found that the participants who were aware of the indications and complications of sleeve gastrectomy before undergoing the procedure were 313 (70.5%) and 303 (68.2%). female patients had significantly more awareness related to the indications (p 〈 0.001) and complications (p=0.001). Patients who had an educational qualification of Masters and above had more awareness regarding indications of SG before surgery than others (p=0.008). Conclusion and Recommendations: According to the findings of our study, knowledge regarding the indications for and complications associated with sleeve gastrectomy is not satisfactory. There is a need to raise public understanding of the indications for and consequences of, sleeve gastrectomy. Key words: Patient awareness, indications, complications, sleeve gastrectomy, Saudi Arabia
    Type of Medium: Online Resource
    URL: Journal
    URL: Article
    DOI: 10.5742/MEWFM
    DOI: 10.5742/MEWFM.2022.9525132
    Language: Unknown
    Publisher: Medi + World International
    Publication Date: 2022
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  • 2
    Online Resource
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    Angelica archangelica and Ginkgo biloba Extracts Recover Functional Blood Hemoglobin Derivatives in Rabbits Exposed to High Altitude
    Bentham Science Publishers Ltd. ; 2022
    In:  Current Pharmaceutical Biotechnology Vol. 23, No. 11 ( 2022-09), p. 1377-1382
    Details
    In: Current Pharmaceutical Biotechnology, Bentham Science Publishers Ltd., Vol. 23, No. 11 ( 2022-09), p. 1377-1382
    Abstract: Shortage of oxygen is a common condition for residents of high-altitude (HA) areas. In mammals, hemoglobin (Hb) has four derivatives: oxyhemoglobin (Hb-O2), carboxyhemoglo-bin (Hb-CO), sulfhemoglobin (Hb-S), and methemoglobin (Met-Hb). In HA areas, aberrant physio-logical performance of blood hemoglobin is well-established. Objective: The study aimed to investigate the influence of 30 days of HA residence on rabbits' total Hb, Hb derivatives, Hb autooxidation rate, and antioxidant enzymes in comparison to low-altitude control rabbits. Further, the study aimed to investigate the effect of antioxidant-rich Angelica archan-gelica and/or Ginkgo biloba extracts on the same parameters in HA-resident rabbits. Methods: Rabbits subjected to 30 days of HA residence were compared to low-altitude control rabbits. HA-residence rabbits were then orally administered 0.11 g/kg b.wt. of Angelica archangelica and/or Ginkgo biloba extract for 14 days. Hb derivatives and Hb autooxidation rate were measured spectro-photometrically. Antioxidant enzymes were estimated using specialized kits. Results: Compared to low-altitude rabbits, 30-day HA-residence rabbits showed a noticeable increase (p 〈 0.05) in Hb-O2 and Hb-CO concentration. In addition, Met-Hb concentration, autooxidation rate of Hb molecules, and activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) exhib-ited a remarkable increase in HA-residence rabbits (p 〈 0.01), reflective of rapid ROS generation. In HA-residence rabbits, both individual and combined treatment with antioxidant-rich extracts for 14 days resulted in recovery to near-normal functional levels of Hb-O2 and Met-Hb, Hb autooxidation rate, and activities of SOD and GPx, while only combined treatment led to Hb-O2 recovery. Conclusion: The findings suggest that functional Hb levels may be recovered by oral administration of A. archangelica, G. biloba, or combined treatments. In conclusion, oxidative stress due to living in HA areas may be avoided by supplementation with natural antioxidants.
