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  • Articles  (119)
  • Medicine  (106)
  • Energy, Environment Protection, Nuclear Power Engineering  (15)
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  • 1
    Electronic Resource
    Electronic Resource
    Les methodes de simulation sur ordinateur en cinetique chimique; Application a l'oxydo-reduction radiochimique du neptunium
    Amsterdam : Elsevier
    International Journal for Radiation Physics and Chemistry 5 (1973), S. 81-90 
    Details
    ISSN: 0020-7055
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0020-7055(73)90030-2
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  • 2
    Electronic Resource
    Electronic Resource
    Radiation-induced intracranial fibrochondrosarcoma (1986)
    Springer
    Journal of neurology 233 (1986), S. 309-310 
    Details
    ISSN: 1432-1459
    Keywords: Fibrochondrosarcoma ; Radiation-induced tumour ; Sarcoma ; Intracranial tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 50-year-old patient developed a left temporal fibrochondrosarcoma 27 years after radiation therapy for a suspected pituitary adenoma. The long latency between the irradiation and the development of the sarcoma and the histological nature of the tumour are unusual features for a malignant radiation-induced intracranial tumour. The histogenesis of fibrochondrosarcoma of the brain is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314165
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  • 3
    Electronic Resource
    Electronic Resource
    Risk Management for Hazardous Materials Transportation: A Local Study in Lyons (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Risk analysis 9 (1989), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: A probabilistic risk assessment study has been undertaken in the French city of Lyons. The issue was to know whether it was justified to forbid hazardous material lorries in the city center and to divert them through the suburbs. Therefore, two routes, the City Center route and the Suburban route were compared. This paper describes the analysis and shows how the results were used in the decision-making process. It also lists the difficulties that are encountered when trying to incorporate formal risk analysis into actual decision-making processes. The risk analysis showed that rerouting is an effective option with respect to all criteria. The mathematical expectation of the number of deaths is divided by three, the reduction on the annual frequency of catastrophic accidents is even more important (about one order of magnitude for accidents involving more than 50 deaths). The spatial analysis proved that the risk was more evenly distributed along the Suburban route. However, the annual expected number of death is low: 0.5 in the worst case. So traditional decision-making approaches do not indicate the necessity of rerouting. Such a situation is believed to be typical for risk management of major hazards. In Lyons, the use of a very small risk aversion factor is sufficient to justify the rerouting option on a formal decision-aiding basis. This is rather unusual, but it is thought that the recognition of the importance of risk aversion by the decision-makers themselves is a very positive outcome from this study.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1539-6924.1989.tb01255.x
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  • 4
    Electronic Resource
    Electronic Resource
    Risk Perception and Social Acceptability of Technologies: The French Case (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Risk analysis 9 (1989), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: The authors present results of a February 1987 survey on judged frequency of mortality causes and risk perception of technologies in a representative sample of the French population. Although the French context is very different, and the impact of public controversies have been very limited on technological choices such as the nuclear energy program, strong similarities in risk perception of technologies are observed with results from U.S. surveys. Results, which could be worthwhile for other countries, suggest that risk perception is influenced by two different types of components. The first influence is the global feeling of “security” that society procures to its members. Such feeling depends on the individual's socioeconomic status, subjective state of health, and personal discomfort in daily life, and explains individual aversion to risk independently of the mortality causes or technologies involved. The second influence is the degree of perceived social legitimization of the activities involving risks. Risks of medical and transportation activities are strongly opposed to illegitimate risky behaviors (smoking, drugs, alcohol); technologies which have been an object of public debate (nuclear plants, the chemical industry, lead in gasoline) have an intermediate position reflecting the remaining uncertainties of public opinion about their risk–benefit balancing. Tentative conclusions for risk communication are proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1539-6924.1989.tb01242.x
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  • 5
    Electronic Resource
    Electronic Resource
    Tumour phase of mycosis fungoides in the tongue (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 20 (1992), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1992.tb00927.x
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  • 6
    Electronic Resource
    Electronic Resource
    Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain (2004)
    Oxford, UK : Blackwell Science, Ltd
    European journal of neuroscience 19 (2004), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A major goal of research on addiction is to identify the molecular mechanisms of long-lasting behavioural alterations induced by drugs of abuse. Cocaine and delta-9-tetrahydrocannabinol (THC) activate extracellular signal-regulated kinase (ERK) in the striatum and blockade of the ERK pathway prevents establishment of conditioned place preference to these drugs. However, it is not known whether activation of ERK in the striatum is specific for these two drugs and/or this brain region. We studied the appearance of phospho-ERK immunoreactive neurons in CD−1 mouse brain following acute administration of drugs commonly abused by humans, cocaine, morphine, nicotine and THC, or of other psychoactive compounds including caffeine, scopolamine, antidepressants and antipsychotics. Each drug generated a distinct regional pattern of ERK activation. All drugs of abuse increased ERK phosphorylation in nucleus accumbens, lateral bed nucleus of the stria terminalis, central amygdala and deep layers of prefrontal cortex, through a dopamine D1 receptor-dependent mechanism. Although some non-addictive drugs moderately activated ERK in a few of these areas, they never induced this combined pattern of strong activation. Antidepressants and caffeine activated ERK in hippocampus and cerebral cortex. Typical antipsychotics mildly activated ERK in dorsal striatum and superficial prefrontal cortex, whereas clozapine had no effect in the striatum, but more widespread effects in cortex and amygdala. Our results outline a subset of structures in which ERK activation might specifically contribute to the long-term effects of drugs of abuse, and suggest mapping ERK activation in brain as a way to identify potential sites of action of psychoactive drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.2004.03278.x
