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  • 1
    Electronic Resource
    Electronic Resource
    A confocal fiber-coupled single-lens theta microscope (1998)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 69 (1998), S. 2956-2963 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A confocal theta microscope using a single water-immersion objective lens is described. The system is based on the Zeiss Axioplan universal microscope, such that the illumination light is coupled into, and the detected light out of, the microscope optics via optical fibers attached to the reflector slider of the microscope. Conventional wide-field, laser-scanning confocal, confocal theta, and 4Pi-confocal theta microscopy modes are available with the system. As the design can be easily adapted to other microscopes, objective lenses, and wavelengths, it allows confocal theta techniques to be implemented in many standard systems. The design constraints and specifications for the microscope are given, as well as a demonstration of its performance. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1149040
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  • 2
    Electronic Resource
    Electronic Resource
    The early Miocene onset of a ventilated circulation regime in the Arctic Ocean (2007)
    [s.l.] : Nature Publishing Group
    Nature 447 (2007), S. 986-990 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Deep-water formation in the northern North Atlantic Ocean and the Arctic Ocean is a key driver of the global thermohaline circulation and hence also of global climate. Deciphering the history of the circulation regime in the Arctic Ocean has long been prevented by the lack of data from cores ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature05924
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Contribution of Southern Ocean surface-water stratification to low atmospheric CO 2 concentrations during the last glacial period (1997)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 389 (1997), S. 929-935 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The nitrogen-isotope record preserved in Southern Ocean sediments, along with several geochemical tracers for the settling fluxes of biogenic matter, reveals patterns of past nutrient supply to phytoplankton and surface-water stratification in this oceanic region. Areal averaging of these spatial ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/40073
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  • 4
    Electronic Resource
    Electronic Resource
    Über die Versorgung des Bruchsackes und dessen Verwendung zum plastischen Verschluß der Bruchpforte bei Leisten- und Schenkelhernien (1952)
    Springer
    Langenbeck's archives of surgery 271 (1952), S. 240-252 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wird über eine neue Methode der Hernienplastik bei Inguinal- und Cruralhernien berichtet, wobei auf folgende 3 Momente besonders Wert gelegt wird: 1. Die sorgfältige Präparation des Bruchsackes und seine ordnungsgemäße Versorgung durch Verlagerung nach medial und oben nach vorheriger Torsion sind die wichtigen Voraussetzungen für die Dauerheilung der Leisten- und Schenkelhernien. 2. Die plastische Wiederherstellung der Bauchwand im Bereiche des Trig. ing. ist grundsätzlich nach den vonBassini aufgestellten Richtlinien vorzunehmen, das Vorgehen wird dabei beim Einzelfall durch die Verhältnisse im Leistenkanal bestimmt. Als ganz besonders wichtig wird bei medialer Leistenhernie und bei cruraler Hernie betrachtet, das Schambeinperiost in die Naht mitzufassen. 3. Der Bruchsack wird bei allen großen Hernien der besprochenen Bruchformen zur Vermehrung der Bauchwandschichten verwendet. Dieser erhöht die Verschlußfestigkeit der Bruchpforte und schützt die Muskulatur vor Quetschung durch das Nahtmaterial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01403805
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of ryanodine on myocardial calcium (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 35-47 
    Details
    ISSN: 1432-1912
    Keywords: Guinea Pig Atrial Muscle ; Ryanodine ; Ryanodine Steady-State Condition ; Post-Rest Potentiation ; Calcium Exchange
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of ryanodine and ryanodine steady-state condition (RSSC) on contractile-related calcium were examined in isolated guinea pig left atrial muscle. 1. RSSC is a specific irreversible condition occurring after a brief exposure to 1×10−7 M ryanodine, followed by washing. It is characterized by elimination of the contraction following a 10-sec rest interval (post-rest) and prolongation of the associated action potential duration (AP50%) from 78.9 to 160.8 msec with minimal alteration in steady-state tension development determined at 1 Hz. 2. Induction of RSSC with a ryanodine-bovine serum albumin conjugate produced similar alterations in post-rest contractile strength and action potential duration. 3. In the presence of 1×10−7 M ryanodine, guinea pig left atria exhibit a significant increase in total 45Ca efflux from two rapidly exchangeable compartments (compartment 1, t 1/2=1.58 min; compartment 2, t 1/2-8.20 min). 4. In atria loaded after the induction of RSSC, total 45Ca release was significantly reduced by 7.2% of the total exchange. 5. The 45Ca exchange space for RSSC atria was reduced from 23.22±0.81 to 19.85±1.22 ml per 100 g muscle without a significant reduction in the total exchange space. 6. From these results, it is concluded that the effects of low concentrations of ryanodine and RSSC are to alter the contractile calcium levels of the tissue, primarily from sarcolemmal membrane sites which regulate post-rest contractile strength and action potential duration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499988