    Type of Medium: Online Resource
    ISSN: 1389-2010
    URL: Article
    DOI: 10.2174/1389201022666211118112356
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
    SSG: 15,3
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  • 3
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    Anti-proliferative effects of the combination of Sulfamethoxazole and Quercetin via caspase3 and NFkB gene regulation: an in vitro and in vivo study
    Springer Science and Business Media LLC ; 2022
    In:  Naunyn-Schmiedeberg's Archives of Pharmacology Vol. 395, No. 2 ( 2022-02), p. 227-246
    Details
    In: Naunyn-Schmiedeberg's Archives of Pharmacology, Springer Science and Business Media LLC, Vol. 395, No. 2 ( 2022-02), p. 227-246
    Type of Medium: Online Resource
    ISSN: 0028-1298 , 1432-1912
    URL: Article
    DOI: 10.1007/s00210-021-02174-3
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1462940-9
    SSG: 15,3
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  • 4
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    The modulatory effect of bee honey against diethyl nitrosamine and carbon tetrachloride instigated hepatocellular carcinoma in Wistar rats
    Oxford University Press (OUP) ; 2021
    In:  Toxicology Research Vol. 10, No. 6 ( 2021-12-22), p. 1092-1103
    Details
    In: Toxicology Research, Oxford University Press (OUP), Vol. 10, No. 6 ( 2021-12-22), p. 1092-1103
    Abstract: Hepatocellular carcinoma (HCC) is a serious threat to human health that has attracted substantial interest. The purpose of this study was to investigate the modulatory effect of bee honey against induced HCC by diethylnitrosamine/carbon tetrachloride (DEN/CCl4) in rats. HCC was induced by a single intraperitoneal dose of DEN (200 mg/kg B.W). Two weeks later, CCl4 (1 ml/kg) was intraperitoneally injected (three times a week). Bee honey was administered orally at 2 g/rat before and after the induction of HCC. The results showed that bee honey administration significantly increased body weight, decreased liver weight, and relative liver weight compared to those in the HCC-induced group. Moreover, a significant decrease in serum alpha-fetoprotein (AFP) as well as AST, ALT, GGT, ALP activities were observed in bee honey administration rats compared with those in HCC-induced group. Also, the hepatic MDA was significantly decreased; in addition, SOD, CAT, and GPx activities were significantly increased in groups treated with bee honey compared with those in the HCC group. The hepatic histopathology alterations caused by DEN/CCl4 injection were ameliorated by bee honey treatment. Likewise, the mRNA expression levels of tumor necrosis factor-alpha (TNF-α), transforming growth factor (TGF-β1), intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), glypican (GP-3), thioredoxin (TRX), and glutaredoxin (GRX) were downregulated, and caspase-3 was upregulated by bee honey treatment compared with untreated HCC-induced group. In conclusion, bee honey has remarkable beneficial effects against HCC induced in rats through its antioxidant, anti-inflammatory, antifibrotic, and antimetastatic effects. Practical Applications The current study confirmed that honey has the potential to act as an antimetastatic factor. Bee honey supplementation either before or after combined injection of DEN/CCl4 exhibited inhibitory and ameliorative effects against DEN/CCl4-induced HCC through its antioxidant, antiproliferative, anti-metastatic, antifibrotic, and apoptosis properties. To our knowledge, this is the first study to describe the molecular mechanisms underlying honey’s effects against DEN/CCl4-induced HCC in rats.
    Type of Medium: Online Resource
    ISSN: 2045-4538
    URL: Article
    DOI: 10.1093/toxres/tfab094
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2684701-2
    SSG: 15,3
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  • 5
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    The chemoprevention of spirulina platensis and garlic against diethylnitrosamine induced liver cancer in rats via amelioration of inflammatory cytokines expression and oxidative stress
    Oxford University Press (OUP) ; 2022
    In:  Toxicology Research Vol. 11, No. 1 ( 2022-02-26), p. 22-31
    Details
    In: Toxicology Research, Oxford University Press (OUP), Vol. 11, No. 1 ( 2022-02-26), p. 22-31
    Abstract: Natural antioxidant products play a vital role in the treatment and prevention of cancer disease because they have no side effects. This study aimed to compare the chemoprotective effect of Spirulina platensis (SP) and garlic against hepatocellular carcinoma (HCC) in rats. This study was being done by using 60 male Wistar rats and divided into four groups. Group (I): normal group. Group (II): HCC group induced by injection of a single dose of DEN (200 mg/kg/I.P) and after 14 days injected CCl4 (1 mg/kg/I.P) 3 times/week/six weeks. Group (III): HCC group received SP orally at a dose (500 mg/kg). Group (IV): HCC group received garlic (250 mg/kg) orally. The results revealed that the Spirulina and garlic treatment have a significant decrease in Glutamate pyruvate transaminase, Glutamate oxaloacetate transaminase, GGT, LDH, and the Malondialdehyde (MDA) activity, and furthermore, a significant increase in the total protein level, the superoxide dismutase (SOD), and Catalase (CAT) activity nearly to normal activity. Furthermore, the hepatic expression of tumor necrosis factor (TNF-α), interleukin-6 (IL-6), inducible nitric oxide synthase, transforming growth factor-beta (TGF-β1), Heat Shock Protein glycoprotein 96 (HSPgp96), and Glypican 3 (GP3) were down regulated by the Spirulina and garlic treatment in comparison with those in HCC group. All findings reported that the chemoprotective of both Spirulina and garlic that have nearly the same effect may be due to antioxidant activity and inhibition of lipid peroxidation, amelioration of pro-inflammatory cytokine, HSPgp96, and GP3.
