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  • 11
    Electronic Resource
    Electronic Resource
    Clinical risk factors and prognostic significance of local recurrence in cutaneous melanoma (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 151 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  True local recurrence (LR) means clinically detectable regrowth of parts of the tumour which were not completely excised. In the literature the term ‘LR’ has been used in a vague and inconsistent manner that may include satellite and in-transit metastasis.Objective  The aim of this study was to establish clinical, histological and surgical risk factors for the manifestation of LR and to evaluate the prognostic significance of LR.Study design  Data from 3960 Stage I and II melanoma patients who visited the melanoma clinic of the Department of Dermatology at the University of Tuebingen from 1980 to 1999 were documented in a prospective manner. A retrospective comparative analysis of patients with and without LR was performed.Results  Of all patients 1·4% had a LR as a first recurrence and 1·7% had a LR in the course of the follow-up period. LR were most frequent after previous clinical or histological misdiagnosis and inadequate therapy. In the univariate analysis significant risk factors for LR-free survival were age, tumour surface area, locality, tumour thickness, level of invasion, histological type, associated naevus, surgery (one step vs. multiple steps) and compliance with recommended excision margins. In the multivarate analysis the factors locality (P 〈 0·0001), tumour thickness (P = 0·0086) and compliance with recommendations on excision margins (P = 0·014) were significant independent risk factors for the manifestation of LR. The overall survival of patients with LR as first progression did not significantly differ from the overall survival of the other patients with melanoma (P = 0·60).Conclusion  True LR is a rare event for which tumour locality, tumour thickness and surgery are independent risk factors. The occurrence of LR might not impair the prognosis of melanoma patients. However, in the published literature numerous definitions of ‘LR’, including lymphogenic metastasis, complicate comparison.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.06050.x
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  • 12
    Electronic Resource
    Electronic Resource
    The dermoscopic classification of atypical melanocytic naevi (Clark naevi) is useful to discriminate benign from malignant melanocytic lesions (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 149 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  The dermoscopic classification is a useful tool for handling patients with atypical naevi (Clark naevi).Objectives  To investigate if the dermoscopic classification of atypical naevi is of any value to discriminate benign from malignant melanocytic lesions.Methods  Consecutive patients (n = 205) were included with 254 suspicious melanocytic lesions, confirmed by histopathology at the Pigmented Lesions Clinic of the Department of Dermatology, University Medical Center, University of Tuebingen, Germany. In this retrospective study, dermoscopic images of benign and malignant melanocytic lesions were classified according to the dermoscopic classification of atypical naevi (reticular, globular, homogeneous or combinations of two of these) and pigmentation (uniform, central hyper- or hypopigmentation, eccentric peripheral hyper- or hypopigmentation, or multifocal hyper- or hypopigmentation). The three-structure type (reticular, globular and homogeneous) was additionally defined.Results  Reticular, homogeneous and reticular–homogeneous types were significantly more frequent in naevi than in melanomas, whereas the three-structure type was significantly more frequent in melanomas (P 〈 0·001). A sensitivity of 86·7%, specificity of 87·7% and diagnostic accuracy of 87·4% was obtained. Uniformly pigmented and centrally hyperpigmented types were significantly more frequent in naevi than in melanomas, whereas eccentric peripheral hyperpigmented and multifocal hyper- or hypopigmented types were significantly more frequent in melanomas (P 〈 0·001).Conclusions  The dermoscopic classification of atypical naevi (Clark naevi) is useful to discriminate benign from malignant melanocytic lesions. The three-structure type and eccentric peripheral hyperpigmentation were significantly more frequently found in malignant than in benign melanocytic lesions. The knowledge of these two dermoscopic types should be helpful for the management of patients presenting with multiple melanocytic lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2003.05343.x
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  • 13
    Electronic Resource
    Electronic Resource