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  • 6
    Electronic Resource
    Electronic Resource
    Plasticity of the landing response of Drosophila melanogaster (1991)
    Springer
    Journal of comparative physiology 169 (1991), S. 323-330 
    Details
    ISSN: 1432-1351
    Keywords: Habituation ; Contralateral sensitization ; Leaky integrator ; Rotation detectors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fruitflies (Drosophila melanogaster) may respond with landing reactions in tethered flight to unilateral progressive motion of single vertical dark stripes. The response frequency to repeated unilateral stimulation has a characteristic time course, a fast increase followed by a slower decrease. This behaviour is explained by the habituation of the input channels to a leaky integrator. The half-life of the integrated signal is in the range of 1 s. ‘Contralateral sensitization’ (CoS) describes the sensitization of the landing response to unilateral stimuli by preceding contralateral stimulation. It acts by increasing the initial reactivity, which habituates. The effects of CoS are thus still obvious after 1 min of repetitive stimulation. CoS can effectively be mediated by movement stimuli as well as by flickering light. We also show that binocular rotation rather than unilateral back to front motion inhibits the landing response (in the monocular part of the visual field). The biological significance of the described temporal characteristics of the landing response system and their possible neuronal basis are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206996
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  • 7
    Electronic Resource
    Electronic Resource
    Non-neuronal cells in the spinal cord of nude and heterozygous mice. I. Ventral horn neuroglia (1981)
    Springer
    Journal of neurocytology 10 (1981), S. 805-818 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A quantitative light microscopic analysis of the ventral grey matter in the lumbar spinal cord of homozygous nude (nu/nu) and heterozygous (nu/+) mice was performed to determine the possible contribution of lymphocytes to normal C.N.S. tissue. If lymphocytes were present in the neuropil, they could be mistaken for neuroglial cells. Athymic nude mice offer a good model, since they lack T-lymphocytes and symptoms of neurological involvement. Mean cell counts from 1 μm sections were tested by analysis of variance. There were no strain differences for the area and number of neurons. The total neuroglial cell count was also similar, but the number of oligodendrocytes decreased 28%, astrocytes increased 51% and microglia were unchanged in the nude compared with the heterozygous mouse. There were no qualitative differences at the ultrastructural level among the neuroglia of either strain. Either the genetic defect retards and alters neuroglial cell development, or some of the small, round dark nuclei belong to lymphocytes, which have earlier migrated into the C.N.S. parenchyma. Lymphocytes could then participate in a cell-mediated immune response with brain macrophages, which are thought to be primarily derived from mononuclear leukocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01262654
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  • 8
    Electronic Resource
    Electronic Resource
    Zur Behandlung von Mineralstoffwechselstörungen des Knochens unter besonderer Berücksichtigung der verzögerten Frakturheilung (1953)
    Springer
    Langenbeck's archives of surgery 274 (1953), S. 159-169 
    Details
    ISSN: 1435-2451
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenjassung Es wird versucht, den Ursachen für das häufig beobachtete Versagen einer einseitigen Calciumbehandlung bei Demineralisation der Knochen, in erster Linie bei verzögerter Frakturenheilung, nachzugehen und die heutige Auffassung von dem normalen und gestörten Mineralstoffwechsel des Skeletsystems zu resümieren. Daraus wird die Erkenntnis abgeleitet, daß es nicht genüge, bei derartigen Zuständen nur einen einzigen Ossifikationsfaktor zu ersetzen, sondern im Sinne einer spezifisehen Organotherapie die Darreichung eines Knochenvollpräparates nottue. Als geeignetes Präparat wurde bei 14 KrankenOssopan angewendet und damit ein regelmäßiger Erfolg erzielt, der nicht nur die deduzierten Erwartungen voll erfüllt hat, sondern diese Darreichung auch in Zukunft und auf breiter Basis empfiehlt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01399749
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  • 9
    Electronic Resource
    Electronic Resource
    Inexpensive analogue amplifier for mechanical recording (1978)
    Springer
    Medical & biological engineering & computing 16 (1978), S. 118-120 
    Details
    ISSN: 1741-0444
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02442946
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  • 10
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    Effects of rapamycin on growth hormone receptor knockout mice [Developmental Biology] (2018)
    National Academy of Sciences
    Details
    Publication Date: 2018-02-14
    Description: It is well documented that inhibition of mTORC1 (defined by Raptor), a complex of mechanistic target of rapamycin (mTOR), extends life span, but less is known about the mechanisms by which mTORC2 (defined by Rictor) impacts longevity. Here, rapamycin (an inhibitor of mTOR) was used in GHR-KO (growth hormone receptor...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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