    Type of Medium: Online Resource
    ISSN: 2045-4538
    URL: Article
    DOI: 10.1093/toxres/tfab118
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2684701-2
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  • 6
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    Molecular and Histopathological Study on the Ameliorative Impacts of Petroselinum Crispum and Apium Graveolens against Experimental Hyperuricemia
    Springer Science and Business Media LLC ; 2020
    In:  Scientific Reports Vol. 10, No. 1 ( 2020-06-11)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2020-06-11)
    Abstract: Hyperuricemia is an abnormal metabolic condition characterized by an increase in uric acid levels in the blood. It is the cause of gout, manifested by inflammatory arthritis, pain and disability. This study examined the possible ameliorative impacts of parsley (PAR) and celery (CEL) as hypouricemic agents at biochemical, molecular and cellular levels. PAR and CEL alone or in combination were orally administered to hyperuricemic (HU) mice and control mice for 10 consecutive days. Serum levels of uric acid and blood urea nitrogen (BUN), xanthine oxidase activity, antioxidants, inflammatory (IL-1β and TNF-α) and anti-inflammatory cytokines (IL-10) were measured. mRNA expression of urate transporters and uric acid excretion genes in renal tissues were examined using qRT-PCR (quantitative real time PCR). Normal histology and immunoreactivity of transforming growth factor-beta 1 (TGF-β1) in kidneys was examined. Administration of PAR and CEL significantly reduced serum BUN and uric acids in HU mice, ameliorated changes in malondialdehyde, catalase, and reduced glutathione, glutathione peroxidase (GPX), IL-1β, TNF-α and IL-10 in hyperuricemic mice. Both effectively normalized the alterations in mURAT-1, mGLUT-9, mOAT-1 and mOAT-3 expression, as well as changes in TGF-β1 immunoreactivity. Interestingly, combined administration of PAR and CEL mitigated all examined measurements synergistically, and improved renal dysfunction in the hyperuricemic mice. The study concluded that PAR and CEL can potentially reduce damaging cellular, molecular and biochemical effects of hyperuricemia both individually and in combination.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-020-66205-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2615211-3
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  • 7
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    Phthalimide Analogs Enhance Genotoxicity of Cyclophosphamide and Inhibit Its Associated Hypoxia
    Frontiers Media SA ; 2022
    In:  Frontiers in Chemistry Vol. 10 ( 2022-4-20)
    Details
    In: Frontiers in Chemistry, Frontiers Media SA, Vol. 10 ( 2022-4-20)
    Abstract: Cyclophosphamide (CP) is a mutagen that is used in cancer chemotherapy, due to its genotoxicity and as an immunosuppressive agent . Thalidomide (TH) is another cancer chemotherapeutic drug. In this study, the cytogenotoxicity and hypoxia modulatory activities of two phthalimide analogs of TH have been evaluated with/without CP. Both analogs have increased CP-stimulated chromosomal aberrations than those induced by TH, including gaps, breaks/fragments, deletions, multiple aberrations, and tetraploidy. The analogs have elevated the cytotoxic effect of CP by inhibiting the mitotic activity, in which analog 2 showed higher mitosis inhibition. CP has induced binucleated and polynucleated bone marrow cells (BMCs), while micronuclei (MN) are absent. TH and analogs have elevated the CP-stimulated binucleated BMCs, while only analogs have increased the CP-induced polynucleated BMCs and inhibited the mononucleated BMCs. MN-BMCs were shown together with mononucleated, binucleated, and polynucleated cells in the CP group. Both analogs have elevated mononucleated and polynucleated MN-BMCs, whereas in presence of CP, TH and analogs have enhanced mononucleated and binucleated MN-BMCs. The analogs significantly induce DNA fragmentation in a comet assay, where analog 1 is the strongest inducer. The treatment of mice with CP has resulted in a high hypoxia status as indicated by high pimonidazole adducts and high HIF-1α and HIF-2α concentrations in lymphocytes. Analogs/CP-treated mice showed low pimonidazole adducts. Both analogs have inhibited HIF-1α concentration but not HIF-2α. Taken together, the study findings suggest that both analogs have a higher potential to induce CP-genotoxicity than TH and that both analogs inhibit CP-hypoxia via the HIF-1α-dependent mechanism, in which analog 1 is a more potent anti-hypoxic agent than analog 2. Analog 1 is suggested as an adjacent CP-complementary agent to induce CP-genotoxicity and to inhibit CP-associated hypoxia.