    Destruction of tumour parenchyma in basal cell carcinoma by tumour-associated neutral proteases: a histochemical study (1991)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 124 (1991), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Proteolytic activity was demonstrated histochemically in frozen sections of basal cell carcinomas (BCCs). After incubation of tissue sections in 0.1 m phosphate buffer with 0.25 m NaCl the tumour epithelium was almost completely destroyed. The basal and squamous cell layers of the disintegrated to varying degrees, particularly where they were directly in contact with tumour epithelium. Serine and metalloprotease inhibitors diminished this tissue destruction, lodoacetate enhanced tumour destruction, urea and potassium thiocyanate even more so. The high proteolytic activity of BCC demonstrated in this study may be an important factor in the proliferative, invasive and destructive behaviour of this tumour.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1991.tb00572.x
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  • 14
    Electronic Resource
    Electronic Resource
    Digital image analysis for diagnosis of cutaneous melanoma. Development of a highly effective computer algorithm based on analysis of 837 melanocytic lesions (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 151 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Digital image analysis has been introduced into the diagnosis of skin lesions based on dermoscopic pictures.Objectives  To develop a computer algorithm for the diagnosis of melanocytic lesions and to compare its diagnostic accuracy with the results of established dermoscopic classification rules.Methods  In the Department of Dermatology, University of Tuebingen, Germany, 837 melanocytic skin lesions were prospectively imaged by a dermoscopy video system in consecutive patients. Of these lesions, 269 were excised and examined by histopathology: 84 were classified as cutaneous melanomas and 185 as benign melanocytic naevi. The remaining 568 lesions were diagnosed by dermoscopy as benign. Digital image analysis was performed in all 837 benign and malignant melanocytic lesions using 64 different analytical parameters.Results  For lesions imaged completely (diameter ≤ 12 mm), three analytical parameters were found to distinguish clearly between benign and malignant lesions, while in incompletely imaged lesions six parameters enabled differentiation. Based on the respective parameters and logistic regression analysis, a diagnostic computer algorithm for melanocytic lesions was developed. Its diagnostic accuracy was 82% for completely imaged and 84% for partially imaged lesions. All 837 melanocytic lesions were classified by established dermoscopic algorithms and the diagnostic accuracy was found to be in the same range (ABCD rule 78%, Menzies' score 83%, seven-point checklist 88%, and seven features for melanoma 81%).Conclusions  A diagnostic algorithm for digital image analysis of melanocytic lesions can achieve the same range of diagnostic accuracy as the application of dermoscopic classification rules by experts. The present diagnostic algorithm, however, still requires a medical expert who is qualified to recognize cutaneous lesions as being of melanocytic origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.06210.x
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  • 15
    Electronic Resource
    Electronic Resource
    Arterial embolization caused by injection of hyaluronic acid (Restylane®) (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 146 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.04707.x
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  • 16
    Electronic Resource
    Electronic Resource
    Intravenous regional anaesthesia for treatment of palmar hyperhidrosis with botulinum toxin type A (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 144 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04104.x
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  • 17
    Electronic Resource
    Electronic Resource
    Detection of melanoma cells in sentinel lymph nodes, bone marrow and peripheral blood by a reverse transcription–polymerase chain reaction assay in patients with primary cutaneous melanoma: association with Breslow's tumour thickness (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 145 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Tyrosinase reverse transcription–polymerase chain reaction (RT–PCR) has been shown to be highly sensitive in detecting tumour cells in melanoma patients. Objective To assess whether the detection of minimal residual disease by RT–PCR is improved by concomitant analysis of sentinel lymph nodes (SLNs), bone marrow (BM) and peripheral blood (PB) in patients with primary melanoma. Methods Thirty-five SLNs, 41 BM samples and 26 PB specimens from 26 patients with primary cutaneous melanoma (tumour thickness ≥ 0·75 mm) were examined by nested RT–PCR for tyrosinase and Melan-A. SLNs and BM samples were also analysed by histopathology. RT–PCR findings were related to tumour thickness of the primary melanoma. Results Overall, melanoma cells were detected by RT–PCR in 13 of 26 patients (50%). Seven patients had positive RT–PCR results in their SLNs (27%), including all patients (n = 4) with histologically positive SLNs, two patients had positive findings in their BM exclusively detected by RT–PCR (8%) and six patients in PB (23%). The presence of tumour cells detected by RT–PCR in SLNs was not related to the presence of melanoma cells in BM and/or PB. The incidence of RT–PCR-positive SLNs was significantly associated with greater tumour thickness (P = 0·004). Both patients with positive RT–PCR findings in their BM had a large tumour thickness (≥ 2 mm). No association between positive RT–PCR findings in PB and greater tumour thickness was observed. Conclusions RT–PCR-positive SLNs were strongly associated with greater tumour thickness, underlining the prognostic significance of SLN positivity. Similar to certain epithelial malignancies, molecular investigation of the BM might provide complementary prognostic information in the early stages of melanoma. In contrast, no association between positive RT–PCR results in PB and increasing tumour thickness was found, implying that RT–PCR findings in PB are of doubtful clinical relevance in primary melanoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04334.x
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  • 18
    Electronic Resource
    Electronic Resource
    Glykolyse und Pentosephosphat-Zyklus in der Epidermis bei Psoriasis vulgaris (1965)
    Springer
    Naturwissenschaften 52 (1965), S. 592-592 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00631363
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  • 19
    Electronic Resource
    Electronic Resource
    Zur enzymatischen Organisation des energieliefernden Stoffwechsels der normalen Meerschweinchenhaut (1965)
    Springer
    Archives of dermatological research 222 (1965), S. 391-402 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Mit adäquater Methodik werden in Meerschweinchenhaut Enzymaktivitäten der Glykolyse, des Pentosephosphat-Cyclus, des Citronensäure-Cyclus und verbundener Reaktionen des Aminosäuremetabolismus gemessen und zum Teil erstmalig im Hautorgan direkt-quantitative nachgewiesen (PGM, HIM, F-6-PK, TIM, GAPDH, PGK, GPM, EN, PK, GLUDH). Der Vergleich mit dem Aktivitätsmuster entsprechender Enzyme der Rattenleber läßt die geordnete Gestalt des Musters epidermaler Enzymaktivitäten sowie ihre Höhe als Zeichen eines aktiven Stoffwechsels deutlich werden. Dabei zeigen sich vergleichbare und organspezifische Abschnitte. Das Enzymaktivitätsmuster der Meerschweinchenepidermis entspricht einem Organ mit hoher Glykolyse sowie hohem Pentosephosphat-Cyclus und Aminosäuremetabolismus bei anscheinend niedrigem aerobem Stoffwechsel (Citronensäure-Cyclus-Atmungskette). Dieser Aufbau des energieliefernden Stoffwechsels trägt der Tatsache Rechnung, daß die Epidermis als synthetisierendes Gewebe zwar einen hohen Energiebedarf hat, jedoch vorwiegend auf Energiegewinnung durch Glykolyse (Milchsäurebildung) angewiesen ist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00515197
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  • 20
    Electronic Resource
    Electronic Resource
    Aktivitätsmuster von Enzymen des energieliefernden Stoffwechsels in normaler menschlicher Epidermis und bei Psoriasis vulgaris (1966)
    Springer
    Archives of dermatological research 225 (1966), S. 398-407 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. In normaler menschlicher Epidermis wurden sämtliche Enzyme der Glykolyse (HK, PGM, HIM, F-6-PK, ALD, TIM, GAPDH, PGK, GPM, EN, PK, LDH), NADP-spezifische Dehydrogenasen (G-6-PDH, 6-PGDH, ME, NADP-spezifische IDH), Glycerin-1-phosphat-Dehydrogenase und Malat-Dehydrogenase quantitativ bestimmt. Das erhaltene Aktivitätsmuster stimmt mit dem der Meerschweinchenepidermis weitgehend überein. 2. Vergleichende Untersuchungen klinisch nicht erkrankter Epidermis von Psoriasis-Patienten ergaben keinen sicheren Anhalt für Enzymaktivitätsveränderungen im Bereich der Glykolyse (ALD, TIM, GAPDH, PK, LDH), des Pentosephosphat-Cyclus (G-6-PDH, 6-PGDH) und anderer NADP-spezifischer Dehydrogenasen (ME, NADP-spezifische IDH). Demgegenüber zeigte das Enzym Glycerin-1-phosphat-Dehydrogenase (Wasserstofftransport, Fettstoffwechsel) in klinisch nicht erkrankter Epidermis bei Psoriasis vulgaris einen Aktivitätsverlust, der weiterer Nachprüfung bedarf.
    Notes: Summary 1. All the enzymes of the glycolysis (HK, PGM, HIM, F-6-PK, ALD, TIM, GAPDH, PGK, GPM, EN, PK, LDH), NADP-linked dehydrogenases (G-6-PDH, 6-PGDH, ME, NADP-linked IDH), glycerol-1-phosphate dehydrogenase und malate dehydrogenase were quantitatively determined in normal human epidermis. The activity pattern agreed to a large extent with that of the guinea pig epidermis. 2. Comparative investigations of clinically non-involved epidermis of patients with psoriasis did not show any definite changes in the enzyme activities of glycolysis (ALD, TIM, GAPDH, PK, LDH), pentose-phosphate cycle (G-6-PDH, 6-PGDH) and other NADP-linked dehydrogenases (ME, NADP-linked IDH). On the other hand, the enzyme glycerol-1-phosphate dehydrogenase (hydrogen transport lipid metabolism) showed a loss in activity in clinically non-involved epidermis of psoriatic patients. This requires further examination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00521131
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