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  • 1
    Online Resource
    Online Resource
    Biomechanics in Oncology (2018)
    Cham : Springer International Publishing
    Details Availability
    Keywords: Biomedical Engineering/Biotechnology ; Oncology   ; Oncology ; Oncology   ; Biomedical engineering ; Oncology ; Biomedical engineering ; Cancer research. ; Neoplasms ; Medical Oncology methods ; Biomechanical Phenomena ; Tumor Microenvironment ; Cell Physiological Phenomena ; Onkologie ; Biomechanik
    Description / Table of Contents: This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology. This book also: Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing, and fluid flow dynamics contribute to tumor progression and the metastatic process Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy Includes insight into NCIs’ role in supporting biomechanics in oncology research Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer
    Type of Medium: Online Resource
    Pages: Online-Ressource (XII, 376 p. 111 illus., 94 illus. in color, online resource)
    Edition: Springer eBook Collection. Biomedical and Life Sciences
    ISBN: 9783319952949
    Series Statement: Advances in Experimental Medicine and Biology 1092
    URL: https://doi.org/10.1007/978-3-319-95294-9
    URL: http://dx.doi.org/10.1007/978-3-319-95294-9
    DOI: 10.1007/978-3-319-95294-9
    RVK:
    XH 2553
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Faceting of tungsten(111) induced by ultrathin palladium films (1991)
    s.l. : American Chemical Society
    Langmuir 7 (1991), S. 3019-3026 
    Details
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/la00060a019
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    PowderX: Windows-95-based program for powder X-ray diffraction data processing (1999)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 32 (1999), S. 838-838 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889899003039
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    LAPODS: a computer program for refinement of lattice parameters using optimal regression (2000)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 33 (2000), S. 1177-1179 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: LAPODS is an upgraded version of the program LAPOD for the refinement of lattice parameters using the method of Cohen [Langford (1971). J. Appl. Cryst. 4, 259–260]. The improved version has a number of advanced features. It can detect the most significant systematic errors automatically by means of a statistical F test; it can also operate in a manual mode with corrections set by the user or input manually. The single-value decomposition (SVD) method is used so that the refinement is now more stable. The general formula to calculate the specimen-transparency error has been incorporated and a transparency correction can now be made when the absorption is intermediate between the limiting cases of `thick' or `thin' samples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889800006622
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  • 5
    Electronic Resource
    Electronic Resource
    The Expression of Cdk5, p35, p39, and Cdk5 Kinase Activity in Developing, Adult, and Aged Rat Brains (2000)
    Springer
    Neurochemical research 25 (2000), S. 923-929 
    Details
    ISSN: 1573-6903
    Keywords: Cdk5 ; p35 ; p39 ; cerebral cortex ; hippocampus ; development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The expression of cyclin-dependent kinase 5 (Cdk5) and its regulatory subunits, p35 and p39, was investigated in rat brain from embryonic day 12 (E12) to postnatal 18 months (18M). The Cdk5 protein levels increased from E12 to postnatal day 7 (P7) and remained at this level until 18M. The Cdk5 kinase activity and the levels of both p35 mRNA and protein were low at E12, became prominent at E18-P14 but then decreased in the adult and aged rat brains of 3M to 18M. In comparison, the expression pattern of p39 appeared to have an inverse relationship to that of Cdk5 and p35. In regional distribution studies, p35 protein levels and Cdk5 kinase activity were significantly higher in the cerebral cortex and hippocampus, but lower in the cerebellum and striatum. These results suggested that Cdk5, p35 and p39 might have region-specific and developmental stage-specific functions in rat brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007544106645
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  • 6
    Electronic Resource
    Electronic Resource
    Mechanics of Leukocyte Deformation and Adhesion to Endothelium in Shear Flow (1999)
    Springer
    Annals of biomedical engineering 27 (1999), S. 298-312 
    Details
    ISSN: 1573-9686
    Keywords: In vivo ; Incipient cell rolling ; Transient contact ; Drag force ; Modeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The mechanics of leukocyte [white blood cell (WBC)] deformation and adhesion to endothelial cells (EC) in shear flow has been investigated. Experimental data on transient WBC–EC adhesion were obtained from in vivo measurements. Microscopic images of WBC–EC contact during incipient WBC rolling revealed that for a given wall shear stress, the contact area increases with time as new bonds are formed at the leading edge, and then decreases with time as the trailing edge of the WBC membrane peels away from the EC. A two-dimensional model (2D) was developed consisting of an elastic ring adhered to a surface under fluid stresses. This ring represents an actin-rich WBC cortical layer and contains an incompressible fluid as the cell interior. All molecular bonds are modeled as elastic springs distributed in the WBC–EC contact region. Variations of the proportionality between wall shear stress (τ w ) in the vicinity of the WBC and the resulting drag force (F s ), i.e., Fs/τw, reveal its decrease with WBC deformation and increasing vessel channel height (2D). The computations also find that the peeling zone between adherent WBC and EC may account for less than 5% of the total contact interface. Computational studies describe the WBC–EC adhesion and the extent of WBC deformation during the adhesive process. © 1999 Biomedical Engineering Society. PAC99: 8717-d, 8719Tt, 8717Aa
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1114/1.143
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  • 7
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    miR-10a restores human mesenchymal stem cell differentiation by repressing KLF4 (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-05-22
    Description: miRNAs have recently been shown to play a significant role in human aging. However, data demonstrating the effects of aging-related miRNAs in human mesenchymal stem cells (hMSCs) are limited. We observed that hMSC differentiation decreased with aging. We also identified that miR-10a expression was significantly decreased with age by comparing the miRNA expression of hMSCs derived from young and aged individuals. Therefore, we hypothesized that the downregulation of miR-10a may be associated with the decreased differentiation capability of hMSCs from aged individuals. Lentiviral constructs were used to up- or downregulate miR-10a in young and old hMSCs. Upregulation of miR-10a resulted in increased differentiation to adipogenic, osteogenic, and chondrogenic lineages and in reduced cell senescence. Conversely, downregulation of miR-10a resulted in decreased cell differentiation and increased cell senescence. A chimeric luciferase reporter system was generated, tagged with the full-length 3'-UTR region of KLF4 harboring the seed-matched sequence with or without four nucleotide mutations. These constructs were cotransfected with the miR-10a mimic into cells. The luciferase activity was significantly repressed by the miR-10a mimic, proving the direct binding of miR-10a to the 3'-UTR of KLF4. Direct suppression of KLF4 in aged hMSCs increased cell differentiation and decreased cell senescence. In conclusion, miR-10a restores the differentiation capability of aged hMSCs through repression of KLF4. Aging-related miRNAs may have broad applications in the restoration of cell dysfunction caused by aging. J. Cell. Physiol. © 2013 Wiley Periodicals, Inc.