    Type of Medium: Online Resource
    ISSN: 2296-2646
    URL: Article
    DOI: 10.3389/fchem.2022.890675
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2711776-5
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  • 8
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    Characterization and in vitro cytotoxic assessment of zinc oxide nano-particles in human epidermoid carcinoma cells
    Elsevier BV ; 2021
    In:  Journal of Environmental Chemical Engineering Vol. 9, No. 4 ( 2021-08), p. 105636-
    Details
    In: Journal of Environmental Chemical Engineering, Elsevier BV, Vol. 9, No. 4 ( 2021-08), p. 105636-
    Type of Medium: Online Resource
    ISSN: 2213-3437
    URL: Article
    DOI: 10.1016/j.jece.2021.105636
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2710047-9
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  • 9
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    Antimicrobial, antioxidant and cytotoxic properties of Chenopodium glaucum L.
    Public Library of Science (PLoS) ; 2021
    In:  PLOS ONE Vol. 16, No. 10 ( 2021-10-29), p. e0255502-
    Details
    In: PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 10 ( 2021-10-29), p. e0255502-
    Abstract: We evaluated phytochemical composition, antibacterial, antifungal, anti-oxidant and cytotoxic properties of aqueous (water) and organic extracts (methanol, ethyl acetate and n -hexane) of Chenopodium glaucum . Highest phenolic content 45 mg gallic acid equivalents (GAE)/g d.w was found in aqueous extract followed by ethyl acetate (41mg GAE/g d.w) and methanol extract (34.46 mg GAE/g d.w). Antibacterial potential of aqueous and organic extracts of C . glaucum was examined against Acinetobacter baumannii , Klebsiella pneumoniae , Escherichia coli and Staphylococcus epidermidis . The aqueous, methanolic, ethyl acetate, and n -hexane extract showed antibacterial activity against A . baumannii , K . pneumoniae , E . coli and S . epidermidis . However, against A . baumannii significantly higher inhibition zone (19 mm and 18.96 mm respectively) was shown by ethyl acetate and methanol extracts. Aqueous extract possessed highest growth inhibition (11 mm) against E . coli . Aqueous, ethyl acetate and methanol extracts showed 9 mm, 10 mm, and 10.33 mm zone of inhibition against the K . pneumoniae . For antifungal activity, the extracts were less effective against Aspergillus niger but showed strong antifungal activity against Aspergillus flavus ( A . flavus ). The antioxidant activity was measured as DPPH (2, 2-diphenyl-1-picrylhydrazyl), H 2 O 2 and ABTS (2, 2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) scavenging activity of free radicals. All the organic extracts of C . glaucum possessed ABTS, DPPH and H 2 O 2 scavenging properties. The highest cytotoxic activity measured as half maximal inhibitory concentration (IC50) against human lungs carcinoma cells was recorded for methanolic (IC50 = 16 μg/mL) and n -hexane (IC50 = 25 μg/mL) extracts, respectively. The Gas chromatography–mass spectrometry (GC-MS) analysis showed 4 major and 26 minor compounds in n -hexane extract and 4 major and 7 minor compounds in methanol extract of the C . glaucum . It is concluded that aqueous and organic extracts of C . glaucum would be potential therapeutic agents and could be exploited on a pilot scale to treat human pathogenic diseases.
    Type of Medium: Online Resource
    ISSN: 1932-6203
    URL: Article
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    DOI: 10.1371/journal.pone.0255502
    DOI: 10.1371/journal.pone.0255502.g001
    DOI: 10.1371/journal.pone.0255502.g002
    DOI: 10.1371/journal.pone.0255502.g003
    DOI: 10.1371/journal.pone.0255502.g004
    DOI: 10.1371/journal.pone.0255502.g005
    DOI: 10.1371/journal.pone.0255502.g006
    DOI: 10.1371/journal.pone.0255502.g007
    DOI: 10.1371/journal.pone.0255502.t001
    DOI: 10.1371/journal.pone.0255502.t002
    Language: English
    Publisher: Public Library of Science (PLoS)
    Publication Date: 2021
    detail.hit.zdb_id: 2267670-3
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  • 10
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    Investigation of the antioxidant defensive role of both AD-MSCs and BM-MSCs in modulating the alteration in the oxidative stress status in various STZ-diabetic rats’ tissues
    Computers, Materials and Continua (Tech Science Press) ; 2021
    In:  BIOCELL Vol. 45, No. 6 ( 2021), p. 1561-1568
    Details
    In: BIOCELL, Computers, Materials and Continua (Tech Science Press), Vol. 45, No. 6 ( 2021), p. 1561-1568
    Type of Medium: Online Resource
    ISSN: 1667-5746
    URL: Article
    DOI: 10.32604/biocell.2021.016869
    Language: English
    Publisher: Computers, Materials and Continua (Tech Science Press)
    Publication Date: 2021
    detail.hit.zdb_id: 2143008-1
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