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  • 7
    Electronic Resource
    Electronic Resource
    Δ9-tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic transmission (2001)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 14 (2001), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: It is now well established that central effects of Δ9-tetrahydrocannabinol (THC), the main psychoactive component of marijuana, are mediated by CB1 cannabinoid receptors. However, intraneuronal signalling pathways activated in vivo by THC remain poorly understood. We show that acute administration of THC induces a progressive and transient activation (i.e. phosphorylation) of the mitogen activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) in the dorsal striatum and the nucleus accumbens (NA). This activation, corresponding to both neuronal cell bodies and the surrounding neuropil, is totally inhibited by the selective antagonist of CB1 cannabinoid receptors, SR 141716A. However, blockade of dopaminergic (DA) D1 receptors by administration of SCH 23390, prior to THC, totally prevents ERK activation in the striatum, thus demonstrating a critical involvement of DA systems in THC-induced ERK activation. DA-D2 and glutamate receptors of NMDA subtypes also participate, albeit to a lesser extent, to THC-induced ERK activation in the striatum, as shown after injection of selective antagonists (raclopride and MK801, respectively). Furthermore, THC-induced phosphorylation of the transcription factor Elk-1, and up-regulation of zif268 mRNA expression are blocked by SL327, a specific inhibitor of MAPK/ERK kinase (MEK), the upstream kinase of ERK, as well as SCH 23390. Finally, using the place-preference paradigm, we show that ERK inhibition blocks THC-induced rewarding properties. Altogether, our data strongly support that ERK activation in the striatum is critically involved in long-term neuronal adaptive responses underlying THC-induced long-term behaviours.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0953-816x.2001.01652.x
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  • 8
    Electronic Resource
    Electronic Resource
    Interacting effects of CO2 partial pressure and temperature on photosynthesis and calcification in a scleractinian coral (2003)
    Oxford, UK : Blackwell Science Ltd
    Global change biology 9 (2003), S. 0 
    Details
    ISSN: 1365-2486
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: We show here that CO2 partial pressure (pCO2) and temperature significantly interact on coral physiology. The effects of increased pCO2 and temperature on photosynthesis, respiration and calcification rates were investigated in the scleractinian coral Stylophora pistillata. Cuttings were exposed to temperatures of 25°C or 28°C and to pCO2 values of ca. 460 or 760 μatm for 5 weeks. The contents of chlorophyll c2 and protein remained constant throughout the experiment, while the chlorophyll a content was significantly affected by temperature, and was higher under the ‘high-temperature–high-pCO2’ condition. The cell-specific density was higher at ‘high pCO2’ than at ‘normal pCO2’ (1.7 vs. 1.4). The net photosynthesis normalized per unit protein was affected by both temperature and pCO2, whereas respiration was not affected by the treatments. Calcification decreased by 50% when temperature and pCO2 were both elevated. Calcification under normal temperature did not change in response to an increased pCO2. This is not in agreement with numerous published papers that describe a negative relationship between marine calcification and CO2. The confounding effect of temperature has the potential to explain a large portion of the variability of the relationship between calcification and pCO2 reported in the literature, and warrants a re-evaluation of the projected decrease of marine calcification by the year 2100.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2486.2003.00678.x
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  • 9
    Electronic Resource
    Electronic Resource
    A new mechanism of antibiotic resistance in Enterobacteriaceae induced by a structural modification of the major porin (2001)
    Oxford, UK : Blackwell Science Ltd
    Molecular microbiology 41 (2001), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In Enterobacter aerogenes, multidrug resistance involves a decrease in outer membrane permeability associated with changes in an as yet uncharacterized porin. We purified the major porin from the wild-type strain and a resistant strain. We characterized this porin, which was found to be an OmpC/OmpF-like protein and analysed its pore-forming properties in lipid bilayers. The porin from the resistant strain was compared with the wild-type protein and we observed (i) that its single-channel conductance was 70% lower than that of the wild type; (ii) that it was three times more selective for cations; (iii) a lack of voltage sensitivity. These results indicate that the clinical strain is able to synthesize a modified porin that decreases the permeability of the outer membrane. Mass spectrometry experiments identified a G to D mutation in the putative loop 3 of the porin. Given the known importance of this loop in determining the pore properties of porins, we suggest that this mutation is responsible for the novel resistance mechanism developed by this clinical strain, with changes in porin channel function acting as a new bacterial strategy for controlling β-lactam diffusion via porins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2958.2001.02501.x
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  • 10
    Electronic Resource
    Electronic Resource
    Involvement of OmpF during reception and translocation steps of colicin N entry (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Molecular microbiology 4 (1990), S. 0 
    Details
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: [125I]-colicin N binds to OmpF receptor sites (70000 per cell) with an average Kassoc of 3.2 × 106 M−1 at 23°C. Monoclonal antibody directed against a cell-surface-exposed epitope of OmpF is able to compete with the binding of the colicin in vitro and also to protect against colicin N in vivo. OmpF is an absolute requirement for colicin N uptake. OmpC cannot serve as a substitute for OmpF during translocation across the outer membrane under receptor bypass conditions, which is in contrast to colicin A. Colicin N does not cross-react with various monoclonal antibodies directed against colicin A.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2958.1990.tb00551.x
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