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  • 11
    Electronic Resource
    Electronic Resource
    Does Tar Belong in the Goeckerman Regimen? (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 21 (1982), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1982.tb03139.x
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  • 12
    Electronic Resource
    Electronic Resource
    Tar (1980)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 19 (1980), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1980.tb00301.x
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  • 13
    Electronic Resource
    Electronic Resource
    Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival (2002)
    [s.l.] : Nature Publishing Group
    Nature medicine 8 (2002), S. 514-517 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The only proven requirement for ascorbic acid (vitamin C) is in preventing scurvy, presumably because it is a cofactor for hydroxylases required for post-translational modifications that stabilize collagen. We have created mice deficient in the mouse ortholog (solute carrier family 23 member 1 or ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/0502-514
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  • 14
    Electronic Resource
    Electronic Resource
    Estimation of Secondary Structure in Ribonucleic Acids (1971)
    [s.l.] : Nature Publishing Group
    Nature 230 (1971), S. 362-367 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A simple method for estimating the secondary structure of an RNA molecule has been proposed on the basis of the knowledge of its ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/230362a0
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  • 15
    Electronic Resource
    Electronic Resource
    Does vitamin C have a pro-oxidant effect? (1998)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 395 (1998), S. 231-231 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The conclusions of the Scientific Correspondence by Podmore et al. are undermined by some unaddressed scientific issues. Podmore et al. gave vitamin C supplements of 500 milligrams to healthy volunteers, and measured levels of vitamin C in plasma and of oxidative DNA adducts in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/26137
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  • 16
    Electronic Resource
    Electronic Resource
    Ascorbic Acid: The Concept of Optimum Requirements (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 498 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb23779.x
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  • 17
    Electronic Resource
    Electronic Resource
    Ascorbic Acid Enhancement of Norepinephrine Biosynthesis in Chromaffin Cells and Chromaffin Vesicles (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 493 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb27194.x
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  • 18
    Electronic Resource
    Electronic Resource
    Hemostatic alterations in cancer patients (1992)
    Springer
    Cancer and metastasis reviews 11 (1992), S. 237-248 
    Details
    ISSN: 1573-7233
    Keywords: hypercoagulability ; thromboembolism ; fibrinopeptide A ; chemotherapy x surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nearly all patients with cancer manifest laboratory evidence of hypercoagulability and some develop clinical thromboembolic disease (TED). Routine laboratory studies of blood coagulation have been performed in several large, prospective trials of the use of anticoagulant drugs in cancer treatment. The results of these studies, as well as data from several smaller studies of more sensitive tests of hypercoagulability [e.g. fibrinopeptide A (FPA); thrombin-antithrombin (TAT) complexes; prothrombin fragment F1+2)], indicate that the levels of some clotting proteins parallel disease activity. However, no studies of sound methodologic design have yet been performed to indicate that any of these tests of blood coagulation can serve as adequate predictors of TED in patients with cancer. In addition to the important role played by tumor-related procoagulants, several other mechanisms may be involved in the pathogenesis of thromboembolic events in patients with cancer, including stasis and endothelial damage. Considerable variability in the relative importance of these mechanisms in the pathogenesis of TED may exist among patients with different types of cancer. The risk for TED associated with surgical procedures in cancer patients is substantial and prophylactic antithrombotic therapy should be considered for most of these patients. Chemotherapy and hormonal therapy of cancer probably increases the likelihood of TED, particularly in those subjects with indwelling venous catheters. This risk has been particularly well-studied in patients with breast cancer treated with tamoxifen plus cytotoxic drugs. The pathogenic mechanisms may be complex but vascular injury is likely as a proximate cause of venous access catheter thrombosis and can be prevented with low dose coumadin therapy. The utility of low dose coumadin anticoagulation in reducing the risk for TED during breast cancer treatment is unknown but is currently being tested in a large, multiinstitutional study. Since chronic coumadin anticoagulation of cancer patients, and single pulse dose heparin prior to intravenous chemotherapy, both prevent thrombin generation, these agents may be of use in reducing the risk of chemotherapy-associated thrombosis. Prophylactic anticoagulation should be considered for high risk patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01307180
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  • 19
    Electronic Resource
    Electronic Resource
    Pharmacokinetic Model of Ascorbic Acid in Healthy Male Volunteers During Depletion and Repletion (1997)
    Springer
    Pharmaceutical research 14 (1997), S. 1133-1139 
    Details
    ISSN: 1573-904X
    Keywords: ascorbic acid ; pharmacokinetics ; human ; models— theoretical ; models—nonlinear ; bioavailability ; ascorbic acid deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. To develop a new pharmacokinetic model for ascorbic acid (vitamin C) since no previously published model describes ascorbic acid absorption and disposition over a broad physiologic range of doses and plasma concentrations. Methods. A new model was developed through exploratory simulations. The model was fitted to pharmacokinetic data obtained from seven healthy volunteers who underwent ascorbic acid depletion then gradual repletion. Concentrations of ascorbic acid were measured in plasma and urine. Final pharmacokinetic model parameter estimates were obtained using nonlinear regression analysis. Results. The new model included saturable absorption, distribution and renal tubular reabsorption parameters. The model described ascorbic acid concentrations in plasma, cells, and urine during depletion and gradual repletion phases with a residual error less than 15%. Conclusions. The model was useful for obtaining a new understanding of the likely causes for the complex concentration-time profile observed during gradual repletion. At doses of 200 to 2500 mg per day, the plateau in pre-dose concentrations is largely due to apparent saturation of tissue uptake and less a function of oral bioavailability and renal excretion than previously thought.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1012186203165
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  • 20
    Electronic Resource
    Electronic Resource
    Electrophoretic transport of solutes in aqueous two-phase systems (1990)
    Weinheim : Wiley-Blackwell
    Electrophoresis 11 (1990), S. 605-611 
    Details
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Electrophoretic transport of proteins across the interface between the phases of an aqueous polymer two-phase system can be greatly impeded in comparison with transport within the individual phase. This effect can be controlled by modifying the affinity of the protein for a phase by suitable manipulations of such variables as pH. The effect is not caused by differences in the electrophoretic velocity between the two phases, nor by large changes in pH at the interface. An analogy exists between this phenomenon and the related subject of diffusion of electrolytes across the phase interface.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150110804
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