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
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  • 8
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    Risk Score to Predict Hospital-Acquired Pneumonia After Spontaneous Intracerebral Hemorrhage [Clinical Sciences] (2014)
    American Heart Association (AHA)
    In: Stroke
    Details
    Publication Date: 2014-08-26
    Description: Background and Purpose— We aimed to develop a risk score (intracerebral hemorrhage–associated pneumonia score, ICH-APS) for predicting hospital-acquired stroke-associated pneumonia (SAP) after ICH. Methods— The ICH-APS was developed based on the China National Stroke Registry (CNSR), in which eligible patients were randomly divided into derivation (60%) and validation (40%) cohorts. Variables routinely collected at presentation were used for predicting SAP after ICH. For testing the added value of hematoma volume measure, we separately developed 2 models with (ICH-APS-B) and without (ICH-APS-A) hematoma volume included. Multivariable logistic regression was performed to identify independent predictors. The area under the receiver operating characteristic curve (AUROC), Hosmer–Lemeshow goodness-of-fit test, and integrated discrimination index were used to assess model discrimination, calibration, and reclassification, respectively. Results— The SAP was 16.4% and 17.7% in the overall derivation (n=2998) and validation (n=2000) cohorts, respectively. A 23-point ICH-APS-A was developed based on a set of predictors and showed good discrimination in the overall derivation (AUROC, 0.75; 95% confidence interval, 0.72–0.77) and validation (AUROC, 0.76; 95% confidence interval, 0.71–0.79) cohorts. The ICH-APS-A was more sensitive for patients with length of stay 〉48 hours (AUROC, 0.78; 95% confidence interval, 0.75–0.81) than those with length of stay 〈48 hours (AUROC, 0.64; 95% confidence interval, 0.55–0.73). The ICH-APS-A was well calibrated (Hosmer–Lemeshow test) in the derivation ( P =0.20) and validation ( P =0.66) cohorts. Similarly, a 26-point ICH-APS-B was established. The ICH-APS-A and ICH-APS-B were not significantly different in discrimination and reclassification for SAP after ICH. Conclusion— The ICH-APSs are valid risk scores for predicting SAP after ICH, especially for patients with length of stay 〉48 hours.
    Keywords: Intracerebral Hemorrhage
    Print ISSN: 0039-2499
    Electronic ISSN: 1524-4628
    Topics: Medicine
    Published by American Heart Association (AHA)
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  • 9
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    Giant switchable photovoltaic effect in organometal trihalide perovskite devices (2015)
    Springer Nature
    Details
    Publication Date: 2015-01-24
    Description: Nature Materials 14, 193 (2015). doi:10.1038/nmat4150 Authors: Zhengguo Xiao, Yongbo Yuan, Yuchuan Shao, Qi Wang, Qingfeng Dong, Cheng Bi, Pankaj Sharma, Alexei Gruverman & Jinsong Huang Organolead trihalide perovskite (OTP) materials are emerging as naturally abundant materials for low-cost, solution-processed and highly efficient solar cells. Here, we show that, in OTP-based photovoltaic devices with vertical and lateral cell configurations, the photocurrent direction can be switched repeatedly by applying a small electric field of 〈1 V μm−1. The switchable photocurrent, generally observed in devices based on ferroelectric materials, reached 20.1 mA cm−2 under one sun illumination in OTP devices with a vertical architecture, which is four orders of magnitude larger than that measured in other ferroelectric photovoltaic devices. This field-switchable photovoltaic effect can be explained by the formation of reversible p–i–n structures induced by ion drift in the perovskite layer. The demonstration of switchable OTP photovoltaics and electric-field-manipulated doping paves the way for innovative solar cell designs and for the exploitation of OTP materials in electrically and optically readable memristors and circuits.
    Print ISSN: 1476-1122
    Electronic ISSN: 1476-4660
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 10
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    Enhanced functional connectivity and increased gray matter volume of insula related to action video game playing (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-04-17
    Description: Research has shown that distinct insular subregions are associated with particular neural networks (e.g., attentional and sensorimotor networks). Based on the evidence that playing action video games (AVGs) facilitates attentional and sensorimotor functions, this study examined the relation between AVG experience and the plasticity of insular subregions and the functional networks therein that are related to attentional and sensorimotor functions. By comparing AVG experts and amateurs, we found that AVG experts had enhanced functional connectivity and grey matter volume in insular subregions. Furthermore, AVG experts exhibited increased functional connectivity between the attentional and sensorimotor networks, and the experience-related enhancement was predominantly evident in the left insula, an understudied brain area. Thus, AVG playing may enhance functional integration of insular subregions and the pertinent networks therein. Scientific Reports 5 doi: 10.1038/srep09763
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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