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  • 11
    Electronic Resource
    Electronic Resource
    Springer
    Primates 11 (1970), S. 97-99 
    ISSN: 0032-8332
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 12
    ISSN: 0032-8332
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Individual variations ofα 1-antitrypsin of the macaques were investigated by means of starch gel electrophoresis. The material comprised a total of 1,084 plasma samples taken from six species, namely,Macaca irus, mulatta, cyclopis, nemestrina, speciosa, andfuscata, including several geographical groups. At least ten phenotypes which were assumed in analogy to human Pi-system to be under genetic control of five codominant alleles tentatively denoted byPi Mac A, B, C, D, E were identified. It was considered that these alleles are commonly possessed by different macaque species. A marked difference in the distribution of allele frequencies was found both within and between species groups. Several aspects of this new polymorphic variation in the macaques were discussed with special reference to the geographical distribution of the alleles and the origins of the Japanese macaque,M. fuscata.
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  • 13
    Electronic Resource
    Electronic Resource
    Springer
    Journal of human genetics 23 (1978), S. 119-125 
    ISSN: 1435-232X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution of Gc subtypes in a sample from 310 unrelated healthy Japanese living in Tokyo was examined by a slab polyacrylamide gel isoelectrofocusing followed by immunofixation. At least 9 phenotypes were distinguished which can be ascribed to four alleles:Gc 1F,Gc 1S,Gc 2 andGc J. The allele frequencies were 0.4656, 0.2590, 0.2574 and 0.0180, respectively. It was confirmed thatGc J has a polymorphic frequency in Japanese. Furthermore, two unusual phenotypes were encountered, one with a variant Gc 1 and the other with a variant Gc 2 protein, indicating the occurrence in Japanese of two further Gc alleles.
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  • 14
    ISSN: 1435-232X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Polymorphism of the fourth component of human complement (C4) was investigated in Japanese using an agarose gel electrophoresis and a slab polyacrylamide gel electrophoresis followed by immunofixation. Three common phenotypes were observed corresponding to the types F, FS and S reported in Europeans. Typing of the family material consisting of 48 matings with 96 offsprings showed no discrepancy from the postulate that C4 polymorphism is controlled by a pair of codominant alleles. In a sample from 291 unrelated healthy Japanese, the allele frequencies ofC4 F andC4 S are estimated at 0.543 and 0.457, respectively.
    Type of Medium: Electronic Resource
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  • 15
    ISSN: 1435-232X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Polymorphisms of the factor B and the second component of human complement were investigated in 220 unrelated healthy Koreans. In the BF system, three phenotypes, S, FS, and F, were observed, while no rare variants were detected. The estimated allele frequencies forBF * S andBF * F were 0.775 and 0.225 respectively. In the C2 system, one common phenotype, C, and three heterozygous types, BC, BHC, and ATC, were observed. The estimated allele frequencies forC2 * C,C2 * B,C2 * BH, andC2 * AT were 0.961, 0.018, 0.011, and 0.009, respectively. Significant positive association betweenC2 * AT andBF * F was found. Gene frequencies in Korean were compared with those in other populations.
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  • 16
    Electronic Resource
    Electronic Resource
    Springer
    Journal of human genetics 32 (1987), S. 83-89 
    ISSN: 1435-232X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The genetic polymorphism of serum group-specific component (Gc) was studied in two Chinese (Han) populations using isoelectric focusing followed by immunofixation. Six common and seven rare variant phenotypes were observed among 155 samples from Beijing and 256 samples from Guangzhou. The frequencies for the common alleles,Gc * 1F,Gc * 1S, andGc * 2, were 0.4774, 0.2000, and 0.3065, respectively, for Beijing, and 0.4316, 0.2891, and 0.2734, respectively, for Guangzhou. Only the frequency ofGc * 1S showed a statistically significant difference between the two localities. The rare Gc variants observed were: Gc 1A3, Gc 1A8, Gc 1C18 and Gc 2A4. Furthermore, two new rare Gc variants were detected and named Gc 1C50 and Gc 2A19.
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  • 17
    Electronic Resource
    Electronic Resource
    Springer
    Journal of human genetics 33 (1988), S. 41-47 
    ISSN: 1435-232X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary C7 polymorphism was investigated in a Japanese population (Tokyo). The C7 protein concentrations and hemolytic C7 activities in the serum samples of various phenotypes were measured by radial immuno-diffusion (RID) and radial diffusion hemolysis (RDH). The mean C7 protein levels for the common phenotypes C7 1, C7 2-1, C7 3-1, and C7 4-1 were 88%, 103%, 63%, and 94% of a standard, while the mean C7 activity levels were 96%, 90%, 63%, and 74%, respectively. Both the protein and the activity levels for C7 3-1 were significantly lower than those determined for the most common phenotype C7 1. The mean levels in two individuals of C7 3 phenotype were only 34% in protein concentration and 47% in functional activity. Concerning the ratio of functional to immunochemical C7 (i.e. the relative specific activity), there was no difference between the phenotypes C7 1 and C7 3-1. On the other hand, the mean hemolytic activity and the relative specific activity for C7 4-1 were significantly lower than those for C7 1.
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  • 18
    ISSN: 1435-232X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution of phenotypes for properdin factor B (BF) has been investigated in 50 IDDM patients and 52 NIDDM patients living in Guangzhou, southern China, using high voltage agarose gel electrophoresis followed by immunofixation. A significant decrease in the frequency of BF F positive patients (p〈0.01) and an increase in the gene frequency ofBF *S (p〈0.005) were found in IDDM as compared to 259 normal controls. The relative risk for the BF F positive patients in IDDM was 0.15. On the other hand, no significant association was observed between BF types and NIDDM.
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  • 19
    ISSN: 1435-232X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Genetic polymorphism of properdin factor B (BF) was investigated in sera from 259 healthy individuals living in Guangzhou, southern China, by means of high voltage agarose gel electrophoresis followed by immunofixation. Besides the common phenotypes, SS, FS, FF and SS07, two rare heterozygous phenotypes tentatively named as SSG1 and SFG2 were observed. The allele frequencies estimated forBF * S, BF * F, BF * S07, BF * SG1 andBF * FG2 were 0.8668, 0.1197, 0.0077, 0.0019 and 0.0039, respectively. Family data indicated an autosomal, codominant inheritance for theBF * FG2 allele.
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  • 20
    Electronic Resource
    Electronic Resource
    Springer
    Journal of human genetics 23 (1978), S. 139-143 
    ISSN: 1435-232X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Haemolysate samples from 414 unrelated Japanese living in Tokyo were examined for GLO phenotypes by starch gel electrophoresis using a tris-citrate-borate-LiOH buffer system, pH 7.4. Three phenotypes were found which were classified as GLO 1 (2; 0.48%) GLO 2-1 (40; 9.66%) and GLO 2 (372; 89.86%). The corresponding gene frequency forGLO 1 was 0.0531 and that forGLO 2 was 0.9469. It was confirmed that theGLO 1 frequency of Japanese is much lower than the values previously reported for Caucasians and Africans.
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